Amino acid dipepetide frequency for Lewinella aurantiaca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.507AlaAla: 8.507 ± 0.102	0.845AlaCys: 0.845 ± 0.026	5.428AlaAsp: 5.428 ± 0.07	5.698AlaGlu: 5.698 ± 0.075	3.627AlaPhe: 3.627 ± 0.053	7.841AlaGly: 7.841 ± 0.082	1.233AlaHis: 1.233 ± 0.035	4.626AlaIle: 4.626 ± 0.063	3.583AlaLys: 3.583 ± 0.068	7.677AlaLeu: 7.677 ± 0.092	1.826AlaMet: 1.826 ± 0.034	3.58AlaAsn: 3.58 ± 0.053	3.757AlaPro: 3.757 ± 0.057	2.819AlaGln: 2.819 ± 0.042	4.235AlaArg: 4.235 ± 0.066	4.71AlaSer: 4.71 ± 0.058	5.234AlaThr: 5.234 ± 0.078	5.44AlaVal: 5.44 ± 0.069	0.972AlaTrp: 0.972 ± 0.027	2.938AlaTyr: 2.938 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.736CysAla: 0.736 ± 0.028	0.151CysCys: 0.151 ± 0.01	0.603CysAsp: 0.603 ± 0.038	0.544CysGlu: 0.544 ± 0.026	0.434CysPhe: 0.434 ± 0.019	0.888CysGly: 0.888 ± 0.035	0.204CysHis: 0.204 ± 0.012	0.483CysIle: 0.483 ± 0.022	0.266CysLys: 0.266 ± 0.015	0.819CysLeu: 0.819 ± 0.021	0.157CysMet: 0.157 ± 0.012	0.41CysAsn: 0.41 ± 0.019	0.528CysPro: 0.528 ± 0.037	0.302CysGln: 0.302 ± 0.016	0.415CysArg: 0.415 ± 0.019	0.747CysSer: 0.747 ± 0.039	0.702CysThr: 0.702 ± 0.033	0.559CysVal: 0.559 ± 0.024	0.098CysTrp: 0.098 ± 0.007	0.279CysTyr: 0.279 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.022AspAla: 5.022 ± 0.077	0.677AspCys: 0.677 ± 0.037	3.746AspAsp: 3.746 ± 0.08	4.144AspGlu: 4.144 ± 0.063	3.51AspPhe: 3.51 ± 0.053	5.718AspGly: 5.718 ± 0.109	1.189AspHis: 1.189 ± 0.027	3.473AspIle: 3.473 ± 0.053	2.487AspLys: 2.487 ± 0.044	6.177AspLeu: 6.177 ± 0.076	1.191AspMet: 1.191 ± 0.034	2.755AspAsn: 2.755 ± 0.055	2.965AspPro: 2.965 ± 0.062	2.159AspGln: 2.159 ± 0.036	3.255AspArg: 3.255 ± 0.05	3.021AspSer: 3.021 ± 0.053	2.956AspThr: 2.956 ± 0.063	4.131AspVal: 4.131 ± 0.058	0.964AspTrp: 0.964 ± 0.023	2.724AspTyr: 2.724 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.686GluAla: 5.686 ± 0.075	0.421GluCys: 0.421 ± 0.021	3.915GluAsp: 3.915 ± 0.049	4.768GluGlu: 4.768 ± 0.064	2.515GluPhe: 2.515 ± 0.041	4.626GluGly: 4.626 ± 0.064	1.14GluHis: 1.14 ± 0.029	3.89GluIle: 3.89 ± 0.05	3.176GluLys: 3.176 ± 0.058	6.789GluLeu: 6.789 ± 0.082	1.749GluMet: 1.749 ± 0.033	2.893GluAsn: 2.893 ± 0.045	2.209GluPro: 2.209 ± 0.039	2.383GluGln: 2.383 ± 0.04	3.671GluArg: 3.671 ± 0.062	2.976GluSer: 2.976 ± 0.043	3.636GluThr: 3.636 ± 0.046	4.907GluVal: 4.907 ± 0.051	0.825GluTrp: 0.825 ± 0.025	2.068GluTyr: 2.068 ± 0.037	0.001GluXaa: 0.001 ± 0.001
Phe	3.579PheAla: 3.579 ± 0.048	0.458PheCys: 0.458 ± 0.017	3.091PheAsp: 3.091 ± 0.049	2.621PheGlu: 2.621 ± 0.041	2.269PhePhe: 2.269 ± 0.041	3.824PheGly: 3.824 ± 0.06	0.809PheHis: 0.809 ± 0.026	2.393PheIle: 2.393 ± 0.036	1.624PheLys: 1.624 ± 0.034	4.349PheLeu: 4.349 ± 0.064	0.889PheMet: 0.889 ± 0.024	2.207PheAsn: 2.207 ± 0.041	1.951PhePro: 1.951 ± 0.038	1.405PheGln: 1.405 ± 0.026	2.54PheArg: 2.54 ± 0.041	3.526PheSer: 3.526 ± 0.058	3.315PheThr: 3.315 ± 0.052	2.968PheVal: 2.968 ± 0.048	0.581PheTrp: 0.581 ± 0.019	1.67PheTyr: 1.67 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.004GlyAla: 6.004 ± 0.079	0.958GlyCys: 0.958 ± 0.04	4.709GlyAsp: 4.709 ± 0.08	5.13GlyGlu: 5.13 ± 0.065	3.727GlyPhe: 3.727 ± 0.058	6.676GlyGly: 6.676 ± 0.11	1.387GlyHis: 1.387 ± 0.035	4.636GlyIle: 4.636 ± 0.059	4.24GlyLys: 4.24 ± 0.067	7.205GlyLeu: 7.205 ± 0.076	1.968GlyMet: 1.968 ± 0.04	3.767GlyAsn: 3.767 ± 0.078	2.666GlyPro: 2.666 ± 0.086	2.743GlyGln: 2.743 ± 0.041	4.076GlyArg: 4.076 ± 0.061	4.812GlySer: 4.812 ± 0.067	5.241GlyThr: 5.241 ± 0.098	5.111GlyVal: 5.111 ± 0.073	1.099GlyTrp: 1.099 ± 0.028	2.927GlyTyr: 2.927 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.23HisAla: 1.23 ± 0.029	0.186HisCys: 0.186 ± 0.011	0.971HisAsp: 0.971 ± 0.026	1.047HisGlu: 1.047 ± 0.026	1.016HisPhe: 1.016 ± 0.028	1.233HisGly: 1.233 ± 0.032	0.558HisHis: 0.558 ± 0.02	0.916HisIle: 0.916 ± 0.027	0.745HisLys: 0.745 ± 0.021	2.116HisLeu: 2.116 ± 0.044	0.277HisMet: 0.277 ± 0.015	0.71HisAsn: 0.71 ± 0.023	1.159HisPro: 1.159 ± 0.032	0.697HisGln: 0.697 ± 0.022	1.069HisArg: 1.069 ± 0.028	0.892HisSer: 0.892 ± 0.023	0.938HisThr: 0.938 ± 0.025	0.996HisVal: 0.996 ± 0.028	0.266HisTrp: 0.266 ± 0.013	0.838HisTyr: 0.838 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.905IleAla: 4.905 ± 0.061	0.589IleCys: 0.589 ± 0.026	3.993IleAsp: 3.993 ± 0.052	3.61IleGlu: 3.61 ± 0.052	2.344IlePhe: 2.344 ± 0.042	4.368IleGly: 4.368 ± 0.061	1.021IleHis: 1.021 ± 0.03	3.324IleIle: 3.324 ± 0.055	2.273IleLys: 2.273 ± 0.047	4.828IleLeu: 4.828 ± 0.058	1.04IleMet: 1.04 ± 0.03	2.767IleAsn: 2.767 ± 0.051	2.663IlePro: 2.663 ± 0.043	1.57IleGln: 1.57 ± 0.028	3.037IleArg: 3.037 ± 0.039	3.89IleSer: 3.89 ± 0.05	3.929IleThr: 3.929 ± 0.072	3.949IleVal: 3.949 ± 0.047	0.581IleTrp: 0.581 ± 0.018	1.841IleTyr: 1.841 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.889LysAla: 3.889 ± 0.073	0.218LysCys: 0.218 ± 0.013	2.631LysAsp: 2.631 ± 0.054	3.121LysGlu: 3.121 ± 0.068	1.551LysPhe: 1.551 ± 0.034	2.996LysGly: 2.996 ± 0.058	0.845LysHis: 0.845 ± 0.028	2.572LysIle: 2.572 ± 0.049	2.722LysLys: 2.722 ± 0.062	4.173LysLeu: 4.173 ± 0.06	1.309LysMet: 1.309 ± 0.031	1.856LysAsn: 1.856 ± 0.037	1.95LysPro: 1.95 ± 0.043	1.567LysGln: 1.567 ± 0.036	2.381LysArg: 2.381 ± 0.053	2.504LysSer: 2.504 ± 0.045	2.644LysThr: 2.644 ± 0.049	3.035LysVal: 3.035 ± 0.051	0.596LysTrp: 0.596 ± 0.02	1.547LysTyr: 1.547 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	8.458LeuAla: 8.458 ± 0.089	0.871LeuCys: 0.871 ± 0.024	5.588LeuAsp: 5.588 ± 0.064	5.955LeuGlu: 5.955 ± 0.074	4.295LeuPhe: 4.295 ± 0.066	6.652LeuGly: 6.652 ± 0.076	1.761LeuHis: 1.761 ± 0.035	5.247LeuIle: 5.247 ± 0.066	4.5LeuLys: 4.5 ± 0.083	10.458LeuLeu: 10.458 ± 0.127	2.012LeuMet: 2.012 ± 0.036	4.367LeuAsn: 4.367 ± 0.054	5.252LeuPro: 5.252 ± 0.063	3.206LeuGln: 3.206 ± 0.049	5.831LeuArg: 5.831 ± 0.072	7.019LeuSer: 7.019 ± 0.07	6.176LeuThr: 6.176 ± 0.072	5.885LeuVal: 5.885 ± 0.069	0.977LeuTrp: 0.977 ± 0.028	2.97LeuTyr: 2.97 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.929MetAla: 1.929 ± 0.041	0.146MetCys: 0.146 ± 0.01	1.243MetAsp: 1.243 ± 0.029	1.34MetGlu: 1.34 ± 0.033	0.655MetPhe: 0.655 ± 0.017	1.459MetGly: 1.459 ± 0.034	0.391MetHis: 0.391 ± 0.015	1.245MetIle: 1.245 ± 0.03	1.389MetLys: 1.389 ± 0.034	2.054MetLeu: 2.054 ± 0.04	0.578MetMet: 0.578 ± 0.019	1.001MetAsn: 1.001 ± 0.024	1.075MetPro: 1.075 ± 0.023	0.764MetGln: 0.764 ± 0.023	1.241MetArg: 1.241 ± 0.028	1.277MetSer: 1.277 ± 0.029	1.413MetThr: 1.413 ± 0.033	1.464MetVal: 1.464 ± 0.032	0.195MetTrp: 0.195 ± 0.011	0.519MetTyr: 0.519 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.323AsnAla: 3.323 ± 0.049	0.518AsnCys: 0.518 ± 0.042	2.834AsnAsp: 2.834 ± 0.054	2.652AsnGlu: 2.652 ± 0.048	2.148AsnPhe: 2.148 ± 0.04	4.084AsnGly: 4.084 ± 0.083	0.809AsnHis: 0.809 ± 0.022	2.586AsnIle: 2.586 ± 0.046	1.724AsnLys: 1.724 ± 0.038	4.256AsnLeu: 4.256 ± 0.054	0.838AsnMet: 0.838 ± 0.023	2.138AsnAsn: 2.138 ± 0.046	2.582AsnPro: 2.582 ± 0.04	1.572AsnGln: 1.572 ± 0.029	2.329AsnArg: 2.329 ± 0.038	2.508AsnSer: 2.508 ± 0.048	2.599AsnThr: 2.599 ± 0.049	2.785AsnVal: 2.785 ± 0.055	0.702AsnTrp: 0.702 ± 0.023	1.909AsnTyr: 1.909 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.67ProAla: 4.67 ± 0.074	0.336ProCys: 0.336 ± 0.039	3.5ProAsp: 3.5 ± 0.06	3.789ProGlu: 3.789 ± 0.046	2.006ProPhe: 2.006 ± 0.038	4.0ProGly: 4.0 ± 0.057	0.738ProHis: 0.738 ± 0.028	2.078ProIle: 2.078 ± 0.037	1.63ProLys: 1.63 ± 0.037	3.962ProLeu: 3.962 ± 0.053	0.801ProMet: 0.801 ± 0.024	2.057ProAsn: 2.057 ± 0.045	1.917ProPro: 1.917 ± 0.056	1.457ProGln: 1.457 ± 0.052	1.798ProArg: 1.798 ± 0.032	2.587ProSer: 2.587 ± 0.043	2.75ProThr: 2.75 ± 0.051	3.716ProVal: 3.716 ± 0.05	0.491ProTrp: 0.491 ± 0.018	1.5ProTyr: 1.5 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.696GlnAla: 2.696 ± 0.037	0.225GlnCys: 0.225 ± 0.013	1.872GlnAsp: 1.872 ± 0.036	2.109GlnGlu: 2.109 ± 0.037	1.405GlnPhe: 1.405 ± 0.032	2.278GlnGly: 2.278 ± 0.101	0.62GlnHis: 0.62 ± 0.021	1.895GlnIle: 1.895 ± 0.033	1.466GlnLys: 1.466 ± 0.032	3.832GlnLeu: 3.832 ± 0.056	0.808GlnMet: 0.808 ± 0.024	1.438GlnAsn: 1.438 ± 0.03	1.613GlnPro: 1.613 ± 0.027	1.528GlnGln: 1.528 ± 0.037	2.058GlnArg: 2.058 ± 0.041	1.966GlnSer: 1.966 ± 0.033	2.009GlnThr: 2.009 ± 0.041	2.302GlnVal: 2.302 ± 0.036	0.436GlnTrp: 0.436 ± 0.017	1.107GlnTyr: 1.107 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.128ArgAla: 4.128 ± 0.058	0.335ArgCys: 0.335 ± 0.015	2.809ArgAsp: 2.809 ± 0.046	3.51ArgGlu: 3.51 ± 0.055	2.755ArgPhe: 2.755 ± 0.045	3.256ArgGly: 3.256 ± 0.053	1.026ArgHis: 1.026 ± 0.028	3.393ArgIle: 3.393 ± 0.05	2.939ArgLys: 2.939 ± 0.052	5.521ArgLeu: 5.521 ± 0.082	1.409ArgMet: 1.409 ± 0.032	2.441ArgAsn: 2.441 ± 0.037	2.311ArgPro: 2.311 ± 0.047	2.062ArgGln: 2.062 ± 0.039	3.21ArgArg: 3.21 ± 0.052	3.072ArgSer: 3.072 ± 0.047	2.892ArgThr: 2.892 ± 0.042	3.388ArgVal: 3.388 ± 0.049	0.766ArgTrp: 0.766 ± 0.025	2.274ArgTyr: 2.274 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.99SerAla: 4.99 ± 0.063	0.717SerCys: 0.717 ± 0.033	3.532SerAsp: 3.532 ± 0.055	3.322SerGlu: 3.322 ± 0.045	3.217SerPhe: 3.217 ± 0.046	5.62SerGly: 5.62 ± 0.07	0.983SerHis: 0.983 ± 0.024	3.601SerIle: 3.601 ± 0.056	2.305SerLys: 2.305 ± 0.047	6.098SerLeu: 6.098 ± 0.074	1.12SerMet: 1.12 ± 0.024	2.497SerAsn: 2.497 ± 0.047	3.01SerPro: 3.01 ± 0.044	1.8SerGln: 1.8 ± 0.032	3.056SerArg: 3.056 ± 0.049	4.04SerSer: 4.04 ± 0.066	3.545SerThr: 3.545 ± 0.065	4.468SerVal: 4.468 ± 0.064	0.814SerTrp: 0.814 ± 0.025	2.355SerTyr: 2.355 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.262ThrAla: 5.262 ± 0.074	0.562ThrCys: 0.562 ± 0.029	4.351ThrAsp: 4.351 ± 0.074	3.659ThrGlu: 3.659 ± 0.049	2.979ThrPhe: 2.979 ± 0.057	5.412ThrGly: 5.412 ± 0.069	0.932ThrHis: 0.932 ± 0.026	4.037ThrIle: 4.037 ± 0.068	2.141ThrLys: 2.141 ± 0.041	5.75ThrLeu: 5.75 ± 0.072	1.068ThrMet: 1.068 ± 0.028	2.663ThrAsn: 2.663 ± 0.049	3.137ThrPro: 3.137 ± 0.054	1.638ThrGln: 1.638 ± 0.04	2.48ThrArg: 2.48 ± 0.036	3.79ThrSer: 3.79 ± 0.069	4.024ThrThr: 4.024 ± 0.074	4.814ThrVal: 4.814 ± 0.103	0.632ThrTrp: 0.632 ± 0.021	2.368ThrTyr: 2.368 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	5.838ValAla: 5.838 ± 0.061	0.681ValCys: 0.681 ± 0.028	4.167ValAsp: 4.167 ± 0.059	4.3ValGlu: 4.3 ± 0.051	3.152ValPhe: 3.152 ± 0.046	4.618ValGly: 4.618 ± 0.053	1.166ValHis: 1.166 ± 0.032	3.913ValIle: 3.913 ± 0.054	2.926ValLys: 2.926 ± 0.054	6.159ValLeu: 6.159 ± 0.075	1.505ValMet: 1.505 ± 0.035	3.17ValAsn: 3.17 ± 0.051	3.017ValPro: 3.017 ± 0.046	2.054ValGln: 2.054 ± 0.032	3.646ValArg: 3.646 ± 0.044	4.716ValSer: 4.716 ± 0.064	4.68ValThr: 4.68 ± 0.109	5.002ValVal: 5.002 ± 0.06	0.754ValTrp: 0.754 ± 0.019	2.385ValTyr: 2.385 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.919TrpAla: 0.919 ± 0.026	0.116TrpCys: 0.116 ± 0.009	0.725TrpAsp: 0.725 ± 0.021	0.78TrpGlu: 0.78 ± 0.021	0.549TrpPhe: 0.549 ± 0.021	0.827TrpGly: 0.827 ± 0.024	0.263TrpHis: 0.263 ± 0.014	0.599TrpIle: 0.599 ± 0.019	0.629TrpLys: 0.629 ± 0.022	1.377TrpLeu: 1.377 ± 0.033	0.331TrpMet: 0.331 ± 0.015	0.569TrpAsn: 0.569 ± 0.02	0.467TrpPro: 0.467 ± 0.02	0.52TrpGln: 0.52 ± 0.018	0.755TrpArg: 0.755 ± 0.022	0.862TrpSer: 0.862 ± 0.031	0.737TrpThr: 0.737 ± 0.023	0.741TrpVal: 0.741 ± 0.024	0.25TrpTrp: 0.25 ± 0.014	0.453TrpTyr: 0.453 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.81TyrAla: 2.81 ± 0.046	0.316TyrCys: 0.316 ± 0.014	2.553TyrAsp: 2.553 ± 0.04	2.145TyrGlu: 2.145 ± 0.037	1.914TyrPhe: 1.914 ± 0.035	2.707TyrGly: 2.707 ± 0.047	0.785TyrHis: 0.785 ± 0.023	1.612TyrIle: 1.612 ± 0.033	1.344TyrLys: 1.344 ± 0.03	3.879TyrLeu: 3.879 ± 0.048	0.503TyrMet: 0.503 ± 0.019	1.615TyrAsn: 1.615 ± 0.037	1.553TyrPro: 1.553 ± 0.033	1.42TyrGln: 1.42 ± 0.03	2.413TyrArg: 2.413 ± 0.047	2.173TyrSer: 2.173 ± 0.044	2.28TyrThr: 2.28 ± 0.054	2.186TyrVal: 2.186 ± 0.034	0.467TyrTrp: 0.467 ± 0.02	1.475TyrTyr: 1.475 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4341 proteins (1692660 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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