Amino acid dipepetide frequency for Mycobacterium phage Taj

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.011AlaAla: 16.011 ± 1.846
0.904AlaCys: 0.904 ± 0.236
7.447AlaAsp: 7.447 ± 0.599
7.5AlaGlu: 7.5 ± 0.658
2.766AlaPhe: 2.766 ± 0.393
11.17AlaGly: 11.17 ± 1.585
2.447AlaHis: 2.447 ± 0.415
4.096AlaIle: 4.096 ± 0.506
3.989AlaLys: 3.989 ± 0.455
8.085AlaLeu: 8.085 ± 0.686
3.032AlaMet: 3.032 ± 0.442
2.5AlaAsn: 2.5 ± 0.326
5.532AlaPro: 5.532 ± 0.668
2.979AlaGln: 2.979 ± 0.42
7.606AlaArg: 7.606 ± 0.648
5.426AlaSer: 5.426 ± 0.567
5.372AlaThr: 5.372 ± 0.528
6.968AlaVal: 6.968 ± 0.609
2.819AlaTrp: 2.819 ± 0.467
1.968AlaTyr: 1.968 ± 0.32
0.0AlaXaa: 0.0 ± 0.0
Cys
1.011CysAla: 1.011 ± 0.297
0.053CysCys: 0.053 ± 0.061
1.383CysAsp: 1.383 ± 0.373
0.532CysGlu: 0.532 ± 0.185
0.426CysPhe: 0.426 ± 0.167
1.543CysGly: 1.543 ± 0.322
0.16CysHis: 0.16 ± 0.086
0.266CysIle: 0.266 ± 0.125
0.479CysLys: 0.479 ± 0.174
0.851CysLeu: 0.851 ± 0.277
0.266CysMet: 0.266 ± 0.099
0.319CysAsn: 0.319 ± 0.124
1.117CysPro: 1.117 ± 0.372
0.319CysGln: 0.319 ± 0.127
0.638CysArg: 0.638 ± 0.212
0.798CysSer: 0.798 ± 0.18
0.691CysThr: 0.691 ± 0.185
0.691CysVal: 0.691 ± 0.166
0.319CysTrp: 0.319 ± 0.114
0.16CysTyr: 0.16 ± 0.083
0.0CysXaa: 0.0 ± 0.0
Asp
6.702AspAla: 6.702 ± 0.631
1.277AspCys: 1.277 ± 0.312
5.053AspAsp: 5.053 ± 0.592
3.989AspGlu: 3.989 ± 0.509
1.862AspPhe: 1.862 ± 0.298
7.234AspGly: 7.234 ± 0.646
1.17AspHis: 1.17 ± 0.246
2.287AspIle: 2.287 ± 0.328
1.596AspLys: 1.596 ± 0.327
5.904AspLeu: 5.904 ± 0.495
1.223AspMet: 1.223 ± 0.277
1.649AspAsn: 1.649 ± 0.33
4.787AspPro: 4.787 ± 0.574
2.128AspGln: 2.128 ± 0.328
5.426AspArg: 5.426 ± 0.711
3.83AspSer: 3.83 ± 0.508
4.947AspThr: 4.947 ± 0.523
4.096AspVal: 4.096 ± 0.539
1.489AspTrp: 1.489 ± 0.296
2.021AspTyr: 2.021 ± 0.332
0.0AspXaa: 0.0 ± 0.0
Glu
6.649GluAla: 6.649 ± 0.605
0.957GluCys: 0.957 ± 0.266
2.66GluAsp: 2.66 ± 0.355
3.032GluGlu: 3.032 ± 0.479
2.553GluPhe: 2.553 ± 0.366
2.979GluGly: 2.979 ± 0.419
1.968GluHis: 1.968 ± 0.482
2.394GluIle: 2.394 ± 0.322
1.702GluLys: 1.702 ± 0.348
5.585GluLeu: 5.585 ± 0.585
1.968GluMet: 1.968 ± 0.346
2.074GluAsn: 2.074 ± 0.304
2.66GluPro: 2.66 ± 0.378
2.766GluGln: 2.766 ± 0.472
5.426GluArg: 5.426 ± 0.724
2.926GluSer: 2.926 ± 0.41
4.043GluThr: 4.043 ± 0.602
3.67GluVal: 3.67 ± 0.472
1.383GluTrp: 1.383 ± 0.23
1.968GluTyr: 1.968 ± 0.347
0.0GluXaa: 0.0 ± 0.0
Phe
3.298PheAla: 3.298 ± 0.462
0.213PheCys: 0.213 ± 0.119
2.766PheAsp: 2.766 ± 0.405
1.596PheGlu: 1.596 ± 0.32
0.957PhePhe: 0.957 ± 0.25
3.085PheGly: 3.085 ± 0.611
0.266PheHis: 0.266 ± 0.127
1.33PheIle: 1.33 ± 0.273
0.851PheLys: 0.851 ± 0.224
1.755PheLeu: 1.755 ± 0.274
0.904PheMet: 0.904 ± 0.241
1.223PheAsn: 1.223 ± 0.356
1.755PhePro: 1.755 ± 0.299
1.064PheGln: 1.064 ± 0.28
1.543PheArg: 1.543 ± 0.273
1.383PheSer: 1.383 ± 0.276
2.606PheThr: 2.606 ± 0.409
1.968PheVal: 1.968 ± 0.318
0.585PheTrp: 0.585 ± 0.142
1.011PheTyr: 1.011 ± 0.246
0.0PheXaa: 0.0 ± 0.0
Gly
9.309GlyAla: 9.309 ± 1.256
1.011GlyCys: 1.011 ± 0.236
6.383GlyAsp: 6.383 ± 0.594
3.617GlyGlu: 3.617 ± 0.462
3.085GlyPhe: 3.085 ± 0.428
10.372GlyGly: 10.372 ± 2.792
2.021GlyHis: 2.021 ± 0.252
4.255GlyIle: 4.255 ± 0.598
2.394GlyLys: 2.394 ± 0.308
5.691GlyLeu: 5.691 ± 0.516
2.447GlyMet: 2.447 ± 0.444
2.926GlyAsn: 2.926 ± 0.402
3.617GlyPro: 3.617 ± 0.513
2.181GlyGln: 2.181 ± 0.585
5.16GlyArg: 5.16 ± 0.601
6.702GlySer: 6.702 ± 1.261
6.968GlyThr: 6.968 ± 0.787
5.479GlyVal: 5.479 ± 0.558
2.819GlyTrp: 2.819 ± 0.419
2.181GlyTyr: 2.181 ± 0.419
0.0GlyXaa: 0.0 ± 0.0
His
1.915HisAla: 1.915 ± 0.406
0.319HisCys: 0.319 ± 0.152
1.489HisAsp: 1.489 ± 0.321
1.117HisGlu: 1.117 ± 0.277
0.319HisPhe: 0.319 ± 0.113
1.596HisGly: 1.596 ± 0.276
0.957HisHis: 0.957 ± 0.289
1.17HisIle: 1.17 ± 0.237
0.798HisLys: 0.798 ± 0.186
1.33HisLeu: 1.33 ± 0.274
0.426HisMet: 0.426 ± 0.14
0.851HisAsn: 0.851 ± 0.177
1.755HisPro: 1.755 ± 0.324
0.851HisGln: 0.851 ± 0.208
2.5HisArg: 2.5 ± 0.405
0.745HisSer: 0.745 ± 0.174
1.383HisThr: 1.383 ± 0.369
1.277HisVal: 1.277 ± 0.264
0.266HisTrp: 0.266 ± 0.11
0.798HisTyr: 0.798 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
5.532IleAla: 5.532 ± 0.538
0.532IleCys: 0.532 ± 0.163
4.043IleAsp: 4.043 ± 0.44
3.457IleGlu: 3.457 ± 0.342
0.851IlePhe: 0.851 ± 0.249
3.298IleGly: 3.298 ± 0.522
1.223IleHis: 1.223 ± 0.247
1.33IleIle: 1.33 ± 0.292
1.064IleLys: 1.064 ± 0.25
1.968IleLeu: 1.968 ± 0.373
0.372IleMet: 0.372 ± 0.135
1.915IleAsn: 1.915 ± 0.31
2.979IlePro: 2.979 ± 0.354
1.489IleGln: 1.489 ± 0.22
2.979IleArg: 2.979 ± 0.403
2.181IleSer: 2.181 ± 0.391
3.351IleThr: 3.351 ± 0.39
2.713IleVal: 2.713 ± 0.339
0.798IleTrp: 0.798 ± 0.24
0.691IleTyr: 0.691 ± 0.204
0.0IleXaa: 0.0 ± 0.0
Lys
3.723LysAla: 3.723 ± 0.44
0.372LysCys: 0.372 ± 0.136
1.33LysAsp: 1.33 ± 0.297
1.436LysGlu: 1.436 ± 0.322
1.117LysPhe: 1.117 ± 0.198
2.606LysGly: 2.606 ± 0.329
1.011LysHis: 1.011 ± 0.23
1.064LysIle: 1.064 ± 0.276
1.383LysLys: 1.383 ± 0.359
2.34LysLeu: 2.34 ± 0.418
0.426LysMet: 0.426 ± 0.13
0.798LysAsn: 0.798 ± 0.195
2.394LysPro: 2.394 ± 0.42
1.596LysGln: 1.596 ± 0.26
2.181LysArg: 2.181 ± 0.311
1.809LysSer: 1.809 ± 0.306
2.34LysThr: 2.34 ± 0.352
2.606LysVal: 2.606 ± 0.332
0.691LysTrp: 0.691 ± 0.204
0.904LysTyr: 0.904 ± 0.203
0.0LysXaa: 0.0 ± 0.0
Leu
7.713LeuAla: 7.713 ± 0.728
0.745LeuCys: 0.745 ± 0.224
5.053LeuAsp: 5.053 ± 0.507
3.723LeuGlu: 3.723 ± 0.486
2.287LeuPhe: 2.287 ± 0.266
5.426LeuGly: 5.426 ± 0.48
1.17LeuHis: 1.17 ± 0.283
3.404LeuIle: 3.404 ± 0.43
2.021LeuLys: 2.021 ± 0.314
4.255LeuLeu: 4.255 ± 0.469
1.436LeuMet: 1.436 ± 0.266
2.34LeuAsn: 2.34 ± 0.38
5.426LeuPro: 5.426 ± 0.642
2.553LeuGln: 2.553 ± 0.425
4.787LeuArg: 4.787 ± 0.595
5.426LeuSer: 5.426 ± 0.405
5.319LeuThr: 5.319 ± 0.478
5.319LeuVal: 5.319 ± 0.535
1.117LeuTrp: 1.117 ± 0.247
2.234LeuTyr: 2.234 ± 0.358
0.0LeuXaa: 0.0 ± 0.0
Met
2.553MetAla: 2.553 ± 0.342
0.266MetCys: 0.266 ± 0.116
1.223MetAsp: 1.223 ± 0.284
0.904MetGlu: 0.904 ± 0.191
0.745MetPhe: 0.745 ± 0.229
1.755MetGly: 1.755 ± 0.296
0.213MetHis: 0.213 ± 0.105
0.904MetIle: 0.904 ± 0.227
0.638MetLys: 0.638 ± 0.189
1.596MetLeu: 1.596 ± 0.259
0.638MetMet: 0.638 ± 0.208
0.745MetAsn: 0.745 ± 0.188
1.436MetPro: 1.436 ± 0.361
0.532MetGln: 0.532 ± 0.128
1.915MetArg: 1.915 ± 0.326
2.872MetSer: 2.872 ± 0.372
2.5MetThr: 2.5 ± 0.398
1.33MetVal: 1.33 ± 0.279
0.319MetTrp: 0.319 ± 0.119
0.266MetTyr: 0.266 ± 0.114
0.0MetXaa: 0.0 ± 0.0
Asn
3.351AsnAla: 3.351 ± 0.46
0.213AsnCys: 0.213 ± 0.109
1.915AsnAsp: 1.915 ± 0.339
1.968AsnGlu: 1.968 ± 0.306
0.904AsnPhe: 0.904 ± 0.324
3.83AsnGly: 3.83 ± 0.443
0.745AsnHis: 0.745 ± 0.176
1.33AsnIle: 1.33 ± 0.515
0.957AsnLys: 0.957 ± 0.224
2.234AsnLeu: 2.234 ± 0.383
0.585AsnMet: 0.585 ± 0.144
1.489AsnAsn: 1.489 ± 0.325
2.287AsnPro: 2.287 ± 0.322
0.957AsnGln: 0.957 ± 0.322
1.968AsnArg: 1.968 ± 0.331
1.862AsnSer: 1.862 ± 0.311
2.021AsnThr: 2.021 ± 0.309
1.702AsnVal: 1.702 ± 0.333
0.745AsnTrp: 0.745 ± 0.198
0.638AsnTyr: 0.638 ± 0.171
0.0AsnXaa: 0.0 ± 0.0
Pro
5.213ProAla: 5.213 ± 0.551
0.585ProCys: 0.585 ± 0.189
4.255ProAsp: 4.255 ± 0.46
4.521ProGlu: 4.521 ± 0.52
1.596ProPhe: 1.596 ± 0.31
6.543ProGly: 6.543 ± 0.787
1.383ProHis: 1.383 ± 0.29
2.128ProIle: 2.128 ± 0.292
1.915ProLys: 1.915 ± 0.361
4.574ProLeu: 4.574 ± 0.53
1.489ProMet: 1.489 ± 0.302
2.181ProAsn: 2.181 ± 0.32
3.67ProPro: 3.67 ± 0.524
1.809ProGln: 1.809 ± 0.325
3.67ProArg: 3.67 ± 0.557
2.926ProSer: 2.926 ± 0.414
3.298ProThr: 3.298 ± 0.433
5.0ProVal: 5.0 ± 0.568
0.745ProTrp: 0.745 ± 0.158
1.33ProTyr: 1.33 ± 0.279
0.0ProXaa: 0.0 ± 0.0
Gln
4.468GlnAla: 4.468 ± 0.611
0.319GlnCys: 0.319 ± 0.18
1.596GlnAsp: 1.596 ± 0.256
1.543GlnGlu: 1.543 ± 0.308
1.011GlnPhe: 1.011 ± 0.243
2.234GlnGly: 2.234 ± 0.445
0.479GlnHis: 0.479 ± 0.146
1.702GlnIle: 1.702 ± 0.282
1.436GlnLys: 1.436 ± 0.266
2.872GlnLeu: 2.872 ± 0.431
0.479GlnMet: 0.479 ± 0.156
0.798GlnAsn: 0.798 ± 0.281
2.128GlnPro: 2.128 ± 0.344
0.904GlnGln: 0.904 ± 0.208
2.713GlnArg: 2.713 ± 0.405
2.128GlnSer: 2.128 ± 0.325
1.862GlnThr: 1.862 ± 0.309
2.447GlnVal: 2.447 ± 0.302
0.798GlnTrp: 0.798 ± 0.196
0.851GlnTyr: 0.851 ± 0.244
0.0GlnXaa: 0.0 ± 0.0
Arg
6.862ArgAla: 6.862 ± 0.554
1.17ArgCys: 1.17 ± 0.277
4.574ArgAsp: 4.574 ± 0.533
5.372ArgGlu: 5.372 ± 0.613
2.34ArgPhe: 2.34 ± 0.374
4.202ArgGly: 4.202 ± 0.439
1.543ArgHis: 1.543 ± 0.333
3.723ArgIle: 3.723 ± 0.579
2.553ArgLys: 2.553 ± 0.409
5.053ArgLeu: 5.053 ± 0.668
2.553ArgMet: 2.553 ± 0.327
2.287ArgAsn: 2.287 ± 0.356
3.457ArgPro: 3.457 ± 0.386
2.021ArgGln: 2.021 ± 0.334
6.064ArgArg: 6.064 ± 0.943
3.777ArgSer: 3.777 ± 0.434
3.67ArgThr: 3.67 ± 0.569
5.532ArgVal: 5.532 ± 0.571
2.074ArgTrp: 2.074 ± 0.33
1.649ArgTyr: 1.649 ± 0.242
0.0ArgXaa: 0.0 ± 0.0
Ser
6.968SerAla: 6.968 ± 1.388
0.585SerCys: 0.585 ± 0.21
3.936SerAsp: 3.936 ± 0.472
3.564SerGlu: 3.564 ± 0.461
2.074SerPhe: 2.074 ± 0.461
6.383SerGly: 6.383 ± 0.8
1.17SerHis: 1.17 ± 0.269
2.872SerIle: 2.872 ± 0.351
2.553SerLys: 2.553 ± 0.357
4.255SerLeu: 4.255 ± 0.505
1.436SerMet: 1.436 ± 0.25
2.074SerAsn: 2.074 ± 0.36
3.138SerPro: 3.138 ± 0.358
1.649SerGln: 1.649 ± 0.252
3.564SerArg: 3.564 ± 0.464
3.245SerSer: 3.245 ± 0.637
3.298SerThr: 3.298 ± 0.414
4.096SerVal: 4.096 ± 0.465
1.436SerTrp: 1.436 ± 0.281
1.33SerTyr: 1.33 ± 0.209
0.0SerXaa: 0.0 ± 0.0
Thr
6.277ThrAla: 6.277 ± 0.615
0.745ThrCys: 0.745 ± 0.226
4.84ThrAsp: 4.84 ± 0.694
3.777ThrGlu: 3.777 ± 0.439
1.915ThrPhe: 1.915 ± 0.356
5.798ThrGly: 5.798 ± 0.631
1.702ThrHis: 1.702 ± 0.31
3.245ThrIle: 3.245 ± 0.384
2.234ThrLys: 2.234 ± 0.363
4.628ThrLeu: 4.628 ± 0.482
1.277ThrMet: 1.277 ± 0.271
2.394ThrAsn: 2.394 ± 0.376
4.362ThrPro: 4.362 ± 0.419
2.128ThrGln: 2.128 ± 0.299
4.149ThrArg: 4.149 ± 0.377
4.096ThrSer: 4.096 ± 0.399
5.532ThrThr: 5.532 ± 0.597
5.745ThrVal: 5.745 ± 0.548
1.17ThrTrp: 1.17 ± 0.273
1.968ThrTyr: 1.968 ± 0.303
0.0ThrXaa: 0.0 ± 0.0
Val
6.915ValAla: 6.915 ± 0.517
1.117ValCys: 1.117 ± 0.239
5.372ValAsp: 5.372 ± 0.551
4.574ValGlu: 4.574 ± 0.548
2.074ValPhe: 2.074 ± 0.331
5.691ValGly: 5.691 ± 0.569
1.277ValHis: 1.277 ± 0.267
3.085ValIle: 3.085 ± 0.415
2.128ValLys: 2.128 ± 0.348
5.0ValLeu: 5.0 ± 0.587
1.33ValMet: 1.33 ± 0.257
1.915ValAsn: 1.915 ± 0.294
4.096ValPro: 4.096 ± 0.464
2.766ValGln: 2.766 ± 0.384
4.362ValArg: 4.362 ± 0.616
4.787ValSer: 4.787 ± 0.545
5.16ValThr: 5.16 ± 0.518
6.543ValVal: 6.543 ± 0.797
1.862ValTrp: 1.862 ± 0.377
1.436ValTyr: 1.436 ± 0.266
0.0ValXaa: 0.0 ± 0.0
Trp
1.862TrpAla: 1.862 ± 0.285
0.319TrpCys: 0.319 ± 0.145
1.543TrpAsp: 1.543 ± 0.276
1.17TrpGlu: 1.17 ± 0.321
0.638TrpPhe: 0.638 ± 0.181
1.064TrpGly: 1.064 ± 0.201
0.532TrpHis: 0.532 ± 0.2
0.957TrpIle: 0.957 ± 0.2
0.798TrpLys: 0.798 ± 0.165
1.968TrpLeu: 1.968 ± 0.311
0.851TrpMet: 0.851 ± 0.232
0.479TrpAsn: 0.479 ± 0.185
1.011TrpPro: 1.011 ± 0.274
1.223TrpGln: 1.223 ± 0.289
2.021TrpArg: 2.021 ± 0.383
1.702TrpSer: 1.702 ± 0.415
1.809TrpThr: 1.809 ± 0.334
1.809TrpVal: 1.809 ± 0.365
0.851TrpTrp: 0.851 ± 0.169
0.532TrpTyr: 0.532 ± 0.16
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.34TyrAla: 2.34 ± 0.405
0.319TyrCys: 0.319 ± 0.118
1.809TyrAsp: 1.809 ± 0.358
1.968TyrGlu: 1.968 ± 0.295
0.638TyrPhe: 0.638 ± 0.214
1.809TyrGly: 1.809 ± 0.346
0.426TyrHis: 0.426 ± 0.145
1.223TyrIle: 1.223 ± 0.267
0.638TyrLys: 0.638 ± 0.197
1.809TyrLeu: 1.809 ± 0.308
0.16TyrMet: 0.16 ± 0.092
0.745TyrAsn: 0.745 ± 0.187
1.223TyrPro: 1.223 ± 0.201
0.851TyrGln: 0.851 ± 0.211
1.809TyrArg: 1.809 ± 0.294
1.011TyrSer: 1.011 ± 0.231
1.809TyrThr: 1.809 ± 0.379
2.5TyrVal: 2.5 ± 0.323
0.851TyrTrp: 0.851 ± 0.213
0.745TyrTyr: 0.745 ± 0.15
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 110 proteins (18801 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski