Amino acid dipepetide frequency for Candidatus Phytoplasma solani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.351AlaAla: 2.351 ± 0.162
0.614AlaCys: 0.614 ± 0.057
1.748AlaAsp: 1.748 ± 0.121
2.173AlaGlu: 2.173 ± 0.14
2.855AlaPhe: 2.855 ± 0.123
2.273AlaGly: 2.273 ± 0.138
0.877AlaHis: 0.877 ± 0.063
4.367AlaIle: 4.367 ± 0.166
4.818AlaLys: 4.818 ± 0.177
6.088AlaLeu: 6.088 ± 0.196
0.829AlaMet: 0.829 ± 0.074
2.719AlaAsn: 2.719 ± 0.114
1.223AlaPro: 1.223 ± 0.092
2.714AlaGln: 2.714 ± 0.143
1.575AlaArg: 1.575 ± 0.093
2.771AlaSer: 2.771 ± 0.136
2.735AlaThr: 2.735 ± 0.161
2.33AlaVal: 2.33 ± 0.13
0.273AlaTrp: 0.273 ± 0.043
1.617AlaTyr: 1.617 ± 0.088
0.0AlaXaa: 0.0 ± 0.0
Cys
0.331CysAla: 0.331 ± 0.041
0.257CysCys: 0.257 ± 0.041
0.462CysAsp: 0.462 ± 0.06
0.373CysGlu: 0.373 ± 0.045
0.877CysPhe: 0.877 ± 0.061
0.509CysGly: 0.509 ± 0.057
0.325CysHis: 0.325 ± 0.044
0.703CysIle: 0.703 ± 0.064
0.625CysLys: 0.625 ± 0.065
1.228CysLeu: 1.228 ± 0.088
0.131CysMet: 0.131 ± 0.031
0.493CysAsn: 0.493 ± 0.057
0.315CysPro: 0.315 ± 0.044
0.64CysGln: 0.64 ± 0.062
0.273CysArg: 0.273 ± 0.035
0.525CysSer: 0.525 ± 0.048
0.294CysThr: 0.294 ± 0.043
0.42CysVal: 0.42 ± 0.042
0.136CysTrp: 0.136 ± 0.034
0.404CysTyr: 0.404 ± 0.049
0.0CysXaa: 0.0 ± 0.0
Asp
2.136AspAla: 2.136 ± 0.122
0.388AspCys: 0.388 ± 0.044
2.141AspAsp: 2.141 ± 0.124
2.63AspGlu: 2.63 ± 0.146
3.307AspPhe: 3.307 ± 0.116
2.236AspGly: 2.236 ± 0.143
0.819AspHis: 0.819 ± 0.054
4.383AspIle: 4.383 ± 0.15
4.85AspLys: 4.85 ± 0.19
5.348AspLeu: 5.348 ± 0.199
0.504AspMet: 0.504 ± 0.043
2.892AspAsn: 2.892 ± 0.128
1.638AspPro: 1.638 ± 0.096
2.267AspGln: 2.267 ± 0.134
1.202AspArg: 1.202 ± 0.075
2.346AspSer: 2.346 ± 0.122
2.01AspThr: 2.01 ± 0.102
2.493AspVal: 2.493 ± 0.134
0.362AspTrp: 0.362 ± 0.051
2.042AspTyr: 2.042 ± 0.097
0.0AspXaa: 0.0 ± 0.0
Glu
3.412GluAla: 3.412 ± 0.151
0.357GluCys: 0.357 ± 0.052
2.225GluAsp: 2.225 ± 0.127
4.824GluGlu: 4.824 ± 0.286
2.85GluPhe: 2.85 ± 0.149
2.351GluGly: 2.351 ± 0.125
0.856GluHis: 0.856 ± 0.068
7.091GluIle: 7.091 ± 0.38
7.38GluLys: 7.38 ± 0.305
5.884GluLeu: 5.884 ± 0.28
1.223GluMet: 1.223 ± 0.091
4.262GluAsn: 4.262 ± 0.216
1.239GluPro: 1.239 ± 0.071
3.338GluGln: 3.338 ± 0.217
1.538GluArg: 1.538 ± 0.113
2.451GluSer: 2.451 ± 0.118
4.141GluThr: 4.141 ± 0.214
3.307GluVal: 3.307 ± 0.148
0.257GluTrp: 0.257 ± 0.037
2.105GluTyr: 2.105 ± 0.142
0.0GluXaa: 0.0 ± 0.0
Phe
2.267PheAla: 2.267 ± 0.126
0.835PheCys: 0.835 ± 0.06
2.997PheAsp: 2.997 ± 0.124
2.955PheGlu: 2.955 ± 0.137
4.251PhePhe: 4.251 ± 0.209
2.183PheGly: 2.183 ± 0.123
1.039PheHis: 1.039 ± 0.086
4.692PheIle: 4.692 ± 0.191
4.776PheLys: 4.776 ± 0.168
7.931PheLeu: 7.931 ± 0.278
0.95PheMet: 0.95 ± 0.074
3.784PheAsn: 3.784 ± 0.141
1.543PhePro: 1.543 ± 0.09
2.777PheGln: 2.777 ± 0.12
1.459PheArg: 1.459 ± 0.087
3.475PheSer: 3.475 ± 0.148
2.372PheThr: 2.372 ± 0.152
2.798PheVal: 2.798 ± 0.137
0.535PheTrp: 0.535 ± 0.046
2.624PheTyr: 2.624 ± 0.136
0.0PheXaa: 0.0 ± 0.0
Gly
2.283GlyAla: 2.283 ± 0.128
0.346GlyCys: 0.346 ± 0.045
1.816GlyAsp: 1.816 ± 0.159
2.194GlyGlu: 2.194 ± 0.201
2.829GlyPhe: 2.829 ± 0.144
2.267GlyGly: 2.267 ± 0.137
0.95GlyHis: 0.95 ± 0.075
4.209GlyIle: 4.209 ± 0.164
4.624GlyLys: 4.624 ± 0.178
4.062GlyLeu: 4.062 ± 0.181
0.945GlyMet: 0.945 ± 0.08
2.068GlyAsn: 2.068 ± 0.112
1.008GlyPro: 1.008 ± 0.114
2.042GlyGln: 2.042 ± 0.116
1.386GlyArg: 1.386 ± 0.094
2.619GlySer: 2.619 ± 0.124
2.861GlyThr: 2.861 ± 0.126
2.614GlyVal: 2.614 ± 0.135
0.252GlyTrp: 0.252 ± 0.041
1.758GlyTyr: 1.758 ± 0.114
0.0GlyXaa: 0.0 ± 0.0
His
0.814HisAla: 0.814 ± 0.071
0.226HisCys: 0.226 ± 0.031
0.74HisAsp: 0.74 ± 0.072
0.945HisGlu: 0.945 ± 0.086
1.459HisPhe: 1.459 ± 0.095
0.814HisGly: 0.814 ± 0.063
0.73HisHis: 0.73 ± 0.069
1.443HisIle: 1.443 ± 0.087
1.585HisLys: 1.585 ± 0.09
2.666HisLeu: 2.666 ± 0.128
0.252HisMet: 0.252 ± 0.037
1.286HisAsn: 1.286 ± 0.08
0.987HisPro: 0.987 ± 0.083
1.506HisGln: 1.506 ± 0.102
0.625HisArg: 0.625 ± 0.061
1.002HisSer: 1.002 ± 0.079
0.961HisThr: 0.961 ± 0.074
0.724HisVal: 0.724 ± 0.06
0.079HisTrp: 0.079 ± 0.019
0.871HisTyr: 0.871 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
5.165IleAla: 5.165 ± 0.192
1.023IleCys: 1.023 ± 0.078
5.012IleAsp: 5.012 ± 0.172
5.6IleGlu: 5.6 ± 0.2
4.671IlePhe: 4.671 ± 0.164
3.706IleGly: 3.706 ± 0.175
1.58IleHis: 1.58 ± 0.094
9.82IleIle: 9.82 ± 0.284
11.216IleLys: 11.216 ± 0.3
8.928IleLeu: 8.928 ± 0.266
1.464IleMet: 1.464 ± 0.093
6.949IleAsn: 6.949 ± 0.243
3.123IlePro: 3.123 ± 0.136
3.999IleGln: 3.999 ± 0.177
2.519IleArg: 2.519 ± 0.115
5.401IleSer: 5.401 ± 0.196
5.941IleThr: 5.941 ± 0.199
4.629IleVal: 4.629 ± 0.155
0.472IleTrp: 0.472 ± 0.055
2.897IleTyr: 2.897 ± 0.154
0.0IleXaa: 0.0 ± 0.0
Lys
4.991LysAla: 4.991 ± 0.197
0.593LysCys: 0.593 ± 0.056
5.354LysAsp: 5.354 ± 0.173
8.886LysGlu: 8.886 ± 0.39
2.976LysPhe: 2.976 ± 0.114
4.099LysGly: 4.099 ± 0.215
2.026LysHis: 2.026 ± 0.1
11.626LysIle: 11.626 ± 0.265
13.405LysLys: 13.405 ± 0.374
8.797LysLeu: 8.797 ± 0.247
2.567LysMet: 2.567 ± 0.112
9.133LysAsn: 9.133 ± 0.35
3.202LysPro: 3.202 ± 0.133
5.459LysGln: 5.459 ± 0.232
3.223LysArg: 3.223 ± 0.142
4.866LysSer: 4.866 ± 0.212
8.849LysThr: 8.849 ± 0.253
4.456LysVal: 4.456 ± 0.162
0.562LysTrp: 0.562 ± 0.064
3.847LysTyr: 3.847 ± 0.158
0.0LysXaa: 0.0 ± 0.0
Leu
5.327LeuAla: 5.327 ± 0.181
0.908LeuCys: 0.908 ± 0.071
4.986LeuAsp: 4.986 ± 0.184
7.763LeuGlu: 7.763 ± 0.292
5.663LeuPhe: 5.663 ± 0.237
5.212LeuGly: 5.212 ± 0.216
1.753LeuHis: 1.753 ± 0.11
9.18LeuIle: 9.18 ± 0.27
12.082LeuLys: 12.082 ± 0.274
10.356LeuLeu: 10.356 ± 0.296
1.911LeuMet: 1.911 ± 0.089
6.645LeuAsn: 6.645 ± 0.177
2.934LeuPro: 2.934 ± 0.146
5.506LeuGln: 5.506 ± 0.247
2.645LeuArg: 2.645 ± 0.116
6.991LeuSer: 6.991 ± 0.208
6.745LeuThr: 6.745 ± 0.188
5.191LeuVal: 5.191 ± 0.182
0.572LeuTrp: 0.572 ± 0.058
2.918LeuTyr: 2.918 ± 0.134
0.0LeuXaa: 0.0 ± 0.0
Met
1.013MetAla: 1.013 ± 0.067
0.126MetCys: 0.126 ± 0.025
0.609MetAsp: 0.609 ± 0.056
0.745MetGlu: 0.745 ± 0.071
0.824MetPhe: 0.824 ± 0.071
0.761MetGly: 0.761 ± 0.062
0.357MetHis: 0.357 ± 0.044
1.816MetIle: 1.816 ± 0.1
1.863MetLys: 1.863 ± 0.096
1.701MetLeu: 1.701 ± 0.097
0.399MetMet: 0.399 ± 0.048
1.191MetAsn: 1.191 ± 0.08
0.572MetPro: 0.572 ± 0.061
1.06MetGln: 1.06 ± 0.078
0.467MetArg: 0.467 ± 0.045
1.155MetSer: 1.155 ± 0.075
1.233MetThr: 1.233 ± 0.084
0.73MetVal: 0.73 ± 0.065
0.084MetTrp: 0.084 ± 0.025
0.425MetTyr: 0.425 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.582AsnAla: 2.582 ± 0.121
0.688AsnCys: 0.688 ± 0.067
2.992AsnAsp: 2.992 ± 0.128
3.984AsnGlu: 3.984 ± 0.214
4.215AsnPhe: 4.215 ± 0.146
1.968AsnGly: 1.968 ± 0.106
1.596AsnHis: 1.596 ± 0.086
5.968AsnIle: 5.968 ± 0.224
7.516AsnLys: 7.516 ± 0.221
7.401AsnLeu: 7.401 ± 0.232
1.107AsnMet: 1.107 ± 0.073
5.805AsnAsn: 5.805 ± 0.228
3.322AsnPro: 3.322 ± 0.165
5.285AsnGln: 5.285 ± 0.412
1.491AsnArg: 1.491 ± 0.089
3.543AsnSer: 3.543 ± 0.144
3.27AsnThr: 3.27 ± 0.164
2.519AsnVal: 2.519 ± 0.121
0.446AsnTrp: 0.446 ± 0.049
3.322AsnTyr: 3.322 ± 0.14
0.0AsnXaa: 0.0 ± 0.0
Pro
1.139ProAla: 1.139 ± 0.091
0.346ProCys: 0.346 ± 0.044
1.412ProAsp: 1.412 ± 0.1
1.979ProGlu: 1.979 ± 0.1
2.031ProPhe: 2.031 ± 0.099
1.244ProGly: 1.244 ± 0.087
0.877ProHis: 0.877 ± 0.072
2.33ProIle: 2.33 ± 0.127
3.086ProLys: 3.086 ± 0.131
3.364ProLeu: 3.364 ± 0.142
0.367ProMet: 0.367 ± 0.043
2.273ProAsn: 2.273 ± 0.114
1.097ProPro: 1.097 ± 0.106
2.11ProGln: 2.11 ± 0.12
0.861ProArg: 0.861 ± 0.064
2.073ProSer: 2.073 ± 0.113
2.031ProThr: 2.031 ± 0.135
1.365ProVal: 1.365 ± 0.079
0.241ProTrp: 0.241 ± 0.034
1.422ProTyr: 1.422 ± 0.103
0.0ProXaa: 0.0 ± 0.0
Gln
3.044GlnAla: 3.044 ± 0.186
0.21GlnCys: 0.21 ± 0.03
2.162GlnAsp: 2.162 ± 0.131
4.293GlnGlu: 4.293 ± 0.254
1.806GlnPhe: 1.806 ± 0.091
2.624GlnGly: 2.624 ± 0.179
0.793GlnHis: 0.793 ± 0.06
6.104GlnIle: 6.104 ± 0.3
8.487GlnLys: 8.487 ± 0.519
5.107GlnLeu: 5.107 ± 0.238
1.118GlnMet: 1.118 ± 0.069
4.488GlnAsn: 4.488 ± 0.18
1.365GlnPro: 1.365 ± 0.094
3.517GlnGln: 3.517 ± 0.246
1.585GlnArg: 1.585 ± 0.089
2.204GlnSer: 2.204 ± 0.112
4.388GlnThr: 4.388 ± 0.18
2.126GlnVal: 2.126 ± 0.129
0.283GlnTrp: 0.283 ± 0.045
1.485GlnTyr: 1.485 ± 0.11
0.0GlnXaa: 0.0 ± 0.0
Arg
1.118ArgAla: 1.118 ± 0.076
0.226ArgCys: 0.226 ± 0.034
1.165ArgAsp: 1.165 ± 0.076
1.716ArgGlu: 1.716 ± 0.104
1.764ArgPhe: 1.764 ± 0.106
1.365ArgGly: 1.365 ± 0.088
0.556ArgHis: 0.556 ± 0.063
2.609ArgIle: 2.609 ± 0.125
3.181ArgLys: 3.181 ± 0.137
2.661ArgLeu: 2.661 ± 0.118
0.567ArgMet: 0.567 ± 0.054
1.842ArgAsn: 1.842 ± 0.114
0.913ArgPro: 0.913 ± 0.072
1.643ArgGln: 1.643 ± 0.086
0.997ArgArg: 0.997 ± 0.073
1.554ArgSer: 1.554 ± 0.093
1.359ArgThr: 1.359 ± 0.087
1.365ArgVal: 1.365 ± 0.089
0.205ArgTrp: 0.205 ± 0.031
1.128ArgTyr: 1.128 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
1.79SerAla: 1.79 ± 0.101
0.625SerCys: 0.625 ± 0.063
2.85SerAsp: 2.85 ± 0.135
2.645SerGlu: 2.645 ± 0.139
4.194SerPhe: 4.194 ± 0.168
2.63SerGly: 2.63 ± 0.128
1.149SerHis: 1.149 ± 0.08
4.215SerIle: 4.215 ± 0.165
5.06SerLys: 5.06 ± 0.139
6.634SerLeu: 6.634 ± 0.201
0.745SerMet: 0.745 ± 0.063
3.469SerAsn: 3.469 ± 0.131
1.853SerPro: 1.853 ± 0.086
4.036SerGln: 4.036 ± 0.231
1.638SerArg: 1.638 ± 0.097
3.317SerSer: 3.317 ± 0.15
2.887SerThr: 2.887 ± 0.168
2.404SerVal: 2.404 ± 0.121
0.31SerTrp: 0.31 ± 0.048
2.278SerTyr: 2.278 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
2.603ThrAla: 2.603 ± 0.156
0.472ThrCys: 0.472 ± 0.054
2.241ThrAsp: 2.241 ± 0.143
2.514ThrGlu: 2.514 ± 0.138
3.359ThrPhe: 3.359 ± 0.159
2.703ThrGly: 2.703 ± 0.159
1.485ThrHis: 1.485 ± 0.092
5.91ThrIle: 5.91 ± 0.23
6.902ThrLys: 6.902 ± 0.277
6.309ThrLeu: 6.309 ± 0.189
0.625ThrMet: 0.625 ± 0.053
4.383ThrAsn: 4.383 ± 0.171
2.693ThrPro: 2.693 ± 0.125
3.632ThrGln: 3.632 ± 0.205
1.38ThrArg: 1.38 ± 0.078
3.354ThrSer: 3.354 ± 0.133
3.999ThrThr: 3.999 ± 0.213
2.955ThrVal: 2.955 ± 0.189
0.331ThrTrp: 0.331 ± 0.047
2.257ThrTyr: 2.257 ± 0.12
0.0ThrXaa: 0.0 ± 0.0
Val
2.855ValAla: 2.855 ± 0.142
0.483ValCys: 0.483 ± 0.056
2.477ValAsp: 2.477 ± 0.133
2.561ValGlu: 2.561 ± 0.135
3.223ValPhe: 3.223 ± 0.149
2.414ValGly: 2.414 ± 0.124
0.619ValHis: 0.619 ± 0.066
4.577ValIle: 4.577 ± 0.179
4.551ValLys: 4.551 ± 0.176
5.569ValLeu: 5.569 ± 0.187
0.798ValMet: 0.798 ± 0.065
2.483ValAsn: 2.483 ± 0.119
1.312ValPro: 1.312 ± 0.091
1.527ValGln: 1.527 ± 0.096
1.181ValArg: 1.181 ± 0.089
2.955ValSer: 2.955 ± 0.133
2.493ValThr: 2.493 ± 0.193
3.391ValVal: 3.391 ± 0.189
0.362ValTrp: 0.362 ± 0.041
1.806ValTyr: 1.806 ± 0.097
0.0ValXaa: 0.0 ± 0.0
Trp
0.226TrpAla: 0.226 ± 0.028
0.084TrpCys: 0.084 ± 0.021
0.294TrpAsp: 0.294 ± 0.042
0.283TrpGlu: 0.283 ± 0.037
0.504TrpPhe: 0.504 ± 0.054
0.283TrpGly: 0.283 ± 0.038
0.147TrpHis: 0.147 ± 0.028
0.441TrpIle: 0.441 ± 0.049
0.441TrpLys: 0.441 ± 0.053
0.751TrpLeu: 0.751 ± 0.063
0.157TrpMet: 0.157 ± 0.031
0.399TrpAsn: 0.399 ± 0.053
0.173TrpPro: 0.173 ± 0.032
0.509TrpGln: 0.509 ± 0.053
0.215TrpArg: 0.215 ± 0.031
0.357TrpSer: 0.357 ± 0.047
0.194TrpThr: 0.194 ± 0.031
0.299TrpVal: 0.299 ± 0.042
0.11TrpTrp: 0.11 ± 0.028
0.346TrpTyr: 0.346 ± 0.047
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.501TyrAla: 1.501 ± 0.097
0.514TyrCys: 0.514 ± 0.051
2.309TyrAsp: 2.309 ± 0.131
2.026TyrGlu: 2.026 ± 0.114
2.588TyrPhe: 2.588 ± 0.133
1.491TyrGly: 1.491 ± 0.082
1.181TyrHis: 1.181 ± 0.074
2.64TyrIle: 2.64 ± 0.14
2.467TyrLys: 2.467 ± 0.138
4.503TyrLeu: 4.503 ± 0.192
0.467TyrMet: 0.467 ± 0.043
2.456TyrAsn: 2.456 ± 0.143
1.139TyrPro: 1.139 ± 0.076
3.622TyrGln: 3.622 ± 0.168
1.674TyrArg: 1.674 ± 0.112
1.769TyrSer: 1.769 ± 0.108
1.344TyrThr: 1.344 ± 0.11
1.522TyrVal: 1.522 ± 0.09
0.341TyrTrp: 0.341 ± 0.045
2.068TyrTyr: 2.068 ± 0.107
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 631 proteins (190526 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski