Amino acid dipepetide frequency for Lettuce ring necrosis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.631AlaAla: 1.631 ± 0.766
0.815AlaCys: 0.815 ± 0.394
0.544AlaAsp: 0.544 ± 0.402
2.175AlaGlu: 2.175 ± 1.15
1.087AlaPhe: 1.087 ± 0.909
1.903AlaGly: 1.903 ± 0.733
0.272AlaHis: 0.272 ± 0.463
3.262AlaIle: 3.262 ± 2.025
2.446AlaLys: 2.446 ± 0.745
2.99AlaLeu: 2.99 ± 0.769
1.631AlaMet: 1.631 ± 0.81
2.446AlaAsn: 2.446 ± 0.86
1.631AlaPro: 1.631 ± 0.856
0.544AlaGln: 0.544 ± 0.402
1.359AlaArg: 1.359 ± 0.392
3.805AlaSer: 3.805 ± 1.181
1.903AlaThr: 1.903 ± 1.195
3.534AlaVal: 3.534 ± 1.57
0.544AlaTrp: 0.544 ± 0.309
1.631AlaTyr: 1.631 ± 0.789
0.0AlaXaa: 0.0 ± 0.0
Cys
0.272CysAla: 0.272 ± 0.463
0.272CysCys: 0.272 ± 0.345
1.631CysAsp: 1.631 ± 0.91
0.815CysGlu: 0.815 ± 0.489
1.087CysPhe: 1.087 ± 0.415
0.544CysGly: 0.544 ± 0.309
0.0CysHis: 0.0 ± 0.0
0.544CysIle: 0.544 ± 0.309
0.815CysLys: 0.815 ± 0.853
1.087CysLeu: 1.087 ± 0.468
0.272CysMet: 0.272 ± 0.345
0.544CysAsn: 0.544 ± 0.309
0.272CysPro: 0.272 ± 0.155
0.272CysGln: 0.272 ± 0.155
0.0CysArg: 0.0 ± 0.0
1.359CysSer: 1.359 ± 0.455
0.815CysThr: 0.815 ± 0.445
0.544CysVal: 0.544 ± 0.309
0.272CysTrp: 0.272 ± 0.155
0.272CysTyr: 0.272 ± 0.345
0.0CysXaa: 0.0 ± 0.0
Asp
2.175AspAla: 2.175 ± 0.54
0.815AspCys: 0.815 ± 0.464
2.175AspAsp: 2.175 ± 0.745
3.805AspGlu: 3.805 ± 1.507
2.446AspPhe: 2.446 ± 1.061
1.087AspGly: 1.087 ± 0.803
1.087AspHis: 1.087 ± 0.832
5.436AspIle: 5.436 ± 0.856
5.98AspLys: 5.98 ± 1.514
4.077AspLeu: 4.077 ± 1.006
2.175AspMet: 2.175 ± 0.728
4.077AspAsn: 4.077 ± 1.598
1.903AspPro: 1.903 ± 0.239
1.903AspGln: 1.903 ± 1.083
1.631AspArg: 1.631 ± 1.453
3.534AspSer: 3.534 ± 2.32
2.446AspThr: 2.446 ± 0.732
2.175AspVal: 2.175 ± 0.947
0.272AspTrp: 0.272 ± 0.155
2.175AspTyr: 2.175 ± 0.683
0.0AspXaa: 0.0 ± 0.0
Glu
2.718GluAla: 2.718 ± 2.008
0.544GluCys: 0.544 ± 0.285
4.893GluAsp: 4.893 ± 1.777
11.416GluGlu: 11.416 ± 2.312
2.446GluPhe: 2.446 ± 1.493
3.805GluGly: 3.805 ± 1.103
1.631GluHis: 1.631 ± 0.357
7.611GluIle: 7.611 ± 1.881
7.067GluLys: 7.067 ± 2.472
7.883GluLeu: 7.883 ± 1.688
2.446GluMet: 2.446 ± 1.112
4.893GluAsn: 4.893 ± 2.167
1.631GluPro: 1.631 ± 0.652
1.631GluGln: 1.631 ± 0.465
4.077GluArg: 4.077 ± 0.681
6.252GluSer: 6.252 ± 0.999
3.805GluThr: 3.805 ± 1.564
3.534GluVal: 3.534 ± 0.965
0.0GluTrp: 0.0 ± 0.0
2.446GluTyr: 2.446 ± 0.739
0.0GluXaa: 0.0 ± 0.0
Phe
1.631PheAla: 1.631 ± 0.64
0.815PheCys: 0.815 ± 0.994
2.446PheAsp: 2.446 ± 0.974
3.534PheGlu: 3.534 ± 0.926
1.903PhePhe: 1.903 ± 1.051
1.631PheGly: 1.631 ± 1.395
1.359PheHis: 1.359 ± 0.568
4.077PheIle: 4.077 ± 0.686
4.077PheLys: 4.077 ± 1.334
4.077PheLeu: 4.077 ± 0.965
0.815PheMet: 0.815 ± 1.226
1.631PheAsn: 1.631 ± 0.326
1.903PhePro: 1.903 ± 1.001
0.544PheGln: 0.544 ± 0.396
1.359PheArg: 1.359 ± 0.506
4.621PheSer: 4.621 ± 1.259
1.903PheThr: 1.903 ± 0.848
1.903PheVal: 1.903 ± 0.495
0.272PheTrp: 0.272 ± 0.155
4.621PheTyr: 4.621 ± 1.443
0.0PheXaa: 0.0 ± 0.0
Gly
1.631GlyAla: 1.631 ± 0.357
0.544GlyCys: 0.544 ± 0.475
2.175GlyAsp: 2.175 ± 0.362
3.534GlyGlu: 3.534 ± 0.588
1.359GlyPhe: 1.359 ± 0.536
4.349GlyGly: 4.349 ± 1.238
0.815GlyHis: 0.815 ± 0.384
3.262GlyIle: 3.262 ± 1.404
6.795GlyLys: 6.795 ± 0.975
3.262GlyLeu: 3.262 ± 1.027
2.175GlyMet: 2.175 ± 0.882
2.175GlyAsn: 2.175 ± 0.733
1.087GlyPro: 1.087 ± 0.803
1.359GlyGln: 1.359 ± 0.34
3.805GlyArg: 3.805 ± 0.785
1.903GlySer: 1.903 ± 0.636
2.99GlyThr: 2.99 ± 0.653
2.718GlyVal: 2.718 ± 0.773
0.272GlyTrp: 0.272 ± 0.155
3.262GlyTyr: 3.262 ± 0.919
0.0GlyXaa: 0.0 ± 0.0
His
0.544HisAla: 0.544 ± 0.309
0.0HisCys: 0.0 ± 0.0
0.815HisAsp: 0.815 ± 0.445
1.087HisGlu: 1.087 ± 0.792
0.815HisPhe: 0.815 ± 0.489
1.903HisGly: 1.903 ± 1.077
0.272HisHis: 0.272 ± 0.155
1.903HisIle: 1.903 ± 0.666
1.359HisLys: 1.359 ± 0.392
2.175HisLeu: 2.175 ± 1.901
0.272HisMet: 0.272 ± 0.345
0.815HisAsn: 0.815 ± 0.464
0.815HisPro: 0.815 ± 0.791
0.272HisGln: 0.272 ± 0.155
0.544HisArg: 0.544 ± 0.285
1.903HisSer: 1.903 ± 0.936
0.544HisThr: 0.544 ± 0.402
0.815HisVal: 0.815 ± 0.464
0.544HisTrp: 0.544 ± 0.69
1.359HisTyr: 1.359 ± 0.523
0.0HisXaa: 0.0 ± 0.0
Ile
2.446IleAla: 2.446 ± 0.724
1.087IleCys: 1.087 ± 0.495
5.436IleAsp: 5.436 ± 0.985
8.97IleGlu: 8.97 ± 1.322
3.534IlePhe: 3.534 ± 1.871
3.534IleGly: 3.534 ± 1.109
2.175IleHis: 2.175 ± 0.612
7.611IleIle: 7.611 ± 1.555
6.524IleLys: 6.524 ± 0.811
8.698IleLeu: 8.698 ± 2.814
1.631IleMet: 1.631 ± 0.928
5.164IleAsn: 5.164 ± 0.936
3.534IlePro: 3.534 ± 0.608
1.631IleGln: 1.631 ± 0.934
5.98IleArg: 5.98 ± 1.134
7.067IleSer: 7.067 ± 1.133
2.718IleThr: 2.718 ± 1.156
5.164IleVal: 5.164 ± 1.171
0.544IleTrp: 0.544 ± 0.309
1.359IleTyr: 1.359 ± 0.455
0.0IleXaa: 0.0 ± 0.0
Lys
4.893LysAla: 4.893 ± 1.769
0.544LysCys: 0.544 ± 0.396
4.077LysAsp: 4.077 ± 1.37
5.708LysGlu: 5.708 ± 0.57
3.534LysPhe: 3.534 ± 1.06
4.077LysGly: 4.077 ± 1.448
1.903LysHis: 1.903 ± 0.666
6.795LysIle: 6.795 ± 1.428
4.621LysLys: 4.621 ± 1.355
11.416LysLeu: 11.416 ± 2.504
3.805LysMet: 3.805 ± 0.447
4.621LysAsn: 4.621 ± 1.186
1.903LysPro: 1.903 ± 0.239
2.446LysGln: 2.446 ± 1.928
3.262LysArg: 3.262 ± 0.696
5.98LysSer: 5.98 ± 1.691
6.795LysThr: 6.795 ± 2.475
8.154LysVal: 8.154 ± 1.711
0.544LysTrp: 0.544 ± 0.309
2.718LysTyr: 2.718 ± 0.914
0.0LysXaa: 0.0 ± 0.0
Leu
5.164LeuAla: 5.164 ± 1.494
1.631LeuCys: 1.631 ± 0.663
4.077LeuAsp: 4.077 ± 1.606
7.067LeuGlu: 7.067 ± 2.811
5.708LeuPhe: 5.708 ± 0.827
5.436LeuGly: 5.436 ± 1.305
1.087LeuHis: 1.087 ± 0.694
7.067LeuIle: 7.067 ± 1.555
7.883LeuLys: 7.883 ± 1.004
10.329LeuLeu: 10.329 ± 1.954
2.99LeuMet: 2.99 ± 0.739
6.524LeuAsn: 6.524 ± 1.973
2.718LeuPro: 2.718 ± 2.224
2.446LeuGln: 2.446 ± 0.605
3.534LeuArg: 3.534 ± 0.688
11.96LeuSer: 11.96 ± 1.629
5.164LeuThr: 5.164 ± 1.22
2.446LeuVal: 2.446 ± 0.745
0.815LeuTrp: 0.815 ± 0.445
3.262LeuTyr: 3.262 ± 0.68
0.0LeuXaa: 0.0 ± 0.0
Met
1.087MetAla: 1.087 ± 0.909
0.0MetCys: 0.0 ± 0.0
2.175MetAsp: 2.175 ± 0.362
1.087MetGlu: 1.087 ± 0.619
1.087MetPhe: 1.087 ± 0.387
1.359MetGly: 1.359 ± 0.506
0.544MetHis: 0.544 ± 0.402
3.805MetIle: 3.805 ± 1.721
2.718MetLys: 2.718 ± 0.765
3.262MetLeu: 3.262 ± 0.578
2.175MetMet: 2.175 ± 0.882
1.631MetAsn: 1.631 ± 0.466
0.544MetPro: 0.544 ± 0.309
0.272MetGln: 0.272 ± 0.463
2.175MetArg: 2.175 ± 0.186
5.436MetSer: 5.436 ± 0.728
1.359MetThr: 1.359 ± 0.773
0.815MetVal: 0.815 ± 0.303
0.0MetTrp: 0.0 ± 0.0
0.544MetTyr: 0.544 ± 0.309
0.0MetXaa: 0.0 ± 0.0
Asn
2.446AsnAla: 2.446 ± 0.656
0.815AsnCys: 0.815 ± 0.384
2.175AsnAsp: 2.175 ± 0.906
3.534AsnGlu: 3.534 ± 0.961
3.262AsnPhe: 3.262 ± 1.607
2.446AsnGly: 2.446 ± 0.974
1.359AsnHis: 1.359 ± 0.536
7.067AsnIle: 7.067 ± 1.384
6.252AsnLys: 6.252 ± 1.176
7.067AsnLeu: 7.067 ± 1.381
0.815AsnMet: 0.815 ± 0.464
3.262AsnAsn: 3.262 ± 1.054
1.631AsnPro: 1.631 ± 0.357
1.087AsnGln: 1.087 ± 0.415
2.718AsnArg: 2.718 ± 0.889
4.349AsnSer: 4.349 ± 0.713
3.262AsnThr: 3.262 ± 0.578
4.077AsnVal: 4.077 ± 1.367
0.272AsnTrp: 0.272 ± 0.155
4.077AsnTyr: 4.077 ± 1.106
0.0AsnXaa: 0.0 ± 0.0
Pro
0.815ProAla: 0.815 ± 0.303
0.0ProCys: 0.0 ± 0.0
1.359ProAsp: 1.359 ± 0.506
2.718ProGlu: 2.718 ± 0.74
1.359ProPhe: 1.359 ± 0.459
1.359ProGly: 1.359 ± 0.536
1.359ProHis: 1.359 ± 1.19
3.262ProIle: 3.262 ± 1.296
2.175ProLys: 2.175 ± 0.831
1.359ProLeu: 1.359 ± 1.289
0.272ProMet: 0.272 ± 0.155
1.903ProAsn: 1.903 ± 0.509
0.544ProPro: 0.544 ± 0.475
0.272ProGln: 0.272 ± 0.155
1.359ProArg: 1.359 ± 0.747
2.99ProSer: 2.99 ± 1.378
2.446ProThr: 2.446 ± 0.793
1.631ProVal: 1.631 ± 1.143
0.0ProTrp: 0.0 ± 0.0
0.544ProTyr: 0.544 ± 0.309
0.0ProXaa: 0.0 ± 0.0
Gln
0.815GlnAla: 0.815 ± 0.527
0.0GlnCys: 0.0 ± 0.0
0.815GlnAsp: 0.815 ± 0.303
0.815GlnGlu: 0.815 ± 0.445
1.631GlnPhe: 1.631 ± 0.635
1.087GlnGly: 1.087 ± 0.964
0.272GlnHis: 0.272 ± 0.155
0.0GlnIle: 0.0 ± 0.0
3.534GlnLys: 3.534 ± 0.813
3.534GlnLeu: 3.534 ± 0.808
1.359GlnMet: 1.359 ± 0.506
1.359GlnAsn: 1.359 ± 0.536
0.272GlnPro: 0.272 ± 0.155
0.815GlnGln: 0.815 ± 0.394
0.815GlnArg: 0.815 ± 0.464
2.175GlnSer: 2.175 ± 0.186
1.087GlnThr: 1.087 ± 0.468
0.815GlnVal: 0.815 ± 0.303
0.544GlnTrp: 0.544 ± 0.691
1.087GlnTyr: 1.087 ± 0.468
0.0GlnXaa: 0.0 ± 0.0
Arg
1.631ArgAla: 1.631 ± 0.664
0.544ArgCys: 0.544 ± 0.402
2.446ArgAsp: 2.446 ± 0.402
5.164ArgGlu: 5.164 ± 1.351
1.631ArgPhe: 1.631 ± 0.769
1.631ArgGly: 1.631 ± 0.635
0.272ArgHis: 0.272 ± 0.155
4.349ArgIle: 4.349 ± 1.222
4.893ArgLys: 4.893 ± 0.489
2.446ArgLeu: 2.446 ± 0.475
1.359ArgMet: 1.359 ± 0.506
3.805ArgAsn: 3.805 ± 0.66
1.631ArgPro: 1.631 ± 0.663
0.544ArgGln: 0.544 ± 0.309
2.175ArgArg: 2.175 ± 0.186
4.077ArgSer: 4.077 ± 1.064
3.262ArgThr: 3.262 ± 0.696
2.175ArgVal: 2.175 ± 0.574
0.0ArgTrp: 0.0 ± 0.0
1.359ArgTyr: 1.359 ± 0.536
0.0ArgXaa: 0.0 ± 0.0
Ser
3.534SerAla: 3.534 ± 0.551
1.087SerCys: 1.087 ± 0.619
4.349SerAsp: 4.349 ± 1.379
8.154SerGlu: 8.154 ± 1.699
4.349SerPhe: 4.349 ± 0.564
4.621SerGly: 4.621 ± 1.228
1.903SerHis: 1.903 ± 0.523
7.067SerIle: 7.067 ± 1.406
8.154SerLys: 8.154 ± 0.739
9.513SerLeu: 9.513 ± 1.262
3.805SerMet: 3.805 ± 1.376
5.164SerAsn: 5.164 ± 0.845
2.175SerPro: 2.175 ± 0.733
1.903SerGln: 1.903 ± 0.782
4.621SerArg: 4.621 ± 0.767
10.329SerSer: 10.329 ± 2.123
4.077SerThr: 4.077 ± 0.67
5.164SerVal: 5.164 ± 1.231
0.544SerTrp: 0.544 ± 0.396
3.805SerTyr: 3.805 ± 0.581
0.0SerXaa: 0.0 ± 0.0
Thr
1.087ThrAla: 1.087 ± 0.415
1.087ThrCys: 1.087 ± 0.495
2.718ThrAsp: 2.718 ± 0.417
5.708ThrGlu: 5.708 ± 1.667
2.446ThrPhe: 2.446 ± 0.626
2.718ThrGly: 2.718 ± 1.543
0.544ThrHis: 0.544 ± 1.098
3.262ThrIle: 3.262 ± 0.919
3.534ThrLys: 3.534 ± 0.677
6.252ThrLeu: 6.252 ± 1.96
1.903ThrMet: 1.903 ± 0.554
4.349ThrAsn: 4.349 ± 1.626
1.631ThrPro: 1.631 ± 0.928
1.359ThrGln: 1.359 ± 0.765
1.631ThrArg: 1.631 ± 0.797
5.98ThrSer: 5.98 ± 1.466
4.621ThrThr: 4.621 ± 0.767
2.175ThrVal: 2.175 ± 1.606
0.0ThrTrp: 0.0 ± 0.0
1.903ThrTyr: 1.903 ± 0.884
0.0ThrXaa: 0.0 ± 0.0
Val
1.359ValAla: 1.359 ± 0.392
0.815ValCys: 0.815 ± 0.464
4.621ValAsp: 4.621 ± 1.032
3.262ValGlu: 3.262 ± 0.903
3.534ValPhe: 3.534 ± 0.995
1.903ValGly: 1.903 ± 0.726
1.359ValHis: 1.359 ± 0.654
3.534ValIle: 3.534 ± 0.652
5.164ValLys: 5.164 ± 1.771
4.077ValLeu: 4.077 ± 0.712
1.087ValMet: 1.087 ± 0.571
3.534ValAsn: 3.534 ± 0.552
0.815ValPro: 0.815 ± 0.384
2.446ValGln: 2.446 ± 0.793
2.175ValArg: 2.175 ± 0.619
5.98ValSer: 5.98 ± 1.175
2.718ValThr: 2.718 ± 1.012
1.903ValVal: 1.903 ± 1.451
0.0ValTrp: 0.0 ± 0.0
1.631ValTyr: 1.631 ± 0.427
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.272TrpCys: 0.272 ± 0.345
0.272TrpAsp: 0.272 ± 0.155
0.272TrpGlu: 0.272 ± 0.345
0.0TrpPhe: 0.0 ± 0.0
0.815TrpGly: 0.815 ± 0.464
0.0TrpHis: 0.0 ± 0.0
1.359TrpIle: 1.359 ± 0.459
0.272TrpLys: 0.272 ± 0.155
0.544TrpLeu: 0.544 ± 0.396
0.0TrpMet: 0.0 ± 0.0
0.544TrpAsn: 0.544 ± 0.475
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.544TrpSer: 0.544 ± 0.309
0.544TrpThr: 0.544 ± 0.309
0.272TrpVal: 0.272 ± 0.155
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.272TyrAla: 0.272 ± 0.463
0.0TyrCys: 0.0 ± 0.0
2.446TyrAsp: 2.446 ± 0.729
1.903TyrGlu: 1.903 ± 1.083
1.903TyrPhe: 1.903 ± 0.782
3.262TyrGly: 3.262 ± 1.305
0.544TyrHis: 0.544 ± 0.691
3.534TyrIle: 3.534 ± 1.031
3.534TyrLys: 3.534 ± 0.754
3.262TyrLeu: 3.262 ± 1.325
0.815TyrMet: 0.815 ± 0.853
3.534TyrAsn: 3.534 ± 0.635
1.087TyrPro: 1.087 ± 0.468
1.087TyrGln: 1.087 ± 0.853
2.175TyrArg: 2.175 ± 0.605
4.077TyrSer: 4.077 ± 0.722
2.446TyrThr: 2.446 ± 1.118
1.903TyrVal: 1.903 ± 0.38
0.272TyrTrp: 0.272 ± 0.155
1.903TyrTyr: 1.903 ± 0.782
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski