Amino acid dipepetide frequency for Candidatus Protochlamydia naegleriophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.169AlaAla: 6.169 ± 0.111	1.127AlaCys: 1.127 ± 0.043	3.369AlaAsp: 3.369 ± 0.064	4.432AlaGlu: 4.432 ± 0.085	3.886AlaPhe: 3.886 ± 0.075	4.45AlaGly: 4.45 ± 0.071	1.91AlaHis: 1.91 ± 0.048	5.857AlaIle: 5.857 ± 0.096	4.705AlaLys: 4.705 ± 0.089	9.322AlaLeu: 9.322 ± 0.143	1.742AlaMet: 1.742 ± 0.054	2.827AlaAsn: 2.827 ± 0.065	2.724AlaPro: 2.724 ± 0.063	3.461AlaGln: 3.461 ± 0.071	3.215AlaArg: 3.215 ± 0.069	4.981AlaSer: 4.981 ± 0.077	3.704AlaThr: 3.704 ± 0.146	4.531AlaVal: 4.531 ± 0.071	0.954AlaTrp: 0.954 ± 0.035	2.712AlaTyr: 2.712 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.835CysAla: 0.835 ± 0.039	0.283CysCys: 0.283 ± 0.021	0.578CysAsp: 0.578 ± 0.031	0.726CysGlu: 0.726 ± 0.032	0.673CysPhe: 0.673 ± 0.029	0.827CysGly: 0.827 ± 0.032	0.427CysHis: 0.427 ± 0.025	0.746CysIle: 0.746 ± 0.032	0.532CysLys: 0.532 ± 0.027	1.678CysLeu: 1.678 ± 0.049	0.256CysMet: 0.256 ± 0.017	0.417CysAsn: 0.417 ± 0.025	0.584CysPro: 0.584 ± 0.031	0.729CysGln: 0.729 ± 0.031	0.644CysArg: 0.644 ± 0.028	0.86CysSer: 0.86 ± 0.033	0.564CysThr: 0.564 ± 0.027	0.726CysVal: 0.726 ± 0.031	0.184CysTrp: 0.184 ± 0.014	0.487CysTyr: 0.487 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.333AspAla: 3.333 ± 0.068	0.617AspCys: 0.617 ± 0.027	2.154AspAsp: 2.154 ± 0.053	3.438AspGlu: 3.438 ± 0.069	2.561AspPhe: 2.561 ± 0.055	2.806AspGly: 2.806 ± 0.066	1.289AspHis: 1.289 ± 0.039	3.108AspIle: 3.108 ± 0.066	2.751AspLys: 2.751 ± 0.067	5.741AspLeu: 5.741 ± 0.091	0.948AspMet: 0.948 ± 0.033	1.66AspAsn: 1.66 ± 0.047	2.553AspPro: 2.553 ± 0.059	2.374AspGln: 2.374 ± 0.054	2.499AspArg: 2.499 ± 0.052	3.069AspSer: 3.069 ± 0.069	1.891AspThr: 1.891 ± 0.051	2.763AspVal: 2.763 ± 0.057	0.718AspTrp: 0.718 ± 0.032	2.047AspTyr: 2.047 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.577GluAla: 5.577 ± 0.094	0.702GluCys: 0.702 ± 0.029	2.983GluAsp: 2.983 ± 0.057	5.89GluGlu: 5.89 ± 0.112	2.461GluPhe: 2.461 ± 0.061	3.992GluGly: 3.992 ± 0.083	1.459GluHis: 1.459 ± 0.04	4.371GluIle: 4.371 ± 0.084	5.263GluLys: 5.263 ± 0.098	6.804GluLeu: 6.804 ± 0.104	1.739GluMet: 1.739 ± 0.046	2.906GluAsn: 2.906 ± 0.062	1.994GluPro: 1.994 ± 0.052	3.357GluGln: 3.357 ± 0.073	3.573GluArg: 3.573 ± 0.067	3.947GluSer: 3.947 ± 0.068	3.163GluThr: 3.163 ± 0.063	3.859GluVal: 3.859 ± 0.077	0.943GluTrp: 0.943 ± 0.04	1.662GluTyr: 1.662 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.405PheAla: 3.405 ± 0.072	0.742PheCys: 0.742 ± 0.038	2.493PheAsp: 2.493 ± 0.057	2.902PheGlu: 2.902 ± 0.06	2.747PhePhe: 2.747 ± 0.07	2.91PheGly: 2.91 ± 0.064	1.171PheHis: 1.171 ± 0.038	3.241PheIle: 3.241 ± 0.057	2.794PheLys: 2.794 ± 0.058	5.114PheLeu: 5.114 ± 0.092	0.956PheMet: 0.956 ± 0.03	2.151PheAsn: 2.151 ± 0.056	1.984PhePro: 1.984 ± 0.052	1.95PheGln: 1.95 ± 0.052	1.786PheArg: 1.786 ± 0.047	3.752PheSer: 3.752 ± 0.063	2.319PheThr: 2.319 ± 0.056	2.653PheVal: 2.653 ± 0.065	0.598PheTrp: 0.598 ± 0.026	1.812PheTyr: 1.812 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.317GlyAla: 4.317 ± 0.163	0.958GlyCys: 0.958 ± 0.04	2.716GlyAsp: 2.716 ± 0.054	3.513GlyGlu: 3.513 ± 0.07	3.012GlyPhe: 3.012 ± 0.065	4.065GlyGly: 4.065 ± 0.088	1.605GlyHis: 1.605 ± 0.043	4.757GlyIle: 4.757 ± 0.086	4.046GlyLys: 4.046 ± 0.076	6.359GlyLeu: 6.359 ± 0.1	1.752GlyMet: 1.752 ± 0.048	2.198GlyAsn: 2.198 ± 0.06	1.854GlyPro: 1.854 ± 0.066	2.541GlyGln: 2.541 ± 0.066	2.861GlyArg: 2.861 ± 0.068	3.936GlySer: 3.936 ± 0.074	3.167GlyThr: 3.167 ± 0.061	3.954GlyVal: 3.954 ± 0.079	0.935GlyTrp: 0.935 ± 0.035	2.351GlyTyr: 2.351 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.819HisAla: 1.819 ± 0.046	0.373HisCys: 0.373 ± 0.02	1.078HisAsp: 1.078 ± 0.036	1.347HisGlu: 1.347 ± 0.039	1.538HisPhe: 1.538 ± 0.045	1.396HisGly: 1.396 ± 0.049	0.917HisHis: 0.917 ± 0.047	1.464HisIle: 1.464 ± 0.04	1.11HisLys: 1.11 ± 0.039	3.445HisLeu: 3.445 ± 0.077	0.479HisMet: 0.479 ± 0.025	0.826HisAsn: 0.826 ± 0.032	1.58HisPro: 1.58 ± 0.045	1.298HisGln: 1.298 ± 0.04	1.218HisArg: 1.218 ± 0.044	1.781HisSer: 1.781 ± 0.045	1.199HisThr: 1.199 ± 0.039	1.414HisVal: 1.414 ± 0.042	0.323HisTrp: 0.323 ± 0.018	1.131HisTyr: 1.131 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.644IleAla: 5.644 ± 0.094	0.951IleCys: 0.951 ± 0.033	4.119IleAsp: 4.119 ± 0.066	4.998IleGlu: 4.998 ± 0.085	2.959IlePhe: 2.959 ± 0.063	4.52IleGly: 4.52 ± 0.087	1.702IleHis: 1.702 ± 0.046	3.962IleIle: 3.962 ± 0.081	3.978IleLys: 3.978 ± 0.077	6.806IleLeu: 6.806 ± 0.09	1.061IleMet: 1.061 ± 0.036	2.826IleAsn: 2.826 ± 0.058	3.403IlePro: 3.403 ± 0.063	3.522IleGln: 3.522 ± 0.075	3.175IleArg: 3.175 ± 0.065	4.3IleSer: 4.3 ± 0.062	3.085IleThr: 3.085 ± 0.077	4.051IleVal: 4.051 ± 0.077	0.672IleTrp: 0.672 ± 0.031	2.155IleTyr: 2.155 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.73LysAla: 4.73 ± 0.084	0.506LysCys: 0.506 ± 0.027	3.094LysAsp: 3.094 ± 0.065	5.438LysGlu: 5.438 ± 0.088	1.741LysPhe: 1.741 ± 0.044	4.07LysGly: 4.07 ± 0.084	1.481LysHis: 1.481 ± 0.042	4.188LysIle: 4.188 ± 0.079	4.861LysLys: 4.861 ± 0.086	5.502LysLeu: 5.502 ± 0.088	1.523LysMet: 1.523 ± 0.043	2.707LysAsn: 2.707 ± 0.057	2.339LysPro: 2.339 ± 0.052	3.419LysGln: 3.419 ± 0.059	3.222LysArg: 3.222 ± 0.062	3.581LysSer: 3.581 ± 0.063	3.319LysThr: 3.319 ± 0.063	3.363LysVal: 3.363 ± 0.08	0.843LysTrp: 0.843 ± 0.033	1.448LysTyr: 1.448 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	9.233LeuAla: 9.233 ± 0.114	1.307LeuCys: 1.307 ± 0.039	5.38LeuAsp: 5.38 ± 0.086	7.347LeuGlu: 7.347 ± 0.126	5.519LeuPhe: 5.519 ± 0.094	6.205LeuGly: 6.205 ± 0.104	2.487LeuHis: 2.487 ± 0.056	7.648LeuIle: 7.648 ± 0.111	7.617LeuLys: 7.617 ± 0.101	11.655LeuLeu: 11.655 ± 0.143	2.563LeuMet: 2.563 ± 0.058	4.954LeuAsn: 4.954 ± 0.081	5.078LeuPro: 5.078 ± 0.092	5.02LeuGln: 5.02 ± 0.094	4.542LeuArg: 4.542 ± 0.071	8.569LeuSer: 8.569 ± 0.12	6.002LeuThr: 6.002 ± 0.085	5.995LeuVal: 5.995 ± 0.094	1.079LeuTrp: 1.079 ± 0.044	3.279LeuTyr: 3.279 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.936MetAla: 1.936 ± 0.053	0.21MetCys: 0.21 ± 0.016	0.979MetAsp: 0.979 ± 0.036	1.284MetGlu: 1.284 ± 0.04	0.643MetPhe: 0.643 ± 0.028	1.619MetGly: 1.619 ± 0.055	0.601MetHis: 0.601 ± 0.029	1.559MetIle: 1.559 ± 0.045	1.368MetLys: 1.368 ± 0.043	2.135MetLeu: 2.135 ± 0.054	0.515MetMet: 0.515 ± 0.026	1.088MetAsn: 1.088 ± 0.037	1.071MetPro: 1.071 ± 0.037	1.217MetGln: 1.217 ± 0.04	1.193MetArg: 1.193 ± 0.04	1.431MetSer: 1.431 ± 0.043	1.453MetThr: 1.453 ± 0.041	1.191MetVal: 1.191 ± 0.038	0.174MetTrp: 0.174 ± 0.014	0.412MetTyr: 0.412 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.838AsnAla: 2.838 ± 0.058	0.543AsnCys: 0.543 ± 0.025	1.784AsnAsp: 1.784 ± 0.05	2.568AsnGlu: 2.568 ± 0.059	1.827AsnPhe: 1.827 ± 0.045	2.593AsnGly: 2.593 ± 0.061	1.19AsnHis: 1.19 ± 0.036	2.309AsnIle: 2.309 ± 0.058	2.074AsnLys: 2.074 ± 0.054	4.727AsnLeu: 4.727 ± 0.088	0.793AsnMet: 0.793 ± 0.029	1.564AsnAsn: 1.564 ± 0.055	2.508AsnPro: 2.508 ± 0.058	2.446AsnGln: 2.446 ± 0.06	2.406AsnArg: 2.406 ± 0.056	2.502AsnSer: 2.502 ± 0.06	1.683AsnThr: 1.683 ± 0.054	2.164AsnVal: 2.164 ± 0.044	0.603AsnTrp: 0.603 ± 0.024	1.473AsnTyr: 1.473 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.076ProAla: 3.076 ± 0.064	0.428ProCys: 0.428 ± 0.023	2.144ProAsp: 2.144 ± 0.056	2.881ProGlu: 2.881 ± 0.061	2.445ProPhe: 2.445 ± 0.053	2.432ProGly: 2.432 ± 0.057	1.265ProHis: 1.265 ± 0.039	3.031ProIle: 3.031 ± 0.062	2.166ProLys: 2.166 ± 0.058	5.127ProLeu: 5.127 ± 0.085	0.794ProMet: 0.794 ± 0.031	1.845ProAsn: 1.845 ± 0.049	1.891ProPro: 1.891 ± 0.08	1.848ProGln: 1.848 ± 0.051	1.539ProArg: 1.539 ± 0.053	3.538ProSer: 3.538 ± 0.087	2.339ProThr: 2.339 ± 0.065	2.637ProVal: 2.637 ± 0.06	0.499ProTrp: 0.499 ± 0.021	1.525ProTyr: 1.525 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.758GlnAla: 4.758 ± 0.084	0.428GlnCys: 0.428 ± 0.025	2.29GlnAsp: 2.29 ± 0.048	3.823GlnGlu: 3.823 ± 0.081	1.909GlnPhe: 1.909 ± 0.056	2.84GlnGly: 2.84 ± 0.071	1.058GlnHis: 1.058 ± 0.033	3.094GlnIle: 3.094 ± 0.058	3.317GlnLys: 3.317 ± 0.06	5.312GlnLeu: 5.312 ± 0.1	1.125GlnMet: 1.125 ± 0.035	1.938GlnAsn: 1.938 ± 0.055	1.856GlnPro: 1.856 ± 0.054	2.697GlnGln: 2.697 ± 0.066	2.199GlnArg: 2.199 ± 0.051	3.022GlnSer: 3.022 ± 0.064	2.873GlnThr: 2.873 ± 0.064	2.783GlnVal: 2.783 ± 0.067	0.558GlnTrp: 0.558 ± 0.028	1.089GlnTyr: 1.089 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.885ArgAla: 2.885 ± 0.064	0.526ArgCys: 0.526 ± 0.024	2.179ArgAsp: 2.179 ± 0.047	3.196ArgGlu: 3.196 ± 0.067	2.386ArgPhe: 2.386 ± 0.053	2.449ArgGly: 2.449 ± 0.066	1.323ArgHis: 1.323 ± 0.037	3.195ArgIle: 3.195 ± 0.066	2.62ArgLys: 2.62 ± 0.056	6.041ArgLeu: 6.041 ± 0.087	1.156ArgMet: 1.156 ± 0.04	1.763ArgAsn: 1.763 ± 0.046	1.717ArgPro: 1.717 ± 0.048	2.475ArgGln: 2.475 ± 0.058	2.38ArgArg: 2.38 ± 0.063	2.933ArgSer: 2.933 ± 0.065	2.077ArgThr: 2.077 ± 0.049	2.722ArgVal: 2.722 ± 0.059	0.629ArgTrp: 0.629 ± 0.027	1.822ArgTyr: 1.822 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.24SerAla: 4.24 ± 0.075	0.945SerCys: 0.945 ± 0.034	3.162SerAsp: 3.162 ± 0.071	3.733SerGlu: 3.733 ± 0.073	3.715SerPhe: 3.715 ± 0.075	3.763SerGly: 3.763 ± 0.08	2.031SerHis: 2.031 ± 0.05	4.734SerIle: 4.734 ± 0.066	3.724SerLys: 3.724 ± 0.068	8.391SerLeu: 8.391 ± 0.108	1.439SerMet: 1.439 ± 0.04	2.819SerAsn: 2.819 ± 0.067	3.136SerPro: 3.136 ± 0.071	3.372SerGln: 3.372 ± 0.062	2.919SerArg: 2.919 ± 0.059	5.192SerSer: 5.192 ± 0.098	3.258SerThr: 3.258 ± 0.071	3.525SerVal: 3.525 ± 0.064	0.818SerTrp: 0.818 ± 0.031	2.384SerTyr: 2.384 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.665ThrAla: 3.665 ± 0.07	0.659ThrCys: 0.659 ± 0.031	2.267ThrAsp: 2.267 ± 0.053	2.521ThrGlu: 2.521 ± 0.054	2.448ThrPhe: 2.448 ± 0.044	3.496ThrGly: 3.496 ± 0.214	1.348ThrHis: 1.348 ± 0.039	3.746ThrIle: 3.746 ± 0.073	2.463ThrLys: 2.463 ± 0.056	5.904ThrLeu: 5.904 ± 0.102	0.934ThrMet: 0.934 ± 0.036	1.896ThrAsn: 1.896 ± 0.048	2.97ThrPro: 2.97 ± 0.07	2.139ThrGln: 2.139 ± 0.056	2.046ThrArg: 2.046 ± 0.048	3.313ThrSer: 3.313 ± 0.067	2.697ThrThr: 2.697 ± 0.064	2.987ThrVal: 2.987 ± 0.061	0.535ThrTrp: 0.535 ± 0.029	1.654ThrTyr: 1.654 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.443ValAla: 4.443 ± 0.073	0.831ValCys: 0.831 ± 0.035	3.286ValAsp: 3.286 ± 0.07	3.965ValGlu: 3.965 ± 0.075	2.691ValPhe: 2.691 ± 0.058	3.745ValGly: 3.745 ± 0.075	1.226ValHis: 1.226 ± 0.038	4.143ValIle: 4.143 ± 0.074	3.641ValLys: 3.641 ± 0.067	5.869ValLeu: 5.869 ± 0.104	1.33ValMet: 1.33 ± 0.046	2.376ValAsn: 2.376 ± 0.052	2.237ValPro: 2.237 ± 0.059	2.413ValGln: 2.413 ± 0.053	2.55ValArg: 2.55 ± 0.064	3.72ValSer: 3.72 ± 0.077	2.799ValThr: 2.799 ± 0.07	3.764ValVal: 3.764 ± 0.08	0.648ValTrp: 0.648 ± 0.028	1.826ValTyr: 1.826 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.738TrpAla: 0.738 ± 0.027	0.143TrpCys: 0.143 ± 0.013	0.541TrpAsp: 0.541 ± 0.027	0.766TrpGlu: 0.766 ± 0.032	0.538TrpPhe: 0.538 ± 0.026	0.757TrpGly: 0.757 ± 0.033	0.334TrpHis: 0.334 ± 0.021	0.973TrpIle: 0.973 ± 0.035	0.881TrpLys: 0.881 ± 0.034	1.494TrpLeu: 1.494 ± 0.045	0.384TrpMet: 0.384 ± 0.021	0.62TrpAsn: 0.62 ± 0.028	0.411TrpPro: 0.411 ± 0.021	0.666TrpGln: 0.666 ± 0.032	0.584TrpArg: 0.584 ± 0.029	0.75TrpSer: 0.75 ± 0.033	0.567TrpThr: 0.567 ± 0.027	0.676TrpVal: 0.676 ± 0.033	0.153TrpTrp: 0.153 ± 0.014	0.336TrpTyr: 0.336 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.44TyrAla: 2.44 ± 0.053	0.477TyrCys: 0.477 ± 0.023	1.726TyrAsp: 1.726 ± 0.066	1.874TyrGlu: 1.874 ± 0.05	1.784TyrPhe: 1.784 ± 0.045	1.963TyrGly: 1.963 ± 0.053	0.914TyrHis: 0.914 ± 0.04	1.765TyrIle: 1.765 ± 0.047	1.464TyrLys: 1.464 ± 0.039	4.05TyrLeu: 4.05 ± 0.078	0.59TyrMet: 0.59 ± 0.028	1.216TyrAsn: 1.216 ± 0.045	1.56TyrPro: 1.56 ± 0.048	2.023TyrGln: 2.023 ± 0.054	1.925TyrArg: 1.925 ± 0.045	2.122TyrSer: 2.122 ± 0.053	1.527TyrThr: 1.527 ± 0.043	1.745TyrVal: 1.745 ± 0.049	0.444TyrTrp: 0.444 ± 0.023	1.355TyrTyr: 1.355 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2571 proteins (847202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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