Amino acid dipepetide frequency for Acinetobacter phage YMC11/11/R3177

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.706AlaAla: 7.706 ± 1.143
0.911AlaCys: 0.911 ± 0.301
4.273AlaAsp: 4.273 ± 0.533
6.935AlaGlu: 6.935 ± 0.87
2.942AlaPhe: 2.942 ± 0.513
4.694AlaGly: 4.694 ± 0.575
1.751AlaHis: 1.751 ± 0.382
5.394AlaIle: 5.394 ± 0.601
6.655AlaLys: 6.655 ± 0.705
7.496AlaLeu: 7.496 ± 0.719
2.312AlaMet: 2.312 ± 0.389
4.413AlaAsn: 4.413 ± 0.567
1.891AlaPro: 1.891 ± 0.405
3.923AlaGln: 3.923 ± 1.025
3.783AlaArg: 3.783 ± 0.458
5.464AlaSer: 5.464 ± 0.801
4.904AlaThr: 4.904 ± 0.624
4.974AlaVal: 4.974 ± 0.548
1.261AlaTrp: 1.261 ± 0.262
2.732AlaTyr: 2.732 ± 0.413
0.0AlaXaa: 0.0 ± 0.0
Cys
0.56CysAla: 0.56 ± 0.218
0.14CysCys: 0.14 ± 0.096
0.771CysAsp: 0.771 ± 0.258
1.821CysGlu: 1.821 ± 0.383
0.35CysPhe: 0.35 ± 0.147
0.63CysGly: 0.63 ± 0.279
0.21CysHis: 0.21 ± 0.125
0.49CysIle: 0.49 ± 0.166
0.771CysLys: 0.771 ± 0.306
0.42CysLeu: 0.42 ± 0.17
0.28CysMet: 0.28 ± 0.136
0.42CysAsn: 0.42 ± 0.189
0.21CysPro: 0.21 ± 0.127
0.42CysGln: 0.42 ± 0.169
0.63CysArg: 0.63 ± 0.241
0.49CysSer: 0.49 ± 0.184
0.49CysThr: 0.49 ± 0.183
0.701CysVal: 0.701 ± 0.232
0.14CysTrp: 0.14 ± 0.099
0.35CysTyr: 0.35 ± 0.179
0.0CysXaa: 0.0 ± 0.0
Asp
4.553AspAla: 4.553 ± 0.618
0.56AspCys: 0.56 ± 0.233
3.923AspAsp: 3.923 ± 0.518
4.203AspGlu: 4.203 ± 0.543
2.872AspPhe: 2.872 ± 0.42
5.254AspGly: 5.254 ± 0.681
1.121AspHis: 1.121 ± 0.363
4.343AspIle: 4.343 ± 0.638
3.853AspLys: 3.853 ± 0.492
5.814AspLeu: 5.814 ± 0.612
1.541AspMet: 1.541 ± 0.343
1.821AspAsn: 1.821 ± 0.313
1.961AspPro: 1.961 ± 0.46
2.382AspGln: 2.382 ± 0.389
2.242AspArg: 2.242 ± 0.372
3.433AspSer: 3.433 ± 0.543
2.172AspThr: 2.172 ± 0.402
3.993AspVal: 3.993 ± 0.554
0.56AspTrp: 0.56 ± 0.173
2.452AspTyr: 2.452 ± 0.421
0.0AspXaa: 0.0 ± 0.0
Glu
7.426GluAla: 7.426 ± 0.884
0.49GluCys: 0.49 ± 0.174
2.942GluAsp: 2.942 ± 0.475
5.324GluGlu: 5.324 ± 0.708
3.503GluPhe: 3.503 ± 0.435
3.643GluGly: 3.643 ± 0.511
1.821GluHis: 1.821 ± 0.392
4.904GluIle: 4.904 ± 0.507
5.744GluLys: 5.744 ± 0.73
6.935GluLeu: 6.935 ± 0.8
1.611GluMet: 1.611 ± 0.343
3.783GluAsn: 3.783 ± 0.521
1.891GluPro: 1.891 ± 0.458
4.343GluGln: 4.343 ± 0.813
4.203GluArg: 4.203 ± 0.616
3.643GluSer: 3.643 ± 0.507
3.082GluThr: 3.082 ± 0.506
4.694GluVal: 4.694 ± 0.555
1.051GluTrp: 1.051 ± 0.329
3.012GluTyr: 3.012 ± 0.501
0.0GluXaa: 0.0 ± 0.0
Phe
2.312PheAla: 2.312 ± 0.321
1.051PheCys: 1.051 ± 0.305
2.382PheAsp: 2.382 ± 0.501
3.292PheGlu: 3.292 ± 0.406
1.681PhePhe: 1.681 ± 0.436
2.242PheGly: 2.242 ± 0.456
0.771PheHis: 0.771 ± 0.208
2.592PheIle: 2.592 ± 0.434
3.433PheLys: 3.433 ± 0.696
1.961PheLeu: 1.961 ± 0.351
0.841PheMet: 0.841 ± 0.196
2.872PheAsn: 2.872 ± 0.345
1.191PhePro: 1.191 ± 0.274
1.891PheGln: 1.891 ± 0.326
1.051PheArg: 1.051 ± 0.242
1.961PheSer: 1.961 ± 0.37
2.102PheThr: 2.102 ± 0.389
2.242PheVal: 2.242 ± 0.472
0.42PheTrp: 0.42 ± 0.156
1.331PheTyr: 1.331 ± 0.32
0.0PheXaa: 0.0 ± 0.0
Gly
5.744GlyAla: 5.744 ± 0.902
0.701GlyCys: 0.701 ± 0.199
3.433GlyAsp: 3.433 ± 0.551
4.764GlyGlu: 4.764 ± 0.51
3.222GlyPhe: 3.222 ± 0.586
6.375GlyGly: 6.375 ± 0.962
0.841GlyHis: 0.841 ± 0.261
3.643GlyIle: 3.643 ± 0.516
5.184GlyLys: 5.184 ± 0.54
4.974GlyLeu: 4.974 ± 0.673
1.541GlyMet: 1.541 ± 0.327
2.732GlyAsn: 2.732 ± 0.452
1.331GlyPro: 1.331 ± 0.285
3.012GlyGln: 3.012 ± 0.499
2.452GlyArg: 2.452 ± 0.507
3.783GlySer: 3.783 ± 0.515
3.643GlyThr: 3.643 ± 0.718
3.573GlyVal: 3.573 ± 0.526
1.401GlyTrp: 1.401 ± 0.304
3.082GlyTyr: 3.082 ± 0.484
0.0GlyXaa: 0.0 ± 0.0
His
1.611HisAla: 1.611 ± 0.412
0.0HisCys: 0.0 ± 0.0
1.331HisAsp: 1.331 ± 0.329
1.821HisGlu: 1.821 ± 0.461
1.051HisPhe: 1.051 ± 0.259
0.771HisGly: 0.771 ± 0.206
0.56HisHis: 0.56 ± 0.244
1.821HisIle: 1.821 ± 0.461
1.261HisLys: 1.261 ± 0.339
2.522HisLeu: 2.522 ± 0.377
0.56HisMet: 0.56 ± 0.191
0.42HisAsn: 0.42 ± 0.153
0.841HisPro: 0.841 ± 0.266
0.771HisGln: 0.771 ± 0.217
0.63HisArg: 0.63 ± 0.214
0.771HisSer: 0.771 ± 0.224
0.28HisThr: 0.28 ± 0.148
1.051HisVal: 1.051 ± 0.305
0.35HisTrp: 0.35 ± 0.177
0.56HisTyr: 0.56 ± 0.224
0.0HisXaa: 0.0 ± 0.0
Ile
4.974IleAla: 4.974 ± 0.666
0.56IleCys: 0.56 ± 0.202
4.694IleAsp: 4.694 ± 0.524
5.184IleGlu: 5.184 ± 0.506
0.981IlePhe: 0.981 ± 0.25
3.643IleGly: 3.643 ± 0.421
0.771IleHis: 0.771 ± 0.246
3.573IleIle: 3.573 ± 0.603
4.694IleLys: 4.694 ± 0.556
3.433IleLeu: 3.433 ± 0.491
1.121IleMet: 1.121 ± 0.256
3.363IleAsn: 3.363 ± 0.46
2.732IlePro: 2.732 ± 0.514
3.222IleGln: 3.222 ± 0.556
2.382IleArg: 2.382 ± 0.432
3.993IleSer: 3.993 ± 0.58
3.292IleThr: 3.292 ± 0.523
3.363IleVal: 3.363 ± 0.451
0.49IleTrp: 0.49 ± 0.205
2.872IleTyr: 2.872 ± 0.579
0.0IleXaa: 0.0 ± 0.0
Lys
7.776LysAla: 7.776 ± 1.247
0.35LysCys: 0.35 ± 0.191
4.273LysAsp: 4.273 ± 0.667
5.044LysGlu: 5.044 ± 0.683
2.592LysPhe: 2.592 ± 0.457
4.483LysGly: 4.483 ± 0.57
1.821LysHis: 1.821 ± 0.369
4.553LysIle: 4.553 ± 0.534
6.165LysLys: 6.165 ± 1.001
6.935LysLeu: 6.935 ± 0.857
1.751LysMet: 1.751 ± 0.369
2.662LysAsn: 2.662 ± 0.411
3.433LysPro: 3.433 ± 0.564
4.343LysGln: 4.343 ± 0.705
3.923LysArg: 3.923 ± 0.489
3.923LysSer: 3.923 ± 0.461
4.623LysThr: 4.623 ± 0.561
4.904LysVal: 4.904 ± 0.569
0.981LysTrp: 0.981 ± 0.294
3.012LysTyr: 3.012 ± 0.454
0.0LysXaa: 0.0 ± 0.0
Leu
7.356LeuAla: 7.356 ± 0.813
1.121LeuCys: 1.121 ± 0.272
4.904LeuAsp: 4.904 ± 0.547
6.375LeuGlu: 6.375 ± 0.753
2.382LeuPhe: 2.382 ± 0.415
5.254LeuGly: 5.254 ± 0.62
1.121LeuHis: 1.121 ± 0.258
4.413LeuIle: 4.413 ± 0.492
7.285LeuLys: 7.285 ± 0.901
6.305LeuLeu: 6.305 ± 0.706
2.032LeuMet: 2.032 ± 0.408
5.814LeuAsn: 5.814 ± 0.724
2.942LeuPro: 2.942 ± 0.531
3.433LeuGln: 3.433 ± 0.48
3.222LeuArg: 3.222 ± 0.519
5.114LeuSer: 5.114 ± 0.636
5.744LeuThr: 5.744 ± 0.558
5.534LeuVal: 5.534 ± 0.493
0.63LeuTrp: 0.63 ± 0.166
3.152LeuTyr: 3.152 ± 0.503
0.0LeuXaa: 0.0 ± 0.0
Met
1.681MetAla: 1.681 ± 0.309
0.35MetCys: 0.35 ± 0.158
1.331MetAsp: 1.331 ± 0.257
1.121MetGlu: 1.121 ± 0.302
0.981MetPhe: 0.981 ± 0.254
1.611MetGly: 1.611 ± 0.299
0.14MetHis: 0.14 ± 0.12
1.191MetIle: 1.191 ± 0.346
2.032MetLys: 2.032 ± 0.414
2.102MetLeu: 2.102 ± 0.471
0.701MetMet: 0.701 ± 0.229
2.032MetAsn: 2.032 ± 0.483
1.261MetPro: 1.261 ± 0.24
0.911MetGln: 0.911 ± 0.237
1.401MetArg: 1.401 ± 0.363
2.172MetSer: 2.172 ± 0.475
1.961MetThr: 1.961 ± 0.379
1.191MetVal: 1.191 ± 0.347
0.0MetTrp: 0.0 ± 0.0
0.49MetTyr: 0.49 ± 0.214
0.0MetXaa: 0.0 ± 0.0
Asn
4.343AsnAla: 4.343 ± 0.822
0.701AsnCys: 0.701 ± 0.235
2.662AsnAsp: 2.662 ± 0.542
3.643AsnGlu: 3.643 ± 0.459
2.102AsnPhe: 2.102 ± 0.472
3.573AsnGly: 3.573 ± 0.681
0.841AsnHis: 0.841 ± 0.233
2.592AsnIle: 2.592 ± 0.453
3.222AsnLys: 3.222 ± 0.462
5.184AsnLeu: 5.184 ± 0.679
1.191AsnMet: 1.191 ± 0.256
2.662AsnAsn: 2.662 ± 0.52
2.172AsnPro: 2.172 ± 0.42
1.961AsnGln: 1.961 ± 0.391
2.172AsnArg: 2.172 ± 0.535
3.292AsnSer: 3.292 ± 0.433
2.102AsnThr: 2.102 ± 0.36
3.082AsnVal: 3.082 ± 0.434
1.261AsnTrp: 1.261 ± 0.252
1.681AsnTyr: 1.681 ± 0.342
0.0AsnXaa: 0.0 ± 0.0
Pro
3.152ProAla: 3.152 ± 0.562
0.14ProCys: 0.14 ± 0.107
3.082ProAsp: 3.082 ± 0.569
3.222ProGlu: 3.222 ± 0.465
0.841ProPhe: 0.841 ± 0.259
1.331ProGly: 1.331 ± 0.543
0.981ProHis: 0.981 ± 0.262
1.961ProIle: 1.961 ± 0.351
2.662ProLys: 2.662 ± 0.451
2.872ProLeu: 2.872 ± 0.555
1.051ProMet: 1.051 ± 0.299
2.032ProAsn: 2.032 ± 0.3
1.471ProPro: 1.471 ± 0.341
1.331ProGln: 1.331 ± 0.295
0.981ProArg: 0.981 ± 0.291
2.242ProSer: 2.242 ± 0.362
2.242ProThr: 2.242 ± 0.458
2.172ProVal: 2.172 ± 0.424
0.07ProTrp: 0.07 ± 0.068
1.191ProTyr: 1.191 ± 0.252
0.0ProXaa: 0.0 ± 0.0
Gln
5.464GlnAla: 5.464 ± 0.954
0.35GlnCys: 0.35 ± 0.148
2.802GlnAsp: 2.802 ± 0.522
3.923GlnGlu: 3.923 ± 0.728
1.051GlnPhe: 1.051 ± 0.255
2.312GlnGly: 2.312 ± 0.36
1.191GlnHis: 1.191 ± 0.279
2.382GlnIle: 2.382 ± 0.402
3.643GlnLys: 3.643 ± 0.721
3.433GlnLeu: 3.433 ± 0.387
1.401GlnMet: 1.401 ± 0.314
2.452GlnAsn: 2.452 ± 0.429
0.981GlnPro: 0.981 ± 0.29
2.102GlnGln: 2.102 ± 0.512
2.662GlnArg: 2.662 ± 0.408
2.312GlnSer: 2.312 ± 0.436
2.592GlnThr: 2.592 ± 0.397
3.012GlnVal: 3.012 ± 0.529
0.56GlnTrp: 0.56 ± 0.185
1.891GlnTyr: 1.891 ± 0.347
0.0GlnXaa: 0.0 ± 0.0
Arg
2.592ArgAla: 2.592 ± 0.436
0.63ArgCys: 0.63 ± 0.168
3.012ArgAsp: 3.012 ± 0.534
2.592ArgGlu: 2.592 ± 0.418
1.961ArgPhe: 1.961 ± 0.371
3.012ArgGly: 3.012 ± 0.428
1.051ArgHis: 1.051 ± 0.268
2.732ArgIle: 2.732 ± 0.399
3.152ArgLys: 3.152 ± 0.371
5.114ArgLeu: 5.114 ± 0.572
1.261ArgMet: 1.261 ± 0.267
2.382ArgAsn: 2.382 ± 0.375
1.471ArgPro: 1.471 ± 0.283
2.522ArgGln: 2.522 ± 0.382
2.452ArgArg: 2.452 ± 0.346
2.102ArgSer: 2.102 ± 0.362
2.592ArgThr: 2.592 ± 0.474
2.662ArgVal: 2.662 ± 0.41
0.56ArgTrp: 0.56 ± 0.165
2.242ArgTyr: 2.242 ± 0.389
0.0ArgXaa: 0.0 ± 0.0
Ser
3.923SerAla: 3.923 ± 0.537
0.28SerCys: 0.28 ± 0.169
3.222SerAsp: 3.222 ± 0.57
3.573SerGlu: 3.573 ± 0.516
3.082SerPhe: 3.082 ± 0.497
4.694SerGly: 4.694 ± 0.466
1.191SerHis: 1.191 ± 0.324
3.222SerIle: 3.222 ± 0.464
5.394SerLys: 5.394 ± 0.673
4.133SerLeu: 4.133 ± 0.522
1.401SerMet: 1.401 ± 0.312
3.292SerAsn: 3.292 ± 0.487
2.592SerPro: 2.592 ± 0.507
2.662SerGln: 2.662 ± 0.462
3.292SerArg: 3.292 ± 0.453
4.273SerSer: 4.273 ± 0.629
2.592SerThr: 2.592 ± 0.387
4.413SerVal: 4.413 ± 0.671
0.56SerTrp: 0.56 ± 0.179
1.751SerTyr: 1.751 ± 0.349
0.0SerXaa: 0.0 ± 0.0
Thr
4.483ThrAla: 4.483 ± 0.611
0.63ThrCys: 0.63 ± 0.256
2.452ThrAsp: 2.452 ± 0.417
3.573ThrGlu: 3.573 ± 0.472
2.242ThrPhe: 2.242 ± 0.399
4.203ThrGly: 4.203 ± 0.526
1.191ThrHis: 1.191 ± 0.288
3.152ThrIle: 3.152 ± 0.572
3.292ThrLys: 3.292 ± 0.356
5.254ThrLeu: 5.254 ± 0.504
0.771ThrMet: 0.771 ± 0.211
2.312ThrAsn: 2.312 ± 0.499
2.872ThrPro: 2.872 ± 0.557
1.891ThrGln: 1.891 ± 0.365
2.592ThrArg: 2.592 ± 0.389
2.592ThrSer: 2.592 ± 0.45
3.292ThrThr: 3.292 ± 0.597
4.063ThrVal: 4.063 ± 0.532
0.56ThrTrp: 0.56 ± 0.174
2.242ThrTyr: 2.242 ± 0.377
0.0ThrXaa: 0.0 ± 0.0
Val
4.904ValAla: 4.904 ± 0.653
0.771ValCys: 0.771 ± 0.242
4.273ValAsp: 4.273 ± 0.567
3.783ValGlu: 3.783 ± 0.566
1.891ValPhe: 1.891 ± 0.366
4.694ValGly: 4.694 ± 0.427
0.911ValHis: 0.911 ± 0.302
3.573ValIle: 3.573 ± 0.547
5.254ValLys: 5.254 ± 0.544
3.853ValLeu: 3.853 ± 0.597
1.961ValMet: 1.961 ± 0.386
3.292ValAsn: 3.292 ± 0.543
2.382ValPro: 2.382 ± 0.373
3.152ValGln: 3.152 ± 0.496
3.082ValArg: 3.082 ± 0.479
4.483ValSer: 4.483 ± 0.585
3.643ValThr: 3.643 ± 0.617
4.974ValVal: 4.974 ± 0.696
1.051ValTrp: 1.051 ± 0.257
1.751ValTyr: 1.751 ± 0.3
0.0ValXaa: 0.0 ± 0.0
Trp
0.981TrpAla: 0.981 ± 0.24
0.35TrpCys: 0.35 ± 0.159
0.841TrpAsp: 0.841 ± 0.21
0.771TrpGlu: 0.771 ± 0.278
0.42TrpPhe: 0.42 ± 0.183
0.701TrpGly: 0.701 ± 0.263
0.28TrpHis: 0.28 ± 0.15
0.981TrpIle: 0.981 ± 0.244
0.63TrpLys: 0.63 ± 0.206
1.891TrpLeu: 1.891 ± 0.346
0.21TrpMet: 0.21 ± 0.112
0.42TrpAsn: 0.42 ± 0.174
0.21TrpPro: 0.21 ± 0.108
0.771TrpGln: 0.771 ± 0.328
0.35TrpArg: 0.35 ± 0.135
0.771TrpSer: 0.771 ± 0.191
0.63TrpThr: 0.63 ± 0.195
0.63TrpVal: 0.63 ± 0.211
0.21TrpTrp: 0.21 ± 0.126
0.49TrpTyr: 0.49 ± 0.164
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.872TyrAla: 2.872 ± 0.406
0.21TyrCys: 0.21 ± 0.119
2.452TyrAsp: 2.452 ± 0.505
3.082TyrGlu: 3.082 ± 0.494
1.471TyrPhe: 1.471 ± 0.301
2.312TyrGly: 2.312 ± 0.457
0.42TyrHis: 0.42 ± 0.151
1.821TyrIle: 1.821 ± 0.367
3.222TyrLys: 3.222 ± 0.413
3.503TyrLeu: 3.503 ± 0.577
1.051TyrMet: 1.051 ± 0.287
1.261TyrAsn: 1.261 ± 0.324
1.191TyrPro: 1.191 ± 0.287
1.471TyrGln: 1.471 ± 0.267
2.592TyrArg: 2.592 ± 0.453
2.732TyrSer: 2.732 ± 0.52
1.681TyrThr: 1.681 ± 0.317
2.452TyrVal: 2.452 ± 0.402
0.42TyrTrp: 0.42 ± 0.176
0.771TyrTyr: 0.771 ± 0.206
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (14276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski