Amino acid dipepetide frequency for Sulfitobacter sp. AM1-D1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.755AlaAla: 16.755 ± 0.158	1.14AlaCys: 1.14 ± 0.03	7.429AlaAsp: 7.429 ± 0.072	8.28AlaGlu: 8.28 ± 0.089	4.241AlaPhe: 4.241 ± 0.055	10.695AlaGly: 10.695 ± 0.098	2.361AlaHis: 2.361 ± 0.039	5.709AlaIle: 5.709 ± 0.063	3.406AlaLys: 3.406 ± 0.063	13.752AlaLeu: 13.752 ± 0.14	3.813AlaMet: 3.813 ± 0.055	2.521AlaAsn: 2.521 ± 0.05	5.834AlaPro: 5.834 ± 0.078	4.592AlaGln: 4.592 ± 0.065	9.158AlaArg: 9.158 ± 0.1	5.372AlaSer: 5.372 ± 0.069	5.907AlaThr: 5.907 ± 0.068	8.641AlaVal: 8.641 ± 0.097	1.445AlaTrp: 1.445 ± 0.037	2.494AlaTyr: 2.494 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.135CysAla: 1.135 ± 0.033	0.113CysCys: 0.113 ± 0.009	0.634CysAsp: 0.634 ± 0.022	0.437CysGlu: 0.437 ± 0.02	0.346CysPhe: 0.346 ± 0.018	0.936CysGly: 0.936 ± 0.029	0.266CysHis: 0.266 ± 0.014	0.427CysIle: 0.427 ± 0.017	0.213CysLys: 0.213 ± 0.012	0.827CysLeu: 0.827 ± 0.026	0.182CysMet: 0.182 ± 0.014	0.222CysAsn: 0.222 ± 0.012	0.484CysPro: 0.484 ± 0.021	0.198CysGln: 0.198 ± 0.013	0.576CysArg: 0.576 ± 0.02	0.414CysSer: 0.414 ± 0.017	0.455CysThr: 0.455 ± 0.021	0.616CysVal: 0.616 ± 0.023	0.126CysTrp: 0.126 ± 0.01	0.223CysTyr: 0.223 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.673AspAla: 7.673 ± 0.085	0.539AspCys: 0.539 ± 0.021	3.715AspAsp: 3.715 ± 0.071	3.39AspGlu: 3.39 ± 0.052	2.34AspPhe: 2.34 ± 0.038	5.81AspGly: 5.81 ± 0.086	1.45AspHis: 1.45 ± 0.032	3.187AspIle: 3.187 ± 0.054	1.647AspLys: 1.647 ± 0.041	6.584AspLeu: 6.584 ± 0.069	1.867AspMet: 1.867 ± 0.036	1.426AspAsn: 1.426 ± 0.038	3.862AspPro: 3.862 ± 0.095	1.872AspGln: 1.872 ± 0.04	4.964AspArg: 4.964 ± 0.06	2.353AspSer: 2.353 ± 0.041	3.34AspThr: 3.34 ± 0.053	4.491AspVal: 4.491 ± 0.055	1.179AspTrp: 1.179 ± 0.029	1.565AspTyr: 1.565 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.778GluAla: 7.778 ± 0.088	0.328GluCys: 0.328 ± 0.016	3.514GluAsp: 3.514 ± 0.054	3.578GluGlu: 3.578 ± 0.063	1.736GluPhe: 1.736 ± 0.037	4.899GluGly: 4.899 ± 0.06	1.048GluHis: 1.048 ± 0.028	3.547GluIle: 3.547 ± 0.049	2.174GluLys: 2.174 ± 0.044	4.961GluLeu: 4.961 ± 0.059	1.873GluMet: 1.873 ± 0.034	1.826GluAsn: 1.826 ± 0.037	2.444GluPro: 2.444 ± 0.045	1.962GluGln: 1.962 ± 0.041	4.161GluArg: 4.161 ± 0.06	2.093GluSer: 2.093 ± 0.037	3.997GluThr: 3.997 ± 0.051	4.548GluVal: 4.548 ± 0.061	0.673GluTrp: 0.673 ± 0.021	1.066GluTyr: 1.066 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.513PheAla: 4.513 ± 0.065	0.451PheCys: 0.451 ± 0.018	3.047PheAsp: 3.047 ± 0.049	2.278PheGlu: 2.278 ± 0.035	1.371PhePhe: 1.371 ± 0.036	3.779PheGly: 3.779 ± 0.055	0.729PheHis: 0.729 ± 0.026	1.647PheIle: 1.647 ± 0.037	0.902PheLys: 0.902 ± 0.03	3.281PheLeu: 3.281 ± 0.053	0.91PheMet: 0.91 ± 0.024	1.02PheAsn: 1.02 ± 0.029	1.5PhePro: 1.5 ± 0.03	0.991PheGln: 0.991 ± 0.029	2.177PheArg: 2.177 ± 0.038	2.022PheSer: 2.022 ± 0.037	2.004PheThr: 2.004 ± 0.04	2.65PheVal: 2.65 ± 0.041	0.58PheTrp: 0.58 ± 0.023	0.886PheTyr: 0.886 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.007GlyAla: 10.007 ± 0.091	0.831GlyCys: 0.831 ± 0.027	4.992GlyAsp: 4.992 ± 0.093	4.545GlyGlu: 4.545 ± 0.059	3.739GlyPhe: 3.739 ± 0.059	7.826GlyGly: 7.826 ± 0.124	1.935GlyHis: 1.935 ± 0.035	4.55GlyIle: 4.55 ± 0.068	3.107GlyLys: 3.107 ± 0.055	9.192GlyLeu: 9.192 ± 0.09	2.742GlyMet: 2.742 ± 0.048	2.307GlyAsn: 2.307 ± 0.065	3.868GlyPro: 3.868 ± 0.056	3.181GlyGln: 3.181 ± 0.047	5.96GlyArg: 5.96 ± 0.072	4.297GlySer: 4.297 ± 0.063	5.02GlyThr: 5.02 ± 0.067	6.532GlyVal: 6.532 ± 0.07	1.461GlyTrp: 1.461 ± 0.036	2.299GlyTyr: 2.299 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.45HisAla: 2.45 ± 0.045	0.23HisCys: 0.23 ± 0.014	1.329HisAsp: 1.329 ± 0.032	1.015HisGlu: 1.015 ± 0.029	0.818HisPhe: 0.818 ± 0.026	1.943HisGly: 1.943 ± 0.042	0.565HisHis: 0.565 ± 0.023	0.954HisIle: 0.954 ± 0.025	0.466HisLys: 0.466 ± 0.021	2.103HisLeu: 2.103 ± 0.041	0.537HisMet: 0.537 ± 0.019	0.434HisAsn: 0.434 ± 0.018	1.381HisPro: 1.381 ± 0.037	0.575HisGln: 0.575 ± 0.02	1.437HisArg: 1.437 ± 0.035	0.81HisSer: 0.81 ± 0.025	0.894HisThr: 0.894 ± 0.027	1.601HisVal: 1.601 ± 0.034	0.332HisTrp: 0.332 ± 0.016	0.539HisTyr: 0.539 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.867IleAla: 6.867 ± 0.072	0.627IleCys: 0.627 ± 0.023	3.59IleAsp: 3.59 ± 0.05	3.474IleGlu: 3.474 ± 0.051	1.742IlePhe: 1.742 ± 0.041	4.957IleGly: 4.957 ± 0.055	0.91IleHis: 0.91 ± 0.025	2.212IleIle: 2.212 ± 0.043	1.371IleLys: 1.371 ± 0.033	4.621IleLeu: 4.621 ± 0.068	1.111IleMet: 1.111 ± 0.029	1.356IleAsn: 1.356 ± 0.031	2.257IlePro: 2.257 ± 0.038	1.148IleGln: 1.148 ± 0.027	3.196IleArg: 3.196 ± 0.05	2.894IleSer: 2.894 ± 0.044	2.878IleThr: 2.878 ± 0.049	3.921IleVal: 3.921 ± 0.061	0.706IleTrp: 0.706 ± 0.023	1.126IleTyr: 1.126 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.617LysAla: 3.617 ± 0.06	0.166LysCys: 0.166 ± 0.013	1.692LysAsp: 1.692 ± 0.036	1.495LysGlu: 1.495 ± 0.037	0.906LysPhe: 0.906 ± 0.026	2.6LysGly: 2.6 ± 0.051	0.578LysHis: 0.578 ± 0.022	1.483LysIle: 1.483 ± 0.036	1.158LysLys: 1.158 ± 0.042	2.818LysLeu: 2.818 ± 0.05	0.831LysMet: 0.831 ± 0.026	0.746LysAsn: 0.746 ± 0.027	1.699LysPro: 1.699 ± 0.036	0.874LysGln: 0.874 ± 0.025	2.123LysArg: 2.123 ± 0.047	1.723LysSer: 1.723 ± 0.038	1.777LysThr: 1.777 ± 0.035	2.269LysVal: 2.269 ± 0.052	0.366LysTrp: 0.366 ± 0.017	0.616LysTyr: 0.616 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.632LeuAla: 12.632 ± 0.116	0.974LeuCys: 0.974 ± 0.03	6.215LeuAsp: 6.215 ± 0.068	5.232LeuGlu: 5.232 ± 0.066	3.431LeuPhe: 3.431 ± 0.052	8.608LeuGly: 8.608 ± 0.103	1.905LeuHis: 1.905 ± 0.04	5.09LeuIle: 5.09 ± 0.068	2.937LeuLys: 2.937 ± 0.05	9.049LeuLeu: 9.049 ± 0.127	2.687LeuMet: 2.687 ± 0.048	2.702LeuAsn: 2.702 ± 0.042	5.558LeuPro: 5.558 ± 0.064	2.712LeuGln: 2.712 ± 0.041	7.291LeuArg: 7.291 ± 0.081	6.463LeuSer: 6.463 ± 0.066	6.011LeuThr: 6.011 ± 0.072	6.872LeuVal: 6.872 ± 0.082	1.238LeuTrp: 1.238 ± 0.03	1.932LeuTyr: 1.932 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.558MetAla: 3.558 ± 0.057	0.212MetCys: 0.212 ± 0.011	1.555MetAsp: 1.555 ± 0.035	1.385MetGlu: 1.385 ± 0.029	0.849MetPhe: 0.849 ± 0.027	2.317MetGly: 2.317 ± 0.039	0.502MetHis: 0.502 ± 0.022	1.634MetIle: 1.634 ± 0.035	1.099MetLys: 1.099 ± 0.032	2.592MetLeu: 2.592 ± 0.044	0.829MetMet: 0.829 ± 0.027	0.926MetAsn: 0.926 ± 0.027	1.559MetPro: 1.559 ± 0.033	1.013MetGln: 1.013 ± 0.029	2.009MetArg: 2.009 ± 0.038	1.721MetSer: 1.721 ± 0.032	2.224MetThr: 2.224 ± 0.038	1.914MetVal: 1.914 ± 0.037	0.243MetTrp: 0.243 ± 0.014	0.377MetTyr: 0.377 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.252AsnAla: 3.252 ± 0.048	0.258AsnCys: 0.258 ± 0.013	1.542AsnAsp: 1.542 ± 0.048	1.219AsnGlu: 1.219 ± 0.034	0.928AsnPhe: 0.928 ± 0.029	2.448AsnGly: 2.448 ± 0.048	0.504AsnHis: 0.504 ± 0.019	1.387AsnIle: 1.387 ± 0.031	0.637AsnLys: 0.637 ± 0.024	2.498AsnLeu: 2.498 ± 0.045	0.7AsnMet: 0.7 ± 0.021	0.694AsnAsn: 0.694 ± 0.027	1.748AsnPro: 1.748 ± 0.035	0.674AsnGln: 0.674 ± 0.021	1.815AsnArg: 1.815 ± 0.041	1.085AsnSer: 1.085 ± 0.029	1.327AsnThr: 1.327 ± 0.033	1.864AsnVal: 1.864 ± 0.04	0.416AsnTrp: 0.416 ± 0.019	0.658AsnTyr: 0.658 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.835ProAla: 5.835 ± 0.071	0.353ProCys: 0.353 ± 0.015	4.187ProAsp: 4.187 ± 0.063	4.106ProGlu: 4.106 ± 0.059	1.962ProPhe: 1.962 ± 0.043	4.536ProGly: 4.536 ± 0.068	1.027ProHis: 1.027 ± 0.027	2.156ProIle: 2.156 ± 0.041	1.531ProLys: 1.531 ± 0.037	4.7ProLeu: 4.7 ± 0.059	1.318ProMet: 1.318 ± 0.032	1.232ProAsn: 1.232 ± 0.026	2.428ProPro: 2.428 ± 0.049	1.784ProGln: 1.784 ± 0.039	3.003ProArg: 3.003 ± 0.05	2.351ProSer: 2.351 ± 0.039	2.474ProThr: 2.474 ± 0.078	4.227ProVal: 4.227 ± 0.064	0.639ProTrp: 0.639 ± 0.021	1.138ProTyr: 1.138 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.984GlnAla: 3.984 ± 0.056	0.199GlnCys: 0.199 ± 0.011	1.82GlnAsp: 1.82 ± 0.036	1.694GlnGlu: 1.694 ± 0.036	1.063GlnPhe: 1.063 ± 0.03	2.605GlnGly: 2.605 ± 0.037	0.566GlnHis: 0.566 ± 0.018	1.935GlnIle: 1.935 ± 0.039	1.0GlnLys: 1.0 ± 0.026	2.695GlnLeu: 2.695 ± 0.051	1.12GlnMet: 1.12 ± 0.027	0.913GlnAsn: 0.913 ± 0.027	1.629GlnPro: 1.629 ± 0.033	1.124GlnGln: 1.124 ± 0.035	2.222GlnArg: 2.222 ± 0.044	1.757GlnSer: 1.757 ± 0.036	1.848GlnThr: 1.848 ± 0.04	2.401GlnVal: 2.401 ± 0.044	0.392GlnTrp: 0.392 ± 0.017	0.598GlnTyr: 0.598 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.506ArgAla: 8.506 ± 0.09	0.472ArgCys: 0.472 ± 0.018	4.666ArgAsp: 4.666 ± 0.058	3.955ArgGlu: 3.955 ± 0.052	2.707ArgPhe: 2.707 ± 0.045	4.784ArgGly: 4.784 ± 0.06	1.69ArgHis: 1.69 ± 0.039	4.031ArgIle: 4.031 ± 0.063	2.253ArgLys: 2.253 ± 0.045	7.401ArgLeu: 7.401 ± 0.086	2.119ArgMet: 2.119 ± 0.039	1.907ArgAsn: 1.907 ± 0.04	3.316ArgPro: 3.316 ± 0.053	2.414ArgGln: 2.414 ± 0.046	5.238ArgArg: 5.238 ± 0.074	3.318ArgSer: 3.318 ± 0.051	3.343ArgThr: 3.343 ± 0.047	4.786ArgVal: 4.786 ± 0.062	0.918ArgTrp: 0.918 ± 0.024	1.606ArgTyr: 1.606 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.808SerAla: 5.808 ± 0.077	0.387SerCys: 0.387 ± 0.016	3.4SerAsp: 3.4 ± 0.059	2.76SerGlu: 2.76 ± 0.047	2.173SerPhe: 2.173 ± 0.04	5.301SerGly: 5.301 ± 0.066	1.063SerHis: 1.063 ± 0.031	2.495SerIle: 2.495 ± 0.051	1.369SerLys: 1.369 ± 0.039	4.786SerLeu: 4.786 ± 0.06	1.384SerMet: 1.384 ± 0.031	1.277SerAsn: 1.277 ± 0.032	2.409SerPro: 2.409 ± 0.041	1.466SerGln: 1.466 ± 0.031	3.197SerArg: 3.197 ± 0.052	2.422SerSer: 2.422 ± 0.049	2.447SerThr: 2.447 ± 0.043	3.744SerVal: 3.744 ± 0.056	0.649SerTrp: 0.649 ± 0.022	1.269SerTyr: 1.269 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.402ThrAla: 6.402 ± 0.072	0.527ThrCys: 0.527 ± 0.02	3.417ThrAsp: 3.417 ± 0.078	3.067ThrGlu: 3.067 ± 0.044	2.054ThrPhe: 2.054 ± 0.044	5.621ThrGly: 5.621 ± 0.071	1.085ThrHis: 1.085 ± 0.03	2.656ThrIle: 2.656 ± 0.055	1.277ThrLys: 1.277 ± 0.034	6.266ThrLeu: 6.266 ± 0.076	1.361ThrMet: 1.361 ± 0.029	1.22ThrAsn: 1.22 ± 0.029	3.454ThrPro: 3.454 ± 0.056	1.59ThrGln: 1.59 ± 0.032	3.658ThrArg: 3.658 ± 0.053	2.671ThrSer: 2.671 ± 0.048	2.846ThrThr: 2.846 ± 0.056	4.31ThrVal: 4.31 ± 0.062	0.718ThrTrp: 0.718 ± 0.025	1.323ThrTyr: 1.323 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.816ValAla: 8.816 ± 0.091	0.653ValCys: 0.653 ± 0.02	4.143ValAsp: 4.143 ± 0.053	4.445ValGlu: 4.445 ± 0.065	2.846ValPhe: 2.846 ± 0.047	5.566ValGly: 5.566 ± 0.072	1.368ValHis: 1.368 ± 0.032	4.254ValIle: 4.254 ± 0.067	2.017ValLys: 2.017 ± 0.046	7.553ValLeu: 7.553 ± 0.079	2.212ValMet: 2.212 ± 0.042	1.946ValAsn: 1.946 ± 0.039	3.815ValPro: 3.815 ± 0.058	2.182ValGln: 2.182 ± 0.035	4.503ValArg: 4.503 ± 0.063	4.217ValSer: 4.217 ± 0.055	4.868ValThr: 4.868 ± 0.068	5.634ValVal: 5.634 ± 0.076	0.938ValTrp: 0.938 ± 0.031	1.492ValTyr: 1.492 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.353TrpAla: 1.353 ± 0.034	0.15TrpCys: 0.15 ± 0.01	0.746TrpAsp: 0.746 ± 0.024	0.65TrpGlu: 0.65 ± 0.02	0.565TrpPhe: 0.565 ± 0.024	0.994TrpGly: 0.994 ± 0.03	0.335TrpHis: 0.335 ± 0.015	0.703TrpIle: 0.703 ± 0.023	0.421TrpLys: 0.421 ± 0.016	1.55TrpLeu: 1.55 ± 0.031	0.44TrpMet: 0.44 ± 0.017	0.398TrpAsn: 0.398 ± 0.016	0.689TrpPro: 0.689 ± 0.023	0.595TrpGln: 0.595 ± 0.02	1.127TrpArg: 1.127 ± 0.031	0.776TrpSer: 0.776 ± 0.024	0.752TrpThr: 0.752 ± 0.025	0.844TrpVal: 0.844 ± 0.026	0.21TrpTrp: 0.21 ± 0.012	0.279TrpTyr: 0.279 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.603TyrAla: 2.603 ± 0.04	0.222TyrCys: 0.222 ± 0.015	1.618TyrAsp: 1.618 ± 0.039	1.2TyrGlu: 1.2 ± 0.032	0.923TyrPhe: 0.923 ± 0.023	2.165TyrGly: 2.165 ± 0.039	0.527TyrHis: 0.527 ± 0.021	0.907TyrIle: 0.907 ± 0.024	0.551TyrLys: 0.551 ± 0.02	2.308TyrLeu: 2.308 ± 0.039	0.482TyrMet: 0.482 ± 0.018	0.581TyrAsn: 0.581 ± 0.022	1.052TyrPro: 1.052 ± 0.026	0.621TyrGln: 0.621 ± 0.022	1.616TyrArg: 1.616 ± 0.038	1.046TyrSer: 1.046 ± 0.028	1.112TyrThr: 1.112 ± 0.023	1.603TyrVal: 1.603 ± 0.037	0.348TyrTrp: 0.348 ± 0.016	0.578TyrTyr: 0.578 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4362 proteins (1380988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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