Amino acid dipepetide frequency for Sulfurifustis variabilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.485AlaAla: 16.485 ± 0.178	1.276AlaCys: 1.276 ± 0.034	5.973AlaAsp: 5.973 ± 0.071	7.396AlaGlu: 7.396 ± 0.104	4.03AlaPhe: 4.03 ± 0.076	10.891AlaGly: 10.891 ± 0.118	2.642AlaHis: 2.642 ± 0.051	5.495AlaIle: 5.495 ± 0.074	3.278AlaLys: 3.278 ± 0.062	14.308AlaLeu: 14.308 ± 0.162	2.798AlaMet: 2.798 ± 0.058	2.429AlaAsn: 2.429 ± 0.045	5.706AlaPro: 5.706 ± 0.073	3.669AlaGln: 3.669 ± 0.06	11.702AlaArg: 11.702 ± 0.141	5.604AlaSer: 5.604 ± 0.072	5.349AlaThr: 5.349 ± 0.08	9.285AlaVal: 9.285 ± 0.104	1.833AlaTrp: 1.833 ± 0.045	2.901AlaTyr: 2.901 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.031	0.129CysCys: 0.129 ± 0.011	0.453CysAsp: 0.453 ± 0.022	0.498CysGlu: 0.498 ± 0.019	0.294CysPhe: 0.294 ± 0.016	0.964CysGly: 0.964 ± 0.031	0.344CysHis: 0.344 ± 0.035	0.293CysIle: 0.293 ± 0.016	0.186CysLys: 0.186 ± 0.016	0.865CysLeu: 0.865 ± 0.027	0.157CysMet: 0.157 ± 0.011	0.226CysAsn: 0.226 ± 0.014	0.596CysPro: 0.596 ± 0.029	0.211CysGln: 0.211 ± 0.014	0.825CysArg: 0.825 ± 0.032	0.447CysSer: 0.447 ± 0.022	0.419CysThr: 0.419 ± 0.018	0.654CysVal: 0.654 ± 0.023	0.091CysTrp: 0.091 ± 0.009	0.244CysTyr: 0.244 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.467AspAla: 6.467 ± 0.067	0.441AspCys: 0.441 ± 0.02	2.792AspAsp: 2.792 ± 0.059	3.455AspGlu: 3.455 ± 0.061	1.922AspPhe: 1.922 ± 0.043	4.609AspGly: 4.609 ± 0.077	1.095AspHis: 1.095 ± 0.028	2.423AspIle: 2.423 ± 0.047	1.372AspLys: 1.372 ± 0.038	5.605AspLeu: 5.605 ± 0.071	1.002AspMet: 1.002 ± 0.033	1.063AspAsn: 1.063 ± 0.036	3.53AspPro: 3.53 ± 0.066	1.251AspGln: 1.251 ± 0.034	4.849AspArg: 4.849 ± 0.061	1.992AspSer: 1.992 ± 0.043	2.353AspThr: 2.353 ± 0.044	4.274AspVal: 4.274 ± 0.067	0.829AspTrp: 0.829 ± 0.027	1.603AspTyr: 1.603 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.652GluAla: 7.652 ± 0.101	0.465GluCys: 0.465 ± 0.022	2.703GluAsp: 2.703 ± 0.048	3.828GluGlu: 3.828 ± 0.071	1.868GluPhe: 1.868 ± 0.038	4.426GluGly: 4.426 ± 0.067	1.621GluHis: 1.621 ± 0.038	3.321GluIle: 3.321 ± 0.056	2.229GluLys: 2.229 ± 0.055	6.568GluLeu: 6.568 ± 0.08	1.334GluMet: 1.334 ± 0.039	1.44GluAsn: 1.44 ± 0.035	3.168GluPro: 3.168 ± 0.052	2.465GluGln: 2.465 ± 0.047	6.955GluArg: 6.955 ± 0.086	2.967GluSer: 2.967 ± 0.059	3.153GluThr: 3.153 ± 0.058	4.372GluVal: 4.372 ± 0.069	0.833GluTrp: 0.833 ± 0.024	1.495GluTyr: 1.495 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.021PheAla: 4.021 ± 0.061	0.332PheCys: 0.332 ± 0.017	2.281PheAsp: 2.281 ± 0.05	2.187PheGlu: 2.187 ± 0.043	1.404PhePhe: 1.404 ± 0.039	3.255PheGly: 3.255 ± 0.061	0.747PheHis: 0.747 ± 0.029	1.356PheIle: 1.356 ± 0.034	0.846PheLys: 0.846 ± 0.028	3.633PheLeu: 3.633 ± 0.067	0.659PheMet: 0.659 ± 0.025	0.937PheAsn: 0.937 ± 0.028	1.685PhePro: 1.685 ± 0.04	0.895PheGln: 0.895 ± 0.029	2.573PheArg: 2.573 ± 0.048	1.691PheSer: 1.691 ± 0.04	1.737PheThr: 1.737 ± 0.039	3.0PheVal: 3.0 ± 0.048	0.516PheTrp: 0.516 ± 0.023	0.987PheTyr: 0.987 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.96GlyAla: 8.96 ± 0.101	0.886GlyCys: 0.886 ± 0.029	4.15GlyAsp: 4.15 ± 0.078	5.349GlyGlu: 5.349 ± 0.077	3.305GlyPhe: 3.305 ± 0.057	6.989GlyGly: 6.989 ± 0.124	1.928GlyHis: 1.928 ± 0.037	4.125GlyIle: 4.125 ± 0.064	2.889GlyLys: 2.889 ± 0.057	8.869GlyLeu: 8.869 ± 0.102	2.242GlyMet: 2.242 ± 0.047	1.924GlyAsn: 1.924 ± 0.055	3.54GlyPro: 3.54 ± 0.054	2.466GlyGln: 2.466 ± 0.051	7.362GlyArg: 7.362 ± 0.097	4.114GlySer: 4.114 ± 0.069	4.424GlyThr: 4.424 ± 0.082	6.597GlyVal: 6.597 ± 0.079	1.414GlyTrp: 1.414 ± 0.038	2.492GlyTyr: 2.492 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.824HisAla: 2.824 ± 0.056	0.261HisCys: 0.261 ± 0.016	1.224HisAsp: 1.224 ± 0.031	1.337HisGlu: 1.337 ± 0.037	0.881HisPhe: 0.881 ± 0.025	2.198HisGly: 2.198 ± 0.042	0.628HisHis: 0.628 ± 0.022	0.826HisIle: 0.826 ± 0.029	0.568HisLys: 0.568 ± 0.021	2.388HisLeu: 2.388 ± 0.052	0.456HisMet: 0.456 ± 0.019	0.538HisAsn: 0.538 ± 0.021	1.575HisPro: 1.575 ± 0.038	0.565HisGln: 0.565 ± 0.021	1.94HisArg: 1.94 ± 0.044	0.904HisSer: 0.904 ± 0.027	1.04HisThr: 1.04 ± 0.027	1.86HisVal: 1.86 ± 0.04	0.34HisTrp: 0.34 ± 0.017	0.75HisTyr: 0.75 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.047IleAla: 6.047 ± 0.081	0.324IleCys: 0.324 ± 0.016	2.976IleAsp: 2.976 ± 0.058	3.478IleGlu: 3.478 ± 0.064	1.237IlePhe: 1.237 ± 0.035	4.16IleGly: 4.16 ± 0.067	0.892IleHis: 0.892 ± 0.025	1.386IleIle: 1.386 ± 0.047	1.282IleLys: 1.282 ± 0.039	3.927IleLeu: 3.927 ± 0.067	0.705IleMet: 0.705 ± 0.029	1.153IleAsn: 1.153 ± 0.035	2.294IlePro: 2.294 ± 0.044	1.106IleGln: 1.106 ± 0.036	3.339IleArg: 3.339 ± 0.048	1.866IleSer: 1.866 ± 0.038	2.109IleThr: 2.109 ± 0.05	3.763IleVal: 3.763 ± 0.06	0.438IleTrp: 0.438 ± 0.02	1.108IleTyr: 1.108 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.081LysAla: 3.081 ± 0.072	0.192LysCys: 0.192 ± 0.012	1.539LysAsp: 1.539 ± 0.042	1.829LysGlu: 1.829 ± 0.044	0.716LysPhe: 0.716 ± 0.029	2.372LysGly: 2.372 ± 0.052	0.673LysHis: 0.673 ± 0.024	1.317LysIle: 1.317 ± 0.036	1.366LysLys: 1.366 ± 0.05	2.879LysLeu: 2.879 ± 0.065	0.653LysMet: 0.653 ± 0.026	0.782LysAsn: 0.782 ± 0.029	1.762LysPro: 1.762 ± 0.041	1.107LysGln: 1.107 ± 0.037	2.698LysArg: 2.698 ± 0.058	1.503LysSer: 1.503 ± 0.039	1.708LysThr: 1.708 ± 0.045	2.103LysVal: 2.103 ± 0.049	0.328LysTrp: 0.328 ± 0.018	0.672LysTyr: 0.672 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.312LeuAla: 15.312 ± 0.189	0.857LeuCys: 0.857 ± 0.024	6.058LeuAsp: 6.058 ± 0.08	6.541LeuGlu: 6.541 ± 0.08	3.661LeuPhe: 3.661 ± 0.07	8.928LeuGly: 8.928 ± 0.103	2.33LeuHis: 2.33 ± 0.046	4.325LeuIle: 4.325 ± 0.075	3.453LeuLys: 3.453 ± 0.072	11.756LeuLeu: 11.756 ± 0.179	1.923LeuMet: 1.923 ± 0.042	2.436LeuAsn: 2.436 ± 0.049	6.012LeuPro: 6.012 ± 0.068	2.632LeuGln: 2.632 ± 0.05	8.806LeuArg: 8.806 ± 0.1	5.448LeuSer: 5.448 ± 0.076	5.163LeuThr: 5.163 ± 0.076	8.477LeuVal: 8.477 ± 0.108	1.31LeuTrp: 1.31 ± 0.04	2.819LeuTyr: 2.819 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.361MetAla: 2.361 ± 0.046	0.14MetCys: 0.14 ± 0.011	0.972MetAsp: 0.972 ± 0.034	1.057MetGlu: 1.057 ± 0.032	0.55MetPhe: 0.55 ± 0.024	1.482MetGly: 1.482 ± 0.046	0.497MetHis: 0.497 ± 0.021	0.919MetIle: 0.919 ± 0.032	0.952MetLys: 0.952 ± 0.028	2.149MetLeu: 2.149 ± 0.045	0.491MetMet: 0.491 ± 0.03	0.691MetAsn: 0.691 ± 0.024	1.219MetPro: 1.219 ± 0.032	0.788MetGln: 0.788 ± 0.029	1.949MetArg: 1.949 ± 0.045	1.305MetSer: 1.305 ± 0.032	1.336MetThr: 1.336 ± 0.031	1.368MetVal: 1.368 ± 0.037	0.198MetTrp: 0.198 ± 0.013	0.402MetTyr: 0.402 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.628AsnAla: 2.628 ± 0.049	0.224AsnCys: 0.224 ± 0.014	1.175AsnAsp: 1.175 ± 0.033	1.309AsnGlu: 1.309 ± 0.035	0.788AsnPhe: 0.788 ± 0.026	2.078AsnGly: 2.078 ± 0.056	0.529AsnHis: 0.529 ± 0.021	0.999AsnIle: 0.999 ± 0.031	0.555AsnLys: 0.555 ± 0.023	2.533AsnLeu: 2.533 ± 0.048	0.437AsnMet: 0.437 ± 0.018	0.589AsnAsn: 0.589 ± 0.033	1.69AsnPro: 1.69 ± 0.048	0.698AsnGln: 0.698 ± 0.03	2.031AsnArg: 2.031 ± 0.047	0.907AsnSer: 0.907 ± 0.035	1.07AsnThr: 1.07 ± 0.037	1.915AsnVal: 1.915 ± 0.045	0.315AsnTrp: 0.315 ± 0.018	0.623AsnTyr: 0.623 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.976ProAla: 6.976 ± 0.093	0.394ProCys: 0.394 ± 0.018	3.61ProAsp: 3.61 ± 0.054	4.133ProGlu: 4.133 ± 0.061	1.865ProPhe: 1.865 ± 0.044	5.18ProGly: 5.18 ± 0.073	1.225ProHis: 1.225 ± 0.035	2.041ProIle: 2.041 ± 0.042	1.474ProLys: 1.474 ± 0.039	5.098ProLeu: 5.098 ± 0.071	1.075ProMet: 1.075 ± 0.03	1.202ProAsn: 1.202 ± 0.041	3.215ProPro: 3.215 ± 0.079	1.4ProGln: 1.4 ± 0.038	3.876ProArg: 3.876 ± 0.065	2.537ProSer: 2.537 ± 0.053	2.302ProThr: 2.302 ± 0.046	4.482ProVal: 4.482 ± 0.067	0.705ProTrp: 0.705 ± 0.028	1.342ProTyr: 1.342 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.003GlnAla: 4.003 ± 0.072	0.237GlnCys: 0.237 ± 0.015	1.214GlnAsp: 1.214 ± 0.036	1.654GlnGlu: 1.654 ± 0.042	0.862GlnPhe: 0.862 ± 0.023	2.237GlnGly: 2.237 ± 0.043	0.646GlnHis: 0.646 ± 0.024	1.38GlnIle: 1.38 ± 0.038	0.927GlnLys: 0.927 ± 0.032	2.829GlnLeu: 2.829 ± 0.044	0.712GlnMet: 0.712 ± 0.025	0.671GlnAsn: 0.671 ± 0.028	1.638GlnPro: 1.638 ± 0.04	1.077GlnGln: 1.077 ± 0.038	2.463GlnArg: 2.463 ± 0.045	1.374GlnSer: 1.374 ± 0.037	1.512GlnThr: 1.512 ± 0.041	2.335GlnVal: 2.335 ± 0.045	0.4GlnTrp: 0.4 ± 0.018	0.752GlnTyr: 0.752 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.416ArgAla: 10.416 ± 0.123	0.728ArgCys: 0.728 ± 0.027	4.515ArgAsp: 4.515 ± 0.066	6.131ArgGlu: 6.131 ± 0.071	3.588ArgPhe: 3.588 ± 0.067	5.788ArgGly: 5.788 ± 0.071	2.327ArgHis: 2.327 ± 0.048	4.133ArgIle: 4.133 ± 0.064	2.3ArgLys: 2.3 ± 0.047	10.569ArgLeu: 10.569 ± 0.107	2.032ArgMet: 2.032 ± 0.04	1.937ArgAsn: 1.937 ± 0.044	4.429ArgPro: 4.429 ± 0.068	2.621ArgGln: 2.621 ± 0.049	8.165ArgArg: 8.165 ± 0.112	3.805ArgSer: 3.805 ± 0.058	3.973ArgThr: 3.973 ± 0.056	6.56ArgVal: 6.56 ± 0.088	1.243ArgTrp: 1.243 ± 0.034	2.575ArgTyr: 2.575 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.496SerAla: 5.496 ± 0.081	0.475SerCys: 0.475 ± 0.022	2.31SerAsp: 2.31 ± 0.053	2.762SerGlu: 2.762 ± 0.047	1.755SerPhe: 1.755 ± 0.042	4.845SerGly: 4.845 ± 0.065	1.106SerHis: 1.106 ± 0.029	2.058SerIle: 2.058 ± 0.048	1.118SerLys: 1.118 ± 0.033	5.105SerLeu: 5.105 ± 0.075	1.002SerMet: 1.002 ± 0.032	1.077SerAsn: 1.077 ± 0.034	2.761SerPro: 2.761 ± 0.053	1.28SerGln: 1.28 ± 0.034	3.821SerArg: 3.821 ± 0.069	2.238SerSer: 2.238 ± 0.051	2.231SerThr: 2.231 ± 0.042	3.525SerVal: 3.525 ± 0.058	0.694SerTrp: 0.694 ± 0.025	1.167SerTyr: 1.167 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.654ThrAla: 5.654 ± 0.076	0.426ThrCys: 0.426 ± 0.022	2.556ThrAsp: 2.556 ± 0.051	2.741ThrGlu: 2.741 ± 0.054	1.647ThrPhe: 1.647 ± 0.041	4.84ThrGly: 4.84 ± 0.073	1.045ThrHis: 1.045 ± 0.031	2.041ThrIle: 2.041 ± 0.048	1.108ThrLys: 1.108 ± 0.033	5.603ThrLeu: 5.603 ± 0.079	0.903ThrMet: 0.903 ± 0.029	1.088ThrAsn: 1.088 ± 0.039	3.057ThrPro: 3.057 ± 0.048	1.265ThrGln: 1.265 ± 0.032	3.793ThrArg: 3.793 ± 0.065	2.226ThrSer: 2.226 ± 0.05	2.423ThrThr: 2.423 ± 0.061	4.268ThrVal: 4.268 ± 0.068	0.633ThrTrp: 0.633 ± 0.022	1.264ThrTyr: 1.264 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.227ValAla: 9.227 ± 0.103	0.768ValCys: 0.768 ± 0.024	4.28ValAsp: 4.28 ± 0.059	4.844ValGlu: 4.844 ± 0.075	2.762ValPhe: 2.762 ± 0.052	5.614ValGly: 5.614 ± 0.072	1.807ValHis: 1.807 ± 0.041	3.683ValIle: 3.683 ± 0.065	2.211ValLys: 2.211 ± 0.048	8.764ValLeu: 8.764 ± 0.102	1.549ValMet: 1.549 ± 0.041	1.909ValAsn: 1.909 ± 0.043	4.289ValPro: 4.289 ± 0.066	2.15ValGln: 2.15 ± 0.039	6.634ValArg: 6.634 ± 0.078	3.985ValSer: 3.985 ± 0.063	4.224ValThr: 4.224 ± 0.074	6.603ValVal: 6.603 ± 0.087	1.026ValTrp: 1.026 ± 0.034	2.188ValTyr: 2.188 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.254TrpAla: 1.254 ± 0.037	0.141TrpCys: 0.141 ± 0.01	0.616TrpAsp: 0.616 ± 0.022	0.748TrpGlu: 0.748 ± 0.026	0.561TrpPhe: 0.561 ± 0.024	0.868TrpGly: 0.868 ± 0.029	0.392TrpHis: 0.392 ± 0.02	0.623TrpIle: 0.623 ± 0.026	0.457TrpLys: 0.457 ± 0.022	1.911TrpLeu: 1.911 ± 0.051	0.305TrpMet: 0.305 ± 0.016	0.389TrpAsn: 0.389 ± 0.024	0.678TrpPro: 0.678 ± 0.023	0.491TrpGln: 0.491 ± 0.018	1.401TrpArg: 1.401 ± 0.034	0.733TrpSer: 0.733 ± 0.025	0.677TrpThr: 0.677 ± 0.026	0.988TrpVal: 0.988 ± 0.03	0.265TrpTrp: 0.265 ± 0.016	0.357TrpTyr: 0.357 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.097TyrAla: 3.097 ± 0.047	0.287TyrCys: 0.287 ± 0.016	1.533TyrAsp: 1.533 ± 0.04	1.582TyrGlu: 1.582 ± 0.038	1.048TyrPhe: 1.048 ± 0.032	2.3TyrGly: 2.3 ± 0.046	0.63TyrHis: 0.63 ± 0.025	0.844TyrIle: 0.844 ± 0.027	0.711TyrLys: 0.711 ± 0.029	2.887TyrLeu: 2.887 ± 0.05	0.388TyrMet: 0.388 ± 0.018	0.613TyrAsn: 0.613 ± 0.024	1.291TyrPro: 1.291 ± 0.036	0.787TyrGln: 0.787 ± 0.029	2.654TyrArg: 2.654 ± 0.046	1.179TyrSer: 1.179 ± 0.029	1.38TyrThr: 1.38 ± 0.038	2.089TyrVal: 2.089 ± 0.044	0.442TyrTrp: 0.442 ± 0.021	0.862TyrTyr: 0.862 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3857 proteins (1182190 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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