Amino acid dipepetide frequency for Brettanomyces naardenensis (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.313AlaAla: 5.313 ± 0.072	0.752AlaCys: 0.752 ± 0.021	3.625AlaAsp: 3.625 ± 0.04	4.174AlaGlu: 4.174 ± 0.049	2.434AlaPhe: 2.434 ± 0.033	3.835AlaGly: 3.835 ± 0.041	1.088AlaHis: 1.088 ± 0.022	3.771AlaIle: 3.771 ± 0.045	4.17AlaLys: 4.17 ± 0.049	5.743AlaLeu: 5.743 ± 0.054	1.372AlaMet: 1.372 ± 0.021	2.773AlaAsn: 2.773 ± 0.032	2.685AlaPro: 2.685 ± 0.049	2.192AlaGln: 2.192 ± 0.045	3.089AlaArg: 3.089 ± 0.037	5.733AlaSer: 5.733 ± 0.065	3.83AlaThr: 3.83 ± 0.052	4.167AlaVal: 4.167 ± 0.045	0.537AlaTrp: 0.537 ± 0.015	1.921AlaTyr: 1.921 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.647CysAla: 0.647 ± 0.018	0.302CysCys: 0.302 ± 0.012	0.653CysAsp: 0.653 ± 0.016	0.584CysGlu: 0.584 ± 0.017	0.644CysPhe: 0.644 ± 0.017	0.897CysGly: 0.897 ± 0.024	0.296CysHis: 0.296 ± 0.012	0.824CysIle: 0.824 ± 0.017	0.662CysLys: 0.662 ± 0.015	1.321CysLeu: 1.321 ± 0.025	0.269CysMet: 0.269 ± 0.01	0.483CysAsn: 0.483 ± 0.014	0.488CysPro: 0.488 ± 0.016	0.362CysGln: 0.362 ± 0.013	0.586CysArg: 0.586 ± 0.016	0.968CysSer: 0.968 ± 0.024	0.579CysThr: 0.579 ± 0.017	0.771CysVal: 0.771 ± 0.019	0.161CysTrp: 0.161 ± 0.009	0.504CysTyr: 0.504 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.569AspAla: 3.569 ± 0.043	0.651AspCys: 0.651 ± 0.018	5.16AspAsp: 5.16 ± 0.074	5.56AspGlu: 5.56 ± 0.069	2.719AspPhe: 2.719 ± 0.03	3.733AspGly: 3.733 ± 0.065	1.101AspHis: 1.101 ± 0.022	3.636AspIle: 3.636 ± 0.044	3.477AspLys: 3.477 ± 0.043	5.917AspLeu: 5.917 ± 0.051	1.183AspMet: 1.183 ± 0.022	2.568AspAsn: 2.568 ± 0.034	2.885AspPro: 2.885 ± 0.039	1.949AspGln: 1.949 ± 0.028	2.833AspArg: 2.833 ± 0.035	5.36AspSer: 5.36 ± 0.052	3.044AspThr: 3.044 ± 0.037	3.81AspVal: 3.81 ± 0.039	0.662AspTrp: 0.662 ± 0.015	2.309AspTyr: 2.309 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	4.363GluAla: 4.363 ± 0.051	0.624GluCys: 0.624 ± 0.015	5.108GluAsp: 5.108 ± 0.052	7.506GluGlu: 7.506 ± 0.114	2.665GluPhe: 2.665 ± 0.034	3.926GluGly: 3.926 ± 0.05	1.114GluHis: 1.114 ± 0.023	3.979GluIle: 3.979 ± 0.045	5.274GluLys: 5.274 ± 0.065	6.523GluLeu: 6.523 ± 0.066	1.62GluMet: 1.62 ± 0.03	3.202GluAsn: 3.202 ± 0.037	2.315GluPro: 2.315 ± 0.039	2.576GluGln: 2.576 ± 0.035	3.734GluArg: 3.734 ± 0.046	5.125GluSer: 5.125 ± 0.058	3.424GluThr: 3.424 ± 0.045	4.236GluVal: 4.236 ± 0.044	0.623GluTrp: 0.623 ± 0.016	2.27GluTyr: 2.27 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	2.628PheAla: 2.628 ± 0.039	0.589PheCys: 0.589 ± 0.015	2.866PheAsp: 2.866 ± 0.036	2.72PheGlu: 2.72 ± 0.035	1.987PhePhe: 1.987 ± 0.033	2.934PheGly: 2.934 ± 0.041	0.903PheHis: 0.903 ± 0.019	2.457PheIle: 2.457 ± 0.036	2.645PheLys: 2.645 ± 0.034	3.916PheLeu: 3.916 ± 0.048	0.862PheMet: 0.862 ± 0.02	2.108PheAsn: 2.108 ± 0.029	1.696PhePro: 1.696 ± 0.028	1.624PheGln: 1.624 ± 0.029	2.038PheArg: 2.038 ± 0.031	3.518PheSer: 3.518 ± 0.039	2.27PheThr: 2.27 ± 0.032	2.845PheVal: 2.845 ± 0.032	0.506PheTrp: 0.506 ± 0.015	1.507PheTyr: 1.507 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	3.554GlyAla: 3.554 ± 0.05	0.788GlyCys: 0.788 ± 0.018	3.588GlyAsp: 3.588 ± 0.041	3.974GlyGlu: 3.974 ± 0.048	2.762GlyPhe: 2.762 ± 0.039	4.218GlyGly: 4.218 ± 0.069	1.2GlyHis: 1.2 ± 0.023	3.607GlyIle: 3.607 ± 0.044	4.12GlyLys: 4.12 ± 0.046	5.48GlyLeu: 5.48 ± 0.05	1.227GlyMet: 1.227 ± 0.023	2.7GlyAsn: 2.7 ± 0.036	2.121GlyPro: 2.121 ± 0.097	1.923GlyGln: 1.923 ± 0.031	3.052GlyArg: 3.052 ± 0.04	5.813GlySer: 5.813 ± 0.059	3.295GlyThr: 3.295 ± 0.038	3.703GlyVal: 3.703 ± 0.049	0.676GlyTrp: 0.676 ± 0.017	2.28GlyTyr: 2.28 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	0.992HisAla: 0.992 ± 0.019	0.28HisCys: 0.28 ± 0.012	1.045HisAsp: 1.045 ± 0.02	1.083HisGlu: 1.083 ± 0.021	0.869HisPhe: 0.869 ± 0.02	1.197HisGly: 1.197 ± 0.023	0.662HisHis: 0.662 ± 0.024	1.091HisIle: 1.091 ± 0.02	1.067HisLys: 1.067 ± 0.021	1.874HisLeu: 1.874 ± 0.028	0.401HisMet: 0.401 ± 0.013	0.797HisAsn: 0.797 ± 0.021	1.124HisPro: 1.124 ± 0.02	0.739HisGln: 0.739 ± 0.016	1.214HisArg: 1.214 ± 0.028	1.718HisSer: 1.718 ± 0.029	0.934HisThr: 0.934 ± 0.019	1.133HisVal: 1.133 ± 0.023	0.224HisTrp: 0.224 ± 0.01	0.737HisTyr: 0.737 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.626IleAla: 3.626 ± 0.039	0.816IleCys: 0.816 ± 0.02	3.993IleAsp: 3.993 ± 0.048	3.755IleGlu: 3.755 ± 0.041	2.44IlePhe: 2.44 ± 0.032	3.416IleGly: 3.416 ± 0.045	1.222IleHis: 1.222 ± 0.022	3.164IleIle: 3.164 ± 0.046	3.342IleLys: 3.342 ± 0.043	5.487IleLeu: 5.487 ± 0.054	1.187IleMet: 1.187 ± 0.021	2.539IleAsn: 2.539 ± 0.032	3.171IlePro: 3.171 ± 0.037	2.086IleGln: 2.086 ± 0.033	2.944IleArg: 2.944 ± 0.035	4.967IleSer: 4.967 ± 0.051	3.086IleThr: 3.086 ± 0.035	3.839IleVal: 3.839 ± 0.05	0.628IleTrp: 0.628 ± 0.016	1.906IleTyr: 1.906 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.998LysAla: 3.998 ± 0.049	0.653LysCys: 0.653 ± 0.018	3.904LysAsp: 3.904 ± 0.051	5.341LysGlu: 5.341 ± 0.065	2.569LysPhe: 2.569 ± 0.033	3.39LysGly: 3.39 ± 0.044	1.21LysHis: 1.21 ± 0.026	3.661LysIle: 3.661 ± 0.041	5.446LysLys: 5.446 ± 0.063	6.58LysLeu: 6.58 ± 0.061	1.479LysMet: 1.479 ± 0.026	2.765LysAsn: 2.765 ± 0.038	2.685LysPro: 2.685 ± 0.043	2.558LysGln: 2.558 ± 0.036	4.009LysArg: 4.009 ± 0.045	4.619LysSer: 4.619 ± 0.048	3.196LysThr: 3.196 ± 0.039	4.425LysVal: 4.425 ± 0.043	0.681LysTrp: 0.681 ± 0.018	2.378LysTyr: 2.378 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	6.231LeuAla: 6.231 ± 0.05	1.239LeuCys: 1.239 ± 0.022	5.784LeuAsp: 5.784 ± 0.047	6.108LeuGlu: 6.108 ± 0.063	3.971LeuPhe: 3.971 ± 0.047	5.303LeuGly: 5.303 ± 0.05	1.825LeuHis: 1.825 ± 0.026	5.293LeuIle: 5.293 ± 0.058	6.678LeuLys: 6.678 ± 0.062	9.207LeuLeu: 9.207 ± 0.095	2.024LeuMet: 2.024 ± 0.032	4.485LeuAsn: 4.485 ± 0.047	4.612LeuPro: 4.612 ± 0.047	3.929LeuGln: 3.929 ± 0.054	5.175LeuArg: 5.175 ± 0.047	8.364LeuSer: 8.364 ± 0.071	5.178LeuThr: 5.178 ± 0.049	5.905LeuVal: 5.905 ± 0.051	0.871LeuTrp: 0.871 ± 0.02	2.95LeuTyr: 2.95 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	1.515MetAla: 1.515 ± 0.024	0.255MetCys: 0.255 ± 0.01	1.31MetAsp: 1.31 ± 0.024	1.309MetGlu: 1.309 ± 0.023	0.866MetPhe: 0.866 ± 0.017	1.263MetGly: 1.263 ± 0.023	0.339MetHis: 0.339 ± 0.011	1.214MetIle: 1.214 ± 0.025	1.461MetLys: 1.461 ± 0.024	1.918MetLeu: 1.918 ± 0.032	0.553MetMet: 0.553 ± 0.014	1.103MetAsn: 1.103 ± 0.023	0.869MetPro: 0.869 ± 0.02	0.69MetGln: 0.69 ± 0.018	1.007MetArg: 1.007 ± 0.022	2.019MetSer: 2.019 ± 0.029	1.242MetThr: 1.242 ± 0.023	1.38MetVal: 1.38 ± 0.024	0.171MetTrp: 0.171 ± 0.008	0.663MetTyr: 0.663 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.706AsnAla: 2.706 ± 0.031	0.576AsnCys: 0.576 ± 0.016	2.796AsnAsp: 2.796 ± 0.035	3.099AsnGlu: 3.099 ± 0.038	2.017AsnPhe: 2.017 ± 0.029	3.194AsnGly: 3.194 ± 0.041	0.852AsnHis: 0.852 ± 0.019	2.434AsnIle: 2.434 ± 0.031	2.411AsnLys: 2.411 ± 0.031	4.176AsnLeu: 4.176 ± 0.04	0.948AsnMet: 0.948 ± 0.021	2.034AsnAsn: 2.034 ± 0.037	2.181AsnPro: 2.181 ± 0.035	1.501AsnGln: 1.501 ± 0.027	2.16AsnArg: 2.16 ± 0.033	4.038AsnSer: 4.038 ± 0.041	2.205AsnThr: 2.205 ± 0.036	2.819AsnVal: 2.819 ± 0.035	0.54AsnTrp: 0.54 ± 0.015	1.747AsnTyr: 1.747 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	2.951ProAla: 2.951 ± 0.047	0.344ProCys: 0.344 ± 0.012	2.595ProAsp: 2.595 ± 0.032	3.519ProGlu: 3.519 ± 0.044	1.917ProPhe: 1.917 ± 0.029	2.375ProGly: 2.375 ± 0.034	0.814ProHis: 0.814 ± 0.02	2.577ProIle: 2.577 ± 0.032	2.768ProLys: 2.768 ± 0.043	4.078ProLeu: 4.078 ± 0.049	0.81ProMet: 0.81 ± 0.018	1.894ProAsn: 1.894 ± 0.026	2.792ProPro: 2.792 ± 0.074	1.921ProGln: 1.921 ± 0.042	2.062ProArg: 2.062 ± 0.035	4.58ProSer: 4.58 ± 0.062	2.76ProThr: 2.76 ± 0.038	3.172ProVal: 3.172 ± 0.075	0.434ProTrp: 0.434 ± 0.015	1.451ProTyr: 1.451 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.284GlnAla: 2.284 ± 0.044	0.407GlnCys: 0.407 ± 0.013	1.793GlnAsp: 1.793 ± 0.028	2.323GlnGlu: 2.323 ± 0.033	1.689GlnPhe: 1.689 ± 0.027	1.929GlnGly: 1.929 ± 0.032	0.716GlnHis: 0.716 ± 0.019	2.247GlnIle: 2.247 ± 0.037	2.373GlnLys: 2.373 ± 0.037	4.122GlnLeu: 4.122 ± 0.049	0.912GlnMet: 0.912 ± 0.019	1.54GlnAsn: 1.54 ± 0.026	1.811GlnPro: 1.811 ± 0.046	3.193GlnGln: 3.193 ± 0.132	2.164GlnArg: 2.164 ± 0.035	2.923GlnSer: 2.923 ± 0.043	1.811GlnThr: 1.811 ± 0.028	2.169GlnVal: 2.169 ± 0.03	0.367GlnTrp: 0.367 ± 0.011	1.302GlnTyr: 1.302 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.031ArgAla: 3.031 ± 0.032	0.616ArgCys: 0.616 ± 0.019	2.843ArgAsp: 2.843 ± 0.035	3.499ArgGlu: 3.499 ± 0.043	2.286ArgPhe: 2.286 ± 0.033	2.832ArgGly: 2.832 ± 0.044	1.123ArgHis: 1.123 ± 0.023	3.086ArgIle: 3.086 ± 0.042	4.009ArgLys: 4.009 ± 0.045	5.229ArgLeu: 5.229 ± 0.055	1.224ArgMet: 1.224 ± 0.019	2.322ArgAsn: 2.322 ± 0.034	2.133ArgPro: 2.133 ± 0.038	2.18ArgGln: 2.18 ± 0.033	3.904ArgArg: 3.904 ± 0.05	4.318ArgSer: 4.318 ± 0.051	2.584ArgThr: 2.584 ± 0.036	2.891ArgVal: 2.891 ± 0.036	0.53ArgTrp: 0.53 ± 0.015	1.882ArgTyr: 1.882 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	5.472SerAla: 5.472 ± 0.067	0.888SerCys: 0.888 ± 0.019	5.011SerAsp: 5.011 ± 0.054	5.295SerGlu: 5.295 ± 0.057	3.748SerPhe: 3.748 ± 0.036	5.373SerGly: 5.373 ± 0.05	1.665SerHis: 1.665 ± 0.028	5.114SerIle: 5.114 ± 0.044	5.45SerLys: 5.45 ± 0.057	8.478SerLeu: 8.478 ± 0.086	1.763SerMet: 1.763 ± 0.03	3.825SerAsn: 3.825 ± 0.044	4.311SerPro: 4.311 ± 0.064	3.246SerGln: 3.246 ± 0.048	4.426SerArg: 4.426 ± 0.045	10.511SerSer: 10.511 ± 0.153	5.474SerThr: 5.474 ± 0.055	5.276SerVal: 5.276 ± 0.048	0.823SerTrp: 0.823 ± 0.017	2.6SerTyr: 2.6 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	3.737ThrAla: 3.737 ± 0.044	0.621ThrCys: 0.621 ± 0.016	3.069ThrAsp: 3.069 ± 0.034	3.365ThrGlu: 3.365 ± 0.045	2.311ThrPhe: 2.311 ± 0.035	3.595ThrGly: 3.595 ± 0.043	0.92ThrHis: 0.92 ± 0.017	3.297ThrIle: 3.297 ± 0.04	3.241ThrLys: 3.241 ± 0.036	4.927ThrLeu: 4.927 ± 0.049	1.024ThrMet: 1.024 ± 0.02	2.329ThrAsn: 2.329 ± 0.032	3.005ThrPro: 3.005 ± 0.042	1.647ThrGln: 1.647 ± 0.028	2.548ThrArg: 2.548 ± 0.032	5.065ThrSer: 5.065 ± 0.074	3.705ThrThr: 3.705 ± 0.072	3.776ThrVal: 3.776 ± 0.041	0.516ThrTrp: 0.516 ± 0.014	1.637ThrTyr: 1.637 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	4.16ValAla: 4.16 ± 0.047	0.865ValCys: 0.865 ± 0.021	4.183ValAsp: 4.183 ± 0.063	4.296ValGlu: 4.296 ± 0.044	2.613ValPhe: 2.613 ± 0.038	3.853ValGly: 3.853 ± 0.058	1.172ValHis: 1.172 ± 0.022	3.639ValIle: 3.639 ± 0.043	4.204ValLys: 4.204 ± 0.046	5.708ValLeu: 5.708 ± 0.051	1.275ValMet: 1.275 ± 0.023	2.856ValAsn: 2.856 ± 0.036	3.159ValPro: 3.159 ± 0.043	2.089ValGln: 2.089 ± 0.034	3.116ValArg: 3.116 ± 0.035	5.565ValSer: 5.565 ± 0.05	3.445ValThr: 3.445 ± 0.043	4.247ValVal: 4.247 ± 0.046	0.612ValTrp: 0.612 ± 0.017	2.086ValTyr: 2.086 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.543TrpAla: 0.543 ± 0.015	0.223TrpCys: 0.223 ± 0.009	0.637TrpAsp: 0.637 ± 0.017	0.571TrpGlu: 0.571 ± 0.016	0.502TrpPhe: 0.502 ± 0.016	0.588TrpGly: 0.588 ± 0.016	0.188TrpHis: 0.188 ± 0.009	0.653TrpIle: 0.653 ± 0.016	0.805TrpLys: 0.805 ± 0.016	0.975TrpLeu: 0.975 ± 0.022	0.261TrpMet: 0.261 ± 0.01	0.545TrpAsn: 0.545 ± 0.016	0.302TrpPro: 0.302 ± 0.01	0.347TrpGln: 0.347 ± 0.012	0.57TrpArg: 0.57 ± 0.017	0.754TrpSer: 0.754 ± 0.02	0.574TrpThr: 0.574 ± 0.017	0.555TrpVal: 0.555 ± 0.017	0.162TrpTrp: 0.162 ± 0.008	0.374TrpTyr: 0.374 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.886TyrAla: 1.886 ± 0.029	0.508TyrCys: 0.508 ± 0.016	2.165TyrAsp: 2.165 ± 0.032	2.125TyrGlu: 2.125 ± 0.031	1.612TyrPhe: 1.612 ± 0.028	2.226TyrGly: 2.226 ± 0.035	0.772TyrHis: 0.772 ± 0.019	1.873TyrIle: 1.873 ± 0.028	1.946TyrLys: 1.946 ± 0.03	3.474TyrLeu: 3.474 ± 0.046	0.754TyrMet: 0.754 ± 0.017	1.566TyrAsn: 1.566 ± 0.026	1.466TyrPro: 1.466 ± 0.025	1.323TyrGln: 1.323 ± 0.026	1.891TyrArg: 1.891 ± 0.026	2.789TyrSer: 2.789 ± 0.035	1.698TyrThr: 1.698 ± 0.028	2.024TyrVal: 2.024 ± 0.031	0.408TyrTrp: 0.408 ± 0.015	1.439TyrTyr: 1.439 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5175 proteins (2563765 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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