Amino acid dipepetide frequency for Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) (Desulfurococcus kamchatkensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.168AlaAla: 4.168 ± 0.119
0.592AlaCys: 0.592 ± 0.038
2.237AlaAsp: 2.237 ± 0.071
3.953AlaGlu: 3.953 ± 0.119
2.28AlaPhe: 2.28 ± 0.084
5.336AlaGly: 5.336 ± 0.127
0.994AlaHis: 0.994 ± 0.053
4.819AlaIle: 4.819 ± 0.12
3.151AlaLys: 3.151 ± 0.1
8.27AlaLeu: 8.27 ± 0.184
1.523AlaMet: 1.523 ± 0.069
1.513AlaAsn: 1.513 ± 0.068
2.197AlaPro: 2.197 ± 0.084
0.971AlaGln: 0.971 ± 0.052
5.114AlaArg: 5.114 ± 0.124
5.611AlaSer: 5.611 ± 0.118
2.959AlaThr: 2.959 ± 0.096
6.347AlaVal: 6.347 ± 0.135
0.814AlaTrp: 0.814 ± 0.046
2.934AlaTyr: 2.934 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.297CysAla: 0.297 ± 0.027
0.06CysCys: 0.06 ± 0.011
0.32CysAsp: 0.32 ± 0.028
0.347CysGlu: 0.347 ± 0.031
0.23CysPhe: 0.23 ± 0.026
0.874CysGly: 0.874 ± 0.052
0.082CysHis: 0.082 ± 0.016
0.704CysIle: 0.704 ± 0.04
0.265CysLys: 0.265 ± 0.027
0.527CysLeu: 0.527 ± 0.036
0.215CysMet: 0.215 ± 0.025
0.335CysAsn: 0.335 ± 0.03
0.624CysPro: 0.624 ± 0.044
0.102CysGln: 0.102 ± 0.015
0.697CysArg: 0.697 ± 0.041
0.609CysSer: 0.609 ± 0.039
0.295CysThr: 0.295 ± 0.031
0.452CysVal: 0.452 ± 0.033
0.105CysTrp: 0.105 ± 0.018
0.245CysTyr: 0.245 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.241AspAla: 3.241 ± 0.09
0.207AspCys: 0.207 ± 0.024
1.713AspAsp: 1.713 ± 0.064
3.746AspGlu: 3.746 ± 0.092
1.566AspPhe: 1.566 ± 0.07
2.662AspGly: 2.662 ± 0.082
0.684AspHis: 0.684 ± 0.046
4.21AspIle: 4.21 ± 0.1
2.971AspLys: 2.971 ± 0.084
4.752AspLeu: 4.752 ± 0.12
0.919AspMet: 0.919 ± 0.044
1.486AspAsn: 1.486 ± 0.056
2.802AspPro: 2.802 ± 0.088
0.722AspGln: 0.722 ± 0.04
2.13AspArg: 2.13 ± 0.076
2.395AspSer: 2.395 ± 0.08
2.257AspThr: 2.257 ± 0.076
4.427AspVal: 4.427 ± 0.116
0.479AspTrp: 0.479 ± 0.038
2.152AspTyr: 2.152 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.891GluAla: 5.891 ± 0.12
0.522GluCys: 0.522 ± 0.038
3.031GluAsp: 3.031 ± 0.093
6.258GluGlu: 6.258 ± 0.159
2.1GluPhe: 2.1 ± 0.084
3.953GluGly: 3.953 ± 0.12
1.259GluHis: 1.259 ± 0.054
5.526GluIle: 5.526 ± 0.146
6.223GluLys: 6.223 ± 0.171
8.275GluLeu: 8.275 ± 0.178
1.328GluMet: 1.328 ± 0.057
2.559GluAsn: 2.559 ± 0.081
2.672GluPro: 2.672 ± 0.09
1.036GluGln: 1.036 ± 0.052
3.793GluArg: 3.793 ± 0.109
3.326GluSer: 3.326 ± 0.088
3.036GluThr: 3.036 ± 0.077
6.085GluVal: 6.085 ± 0.135
0.874GluTrp: 0.874 ± 0.051
3.641GluTyr: 3.641 ± 0.104
0.0GluXaa: 0.0 ± 0.0
Phe
1.698PheAla: 1.698 ± 0.078
0.232PheCys: 0.232 ± 0.025
1.421PheAsp: 1.421 ± 0.053
1.925PheGlu: 1.925 ± 0.065
1.186PhePhe: 1.186 ± 0.062
1.661PheGly: 1.661 ± 0.064
0.627PheHis: 0.627 ± 0.043
3.736PheIle: 3.736 ± 0.116
2.747PheLys: 2.747 ± 0.076
2.904PheLeu: 2.904 ± 0.089
0.936PheMet: 0.936 ± 0.048
1.858PheAsn: 1.858 ± 0.075
1.144PhePro: 1.144 ± 0.051
0.664PheGln: 0.664 ± 0.039
1.616PheArg: 1.616 ± 0.068
2.267PheSer: 2.267 ± 0.082
2.592PheThr: 2.592 ± 0.089
1.638PheVal: 1.638 ± 0.058
0.297PheTrp: 0.297 ± 0.029
1.473PheTyr: 1.473 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.008GlyAla: 4.008 ± 0.112
0.694GlyCys: 0.694 ± 0.057
3.713GlyAsp: 3.713 ± 0.099
5.451GlyGlu: 5.451 ± 0.111
3.925GlyPhe: 3.925 ± 0.102
5.274GlyGly: 5.274 ± 0.119
1.061GlyHis: 1.061 ± 0.051
5.9GlyIle: 5.9 ± 0.123
4.387GlyLys: 4.387 ± 0.106
8.582GlyLeu: 8.582 ± 0.159
1.688GlyMet: 1.688 ± 0.068
2.13GlyAsn: 2.13 ± 0.068
1.963GlyPro: 1.963 ± 0.083
1.019GlyGln: 1.019 ± 0.053
4.794GlyArg: 4.794 ± 0.107
4.747GlySer: 4.747 ± 0.12
2.487GlyThr: 2.487 ± 0.078
7.484GlyVal: 7.484 ± 0.141
0.971GlyTrp: 0.971 ± 0.047
3.546GlyTyr: 3.546 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
1.176HisAla: 1.176 ± 0.054
0.135HisCys: 0.135 ± 0.018
0.694HisAsp: 0.694 ± 0.038
1.174HisGlu: 1.174 ± 0.054
0.385HisPhe: 0.385 ± 0.032
1.958HisGly: 1.958 ± 0.075
0.357HisHis: 0.357 ± 0.031
1.219HisIle: 1.219 ± 0.057
0.602HisLys: 0.602 ± 0.039
1.543HisLeu: 1.543 ± 0.074
0.439HisMet: 0.439 ± 0.03
0.41HisAsn: 0.41 ± 0.031
1.119HisPro: 1.119 ± 0.058
0.302HisGln: 0.302 ± 0.028
1.091HisArg: 1.091 ± 0.05
0.909HisSer: 0.909 ± 0.052
0.692HisThr: 0.692 ± 0.035
1.533HisVal: 1.533 ± 0.068
0.197HisTrp: 0.197 ± 0.022
0.757HisTyr: 0.757 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.817IleAla: 6.817 ± 0.162
0.517IleCys: 0.517 ± 0.035
4.852IleAsp: 4.852 ± 0.116
6.248IleGlu: 6.248 ± 0.143
1.94IlePhe: 1.94 ± 0.077
6.213IleGly: 6.213 ± 0.144
1.628IleHis: 1.628 ± 0.061
7.176IleIle: 7.176 ± 0.156
3.883IleLys: 3.883 ± 0.101
9.014IleLeu: 9.014 ± 0.167
1.78IleMet: 1.78 ± 0.066
2.824IleAsn: 2.824 ± 0.09
4.615IlePro: 4.615 ± 0.115
1.648IleGln: 1.648 ± 0.075
4.325IleArg: 4.325 ± 0.095
5.199IleSer: 5.199 ± 0.116
4.023IleThr: 4.023 ± 0.108
7.783IleVal: 7.783 ± 0.138
0.677IleTrp: 0.677 ± 0.043
3.943IleTyr: 3.943 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
4.465LysAla: 4.465 ± 0.122
0.629LysCys: 0.629 ± 0.042
2.038LysAsp: 2.038 ± 0.078
3.935LysGlu: 3.935 ± 0.127
0.946LysPhe: 0.946 ± 0.059
4.262LysGly: 4.262 ± 0.109
1.196LysHis: 1.196 ± 0.061
5.199LysIle: 5.199 ± 0.134
3.359LysLys: 3.359 ± 0.113
6.225LysLeu: 6.225 ± 0.123
1.321LysMet: 1.321 ± 0.061
1.893LysAsn: 1.893 ± 0.078
3.858LysPro: 3.858 ± 0.113
1.346LysGln: 1.346 ± 0.062
3.216LysArg: 3.216 ± 0.086
2.859LysSer: 2.859 ± 0.087
3.496LysThr: 3.496 ± 0.101
3.873LysVal: 3.873 ± 0.096
0.689LysTrp: 0.689 ± 0.043
3.189LysTyr: 3.189 ± 0.098
0.0LysXaa: 0.0 ± 0.0
Leu
7.966LeuAla: 7.966 ± 0.191
0.549LeuCys: 0.549 ± 0.038
5.037LeuAsp: 5.037 ± 0.136
7.886LeuGlu: 7.886 ± 0.134
3.446LeuPhe: 3.446 ± 0.12
7.668LeuGly: 7.668 ± 0.171
1.755LeuHis: 1.755 ± 0.063
7.961LeuIle: 7.961 ± 0.183
6.749LeuLys: 6.749 ± 0.138
11.287LeuLeu: 11.287 ± 0.252
2.522LeuMet: 2.522 ± 0.067
4.115LeuAsn: 4.115 ± 0.102
4.033LeuPro: 4.033 ± 0.098
1.863LeuGln: 1.863 ± 0.069
6.819LeuArg: 6.819 ± 0.125
7.371LeuSer: 7.371 ± 0.157
5.461LeuThr: 5.461 ± 0.15
8.864LeuVal: 8.864 ± 0.158
1.039LeuTrp: 1.039 ± 0.055
4.41LeuTyr: 4.41 ± 0.103
0.0LeuXaa: 0.0 ± 0.0
Met
1.528MetAla: 1.528 ± 0.067
0.115MetCys: 0.115 ± 0.016
1.361MetAsp: 1.361 ± 0.05
1.531MetGlu: 1.531 ± 0.059
0.664MetPhe: 0.664 ± 0.037
1.87MetGly: 1.87 ± 0.067
0.462MetHis: 0.462 ± 0.034
1.848MetIle: 1.848 ± 0.072
1.386MetLys: 1.386 ± 0.063
2.602MetLeu: 2.602 ± 0.082
0.509MetMet: 0.509 ± 0.036
0.929MetAsn: 0.929 ± 0.046
1.081MetPro: 1.081 ± 0.056
0.372MetGln: 0.372 ± 0.029
1.356MetArg: 1.356 ± 0.067
1.7MetSer: 1.7 ± 0.064
0.881MetThr: 0.881 ± 0.041
2.07MetVal: 2.07 ± 0.079
0.195MetTrp: 0.195 ± 0.024
0.934MetTyr: 0.934 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
2.475AsnAla: 2.475 ± 0.086
0.277AsnCys: 0.277 ± 0.028
1.256AsnAsp: 1.256 ± 0.059
2.237AsnGlu: 2.237 ± 0.075
0.637AsnPhe: 0.637 ± 0.046
2.579AsnGly: 2.579 ± 0.086
0.542AsnHis: 0.542 ± 0.034
4.083AsnIle: 4.083 ± 0.114
1.845AsnLys: 1.845 ± 0.07
2.884AsnLeu: 2.884 ± 0.089
0.954AsnMet: 0.954 ± 0.045
1.591AsnAsn: 1.591 ± 0.07
2.624AsnPro: 2.624 ± 0.083
0.552AsnGln: 0.552 ± 0.041
1.683AsnArg: 1.683 ± 0.068
1.651AsnSer: 1.651 ± 0.071
2.482AsnThr: 2.482 ± 0.102
2.44AsnVal: 2.44 ± 0.076
0.337AsnTrp: 0.337 ± 0.029
1.491AsnTyr: 1.491 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
2.377ProAla: 2.377 ± 0.074
0.355ProCys: 0.355 ± 0.032
2.285ProAsp: 2.285 ± 0.089
3.359ProGlu: 3.359 ± 0.099
1.693ProPhe: 1.693 ± 0.065
4.687ProGly: 4.687 ± 0.113
0.834ProHis: 0.834 ± 0.048
2.569ProIle: 2.569 ± 0.09
1.406ProLys: 1.406 ± 0.072
5.081ProLeu: 5.081 ± 0.12
0.814ProMet: 0.814 ± 0.048
0.951ProAsn: 0.951 ± 0.048
2.485ProPro: 2.485 ± 0.075
0.921ProGln: 0.921 ± 0.051
2.827ProArg: 2.827 ± 0.081
3.236ProSer: 3.236 ± 0.094
1.7ProThr: 1.7 ± 0.068
4.637ProVal: 4.637 ± 0.096
0.689ProTrp: 0.689 ± 0.046
1.988ProTyr: 1.988 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
1.433GlnAla: 1.433 ± 0.061
0.165GlnCys: 0.165 ± 0.023
0.687GlnAsp: 0.687 ± 0.041
1.089GlnGlu: 1.089 ± 0.049
0.432GlnPhe: 0.432 ± 0.032
1.676GlnGly: 1.676 ± 0.06
0.327GlnHis: 0.327 ± 0.032
0.949GlnIle: 0.949 ± 0.048
0.729GlnLys: 0.729 ± 0.044
2.06GlnLeu: 2.06 ± 0.068
0.387GlnMet: 0.387 ± 0.029
0.467GlnAsn: 0.467 ± 0.035
0.944GlnPro: 0.944 ± 0.055
0.507GlnGln: 0.507 ± 0.039
1.024GlnArg: 1.024 ± 0.056
0.886GlnSer: 0.886 ± 0.047
0.609GlnThr: 0.609 ± 0.041
1.805GlnVal: 1.805 ± 0.069
0.21GlnTrp: 0.21 ± 0.021
0.921GlnTyr: 0.921 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.254ArgAla: 3.254 ± 0.094
0.489ArgCys: 0.489 ± 0.036
3.756ArgAsp: 3.756 ± 0.094
5.596ArgGlu: 5.596 ± 0.134
2.085ArgPhe: 2.085 ± 0.067
4.502ArgGly: 4.502 ± 0.11
1.121ArgHis: 1.121 ± 0.052
5.816ArgIle: 5.816 ± 0.141
3.603ArgLys: 3.603 ± 0.098
6.632ArgLeu: 6.632 ± 0.131
1.259ArgMet: 1.259 ± 0.058
2.162ArgAsn: 2.162 ± 0.07
1.945ArgPro: 1.945 ± 0.076
1.031ArgGln: 1.031 ± 0.056
4.487ArgArg: 4.487 ± 0.11
3.206ArgSer: 3.206 ± 0.097
2.008ArgThr: 2.008 ± 0.075
5.656ArgVal: 5.656 ± 0.132
0.587ArgTrp: 0.587 ± 0.037
2.727ArgTyr: 2.727 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
3.049SerAla: 3.049 ± 0.087
0.367SerCys: 0.367 ± 0.03
2.752SerAsp: 2.752 ± 0.074
4.148SerGlu: 4.148 ± 0.101
2.008SerPhe: 2.008 ± 0.065
4.779SerGly: 4.779 ± 0.101
0.999SerHis: 0.999 ± 0.052
6.992SerIle: 6.992 ± 0.147
3.723SerLys: 3.723 ± 0.105
6.652SerLeu: 6.652 ± 0.153
2.068SerMet: 2.068 ± 0.086
2.287SerAsn: 2.287 ± 0.091
2.749SerPro: 2.749 ± 0.07
1.351SerGln: 1.351 ± 0.06
4.732SerArg: 4.732 ± 0.127
5.131SerSer: 5.131 ± 0.146
3.406SerThr: 3.406 ± 0.095
4.198SerVal: 4.198 ± 0.113
0.779SerTrp: 0.779 ± 0.053
2.51SerTyr: 2.51 ± 0.098
0.0SerXaa: 0.0 ± 0.0
Thr
2.996ThrAla: 2.996 ± 0.097
0.474ThrCys: 0.474 ± 0.041
1.558ThrAsp: 1.558 ± 0.062
2.083ThrGlu: 2.083 ± 0.071
1.036ThrPhe: 1.036 ± 0.059
5.059ThrGly: 5.059 ± 0.131
0.914ThrHis: 0.914 ± 0.046
4.415ThrIle: 4.415 ± 0.109
1.481ThrLys: 1.481 ± 0.063
5.151ThrLeu: 5.151 ± 0.134
1.244ThrMet: 1.244 ± 0.05
1.239ThrAsn: 1.239 ± 0.053
2.971ThrPro: 2.971 ± 0.087
0.906ThrGln: 0.906 ± 0.057
3.301ThrArg: 3.301 ± 0.092
3.566ThrSer: 3.566 ± 0.108
2.984ThrThr: 2.984 ± 0.292
3.943ThrVal: 3.943 ± 0.126
0.569ThrTrp: 0.569 ± 0.038
2.008ThrTyr: 2.008 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
5.708ValAla: 5.708 ± 0.124
0.497ValCys: 0.497 ± 0.037
4.482ValAsp: 4.482 ± 0.111
7.329ValGlu: 7.329 ± 0.162
4.015ValPhe: 4.015 ± 0.118
4.47ValGly: 4.47 ± 0.107
0.999ValHis: 0.999 ± 0.051
6.799ValIle: 6.799 ± 0.127
6.829ValLys: 6.829 ± 0.128
8.657ValLeu: 8.657 ± 0.136
1.683ValMet: 1.683 ± 0.07
3.658ValAsn: 3.658 ± 0.107
2.732ValPro: 2.732 ± 0.081
1.104ValGln: 1.104 ± 0.05
4.61ValArg: 4.61 ± 0.128
5.818ValSer: 5.818 ± 0.139
3.721ValThr: 3.721 ± 0.113
7.943ValVal: 7.943 ± 0.158
0.689ValTrp: 0.689 ± 0.042
3.995ValTyr: 3.995 ± 0.095
0.0ValXaa: 0.0 ± 0.0
Trp
0.559TrpAla: 0.559 ± 0.036
0.082TrpCys: 0.082 ± 0.012
0.504TrpAsp: 0.504 ± 0.035
0.589TrpGlu: 0.589 ± 0.04
0.517TrpPhe: 0.517 ± 0.036
0.802TrpGly: 0.802 ± 0.053
0.192TrpHis: 0.192 ± 0.022
0.974TrpIle: 0.974 ± 0.06
0.532TrpLys: 0.532 ± 0.042
1.256TrpLeu: 1.256 ± 0.06
0.327TrpMet: 0.327 ± 0.03
0.4TrpAsn: 0.4 ± 0.034
0.317TrpPro: 0.317 ± 0.03
0.18TrpGln: 0.18 ± 0.02
0.991TrpArg: 0.991 ± 0.051
0.896TrpSer: 0.896 ± 0.055
0.32TrpThr: 0.32 ± 0.036
0.899TrpVal: 0.899 ± 0.048
0.217TrpTrp: 0.217 ± 0.023
0.412TrpTyr: 0.412 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.679TyrAla: 2.679 ± 0.085
0.424TyrCys: 0.424 ± 0.036
1.825TyrAsp: 1.825 ± 0.071
2.507TyrGlu: 2.507 ± 0.084
1.531TyrPhe: 1.531 ± 0.066
3.541TyrGly: 3.541 ± 0.098
0.657TyrHis: 0.657 ± 0.039
4.212TyrIle: 4.212 ± 0.108
2.122TyrLys: 2.122 ± 0.069
4.445TyrLeu: 4.445 ± 0.113
1.476TyrMet: 1.476 ± 0.063
1.813TyrAsn: 1.813 ± 0.083
2.02TyrPro: 2.02 ± 0.079
0.709TyrGln: 0.709 ± 0.046
3.316TyrArg: 3.316 ± 0.079
3.294TyrSer: 3.294 ± 0.094
2.49TyrThr: 2.49 ± 0.083
3.661TyrVal: 3.661 ± 0.088
0.552TyrTrp: 0.552 ± 0.044
2.197TyrTyr: 2.197 ± 0.09
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1470 proteins (400476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski