Amino acid dipepetide frequency for Geofilum rubicundum JCM 15548

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.532AlaAla: 5.532 ± 0.083	0.66AlaCys: 0.66 ± 0.025	4.046AlaAsp: 4.046 ± 0.062	4.478AlaGlu: 4.478 ± 0.061	3.599AlaPhe: 3.599 ± 0.057	5.439AlaGly: 5.439 ± 0.075	1.536AlaHis: 1.536 ± 0.036	5.086AlaIle: 5.086 ± 0.075	3.198AlaLys: 3.198 ± 0.05	7.312AlaLeu: 7.312 ± 0.086	1.867AlaMet: 1.867 ± 0.039	3.03AlaAsn: 3.03 ± 0.051	2.546AlaPro: 2.546 ± 0.049	2.671AlaGln: 2.671 ± 0.048	3.282AlaArg: 3.282 ± 0.053	4.607AlaSer: 4.607 ± 0.065	3.694AlaThr: 3.694 ± 0.06	4.583AlaVal: 4.583 ± 0.065	0.866AlaTrp: 0.866 ± 0.026	2.639AlaTyr: 2.639 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.431CysAla: 0.431 ± 0.018	0.077CysCys: 0.077 ± 0.006	0.432CysAsp: 0.432 ± 0.019	0.452CysGlu: 0.452 ± 0.019	0.391CysPhe: 0.391 ± 0.019	0.606CysGly: 0.606 ± 0.022	0.213CysHis: 0.213 ± 0.014	0.424CysIle: 0.424 ± 0.019	0.329CysLys: 0.329 ± 0.015	0.65CysLeu: 0.65 ± 0.021	0.179CysMet: 0.179 ± 0.012	0.338CysAsn: 0.338 ± 0.018	0.359CysPro: 0.359 ± 0.02	0.325CysGln: 0.325 ± 0.017	0.405CysArg: 0.405 ± 0.018	0.516CysSer: 0.516 ± 0.021	0.344CysThr: 0.344 ± 0.017	0.429CysVal: 0.429 ± 0.019	0.099CysTrp: 0.099 ± 0.009	0.303CysTyr: 0.303 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.987AspAla: 3.987 ± 0.057	0.413AspCys: 0.413 ± 0.018	2.822AspAsp: 2.822 ± 0.05	3.817AspGlu: 3.817 ± 0.052	3.349AspPhe: 3.349 ± 0.055	4.188AspGly: 4.188 ± 0.07	1.208AspHis: 1.208 ± 0.027	3.868AspIle: 3.868 ± 0.056	3.111AspLys: 3.111 ± 0.052	5.56AspLeu: 5.56 ± 0.061	1.331AspMet: 1.331 ± 0.031	2.687AspAsn: 2.687 ± 0.052	2.065AspPro: 2.065 ± 0.038	2.096AspGln: 2.096 ± 0.044	2.453AspArg: 2.453 ± 0.042	2.877AspSer: 2.877 ± 0.045	2.439AspThr: 2.439 ± 0.045	3.632AspVal: 3.632 ± 0.05	0.859AspTrp: 0.859 ± 0.025	2.719AspTyr: 2.719 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.355GluAla: 5.355 ± 0.062	0.323GluCys: 0.323 ± 0.017	3.442GluAsp: 3.442 ± 0.054	4.889GluGlu: 4.889 ± 0.082	2.63GluPhe: 2.63 ± 0.049	4.433GluGly: 4.433 ± 0.062	1.2GluHis: 1.2 ± 0.033	4.631GluIle: 4.631 ± 0.062	4.82GluLys: 4.82 ± 0.075	6.333GluLeu: 6.333 ± 0.072	2.153GluMet: 2.153 ± 0.038	3.586GluAsn: 3.586 ± 0.054	2.002GluPro: 2.002 ± 0.045	2.528GluGln: 2.528 ± 0.043	3.101GluArg: 3.101 ± 0.05	3.527GluSer: 3.527 ± 0.05	3.465GluThr: 3.465 ± 0.047	4.94GluVal: 4.94 ± 0.069	0.858GluTrp: 0.858 ± 0.024	2.161GluTyr: 2.161 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.815PheAla: 2.815 ± 0.052	0.4PheCys: 0.4 ± 0.02	3.014PheAsp: 3.014 ± 0.048	3.292PheGlu: 3.292 ± 0.048	2.643PhePhe: 2.643 ± 0.054	3.388PheGly: 3.388 ± 0.055	0.992PheHis: 0.992 ± 0.028	3.169PheIle: 3.169 ± 0.05	2.76PheLys: 2.76 ± 0.047	4.74PheLeu: 4.74 ± 0.069	1.284PheMet: 1.284 ± 0.029	2.792PheAsn: 2.792 ± 0.051	1.848PhePro: 1.848 ± 0.037	1.59PheGln: 1.59 ± 0.033	2.168PheArg: 2.168 ± 0.045	4.045PheSer: 4.045 ± 0.06	2.682PheThr: 2.682 ± 0.043	3.152PheVal: 3.152 ± 0.049	0.673PheTrp: 0.673 ± 0.02	2.05PheTyr: 2.05 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.821GlyAla: 4.821 ± 0.068	0.64GlyCys: 0.64 ± 0.031	3.768GlyAsp: 3.768 ± 0.068	4.318GlyGlu: 4.318 ± 0.059	3.697GlyPhe: 3.697 ± 0.061	4.981GlyGly: 4.981 ± 0.078	1.569GlyHis: 1.569 ± 0.035	5.098GlyIle: 5.098 ± 0.072	3.998GlyLys: 3.998 ± 0.066	6.819GlyLeu: 6.819 ± 0.08	2.006GlyMet: 2.006 ± 0.04	3.314GlyAsn: 3.314 ± 0.064	1.819GlyPro: 1.819 ± 0.039	2.826GlyGln: 2.826 ± 0.047	3.131GlyArg: 3.131 ± 0.058	4.611GlySer: 4.611 ± 0.078	3.987GlyThr: 3.987 ± 0.06	4.927GlyVal: 4.927 ± 0.074	1.05GlyTrp: 1.05 ± 0.028	2.956GlyTyr: 2.956 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.344HisAla: 1.344 ± 0.032	0.212HisCys: 0.212 ± 0.015	0.947HisAsp: 0.947 ± 0.03	1.184HisGlu: 1.184 ± 0.026	1.297HisPhe: 1.297 ± 0.027	1.368HisGly: 1.368 ± 0.031	0.67HisHis: 0.67 ± 0.025	1.442HisIle: 1.442 ± 0.033	1.14HisLys: 1.14 ± 0.03	2.458HisLeu: 2.458 ± 0.05	0.425HisMet: 0.425 ± 0.018	0.972HisAsn: 0.972 ± 0.029	1.304HisPro: 1.304 ± 0.033	1.048HisGln: 1.048 ± 0.026	0.95HisArg: 0.95 ± 0.028	1.278HisSer: 1.278 ± 0.029	1.063HisThr: 1.063 ± 0.028	1.098HisVal: 1.098 ± 0.026	0.302HisTrp: 0.302 ± 0.013	0.945HisTyr: 0.945 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.587IleAla: 4.587 ± 0.063	0.537IleCys: 0.537 ± 0.019	4.133IleAsp: 4.133 ± 0.059	4.802IleGlu: 4.802 ± 0.061	2.859IlePhe: 2.859 ± 0.043	4.584IleGly: 4.584 ± 0.066	1.589IleHis: 1.589 ± 0.038	4.457IleIle: 4.457 ± 0.077	4.009IleLys: 4.009 ± 0.062	5.928IleLeu: 5.928 ± 0.085	1.381IleMet: 1.381 ± 0.033	3.599IleAsn: 3.599 ± 0.056	3.101IlePro: 3.101 ± 0.051	2.529IleGln: 2.529 ± 0.045	3.325IleArg: 3.325 ± 0.055	4.968IleSer: 4.968 ± 0.069	3.881IleThr: 3.881 ± 0.063	4.147IleVal: 4.147 ± 0.056	0.826IleTrp: 0.826 ± 0.026	2.437IleTyr: 2.437 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.466LysAla: 4.466 ± 0.067	0.337LysCys: 0.337 ± 0.016	3.263LysAsp: 3.263 ± 0.059	4.541LysGlu: 4.541 ± 0.068	1.898LysPhe: 1.898 ± 0.036	4.228LysGly: 4.228 ± 0.063	1.21LysHis: 1.21 ± 0.027	3.891LysIle: 3.891 ± 0.062	4.118LysLys: 4.118 ± 0.076	4.731LysLeu: 4.731 ± 0.061	1.818LysMet: 1.818 ± 0.036	3.078LysAsn: 3.078 ± 0.052	2.085LysPro: 2.085 ± 0.042	2.053LysGln: 2.053 ± 0.042	2.661LysArg: 2.661 ± 0.048	3.423LysSer: 3.423 ± 0.057	3.24LysThr: 3.24 ± 0.058	3.964LysVal: 3.964 ± 0.064	0.765LysTrp: 0.765 ± 0.023	2.188LysTyr: 2.188 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.73LeuAla: 6.73 ± 0.073	0.623LeuCys: 0.623 ± 0.024	4.841LeuAsp: 4.841 ± 0.056	6.111LeuGlu: 6.111 ± 0.073	5.01LeuPhe: 5.01 ± 0.07	5.717LeuGly: 5.717 ± 0.071	1.844LeuHis: 1.844 ± 0.035	6.358LeuIle: 6.358 ± 0.077	6.673LeuLys: 6.673 ± 0.08	9.763LeuLeu: 9.763 ± 0.116	2.641LeuMet: 2.641 ± 0.038	5.272LeuAsn: 5.272 ± 0.06	4.219LeuPro: 4.219 ± 0.059	3.397LeuGln: 3.397 ± 0.054	4.066LeuArg: 4.066 ± 0.055	7.338LeuSer: 7.338 ± 0.078	5.413LeuThr: 5.413 ± 0.062	6.05LeuVal: 6.05 ± 0.069	1.131LeuTrp: 1.131 ± 0.032	3.199LeuTyr: 3.199 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.592MetAla: 2.592 ± 0.04	0.129MetCys: 0.129 ± 0.009	1.687MetAsp: 1.687 ± 0.035	1.86MetGlu: 1.86 ± 0.039	0.892MetPhe: 0.892 ± 0.026	2.067MetGly: 2.067 ± 0.041	0.519MetHis: 0.519 ± 0.02	1.483MetIle: 1.483 ± 0.032	1.732MetLys: 1.732 ± 0.036	2.246MetLeu: 2.246 ± 0.046	0.729MetMet: 0.729 ± 0.023	1.255MetAsn: 1.255 ± 0.031	1.194MetPro: 1.194 ± 0.03	0.995MetGln: 0.995 ± 0.031	1.181MetArg: 1.181 ± 0.029	1.438MetSer: 1.438 ± 0.031	1.407MetThr: 1.407 ± 0.035	2.156MetVal: 2.156 ± 0.042	0.227MetTrp: 0.227 ± 0.013	0.656MetTyr: 0.656 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.379AsnAla: 3.379 ± 0.055	0.374AsnCys: 0.374 ± 0.014	2.624AsnAsp: 2.624 ± 0.047	3.071AsnGlu: 3.071 ± 0.049	2.227AsnPhe: 2.227 ± 0.047	3.876AsnGly: 3.876 ± 0.066	1.171AsnHis: 1.171 ± 0.03	3.571AsnIle: 3.571 ± 0.053	2.715AsnLys: 2.715 ± 0.044	4.553AsnLeu: 4.553 ± 0.066	1.196AsnMet: 1.196 ± 0.03	2.82AsnAsn: 2.82 ± 0.048	2.585AsnPro: 2.585 ± 0.044	2.131AsnGln: 2.131 ± 0.044	2.494AsnArg: 2.494 ± 0.037	3.07AsnSer: 3.07 ± 0.05	2.651AsnThr: 2.651 ± 0.045	2.941AsnVal: 2.941 ± 0.05	0.783AsnTrp: 0.783 ± 0.025	2.261AsnTyr: 2.261 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.934ProAla: 2.934 ± 0.055	0.256ProCys: 0.256 ± 0.015	2.851ProAsp: 2.851 ± 0.045	3.413ProGlu: 3.413 ± 0.054	2.095ProPhe: 2.095 ± 0.036	3.034ProGly: 3.034 ± 0.05	0.88ProHis: 0.88 ± 0.024	2.305ProIle: 2.305 ± 0.035	1.777ProLys: 1.777 ± 0.043	3.604ProLeu: 3.604 ± 0.051	1.014ProMet: 1.014 ± 0.028	1.708ProAsn: 1.708 ± 0.034	1.15ProPro: 1.15 ± 0.03	1.345ProGln: 1.345 ± 0.034	1.345ProArg: 1.345 ± 0.03	2.442ProSer: 2.442 ± 0.044	1.864ProThr: 1.864 ± 0.039	3.433ProVal: 3.433 ± 0.055	0.487ProTrp: 0.487 ± 0.018	1.521ProTyr: 1.521 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.589GlnAla: 2.589 ± 0.045	0.197GlnCys: 0.197 ± 0.012	1.512GlnAsp: 1.512 ± 0.032	2.378GlnGlu: 2.378 ± 0.041	1.707GlnPhe: 1.707 ± 0.041	2.11GlnGly: 2.11 ± 0.041	0.731GlnHis: 0.731 ± 0.022	2.568GlnIle: 2.568 ± 0.05	2.654GlnLys: 2.654 ± 0.054	4.159GlnLeu: 4.159 ± 0.059	1.169GlnMet: 1.169 ± 0.028	1.929GlnAsn: 1.929 ± 0.043	1.567GlnPro: 1.567 ± 0.035	1.731GlnGln: 1.731 ± 0.048	1.766GlnArg: 1.766 ± 0.037	2.417GlnSer: 2.417 ± 0.044	1.986GlnThr: 1.986 ± 0.039	2.509GlnVal: 2.509 ± 0.046	0.574GlnTrp: 0.574 ± 0.02	1.378GlnTyr: 1.378 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.703ArgAla: 2.703 ± 0.045	0.285ArgCys: 0.285 ± 0.016	2.391ArgAsp: 2.391 ± 0.044	3.075ArgGlu: 3.075 ± 0.052	2.603ArgPhe: 2.603 ± 0.045	2.463ArgGly: 2.463 ± 0.047	1.05ArgHis: 1.05 ± 0.03	3.308ArgIle: 3.308 ± 0.044	2.787ArgLys: 2.787 ± 0.048	4.712ArgLeu: 4.712 ± 0.054	1.467ArgMet: 1.467 ± 0.035	2.324ArgAsn: 2.324 ± 0.039	1.743ArgPro: 1.743 ± 0.039	1.976ArgGln: 1.976 ± 0.042	2.06ArgArg: 2.06 ± 0.042	2.634ArgSer: 2.634 ± 0.044	2.14ArgThr: 2.14 ± 0.039	2.891ArgVal: 2.891 ± 0.051	0.642ArgTrp: 0.642 ± 0.026	1.993ArgTyr: 1.993 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.506SerAla: 4.506 ± 0.061	0.51SerCys: 0.51 ± 0.021	3.83SerAsp: 3.83 ± 0.051	4.071SerGlu: 4.071 ± 0.054	3.563SerPhe: 3.563 ± 0.05	5.489SerGly: 5.489 ± 0.073	1.39SerHis: 1.39 ± 0.031	4.469SerIle: 4.469 ± 0.068	3.144SerLys: 3.144 ± 0.057	6.211SerLeu: 6.211 ± 0.064	1.595SerMet: 1.595 ± 0.033	3.027SerAsn: 3.027 ± 0.05	2.568SerPro: 2.568 ± 0.045	2.244SerGln: 2.244 ± 0.034	2.992SerArg: 2.992 ± 0.049	4.343SerSer: 4.343 ± 0.071	3.358SerThr: 3.358 ± 0.05	4.512SerVal: 4.512 ± 0.055	0.861SerTrp: 0.861 ± 0.03	2.546SerTyr: 2.546 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.823ThrAla: 3.823 ± 0.058	0.38ThrCys: 0.38 ± 0.021	3.115ThrAsp: 3.115 ± 0.047	3.118ThrGlu: 3.118 ± 0.051	2.571ThrPhe: 2.571 ± 0.041	4.594ThrGly: 4.594 ± 0.059	1.116ThrHis: 1.116 ± 0.029	4.104ThrIle: 4.104 ± 0.063	2.377ThrLys: 2.377 ± 0.043	4.914ThrLeu: 4.914 ± 0.064	1.131ThrMet: 1.131 ± 0.031	2.514ThrAsn: 2.514 ± 0.046	2.569ThrPro: 2.569 ± 0.041	1.733ThrGln: 1.733 ± 0.034	2.229ThrArg: 2.229 ± 0.043	3.451ThrSer: 3.451 ± 0.055	3.068ThrThr: 3.068 ± 0.056	3.611ThrVal: 3.611 ± 0.066	0.664ThrTrp: 0.664 ± 0.025	2.046ThrTyr: 2.046 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.781ValAla: 4.781 ± 0.065	0.52ValCys: 0.52 ± 0.023	3.799ValAsp: 3.799 ± 0.051	4.399ValGlu: 4.399 ± 0.057	3.632ValPhe: 3.632 ± 0.058	4.078ValGly: 4.078 ± 0.061	1.303ValHis: 1.303 ± 0.033	4.443ValIle: 4.443 ± 0.06	3.919ValLys: 3.919 ± 0.06	6.506ValLeu: 6.506 ± 0.072	1.686ValMet: 1.686 ± 0.034	3.403ValAsn: 3.403 ± 0.061	2.7ValPro: 2.7 ± 0.045	2.052ValGln: 2.052 ± 0.033	2.923ValArg: 2.923 ± 0.048	4.771ValSer: 4.771 ± 0.063	3.723ValThr: 3.723 ± 0.066	5.155ValVal: 5.155 ± 0.068	0.85ValTrp: 0.85 ± 0.028	2.508ValTyr: 2.508 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.807TrpAla: 0.807 ± 0.025	0.116TrpCys: 0.116 ± 0.007	0.779TrpAsp: 0.779 ± 0.028	0.859TrpGlu: 0.859 ± 0.026	0.646TrpPhe: 0.646 ± 0.025	0.933TrpGly: 0.933 ± 0.029	0.309TrpHis: 0.309 ± 0.016	0.809TrpIle: 0.809 ± 0.025	0.683TrpLys: 0.683 ± 0.026	1.328TrpLeu: 1.328 ± 0.035	0.487TrpMet: 0.487 ± 0.021	0.697TrpAsn: 0.697 ± 0.023	0.455TrpPro: 0.455 ± 0.02	0.604TrpGln: 0.604 ± 0.022	0.645TrpArg: 0.645 ± 0.023	0.866TrpSer: 0.866 ± 0.029	0.696TrpThr: 0.696 ± 0.023	0.896TrpVal: 0.896 ± 0.026	0.256TrpTrp: 0.256 ± 0.012	0.459TrpTyr: 0.459 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.489TyrAla: 2.489 ± 0.04	0.314TyrCys: 0.314 ± 0.015	2.181TyrAsp: 2.181 ± 0.046	2.249TyrGlu: 2.249 ± 0.04	2.189TyrPhe: 2.189 ± 0.039	2.758TyrGly: 2.758 ± 0.057	0.947TyrHis: 0.947 ± 0.025	2.198TyrIle: 2.198 ± 0.045	2.016TyrLys: 2.016 ± 0.042	3.868TyrLeu: 3.868 ± 0.06	0.888TyrMet: 0.888 ± 0.025	2.146TyrAsn: 2.146 ± 0.045	1.581TyrPro: 1.581 ± 0.035	1.756TyrGln: 1.756 ± 0.037	2.072TyrArg: 2.072 ± 0.041	2.604TyrSer: 2.604 ± 0.048	2.027TyrThr: 2.027 ± 0.041	2.122TyrVal: 2.122 ± 0.037	0.558TyrTrp: 0.558 ± 0.021	1.781TyrTyr: 1.781 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4411 proteins (1419689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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