Amino acid dipepetide frequency for Natranaerovirga pectinivora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.377AlaAla: 3.377 ± 0.079	0.511AlaCys: 0.511 ± 0.025	2.442AlaAsp: 2.442 ± 0.055	3.222AlaGlu: 3.222 ± 0.066	2.687AlaPhe: 2.687 ± 0.066	3.653AlaGly: 3.653 ± 0.083	0.907AlaHis: 0.907 ± 0.031	5.688AlaIle: 5.688 ± 0.09	4.031AlaLys: 4.031 ± 0.081	6.062AlaLeu: 6.062 ± 0.091	1.525AlaMet: 1.525 ± 0.041	2.751AlaAsn: 2.751 ± 0.066	1.392AlaPro: 1.392 ± 0.044	1.461AlaGln: 1.461 ± 0.049	1.949AlaArg: 1.949 ± 0.057	3.287AlaSer: 3.287 ± 0.067	2.925AlaThr: 2.925 ± 0.065	3.718AlaVal: 3.718 ± 0.068	0.343AlaTrp: 0.343 ± 0.02	2.284AlaTyr: 2.284 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.45CysAla: 0.45 ± 0.021	0.148CysCys: 0.148 ± 0.014	0.517CysAsp: 0.517 ± 0.026	0.582CysGlu: 0.582 ± 0.024	0.407CysPhe: 0.407 ± 0.023	0.775CysGly: 0.775 ± 0.032	0.218CysHis: 0.218 ± 0.017	0.884CysIle: 0.884 ± 0.027	0.682CysLys: 0.682 ± 0.031	0.757CysLeu: 0.757 ± 0.029	0.204CysMet: 0.204 ± 0.016	0.561CysAsn: 0.561 ± 0.026	0.423CysPro: 0.423 ± 0.024	0.227CysGln: 0.227 ± 0.016	0.337CysArg: 0.337 ± 0.019	0.597CysSer: 0.597 ± 0.029	0.476CysThr: 0.476 ± 0.021	0.558CysVal: 0.558 ± 0.027	0.062CysTrp: 0.062 ± 0.008	0.395CysTyr: 0.395 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.674AspAla: 2.674 ± 0.057	0.446AspCys: 0.446 ± 0.026	2.794AspAsp: 2.794 ± 0.072	4.6AspGlu: 4.6 ± 0.078	2.751AspPhe: 2.751 ± 0.053	3.384AspGly: 3.384 ± 0.078	0.89AspHis: 0.89 ± 0.028	5.911AspIle: 5.911 ± 0.095	4.271AspLys: 4.271 ± 0.08	5.239AspLeu: 5.239 ± 0.078	1.377AspMet: 1.377 ± 0.039	3.065AspAsn: 3.065 ± 0.064	1.536AspPro: 1.536 ± 0.083	1.421AspGln: 1.421 ± 0.045	2.0AspArg: 2.0 ± 0.051	2.836AspSer: 2.836 ± 0.06	2.788AspThr: 2.788 ± 0.062	3.589AspVal: 3.589 ± 0.064	0.458AspTrp: 0.458 ± 0.025	2.681AspTyr: 2.681 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.386GluAla: 4.386 ± 0.086	0.555GluCys: 0.555 ± 0.025	4.383GluAsp: 4.383 ± 0.072	7.507GluGlu: 7.507 ± 0.123	2.99GluPhe: 2.99 ± 0.053	4.392GluGly: 4.392 ± 0.084	1.096GluHis: 1.096 ± 0.034	7.307GluIle: 7.307 ± 0.094	6.916GluLys: 6.916 ± 0.102	7.179GluLeu: 7.179 ± 0.092	2.106GluMet: 2.106 ± 0.054	4.716GluAsn: 4.716 ± 0.08	1.808GluPro: 1.808 ± 0.065	2.305GluGln: 2.305 ± 0.06	2.723GluArg: 2.723 ± 0.058	3.685GluSer: 3.685 ± 0.064	3.24GluThr: 3.24 ± 0.065	5.439GluVal: 5.439 ± 0.099	0.531GluTrp: 0.531 ± 0.026	3.143GluTyr: 3.143 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.34PheAla: 2.34 ± 0.055	0.443PheCys: 0.443 ± 0.024	2.681PheAsp: 2.681 ± 0.061	2.997PheGlu: 2.997 ± 0.062	2.123PhePhe: 2.123 ± 0.064	2.97PheGly: 2.97 ± 0.065	0.625PheHis: 0.625 ± 0.03	4.552PheIle: 4.552 ± 0.093	3.043PheLys: 3.043 ± 0.056	3.968PheLeu: 3.968 ± 0.08	1.111PheMet: 1.111 ± 0.037	2.89PheAsn: 2.89 ± 0.06	1.249PhePro: 1.249 ± 0.039	1.119PheGln: 1.119 ± 0.033	1.429PheArg: 1.429 ± 0.043	3.097PheSer: 3.097 ± 0.065	2.378PheThr: 2.378 ± 0.051	3.043PheVal: 3.043 ± 0.07	0.321PheTrp: 0.321 ± 0.02	1.902PheTyr: 1.902 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	3.749GlyAla: 3.749 ± 0.089	0.777GlyCys: 0.777 ± 0.029	3.115GlyAsp: 3.115 ± 0.059	4.094GlyGlu: 4.094 ± 0.08	3.257GlyPhe: 3.257 ± 0.075	3.969GlyGly: 3.969 ± 0.09	1.12GlyHis: 1.12 ± 0.038	6.739GlyIle: 6.739 ± 0.097	4.901GlyLys: 4.901 ± 0.084	5.959GlyLeu: 5.959 ± 0.096	1.766GlyMet: 1.766 ± 0.045	3.289GlyAsn: 3.289 ± 0.071	1.421GlyPro: 1.421 ± 0.077	1.846GlyGln: 1.846 ± 0.048	2.384GlyArg: 2.384 ± 0.057	3.709GlySer: 3.709 ± 0.07	3.466GlyThr: 3.466 ± 0.076	4.606GlyVal: 4.606 ± 0.082	0.554GlyTrp: 0.554 ± 0.028	3.051GlyTyr: 3.051 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.646HisAla: 0.646 ± 0.029	0.209HisCys: 0.209 ± 0.016	0.638HisAsp: 0.638 ± 0.031	0.68HisGlu: 0.68 ± 0.025	0.785HisPhe: 0.785 ± 0.03	0.919HisGly: 0.919 ± 0.031	0.362HisHis: 0.362 ± 0.023	1.816HisIle: 1.816 ± 0.042	1.197HisLys: 1.197 ± 0.042	1.624HisLeu: 1.624 ± 0.047	0.421HisMet: 0.421 ± 0.021	1.13HisAsn: 1.13 ± 0.036	0.749HisPro: 0.749 ± 0.029	0.502HisGln: 0.502 ± 0.025	0.654HisArg: 0.654 ± 0.029	1.108HisSer: 1.108 ± 0.036	0.907HisThr: 0.907 ± 0.036	0.686HisVal: 0.686 ± 0.028	0.187HisTrp: 0.187 ± 0.014	0.811HisTyr: 0.811 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.574IleAla: 5.574 ± 0.085	1.02IleCys: 1.02 ± 0.035	5.896IleAsp: 5.896 ± 0.076	7.679IleGlu: 7.679 ± 0.094	3.98IlePhe: 3.98 ± 0.079	6.6IleGly: 6.6 ± 0.113	1.532IleHis: 1.532 ± 0.04	10.135IleIle: 10.135 ± 0.149	7.86IleLys: 7.86 ± 0.103	8.685IleLeu: 8.685 ± 0.121	2.268IleMet: 2.268 ± 0.052	6.439IleAsn: 6.439 ± 0.09	3.407IlePro: 3.407 ± 0.067	2.795IleGln: 2.795 ± 0.053	3.437IleArg: 3.437 ± 0.057	6.428IleSer: 6.428 ± 0.088	5.45IleThr: 5.45 ± 0.09	6.324IleVal: 6.324 ± 0.093	0.64IleTrp: 0.64 ± 0.03	3.593IleTyr: 3.593 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	4.421LysAla: 4.421 ± 0.077	0.6LysCys: 0.6 ± 0.028	5.081LysAsp: 5.081 ± 0.091	8.288LysGlu: 8.288 ± 0.117	2.371LysPhe: 2.371 ± 0.052	4.727LysGly: 4.727 ± 0.081	1.2LysHis: 1.2 ± 0.034	6.782LysIle: 6.782 ± 0.084	7.26LysLys: 7.26 ± 0.112	6.362LysLeu: 6.362 ± 0.091	2.12LysMet: 2.12 ± 0.045	5.006LysAsn: 5.006 ± 0.079	2.034LysPro: 2.034 ± 0.045	2.091LysGln: 2.091 ± 0.054	2.972LysArg: 2.972 ± 0.06	4.256LysSer: 4.256 ± 0.071	3.916LysThr: 3.916 ± 0.07	5.383LysVal: 5.383 ± 0.081	0.549LysTrp: 0.549 ± 0.029	3.292LysTyr: 3.292 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	5.112LeuAla: 5.112 ± 0.085	0.891LeuCys: 0.891 ± 0.034	5.263LeuAsp: 5.263 ± 0.086	7.238LeuGlu: 7.238 ± 0.1	4.127LeuPhe: 4.127 ± 0.084	6.188LeuGly: 6.188 ± 0.088	1.277LeuHis: 1.277 ± 0.042	8.831LeuIle: 8.831 ± 0.121	7.276LeuLys: 7.276 ± 0.113	8.965LeuLeu: 8.965 ± 0.15	2.561LeuMet: 2.561 ± 0.055	5.54LeuAsn: 5.54 ± 0.078	2.991LeuPro: 2.991 ± 0.053	2.546LeuGln: 2.546 ± 0.055	3.305LeuArg: 3.305 ± 0.06	6.472LeuSer: 6.472 ± 0.098	4.727LeuThr: 4.727 ± 0.073	5.777LeuVal: 5.777 ± 0.082	0.625LeuTrp: 0.625 ± 0.029	3.512LeuTyr: 3.512 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	1.764MetAla: 1.764 ± 0.047	0.203MetCys: 0.203 ± 0.018	1.59MetAsp: 1.59 ± 0.041	1.798MetGlu: 1.798 ± 0.043	0.994MetPhe: 0.994 ± 0.035	1.672MetGly: 1.672 ± 0.044	0.345MetHis: 0.345 ± 0.018	2.292MetIle: 2.292 ± 0.056	2.255MetLys: 2.255 ± 0.058	2.187MetLeu: 2.187 ± 0.052	0.67MetMet: 0.67 ± 0.029	1.753MetAsn: 1.753 ± 0.049	0.993MetPro: 0.993 ± 0.035	0.649MetGln: 0.649 ± 0.028	0.848MetArg: 0.848 ± 0.031	1.651MetSer: 1.651 ± 0.045	1.314MetThr: 1.314 ± 0.037	1.764MetVal: 1.764 ± 0.043	0.175MetTrp: 0.175 ± 0.016	0.874MetTyr: 0.874 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.945AsnAla: 2.945 ± 0.066	0.511AsnCys: 0.511 ± 0.028	2.99AsnAsp: 2.99 ± 0.065	4.613AsnGlu: 4.613 ± 0.08	2.381AsnPhe: 2.381 ± 0.058	3.501AsnGly: 3.501 ± 0.072	1.079AsnHis: 1.079 ± 0.036	6.56AsnIle: 6.56 ± 0.107	5.127AsnLys: 5.127 ± 0.085	5.228AsnLeu: 5.228 ± 0.089	1.615AsnMet: 1.615 ± 0.043	4.812AsnAsn: 4.812 ± 0.105	2.22AsnPro: 2.22 ± 0.053	2.055AsnGln: 2.055 ± 0.053	2.263AsnArg: 2.263 ± 0.054	3.302AsnSer: 3.302 ± 0.075	3.313AsnThr: 3.313 ± 0.075	3.577AsnVal: 3.577 ± 0.069	0.458AsnTrp: 0.458 ± 0.021	2.715AsnTyr: 2.715 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.425ProAla: 1.425 ± 0.044	0.275ProCys: 0.275 ± 0.016	1.634ProAsp: 1.634 ± 0.053	2.345ProGlu: 2.345 ± 0.054	1.487ProPhe: 1.487 ± 0.04	1.864ProGly: 1.864 ± 0.066	0.553ProHis: 0.553 ± 0.031	3.111ProIle: 3.111 ± 0.064	2.005ProLys: 2.005 ± 0.052	2.803ProLeu: 2.803 ± 0.056	0.722ProMet: 0.722 ± 0.032	1.842ProAsn: 1.842 ± 0.047	0.829ProPro: 0.829 ± 0.041	0.867ProGln: 0.867 ± 0.036	0.964ProArg: 0.964 ± 0.031	2.008ProSer: 2.008 ± 0.05	1.836ProThr: 1.836 ± 0.062	2.089ProVal: 2.089 ± 0.061	0.292ProTrp: 0.292 ± 0.02	1.401ProTyr: 1.401 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.395GlnAla: 1.395 ± 0.041	0.254GlnCys: 0.254 ± 0.018	1.395GlnAsp: 1.395 ± 0.039	2.313GlnGlu: 2.313 ± 0.052	1.185GlnPhe: 1.185 ± 0.038	1.85GlnGly: 1.85 ± 0.048	0.425GlnHis: 0.425 ± 0.023	2.639GlnIle: 2.639 ± 0.059	2.239GlnLys: 2.239 ± 0.056	2.886GlnLeu: 2.886 ± 0.065	0.77GlnMet: 0.77 ± 0.033	1.554GlnAsn: 1.554 ± 0.042	0.863GlnPro: 0.863 ± 0.042	0.982GlnGln: 0.982 ± 0.038	1.141GlnArg: 1.141 ± 0.041	1.607GlnSer: 1.607 ± 0.044	1.294GlnThr: 1.294 ± 0.042	1.95GlnVal: 1.95 ± 0.048	0.273GlnTrp: 0.273 ± 0.018	1.284GlnTyr: 1.284 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.967ArgAla: 1.967 ± 0.05	0.336ArgCys: 0.336 ± 0.018	1.97ArgAsp: 1.97 ± 0.057	2.75ArgGlu: 2.75 ± 0.061	1.647ArgPhe: 1.647 ± 0.045	2.111ArgGly: 2.111 ± 0.051	0.611ArgHis: 0.611 ± 0.028	3.573ArgIle: 3.573 ± 0.063	2.814ArgLys: 2.814 ± 0.06	3.324ArgLeu: 3.324 ± 0.062	1.037ArgMet: 1.037 ± 0.033	2.105ArgAsn: 2.105 ± 0.048	1.068ArgPro: 1.068 ± 0.044	1.081ArgGln: 1.081 ± 0.037	1.52ArgArg: 1.52 ± 0.047	1.828ArgSer: 1.828 ± 0.044	1.833ArgThr: 1.833 ± 0.049	2.519ArgVal: 2.519 ± 0.054	0.321ArgTrp: 0.321 ± 0.017	1.532ArgTyr: 1.532 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	2.937SerAla: 2.937 ± 0.06	0.522SerCys: 0.522 ± 0.028	3.004SerAsp: 3.004 ± 0.058	3.974SerGlu: 3.974 ± 0.073	3.094SerPhe: 3.094 ± 0.073	4.033SerGly: 4.033 ± 0.075	1.009SerHis: 1.009 ± 0.032	6.383SerIle: 6.383 ± 0.092	4.704SerLys: 4.704 ± 0.076	5.682SerLeu: 5.682 ± 0.107	1.51SerMet: 1.51 ± 0.045	3.698SerAsn: 3.698 ± 0.071	1.735SerPro: 1.735 ± 0.043	1.908SerGln: 1.908 ± 0.052	2.252SerArg: 2.252 ± 0.057	3.789SerSer: 3.789 ± 0.073	3.221SerThr: 3.221 ± 0.062	3.818SerVal: 3.818 ± 0.063	0.409SerTrp: 0.409 ± 0.022	2.489SerTyr: 2.489 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	2.916ThrAla: 2.916 ± 0.062	0.42ThrCys: 0.42 ± 0.023	2.522ThrAsp: 2.522 ± 0.059	3.254ThrGlu: 3.254 ± 0.058	2.382ThrPhe: 2.382 ± 0.051	3.774ThrGly: 3.774 ± 0.092	0.908ThrHis: 0.908 ± 0.032	5.391ThrIle: 5.391 ± 0.085	3.628ThrLys: 3.628 ± 0.069	5.189ThrLeu: 5.189 ± 0.086	1.226ThrMet: 1.226 ± 0.04	2.966ThrAsn: 2.966 ± 0.061	1.992ThrPro: 1.992 ± 0.054	1.384ThrGln: 1.384 ± 0.041	1.754ThrArg: 1.754 ± 0.049	3.16ThrSer: 3.16 ± 0.061	2.918ThrThr: 2.918 ± 0.065	3.694ThrVal: 3.694 ± 0.071	0.376ThrTrp: 0.376 ± 0.021	2.157ThrTyr: 2.157 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	3.825ValAla: 3.825 ± 0.078	0.627ValCys: 0.627 ± 0.028	3.85ValAsp: 3.85 ± 0.082	4.824ValGlu: 4.824 ± 0.085	3.19ValPhe: 3.19 ± 0.068	4.302ValGly: 4.302 ± 0.054	0.985ValHis: 0.985 ± 0.034	6.463ValIle: 6.463 ± 0.093	4.724ValLys: 4.724 ± 0.077	6.516ValLeu: 6.516 ± 0.097	1.621ValMet: 1.621 ± 0.047	3.784ValAsn: 3.784 ± 0.07	2.107ValPro: 2.107 ± 0.055	1.679ValGln: 1.679 ± 0.045	2.132ValArg: 2.132 ± 0.047	4.241ValSer: 4.241 ± 0.073	3.481ValThr: 3.481 ± 0.077	4.866ValVal: 4.866 ± 0.085	0.411ValTrp: 0.411 ± 0.023	2.633ValTyr: 2.633 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.381TrpAla: 0.381 ± 0.024	0.078TrpCys: 0.078 ± 0.01	0.475TrpAsp: 0.475 ± 0.025	0.554TrpGlu: 0.554 ± 0.029	0.362TrpPhe: 0.362 ± 0.02	0.514TrpGly: 0.514 ± 0.027	0.157TrpHis: 0.157 ± 0.012	0.682TrpIle: 0.682 ± 0.028	0.496TrpLys: 0.496 ± 0.026	0.731TrpLeu: 0.731 ± 0.035	0.202TrpMet: 0.202 ± 0.015	0.407TrpAsn: 0.407 ± 0.024	0.178TrpPro: 0.178 ± 0.013	0.227TrpGln: 0.227 ± 0.017	0.305TrpArg: 0.305 ± 0.019	0.422TrpSer: 0.422 ± 0.024	0.316TrpThr: 0.316 ± 0.021	0.521TrpVal: 0.521 ± 0.025	0.079TrpTrp: 0.079 ± 0.011	0.318TrpTyr: 0.318 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.929TyrAla: 1.929 ± 0.042	0.434TyrCys: 0.434 ± 0.024	2.47TyrAsp: 2.47 ± 0.054	3.098TyrGlu: 3.098 ± 0.061	2.081TyrPhe: 2.081 ± 0.061	2.575TyrGly: 2.575 ± 0.061	0.732TyrHis: 0.732 ± 0.033	4.002TyrIle: 4.002 ± 0.067	3.281TyrLys: 3.281 ± 0.061	3.877TyrLeu: 3.877 ± 0.075	0.955TyrMet: 0.955 ± 0.035	2.957TyrAsn: 2.957 ± 0.064	1.358TyrPro: 1.358 ± 0.037	1.156TyrGln: 1.156 ± 0.04	1.578TyrArg: 1.578 ± 0.043	2.692TyrSer: 2.692 ± 0.062	2.213TyrThr: 2.213 ± 0.057	2.337TyrVal: 2.337 ± 0.052	0.341TyrTrp: 0.341 ± 0.019	2.08TyrTyr: 2.08 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2857 proteins (886605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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