Amino acid dipepetide frequency for Candidatus Thioglobus singularis PS1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.3AlaAla: 5.3 ± 0.168	0.769AlaCys: 0.769 ± 0.04	3.454AlaAsp: 3.454 ± 0.088	4.273AlaGlu: 4.273 ± 0.123	3.187AlaPhe: 3.187 ± 0.093	5.223AlaGly: 5.223 ± 0.128	1.362AlaHis: 1.362 ± 0.055	6.166AlaIle: 6.166 ± 0.115	4.708AlaLys: 4.708 ± 0.098	7.786AlaLeu: 7.786 ± 0.126	2.144AlaMet: 2.144 ± 0.068	3.384AlaAsn: 3.384 ± 0.078	2.199AlaPro: 2.199 ± 0.075	2.266AlaGln: 2.266 ± 0.059	2.626AlaArg: 2.626 ± 0.076	5.28AlaSer: 5.28 ± 0.095	3.466AlaThr: 3.466 ± 0.09	4.465AlaVal: 4.465 ± 0.096	0.695AlaTrp: 0.695 ± 0.042	2.193AlaTyr: 2.193 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	0.682CysAla: 0.682 ± 0.038	0.144CysCys: 0.144 ± 0.018	0.64CysAsp: 0.64 ± 0.033	0.625CysGlu: 0.625 ± 0.034	0.492CysPhe: 0.492 ± 0.028	0.978CysGly: 0.978 ± 0.04	0.287CysHis: 0.287 ± 0.024	0.699CysIle: 0.699 ± 0.036	0.545CysLys: 0.545 ± 0.036	0.978CysLeu: 0.978 ± 0.044	0.234CysMet: 0.234 ± 0.018	0.528CysAsn: 0.528 ± 0.032	0.501CysPro: 0.501 ± 0.034	0.372CysGln: 0.372 ± 0.026	0.378CysArg: 0.378 ± 0.025	0.805CysSer: 0.805 ± 0.04	0.46CysThr: 0.46 ± 0.029	0.72CysVal: 0.72 ± 0.034	0.127CysTrp: 0.127 ± 0.017	0.342CysTyr: 0.342 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.806AspAla: 3.806 ± 0.095	0.649AspCys: 0.649 ± 0.033	3.135AspAsp: 3.135 ± 0.09	4.034AspGlu: 4.034 ± 0.089	2.898AspPhe: 2.898 ± 0.076	3.726AspGly: 3.726 ± 0.095	1.065AspHis: 1.065 ± 0.045	4.436AspIle: 4.436 ± 0.097	3.565AspLys: 3.565 ± 0.095	5.751AspLeu: 5.751 ± 0.108	1.432AspMet: 1.432 ± 0.053	2.767AspAsn: 2.767 ± 0.08	1.901AspPro: 1.901 ± 0.063	2.03AspGln: 2.03 ± 0.064	2.061AspArg: 2.061 ± 0.062	4.303AspSer: 4.303 ± 0.094	2.494AspThr: 2.494 ± 0.073	3.772AspVal: 3.772 ± 0.087	0.784AspTrp: 0.784 ± 0.042	2.178AspTyr: 2.178 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	4.636GluAla: 4.636 ± 0.124	0.594GluCys: 0.594 ± 0.032	3.282GluAsp: 3.282 ± 0.086	4.125GluGlu: 4.125 ± 0.117	2.598GluPhe: 2.598 ± 0.069	3.798GluGly: 3.798 ± 0.085	1.204GluHis: 1.204 ± 0.045	5.412GluIle: 5.412 ± 0.111	4.943GluLys: 4.943 ± 0.112	6.527GluLeu: 6.527 ± 0.121	1.975GluMet: 1.975 ± 0.061	3.684GluAsn: 3.684 ± 0.105	1.89GluPro: 1.89 ± 0.064	2.057GluGln: 2.057 ± 0.065	2.577GluArg: 2.577 ± 0.079	4.706GluSer: 4.706 ± 0.095	3.012GluThr: 3.012 ± 0.078	4.611GluVal: 4.611 ± 0.1	0.68GluTrp: 0.68 ± 0.03	1.806GluTyr: 1.806 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.949PheAla: 2.949 ± 0.085	0.543PheCys: 0.543 ± 0.031	3.006PheAsp: 3.006 ± 0.072	2.946PheGlu: 2.946 ± 0.073	2.155PhePhe: 2.155 ± 0.082	3.344PheGly: 3.344 ± 0.083	0.845PheHis: 0.845 ± 0.04	3.534PheIle: 3.534 ± 0.099	2.704PheLys: 2.704 ± 0.064	4.239PheLeu: 4.239 ± 0.107	1.065PheMet: 1.065 ± 0.048	2.507PheAsn: 2.507 ± 0.073	1.593PhePro: 1.593 ± 0.049	1.303PheGln: 1.303 ± 0.049	1.415PheArg: 1.415 ± 0.058	3.838PheSer: 3.838 ± 0.092	2.157PheThr: 2.157 ± 0.07	2.974PheVal: 2.974 ± 0.078	0.6PheTrp: 0.6 ± 0.035	1.495PheTyr: 1.495 ± 0.063	0.0PheXaa: 0.0 ± 0.0
Gly	5.249GlyAla: 5.249 ± 0.117	0.91GlyCys: 0.91 ± 0.046	3.572GlyAsp: 3.572 ± 0.078	4.085GlyGlu: 4.085 ± 0.092	3.532GlyPhe: 3.532 ± 0.08	5.097GlyGly: 5.097 ± 0.133	1.548GlyHis: 1.548 ± 0.053	5.441GlyIle: 5.441 ± 0.1	4.315GlyLys: 4.315 ± 0.097	6.727GlyLeu: 6.727 ± 0.133	2.017GlyMet: 2.017 ± 0.066	2.814GlyAsn: 2.814 ± 0.073	1.914GlyPro: 1.914 ± 0.063	2.266GlyGln: 2.266 ± 0.065	2.645GlyArg: 2.645 ± 0.076	4.968GlySer: 4.968 ± 0.108	3.367GlyThr: 3.367 ± 0.096	5.287GlyVal: 5.287 ± 0.091	0.944GlyTrp: 0.944 ± 0.046	2.397GlyTyr: 2.397 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.25HisAla: 1.25 ± 0.047	0.3HisCys: 0.3 ± 0.022	0.967HisAsp: 0.967 ± 0.047	1.005HisGlu: 1.005 ± 0.043	1.012HisPhe: 1.012 ± 0.044	1.396HisGly: 1.396 ± 0.055	0.539HisHis: 0.539 ± 0.037	1.44HisIle: 1.44 ± 0.057	1.183HisLys: 1.183 ± 0.052	1.954HisLeu: 1.954 ± 0.057	0.537HisMet: 0.537 ± 0.03	0.953HisAsn: 0.953 ± 0.039	1.092HisPro: 1.092 ± 0.039	0.862HisGln: 0.862 ± 0.036	0.794HisArg: 0.794 ± 0.041	1.466HisSer: 1.466 ± 0.049	0.961HisThr: 0.961 ± 0.043	1.109HisVal: 1.109 ± 0.046	0.226HisTrp: 0.226 ± 0.022	0.765HisTyr: 0.765 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.379IleAla: 6.379 ± 0.12	0.879IleCys: 0.879 ± 0.042	5.488IleAsp: 5.488 ± 0.098	5.732IleGlu: 5.732 ± 0.129	3.358IlePhe: 3.358 ± 0.101	5.752IleGly: 5.752 ± 0.118	1.508IleHis: 1.508 ± 0.056	5.918IleIle: 5.918 ± 0.13	5.523IleLys: 5.523 ± 0.109	7.021IleLeu: 7.021 ± 0.139	1.753IleMet: 1.753 ± 0.058	4.725IleAsn: 4.725 ± 0.092	2.97IlePro: 2.97 ± 0.081	2.438IleGln: 2.438 ± 0.077	2.649IleArg: 2.649 ± 0.071	6.364IleSer: 6.364 ± 0.113	4.005IleThr: 4.005 ± 0.087	5.067IleVal: 5.067 ± 0.103	0.621IleTrp: 0.621 ± 0.032	2.361IleTyr: 2.361 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	4.683LysAla: 4.683 ± 0.116	0.477LysCys: 0.477 ± 0.029	4.15LysAsp: 4.15 ± 0.091	4.687LysGlu: 4.687 ± 0.106	2.163LysPhe: 2.163 ± 0.069	3.941LysGly: 3.941 ± 0.092	1.259LysHis: 1.259 ± 0.05	5.215LysIle: 5.215 ± 0.1	5.207LysLys: 5.207 ± 0.109	5.948LysLeu: 5.948 ± 0.109	1.759LysMet: 1.759 ± 0.058	4.157LysAsn: 4.157 ± 0.096	2.381LysPro: 2.381 ± 0.079	2.307LysGln: 2.307 ± 0.065	2.625LysArg: 2.625 ± 0.071	4.883LysSer: 4.883 ± 0.097	3.717LysThr: 3.717 ± 0.095	4.415LysVal: 4.415 ± 0.095	0.593LysTrp: 0.593 ± 0.03	1.971LysTyr: 1.971 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	7.203LeuAla: 7.203 ± 0.116	0.959LeuCys: 0.959 ± 0.047	5.707LeuAsp: 5.707 ± 0.112	6.301LeuGlu: 6.301 ± 0.129	4.241LeuPhe: 4.241 ± 0.12	6.937LeuGly: 6.937 ± 0.15	1.561LeuHis: 1.561 ± 0.059	8.081LeuIle: 8.081 ± 0.138	6.694LeuLys: 6.694 ± 0.126	9.235LeuLeu: 9.235 ± 0.162	2.733LeuMet: 2.733 ± 0.071	5.171LeuAsn: 5.171 ± 0.11	3.815LeuPro: 3.815 ± 0.087	2.6LeuGln: 2.6 ± 0.075	3.472LeuArg: 3.472 ± 0.084	8.624LeuSer: 8.624 ± 0.142	5.059LeuThr: 5.059 ± 0.096	6.079LeuVal: 6.079 ± 0.115	0.91LeuTrp: 0.91 ± 0.05	2.533LeuTyr: 2.533 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.178MetAla: 2.178 ± 0.068	0.194MetCys: 0.194 ± 0.02	1.373MetAsp: 1.373 ± 0.049	1.305MetGlu: 1.305 ± 0.047	0.902MetPhe: 0.902 ± 0.042	1.958MetGly: 1.958 ± 0.062	0.534MetHis: 0.534 ± 0.033	2.074MetIle: 2.074 ± 0.065	1.838MetLys: 1.838 ± 0.061	2.45MetLeu: 2.45 ± 0.073	0.775MetMet: 0.775 ± 0.037	1.419MetAsn: 1.419 ± 0.053	1.31MetPro: 1.31 ± 0.045	0.94MetGln: 0.94 ± 0.043	1.046MetArg: 1.046 ± 0.049	2.454MetSer: 2.454 ± 0.074	1.54MetThr: 1.54 ± 0.053	1.696MetVal: 1.696 ± 0.054	0.235MetTrp: 0.235 ± 0.022	0.555MetTyr: 0.555 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.472AsnAla: 3.472 ± 0.085	0.526AsnCys: 0.526 ± 0.034	2.847AsnAsp: 2.847 ± 0.067	3.257AsnGlu: 3.257 ± 0.086	2.389AsnPhe: 2.389 ± 0.072	3.16AsnGly: 3.16 ± 0.083	1.109AsnHis: 1.109 ± 0.047	4.514AsnIle: 4.514 ± 0.097	3.485AsnLys: 3.485 ± 0.085	5.316AsnLeu: 5.316 ± 0.129	1.164AsnMet: 1.164 ± 0.044	3.08AsnAsn: 3.08 ± 0.088	2.306AsnPro: 2.306 ± 0.058	2.199AsnGln: 2.199 ± 0.062	1.947AsnArg: 1.947 ± 0.051	3.908AsnSer: 3.908 ± 0.096	2.452AsnThr: 2.452 ± 0.067	2.752AsnVal: 2.752 ± 0.086	0.629AsnTrp: 0.629 ± 0.037	1.781AsnTyr: 1.781 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.152ProAla: 2.152 ± 0.085	0.355ProCys: 0.355 ± 0.026	2.131ProAsp: 2.131 ± 0.064	2.824ProGlu: 2.824 ± 0.079	1.685ProPhe: 1.685 ± 0.059	2.465ProGly: 2.465 ± 0.063	0.75ProHis: 0.75 ± 0.04	2.949ProIle: 2.949 ± 0.071	2.372ProLys: 2.372 ± 0.077	3.367ProLeu: 3.367 ± 0.095	1.003ProMet: 1.003 ± 0.039	1.918ProAsn: 1.918 ± 0.063	1.016ProPro: 1.016 ± 0.046	1.027ProGln: 1.027 ± 0.043	1.101ProArg: 1.101 ± 0.049	2.742ProSer: 2.742 ± 0.083	1.878ProThr: 1.878 ± 0.064	2.497ProVal: 2.497 ± 0.069	0.498ProTrp: 0.498 ± 0.032	1.107ProTyr: 1.107 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.381GlnAla: 2.381 ± 0.068	0.294GlnCys: 0.294 ± 0.025	1.635GlnAsp: 1.635 ± 0.054	1.973GlnGlu: 1.973 ± 0.063	1.362GlnPhe: 1.362 ± 0.058	2.121GlnGly: 2.121 ± 0.069	0.579GlnHis: 0.579 ± 0.035	2.822GlnIle: 2.822 ± 0.084	2.68GlnLys: 2.68 ± 0.081	3.208GlnLeu: 3.208 ± 0.083	0.955GlnMet: 0.955 ± 0.042	1.823GlnAsn: 1.823 ± 0.055	0.919GlnPro: 0.919 ± 0.039	1.126GlnGln: 1.126 ± 0.052	1.318GlnArg: 1.318 ± 0.053	2.628GlnSer: 2.628 ± 0.066	1.618GlnThr: 1.618 ± 0.053	2.18GlnVal: 2.18 ± 0.064	0.374GlnTrp: 0.374 ± 0.028	1.014GlnTyr: 1.014 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.663ArgAla: 2.663 ± 0.074	0.391ArgCys: 0.391 ± 0.026	2.161ArgAsp: 2.161 ± 0.075	2.421ArgGlu: 2.421 ± 0.072	1.935ArgPhe: 1.935 ± 0.068	2.306ArgGly: 2.306 ± 0.069	0.82ArgHis: 0.82 ± 0.042	2.868ArgIle: 2.868 ± 0.063	2.269ArgLys: 2.269 ± 0.071	3.794ArgLeu: 3.794 ± 0.087	1.02ArgMet: 1.02 ± 0.048	1.643ArgAsn: 1.643 ± 0.058	1.276ArgPro: 1.276 ± 0.048	1.398ArgGln: 1.398 ± 0.057	1.631ArgArg: 1.631 ± 0.057	2.524ArgSer: 2.524 ± 0.064	1.652ArgThr: 1.652 ± 0.055	2.708ArgVal: 2.708 ± 0.08	0.427ArgTrp: 0.427 ± 0.029	1.21ArgTyr: 1.21 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.156SerAla: 5.156 ± 0.099	0.779SerCys: 0.779 ± 0.039	4.264SerAsp: 4.264 ± 0.109	5.057SerGlu: 5.057 ± 0.103	3.855SerPhe: 3.855 ± 0.09	5.751SerGly: 5.751 ± 0.111	1.584SerHis: 1.584 ± 0.054	6.442SerIle: 6.442 ± 0.125	5.346SerLys: 5.346 ± 0.108	7.701SerLeu: 7.701 ± 0.143	2.085SerMet: 2.085 ± 0.063	4.131SerAsn: 4.131 ± 0.103	2.587SerPro: 2.587 ± 0.073	2.735SerGln: 2.735 ± 0.076	2.843SerArg: 2.843 ± 0.082	6.233SerSer: 6.233 ± 0.127	3.384SerThr: 3.384 ± 0.087	4.829SerVal: 4.829 ± 0.086	0.849SerTrp: 0.849 ± 0.04	2.342SerTyr: 2.342 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	3.333ThrAla: 3.333 ± 0.086	0.48ThrCys: 0.48 ± 0.036	2.659ThrAsp: 2.659 ± 0.06	2.775ThrGlu: 2.775 ± 0.084	2.087ThrPhe: 2.087 ± 0.065	3.646ThrGly: 3.646 ± 0.092	1.117ThrHis: 1.117 ± 0.049	3.95ThrIle: 3.95 ± 0.1	2.83ThrLys: 2.83 ± 0.077	5.363ThrLeu: 5.363 ± 0.092	1.265ThrMet: 1.265 ± 0.045	2.463ThrAsn: 2.463 ± 0.063	2.25ThrPro: 2.25 ± 0.067	1.685ThrGln: 1.685 ± 0.059	1.785ThrArg: 1.785 ± 0.055	3.772ThrSer: 3.772 ± 0.099	2.465ThrThr: 2.465 ± 0.088	2.97ThrVal: 2.97 ± 0.08	0.509ThrTrp: 0.509 ± 0.034	1.478ThrTyr: 1.478 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.752ValAla: 4.752 ± 0.094	0.748ValCys: 0.748 ± 0.038	4.068ValAsp: 4.068 ± 0.099	4.178ValGlu: 4.178 ± 0.085	3.107ValPhe: 3.107 ± 0.086	4.571ValGly: 4.571 ± 0.118	1.155ValHis: 1.155 ± 0.048	5.64ValIle: 5.64 ± 0.125	3.73ValLys: 3.73 ± 0.084	6.06ValLeu: 6.06 ± 0.112	1.882ValMet: 1.882 ± 0.059	3.209ValAsn: 3.209 ± 0.084	2.269ValPro: 2.269 ± 0.061	1.749ValGln: 1.749 ± 0.054	2.387ValArg: 2.387 ± 0.069	5.249ValSer: 5.249 ± 0.105	3.291ValThr: 3.291 ± 0.084	4.647ValVal: 4.647 ± 0.102	0.646ValTrp: 0.646 ± 0.033	1.707ValTyr: 1.707 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.689TrpAla: 0.689 ± 0.035	0.139TrpCys: 0.139 ± 0.018	0.553TrpAsp: 0.553 ± 0.036	0.593TrpGlu: 0.593 ± 0.033	0.612TrpPhe: 0.612 ± 0.036	0.779TrpGly: 0.779 ± 0.04	0.31TrpHis: 0.31 ± 0.025	0.855TrpIle: 0.855 ± 0.039	0.64TrpLys: 0.64 ± 0.037	1.229TrpLeu: 1.229 ± 0.059	0.292TrpMet: 0.292 ± 0.023	0.503TrpAsn: 0.503 ± 0.035	0.353TrpPro: 0.353 ± 0.03	0.465TrpGln: 0.465 ± 0.029	0.461TrpArg: 0.461 ± 0.033	0.784TrpSer: 0.784 ± 0.038	0.539TrpThr: 0.539 ± 0.037	0.646TrpVal: 0.646 ± 0.041	0.146TrpTrp: 0.146 ± 0.016	0.348TrpTyr: 0.348 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.034TyrAla: 2.034 ± 0.065	0.405TyrCys: 0.405 ± 0.026	1.696TyrAsp: 1.696 ± 0.052	1.924TyrGlu: 1.924 ± 0.075	1.645TyrPhe: 1.645 ± 0.07	2.146TyrGly: 2.146 ± 0.063	0.676TyrHis: 0.676 ± 0.032	2.055TyrIle: 2.055 ± 0.06	1.96TyrLys: 1.96 ± 0.064	3.263TyrLeu: 3.263 ± 0.082	0.684TyrMet: 0.684 ± 0.037	1.411TyrAsn: 1.411 ± 0.053	1.293TyrPro: 1.293 ± 0.051	1.187TyrGln: 1.187 ± 0.05	1.356TyrArg: 1.356 ± 0.054	2.421TyrSer: 2.421 ± 0.067	1.364TyrThr: 1.364 ± 0.056	1.622TyrVal: 1.622 ± 0.057	0.442TyrTrp: 0.442 ± 0.03	1.094TyrTyr: 1.094 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1681 proteins (526563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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