Amino acid dipepetide frequency for Melon chlorotic spot virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.48AlaAla: 1.48 ± 0.969
0.925AlaCys: 0.925 ± 0.375
1.295AlaAsp: 1.295 ± 0.652
2.775AlaGlu: 2.775 ± 0.965
1.48AlaPhe: 1.48 ± 0.726
2.22AlaGly: 2.22 ± 0.39
0.555AlaHis: 0.555 ± 0.283
4.07AlaIle: 4.07 ± 1.213
3.7AlaLys: 3.7 ± 0.819
3.515AlaLeu: 3.515 ± 1.045
0.925AlaMet: 0.925 ± 0.636
2.59AlaAsn: 2.59 ± 0.79
2.405AlaPro: 2.405 ± 0.68
1.11AlaGln: 1.11 ± 0.463
2.22AlaArg: 2.22 ± 0.561
1.85AlaSer: 1.85 ± 0.415
2.775AlaThr: 2.775 ± 0.533
2.405AlaVal: 2.405 ± 0.996
0.37AlaTrp: 0.37 ± 0.408
1.665AlaTyr: 1.665 ± 0.523
0.0AlaXaa: 0.0 ± 0.0
Cys
0.925CysAla: 0.925 ± 0.42
0.555CysCys: 0.555 ± 0.311
0.555CysAsp: 0.555 ± 0.229
0.555CysGlu: 0.555 ± 0.229
1.11CysPhe: 1.11 ± 0.293
0.37CysGly: 0.37 ± 0.34
0.185CysHis: 0.185 ± 0.35
0.925CysIle: 0.925 ± 0.655
1.48CysLys: 1.48 ± 0.776
1.48CysLeu: 1.48 ± 0.469
0.925CysMet: 0.925 ± 0.335
0.74CysAsn: 0.74 ± 0.529
1.11CysPro: 1.11 ± 0.763
0.555CysGln: 0.555 ± 0.375
1.295CysArg: 1.295 ± 0.697
2.405CysSer: 2.405 ± 1.088
1.295CysThr: 1.295 ± 0.383
0.925CysVal: 0.925 ± 0.454
0.0CysTrp: 0.0 ± 0.0
2.035CysTyr: 2.035 ± 0.734
0.0CysXaa: 0.0 ± 0.0
Asp
2.96AspAla: 2.96 ± 0.556
1.295AspCys: 1.295 ± 0.368
5.18AspAsp: 5.18 ± 1.129
4.44AspGlu: 4.44 ± 1.409
2.775AspPhe: 2.775 ± 0.706
1.85AspGly: 1.85 ± 0.481
0.925AspHis: 0.925 ± 0.494
4.625AspIle: 4.625 ± 0.986
3.33AspLys: 3.33 ± 0.858
7.586AspLeu: 7.586 ± 1.194
2.775AspMet: 2.775 ± 0.51
2.59AspAsn: 2.59 ± 0.699
3.33AspPro: 3.33 ± 0.468
1.665AspGln: 1.665 ± 0.704
1.665AspArg: 1.665 ± 0.404
4.44AspSer: 4.44 ± 0.823
2.405AspThr: 2.405 ± 0.63
4.07AspVal: 4.07 ± 0.794
0.185AspTrp: 0.185 ± 0.353
2.22AspTyr: 2.22 ± 0.722
0.0AspXaa: 0.0 ± 0.0
Glu
2.035GluAla: 2.035 ± 0.641
1.11GluCys: 1.11 ± 0.803
4.07GluAsp: 4.07 ± 1.158
5.55GluGlu: 5.55 ± 0.749
2.775GluPhe: 2.775 ± 0.56
2.96GluGly: 2.96 ± 0.508
0.74GluHis: 0.74 ± 0.37
5.55GluIle: 5.55 ± 1.515
3.885GluLys: 3.885 ± 0.891
4.81GluLeu: 4.81 ± 0.792
3.515GluMet: 3.515 ± 0.638
3.885GluAsn: 3.885 ± 0.615
2.775GluPro: 2.775 ± 0.992
2.035GluGln: 2.035 ± 0.606
1.85GluArg: 1.85 ± 0.449
3.885GluSer: 3.885 ± 1.008
4.81GluThr: 4.81 ± 1.6
4.44GluVal: 4.44 ± 0.766
0.555GluTrp: 0.555 ± 0.311
2.775GluTyr: 2.775 ± 0.781
0.0GluXaa: 0.0 ± 0.0
Phe
1.295PheAla: 1.295 ± 0.497
0.74PheCys: 0.74 ± 0.324
2.96PheAsp: 2.96 ± 0.962
2.035PheGlu: 2.035 ± 0.562
1.665PhePhe: 1.665 ± 0.609
1.85PheGly: 1.85 ± 0.674
0.74PheHis: 0.74 ± 0.295
3.33PheIle: 3.33 ± 0.684
3.33PheLys: 3.33 ± 0.87
4.625PheLeu: 4.625 ± 0.897
2.035PheMet: 2.035 ± 0.9
3.515PheAsn: 3.515 ± 0.804
3.145PhePro: 3.145 ± 0.507
1.665PheGln: 1.665 ± 0.537
2.405PheArg: 2.405 ± 0.63
3.515PheSer: 3.515 ± 1.062
2.22PheThr: 2.22 ± 0.629
1.665PheVal: 1.665 ± 0.751
0.185PheTrp: 0.185 ± 0.104
2.405PheTyr: 2.405 ± 0.486
0.0PheXaa: 0.0 ± 0.0
Gly
1.85GlyAla: 1.85 ± 0.738
0.74GlyCys: 0.74 ± 0.412
0.925GlyAsp: 0.925 ± 0.499
1.665GlyGlu: 1.665 ± 0.616
2.59GlyPhe: 2.59 ± 0.832
1.48GlyGly: 1.48 ± 0.48
1.85GlyHis: 1.85 ± 0.4
4.44GlyIle: 4.44 ± 0.82
1.85GlyLys: 1.85 ± 0.842
4.44GlyLeu: 4.44 ± 0.906
1.295GlyMet: 1.295 ± 0.532
2.59GlyAsn: 2.59 ± 0.767
0.74GlyPro: 0.74 ± 0.313
0.925GlyGln: 0.925 ± 0.371
1.665GlyArg: 1.665 ± 0.454
4.995GlySer: 4.995 ± 1.128
2.22GlyThr: 2.22 ± 0.656
2.035GlyVal: 2.035 ± 0.557
0.555GlyTrp: 0.555 ± 0.221
2.22GlyTyr: 2.22 ± 0.476
0.0GlyXaa: 0.0 ± 0.0
His
1.11HisAla: 1.11 ± 0.329
0.555HisCys: 0.555 ± 0.408
0.74HisAsp: 0.74 ± 0.341
0.925HisGlu: 0.925 ± 0.289
0.74HisPhe: 0.74 ± 0.414
0.74HisGly: 0.74 ± 0.414
0.555HisHis: 0.555 ± 0.269
1.295HisIle: 1.295 ± 0.753
1.48HisLys: 1.48 ± 0.82
2.22HisLeu: 2.22 ± 0.684
0.74HisMet: 0.74 ± 0.505
2.035HisAsn: 2.035 ± 0.493
0.555HisPro: 0.555 ± 0.221
0.555HisGln: 0.555 ± 0.377
0.37HisArg: 0.37 ± 0.301
1.11HisSer: 1.11 ± 0.434
1.11HisThr: 1.11 ± 0.622
1.11HisVal: 1.11 ± 0.521
0.555HisTrp: 0.555 ± 0.337
1.11HisTyr: 1.11 ± 0.479
0.0HisXaa: 0.0 ± 0.0
Ile
5.18IleAla: 5.18 ± 1.682
2.22IleCys: 2.22 ± 0.576
3.33IleAsp: 3.33 ± 0.653
4.44IleGlu: 4.44 ± 1.438
2.775IlePhe: 2.775 ± 0.69
4.44IleGly: 4.44 ± 1.127
2.035IleHis: 2.035 ± 0.339
5.92IleIle: 5.92 ± 0.798
4.995IleLys: 4.995 ± 0.617
7.586IleLeu: 7.586 ± 1.215
1.665IleMet: 1.665 ± 0.698
3.515IleAsn: 3.515 ± 0.94
3.515IlePro: 3.515 ± 0.698
2.775IleGln: 2.775 ± 0.833
3.885IleArg: 3.885 ± 0.933
9.066IleSer: 9.066 ± 1.362
4.07IleThr: 4.07 ± 1.222
4.255IleVal: 4.255 ± 1.282
0.74IleTrp: 0.74 ± 0.414
5.55IleTyr: 5.55 ± 1.361
0.0IleXaa: 0.0 ± 0.0
Lys
3.145LysAla: 3.145 ± 1.176
0.925LysCys: 0.925 ± 0.329
5.55LysAsp: 5.55 ± 1.223
4.07LysGlu: 4.07 ± 1.05
3.7LysPhe: 3.7 ± 0.94
3.145LysGly: 3.145 ± 0.859
0.74LysHis: 0.74 ± 0.3
3.885LysIle: 3.885 ± 0.629
5.92LysLys: 5.92 ± 0.958
6.29LysLeu: 6.29 ± 0.991
1.48LysMet: 1.48 ± 0.367
3.7LysAsn: 3.7 ± 1.006
2.405LysPro: 2.405 ± 1.088
2.22LysGln: 2.22 ± 0.439
4.07LysArg: 4.07 ± 0.876
4.07LysSer: 4.07 ± 0.514
4.07LysThr: 4.07 ± 0.506
3.145LysVal: 3.145 ± 0.55
0.74LysTrp: 0.74 ± 0.274
3.145LysTyr: 3.145 ± 0.51
0.0LysXaa: 0.0 ± 0.0
Leu
3.515LeuAla: 3.515 ± 1.215
0.925LeuCys: 0.925 ± 0.525
6.66LeuAsp: 6.66 ± 1.328
4.44LeuGlu: 4.44 ± 0.766
4.625LeuPhe: 4.625 ± 1.655
4.995LeuGly: 4.995 ± 1.235
2.775LeuHis: 2.775 ± 0.649
8.511LeuIle: 8.511 ± 1.118
7.771LeuLys: 7.771 ± 1.038
11.656LeuLeu: 11.656 ± 1.365
3.33LeuMet: 3.33 ± 0.82
6.105LeuAsn: 6.105 ± 1.3
2.22LeuPro: 2.22 ± 0.758
2.59LeuGln: 2.59 ± 0.559
4.995LeuArg: 4.995 ± 1.655
9.621LeuSer: 9.621 ± 1.037
5.365LeuThr: 5.365 ± 1.272
7.031LeuVal: 7.031 ± 1.928
1.295LeuTrp: 1.295 ± 0.343
4.255LeuTyr: 4.255 ± 1.636
0.0LeuXaa: 0.0 ± 0.0
Met
2.59MetAla: 2.59 ± 1.169
0.37MetCys: 0.37 ± 0.207
2.59MetAsp: 2.59 ± 0.776
3.885MetGlu: 3.885 ± 0.616
0.925MetPhe: 0.925 ± 0.351
0.555MetGly: 0.555 ± 0.496
0.555MetHis: 0.555 ± 0.311
3.145MetIle: 3.145 ± 0.822
2.035MetLys: 2.035 ± 0.592
3.33MetLeu: 3.33 ± 0.513
0.74MetMet: 0.74 ± 0.301
1.665MetAsn: 1.665 ± 0.569
1.295MetPro: 1.295 ± 0.46
0.555MetGln: 0.555 ± 0.311
1.11MetArg: 1.11 ± 0.401
1.85MetSer: 1.85 ± 0.59
1.295MetThr: 1.295 ± 0.373
1.295MetVal: 1.295 ± 0.575
0.37MetTrp: 0.37 ± 0.393
0.925MetTyr: 0.925 ± 0.289
0.0MetXaa: 0.0 ± 0.0
Asn
0.925AsnAla: 0.925 ± 0.351
1.665AsnCys: 1.665 ± 0.776
3.33AsnAsp: 3.33 ± 0.732
2.59AsnGlu: 2.59 ± 0.702
3.145AsnPhe: 3.145 ± 1.23
1.11AsnGly: 1.11 ± 0.329
1.665AsnHis: 1.665 ± 0.651
5.55AsnIle: 5.55 ± 0.915
3.515AsnLys: 3.515 ± 1.139
7.956AsnLeu: 7.956 ± 1.57
2.035AsnMet: 2.035 ± 0.559
4.255AsnAsn: 4.255 ± 0.94
2.035AsnPro: 2.035 ± 0.428
1.48AsnGln: 1.48 ± 0.426
2.035AsnArg: 2.035 ± 0.553
5.365AsnSer: 5.365 ± 0.694
3.885AsnThr: 3.885 ± 0.847
2.405AsnVal: 2.405 ± 0.925
1.11AsnTrp: 1.11 ± 0.426
2.775AsnTyr: 2.775 ± 0.88
0.0AsnXaa: 0.0 ± 0.0
Pro
1.295ProAla: 1.295 ± 0.908
0.37ProCys: 0.37 ± 0.21
2.775ProAsp: 2.775 ± 0.705
5.18ProGlu: 5.18 ± 0.843
2.22ProPhe: 2.22 ± 0.659
2.22ProGly: 2.22 ± 0.743
0.37ProHis: 0.37 ± 0.207
3.145ProIle: 3.145 ± 0.649
2.59ProLys: 2.59 ± 0.394
2.22ProLeu: 2.22 ± 0.852
0.925ProMet: 0.925 ± 0.508
2.035ProAsn: 2.035 ± 0.733
0.555ProPro: 0.555 ± 0.283
0.925ProGln: 0.925 ± 0.501
0.555ProArg: 0.555 ± 0.541
2.405ProSer: 2.405 ± 0.729
3.515ProThr: 3.515 ± 0.75
2.59ProVal: 2.59 ± 0.698
0.0ProTrp: 0.0 ± 0.0
1.11ProTyr: 1.11 ± 0.376
0.0ProXaa: 0.0 ± 0.0
Gln
2.035GlnAla: 2.035 ± 0.733
0.37GlnCys: 0.37 ± 0.423
1.665GlnAsp: 1.665 ± 1.08
1.48GlnGlu: 1.48 ± 0.533
1.665GlnPhe: 1.665 ± 0.511
1.48GlnGly: 1.48 ± 0.453
0.925GlnHis: 0.925 ± 0.311
1.665GlnIle: 1.665 ± 0.533
2.775GlnLys: 2.775 ± 0.624
2.96GlnLeu: 2.96 ± 0.513
1.295GlnMet: 1.295 ± 0.562
1.295GlnAsn: 1.295 ± 0.431
1.11GlnPro: 1.11 ± 0.368
0.555GlnGln: 0.555 ± 0.283
1.48GlnArg: 1.48 ± 0.433
2.035GlnSer: 2.035 ± 0.968
1.85GlnThr: 1.85 ± 0.547
2.775GlnVal: 2.775 ± 0.678
0.555GlnTrp: 0.555 ± 0.37
1.11GlnTyr: 1.11 ± 0.536
0.0GlnXaa: 0.0 ± 0.0
Arg
1.48ArgAla: 1.48 ± 0.651
0.37ArgCys: 0.37 ± 0.47
2.775ArgAsp: 2.775 ± 0.696
2.775ArgGlu: 2.775 ± 1.111
1.48ArgPhe: 1.48 ± 0.971
1.48ArgGly: 1.48 ± 0.401
0.74ArgHis: 0.74 ± 0.697
3.7ArgIle: 3.7 ± 0.563
2.035ArgLys: 2.035 ± 0.767
5.365ArgLeu: 5.365 ± 0.906
0.925ArgMet: 0.925 ± 0.424
3.33ArgAsn: 3.33 ± 0.977
1.665ArgPro: 1.665 ± 0.454
2.22ArgGln: 2.22 ± 0.641
1.48ArgArg: 1.48 ± 0.542
4.255ArgSer: 4.255 ± 0.701
3.145ArgThr: 3.145 ± 1.101
2.775ArgVal: 2.775 ± 0.796
0.74ArgTrp: 0.74 ± 0.368
2.035ArgTyr: 2.035 ± 0.515
0.0ArgXaa: 0.0 ± 0.0
Ser
2.22SerAla: 2.22 ± 0.856
2.405SerCys: 2.405 ± 0.953
5.18SerAsp: 5.18 ± 0.65
5.92SerGlu: 5.92 ± 1.09
2.96SerPhe: 2.96 ± 1.37
3.7SerGly: 3.7 ± 1.164
1.295SerHis: 1.295 ± 0.668
7.771SerIle: 7.771 ± 1.26
4.995SerLys: 4.995 ± 0.953
9.621SerLeu: 9.621 ± 1.433
2.59SerMet: 2.59 ± 0.726
3.515SerAsn: 3.515 ± 0.729
2.59SerPro: 2.59 ± 1.058
1.295SerGln: 1.295 ± 0.538
3.885SerArg: 3.885 ± 0.492
7.771SerSer: 7.771 ± 1.099
5.55SerThr: 5.55 ± 1.493
4.995SerVal: 4.995 ± 0.726
0.74SerTrp: 0.74 ± 0.274
3.7SerTyr: 3.7 ± 0.991
0.0SerXaa: 0.0 ± 0.0
Thr
2.035ThrAla: 2.035 ± 0.498
1.295ThrCys: 1.295 ± 0.924
2.035ThrAsp: 2.035 ± 0.499
3.7ThrGlu: 3.7 ± 0.55
2.96ThrPhe: 2.96 ± 0.897
2.59ThrGly: 2.59 ± 0.463
1.11ThrHis: 1.11 ± 0.388
4.625ThrIle: 4.625 ± 0.88
3.33ThrLys: 3.33 ± 1.072
6.475ThrLeu: 6.475 ± 1.53
2.035ThrMet: 2.035 ± 0.724
4.625ThrAsn: 4.625 ± 0.723
1.665ThrPro: 1.665 ± 0.666
2.035ThrGln: 2.035 ± 0.507
3.33ThrArg: 3.33 ± 0.781
4.07ThrSer: 4.07 ± 0.921
3.33ThrThr: 3.33 ± 0.885
3.885ThrVal: 3.885 ± 0.772
0.37ThrTrp: 0.37 ± 0.207
2.22ThrTyr: 2.22 ± 0.624
0.0ThrXaa: 0.0 ± 0.0
Val
1.85ValAla: 1.85 ± 0.569
1.295ValCys: 1.295 ± 0.899
4.625ValAsp: 4.625 ± 1.14
3.145ValGlu: 3.145 ± 0.901
3.145ValPhe: 3.145 ± 0.998
1.85ValGly: 1.85 ± 0.542
0.555ValHis: 0.555 ± 0.297
4.81ValIle: 4.81 ± 1.04
3.7ValLys: 3.7 ± 0.92
5.55ValLeu: 5.55 ± 0.881
1.48ValMet: 1.48 ± 0.544
2.775ValAsn: 2.775 ± 0.872
2.775ValPro: 2.775 ± 0.945
3.33ValGln: 3.33 ± 0.883
3.33ValArg: 3.33 ± 1.003
4.995ValSer: 4.995 ± 1.189
2.59ValThr: 2.59 ± 0.765
4.44ValVal: 4.44 ± 0.988
0.74ValTrp: 0.74 ± 0.296
2.59ValTyr: 2.59 ± 1.021
0.0ValXaa: 0.0 ± 0.0
Trp
0.74TrpAla: 0.74 ± 0.274
0.555TrpCys: 0.555 ± 0.333
0.925TrpAsp: 0.925 ± 0.386
0.925TrpGlu: 0.925 ± 0.352
0.925TrpPhe: 0.925 ± 0.276
0.185TrpGly: 0.185 ± 0.104
0.0TrpHis: 0.0 ± 0.0
1.295TrpIle: 1.295 ± 0.392
0.37TrpLys: 0.37 ± 0.426
1.295TrpLeu: 1.295 ± 0.273
0.0TrpMet: 0.0 ± 0.287
0.74TrpAsn: 0.74 ± 0.329
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.925TrpSer: 0.925 ± 0.354
0.0TrpThr: 0.0 ± 0.0
0.555TrpVal: 0.555 ± 0.311
0.0TrpTrp: 0.0 ± 0.0
0.37TrpTyr: 0.37 ± 0.327
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.665TyrAla: 1.665 ± 0.41
0.74TyrCys: 0.74 ± 0.544
3.145TyrAsp: 3.145 ± 1.185
3.515TyrGlu: 3.515 ± 1.017
1.665TyrPhe: 1.665 ± 0.798
1.85TyrGly: 1.85 ± 0.731
1.295TyrHis: 1.295 ± 0.742
3.7TyrIle: 3.7 ± 0.707
3.33TyrLys: 3.33 ± 0.683
3.7TyrLeu: 3.7 ± 0.693
0.185TyrMet: 0.185 ± 0.104
3.33TyrAsn: 3.33 ± 0.761
1.11TyrPro: 1.11 ± 0.541
2.59TyrGln: 2.59 ± 0.531
3.145TyrArg: 3.145 ± 0.802
4.07TyrSer: 4.07 ± 0.939
2.22TyrThr: 2.22 ± 0.753
2.775TyrVal: 2.775 ± 0.726
0.185TyrTrp: 0.185 ± 0.104
2.035TyrTyr: 2.035 ± 0.915
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (5406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski