Amino acid dipepetide frequency for Oceanobacillus sp. 160

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.822AlaAla: 5.822 ± 0.087	0.573AlaCys: 0.573 ± 0.022	3.528AlaAsp: 3.528 ± 0.063	4.792AlaGlu: 4.792 ± 0.091	3.352AlaPhe: 3.352 ± 0.061	5.198AlaGly: 5.198 ± 0.085	1.161AlaHis: 1.161 ± 0.034	6.628AlaIle: 6.628 ± 0.085	4.569AlaLys: 4.569 ± 0.071	7.002AlaLeu: 7.002 ± 0.081	1.941AlaMet: 1.941 ± 0.045	3.273AlaAsn: 3.273 ± 0.053	2.019AlaPro: 2.019 ± 0.045	1.932AlaGln: 1.932 ± 0.042	2.465AlaArg: 2.465 ± 0.051	4.024AlaSer: 4.024 ± 0.059	3.731AlaThr: 3.731 ± 0.063	5.187AlaVal: 5.187 ± 0.077	0.611AlaTrp: 0.611 ± 0.025	2.3AlaTyr: 2.3 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.341CysAla: 0.341 ± 0.019	0.065CysCys: 0.065 ± 0.01	0.339CysAsp: 0.339 ± 0.018	0.358CysGlu: 0.358 ± 0.022	0.253CysPhe: 0.253 ± 0.017	0.557CysGly: 0.557 ± 0.022	0.167CysHis: 0.167 ± 0.012	0.491CysIle: 0.491 ± 0.022	0.323CysLys: 0.323 ± 0.016	0.565CysLeu: 0.565 ± 0.023	0.149CysMet: 0.149 ± 0.013	0.293CysAsn: 0.293 ± 0.017	0.281CysPro: 0.281 ± 0.017	0.18CysGln: 0.18 ± 0.015	0.202CysArg: 0.202 ± 0.014	0.411CysSer: 0.411 ± 0.019	0.329CysThr: 0.329 ± 0.019	0.325CysVal: 0.325 ± 0.018	0.055CysTrp: 0.055 ± 0.007	0.217CysTyr: 0.217 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.491AspAla: 3.491 ± 0.057	0.321AspCys: 0.321 ± 0.016	2.618AspAsp: 2.618 ± 0.055	4.488AspGlu: 4.488 ± 0.077	2.471AspPhe: 2.471 ± 0.051	3.478AspGly: 3.478 ± 0.065	1.066AspHis: 1.066 ± 0.041	4.428AspIle: 4.428 ± 0.064	3.387AspLys: 3.387 ± 0.058	4.943AspLeu: 4.943 ± 0.068	1.314AspMet: 1.314 ± 0.031	2.381AspAsn: 2.381 ± 0.052	1.987AspPro: 1.987 ± 0.047	1.871AspGln: 1.871 ± 0.035	2.14AspArg: 2.14 ± 0.045	2.895AspSer: 2.895 ± 0.051	2.561AspThr: 2.561 ± 0.055	3.723AspVal: 3.723 ± 0.067	0.597AspTrp: 0.597 ± 0.025	2.337AspTyr: 2.337 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.462GluAla: 5.462 ± 0.08	0.309GluCys: 0.309 ± 0.018	3.91GluAsp: 3.91 ± 0.068	7.072GluGlu: 7.072 ± 0.111	2.624GluPhe: 2.624 ± 0.053	4.123GluGly: 4.123 ± 0.069	1.481GluHis: 1.481 ± 0.039	6.326GluIle: 6.326 ± 0.078	6.605GluLys: 6.605 ± 0.103	7.236GluLeu: 7.236 ± 0.088	2.251GluMet: 2.251 ± 0.048	4.139GluAsn: 4.139 ± 0.066	2.01GluPro: 2.01 ± 0.046	3.517GluGln: 3.517 ± 0.064	3.289GluArg: 3.289 ± 0.059	3.795GluSer: 3.795 ± 0.062	3.973GluThr: 3.973 ± 0.06	5.264GluVal: 5.264 ± 0.084	0.814GluTrp: 0.814 ± 0.026	2.458GluTyr: 2.458 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.111PheAla: 3.111 ± 0.054	0.29PheCys: 0.29 ± 0.017	2.401PheAsp: 2.401 ± 0.051	2.773PheGlu: 2.773 ± 0.052	2.282PhePhe: 2.282 ± 0.064	3.345PheGly: 3.345 ± 0.061	0.933PheHis: 0.933 ± 0.03	4.378PheIle: 4.378 ± 0.082	2.401PheLys: 2.401 ± 0.044	4.404PheLeu: 4.404 ± 0.086	1.159PheMet: 1.159 ± 0.029	2.093PheAsn: 2.093 ± 0.046	1.675PhePro: 1.675 ± 0.045	1.584PheGln: 1.584 ± 0.039	1.462PheArg: 1.462 ± 0.038	3.189PheSer: 3.189 ± 0.059	2.672PheThr: 2.672 ± 0.054	2.979PheVal: 2.979 ± 0.057	0.488PheTrp: 0.488 ± 0.026	1.807PheTyr: 1.807 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.745GlyAla: 4.745 ± 0.082	0.468GlyCys: 0.468 ± 0.02	3.263GlyAsp: 3.263 ± 0.063	4.628GlyGlu: 4.628 ± 0.085	3.401GlyPhe: 3.401 ± 0.056	4.781GlyGly: 4.781 ± 0.068	1.268GlyHis: 1.268 ± 0.037	6.489GlyIle: 6.489 ± 0.096	4.892GlyLys: 4.892 ± 0.07	6.352GlyLeu: 6.352 ± 0.091	2.074GlyMet: 2.074 ± 0.046	3.061GlyAsn: 3.061 ± 0.052	1.693GlyPro: 1.693 ± 0.051	1.998GlyGln: 1.998 ± 0.04	2.51GlyArg: 2.51 ± 0.052	4.009GlySer: 4.009 ± 0.061	4.023GlyThr: 4.023 ± 0.07	4.719GlyVal: 4.719 ± 0.078	0.767GlyTrp: 0.767 ± 0.026	2.73GlyTyr: 2.73 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.306HisAla: 1.306 ± 0.029	0.167HisCys: 0.167 ± 0.012	1.018HisAsp: 1.018 ± 0.034	1.283HisGlu: 1.283 ± 0.035	0.97HisPhe: 0.97 ± 0.03	1.397HisGly: 1.397 ± 0.037	0.618HisHis: 0.618 ± 0.029	1.495HisIle: 1.495 ± 0.037	0.958HisLys: 0.958 ± 0.034	1.954HisLeu: 1.954 ± 0.049	0.466HisMet: 0.466 ± 0.02	0.809HisAsn: 0.809 ± 0.029	1.008HisPro: 1.008 ± 0.03	0.775HisGln: 0.775 ± 0.026	0.808HisArg: 0.808 ± 0.027	1.151HisSer: 1.151 ± 0.034	0.936HisThr: 0.936 ± 0.033	1.326HisVal: 1.326 ± 0.035	0.209HisTrp: 0.209 ± 0.014	0.88HisTyr: 0.88 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.736IleAla: 6.736 ± 0.092	0.577IleCys: 0.577 ± 0.024	4.858IleAsp: 4.858 ± 0.065	6.443IleGlu: 6.443 ± 0.075	3.665IlePhe: 3.665 ± 0.069	6.477IleGly: 6.477 ± 0.088	1.71IleHis: 1.71 ± 0.041	7.544IleIle: 7.544 ± 0.109	4.953IleLys: 4.953 ± 0.07	7.807IleLeu: 7.807 ± 0.109	1.976IleMet: 1.976 ± 0.045	4.08IleAsn: 4.08 ± 0.068	3.551IlePro: 3.551 ± 0.056	3.02IleGln: 3.02 ± 0.053	3.149IleArg: 3.149 ± 0.059	5.417IleSer: 5.417 ± 0.081	4.945IleThr: 4.945 ± 0.067	5.848IleVal: 5.848 ± 0.092	0.674IleTrp: 0.674 ± 0.026	2.687IleTyr: 2.687 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.347LysAla: 4.347 ± 0.068	0.251LysCys: 0.251 ± 0.019	3.751LysAsp: 3.751 ± 0.064	6.74LysGlu: 6.74 ± 0.095	1.933LysPhe: 1.933 ± 0.041	4.069LysGly: 4.069 ± 0.074	1.318LysHis: 1.318 ± 0.036	4.825LysIle: 4.825 ± 0.064	5.314LysLys: 5.314 ± 0.088	5.971LysLeu: 5.971 ± 0.069	2.053LysMet: 2.053 ± 0.045	3.545LysAsn: 3.545 ± 0.061	2.016LysPro: 2.016 ± 0.043	3.304LysGln: 3.304 ± 0.063	3.02LysArg: 3.02 ± 0.055	3.513LysSer: 3.513 ± 0.051	3.306LysThr: 3.306 ± 0.056	4.506LysVal: 4.506 ± 0.075	0.735LysTrp: 0.735 ± 0.032	2.198LysTyr: 2.198 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.136LeuAla: 7.136 ± 0.077	0.545LeuCys: 0.545 ± 0.026	5.032LeuAsp: 5.032 ± 0.067	6.771LeuGlu: 6.771 ± 0.084	4.894LeuPhe: 4.894 ± 0.091	6.36LeuGly: 6.36 ± 0.081	1.803LeuHis: 1.803 ± 0.044	7.964LeuIle: 7.964 ± 0.113	6.063LeuLys: 6.063 ± 0.092	9.865LeuLeu: 9.865 ± 0.124	2.405LeuMet: 2.405 ± 0.045	4.578LeuAsn: 4.578 ± 0.064	3.796LeuPro: 3.796 ± 0.058	3.525LeuGln: 3.525 ± 0.059	3.396LeuArg: 3.396 ± 0.057	6.348LeuSer: 6.348 ± 0.085	5.618LeuThr: 5.618 ± 0.072	6.194LeuVal: 6.194 ± 0.077	0.771LeuTrp: 0.771 ± 0.032	3.021LeuTyr: 3.021 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.916MetAla: 1.916 ± 0.043	0.132MetCys: 0.132 ± 0.013	1.502MetAsp: 1.502 ± 0.035	2.139MetGlu: 2.139 ± 0.046	1.035MetPhe: 1.035 ± 0.034	1.787MetGly: 1.787 ± 0.044	0.428MetHis: 0.428 ± 0.019	2.18MetIle: 2.18 ± 0.047	2.359MetLys: 2.359 ± 0.044	2.49MetLeu: 2.49 ± 0.05	0.778MetMet: 0.778 ± 0.032	1.585MetAsn: 1.585 ± 0.041	0.924MetPro: 0.924 ± 0.032	0.963MetGln: 0.963 ± 0.032	1.031MetArg: 1.031 ± 0.034	1.564MetSer: 1.564 ± 0.044	1.531MetThr: 1.531 ± 0.034	1.766MetVal: 1.766 ± 0.038	0.192MetTrp: 0.192 ± 0.014	0.732MetTyr: 0.732 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.069AsnAla: 3.069 ± 0.061	0.278AsnCys: 0.278 ± 0.017	2.455AsnAsp: 2.455 ± 0.051	4.009AsnGlu: 4.009 ± 0.066	1.906AsnPhe: 1.906 ± 0.045	3.513AsnGly: 3.513 ± 0.065	1.104AsnHis: 1.104 ± 0.031	3.98AsnIle: 3.98 ± 0.067	3.348AsnLys: 3.348 ± 0.058	4.247AsnLeu: 4.247 ± 0.068	1.288AsnMet: 1.288 ± 0.033	2.618AsnAsn: 2.618 ± 0.073	2.26AsnPro: 2.26 ± 0.044	2.236AsnGln: 2.236 ± 0.048	2.122AsnArg: 2.122 ± 0.043	2.554AsnSer: 2.554 ± 0.049	2.385AsnThr: 2.385 ± 0.048	3.204AsnVal: 3.204 ± 0.054	0.639AsnTrp: 0.639 ± 0.023	1.914AsnTyr: 1.914 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.268ProAla: 2.268 ± 0.049	0.164ProCys: 0.164 ± 0.013	1.995ProAsp: 1.995 ± 0.044	3.045ProGlu: 3.045 ± 0.059	1.923ProPhe: 1.923 ± 0.043	2.237ProGly: 2.237 ± 0.055	0.643ProHis: 0.643 ± 0.027	3.112ProIle: 3.112 ± 0.049	2.05ProLys: 2.05 ± 0.045	3.316ProLeu: 3.316 ± 0.057	0.827ProMet: 0.827 ± 0.031	1.817ProAsn: 1.817 ± 0.041	0.857ProPro: 0.857 ± 0.03	1.016ProGln: 1.016 ± 0.034	1.039ProArg: 1.039 ± 0.03	2.172ProSer: 2.172 ± 0.043	2.036ProThr: 2.036 ± 0.04	2.631ProVal: 2.631 ± 0.052	0.335ProTrp: 0.335 ± 0.02	1.347ProTyr: 1.347 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.805GlnAla: 2.805 ± 0.055	0.156GlnCys: 0.156 ± 0.014	1.754GlnAsp: 1.754 ± 0.046	2.94GlnGlu: 2.94 ± 0.056	1.631GlnPhe: 1.631 ± 0.041	2.122GlnGly: 2.122 ± 0.044	0.705GlnHis: 0.705 ± 0.025	2.735GlnIle: 2.735 ± 0.055	2.387GlnLys: 2.387 ± 0.052	4.065GlnLeu: 4.065 ± 0.069	1.093GlnMet: 1.093 ± 0.032	1.618GlnAsn: 1.618 ± 0.04	1.09GlnPro: 1.09 ± 0.037	1.718GlnGln: 1.718 ± 0.044	1.421GlnArg: 1.421 ± 0.039	2.074GlnSer: 2.074 ± 0.044	1.966GlnThr: 1.966 ± 0.041	2.398GlnVal: 2.398 ± 0.043	0.359GlnTrp: 0.359 ± 0.021	1.233GlnTyr: 1.233 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.287ArgAla: 2.287 ± 0.052	0.218ArgCys: 0.218 ± 0.013	2.081ArgAsp: 2.081 ± 0.046	3.002ArgGlu: 3.002 ± 0.046	1.817ArgPhe: 1.817 ± 0.045	2.191ArgGly: 2.191 ± 0.049	0.68ArgHis: 0.68 ± 0.027	3.207ArgIle: 3.207 ± 0.059	3.04ArgLys: 3.04 ± 0.054	3.739ArgLeu: 3.739 ± 0.062	1.19ArgMet: 1.19 ± 0.031	2.016ArgAsn: 2.016 ± 0.043	1.185ArgPro: 1.185 ± 0.034	1.381ArgGln: 1.381 ± 0.035	1.661ArgArg: 1.661 ± 0.039	2.045ArgSer: 2.045 ± 0.044	1.958ArgThr: 1.958 ± 0.044	2.479ArgVal: 2.479 ± 0.051	0.383ArgTrp: 0.383 ± 0.019	1.488ArgTyr: 1.488 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.633SerAla: 3.633 ± 0.057	0.308SerCys: 0.308 ± 0.017	2.886SerAsp: 2.886 ± 0.053	4.032SerGlu: 4.032 ± 0.07	3.18SerPhe: 3.18 ± 0.055	4.437SerGly: 4.437 ± 0.062	1.114SerHis: 1.114 ± 0.034	5.588SerIle: 5.588 ± 0.079	3.784SerLys: 3.784 ± 0.062	5.918SerLeu: 5.918 ± 0.071	1.66SerMet: 1.66 ± 0.044	2.883SerAsn: 2.883 ± 0.05	2.046SerPro: 2.046 ± 0.036	1.778SerGln: 1.778 ± 0.042	2.234SerArg: 2.234 ± 0.05	3.816SerSer: 3.816 ± 0.062	3.209SerThr: 3.209 ± 0.052	3.987SerVal: 3.987 ± 0.065	0.643SerTrp: 0.643 ± 0.03	2.278SerTyr: 2.278 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.049ThrAla: 4.049 ± 0.068	0.297ThrCys: 0.297 ± 0.017	2.854ThrAsp: 2.854 ± 0.049	3.785ThrGlu: 3.785 ± 0.067	2.573ThrPhe: 2.573 ± 0.05	4.144ThrGly: 4.144 ± 0.064	0.96ThrHis: 0.96 ± 0.026	5.102ThrIle: 5.102 ± 0.062	3.425ThrLys: 3.425 ± 0.061	5.053ThrLeu: 5.053 ± 0.075	1.372ThrMet: 1.372 ± 0.041	2.787ThrAsn: 2.787 ± 0.052	2.171ThrPro: 2.171 ± 0.046	1.347ThrGln: 1.347 ± 0.035	1.772ThrArg: 1.772 ± 0.039	3.35ThrSer: 3.35 ± 0.058	3.099ThrThr: 3.099 ± 0.061	4.025ThrVal: 4.025 ± 0.069	0.539ThrTrp: 0.539 ± 0.023	1.966ThrTyr: 1.966 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.858ValAla: 4.858 ± 0.07	0.455ValCys: 0.455 ± 0.022	3.726ValAsp: 3.726 ± 0.075	5.039ValGlu: 5.039 ± 0.081	3.117ValPhe: 3.117 ± 0.061	4.495ValGly: 4.495 ± 0.071	1.299ValHis: 1.299 ± 0.034	6.1ValIle: 6.1 ± 0.085	4.268ValLys: 4.268 ± 0.064	6.495ValLeu: 6.495 ± 0.094	1.826ValMet: 1.826 ± 0.038	3.307ValAsn: 3.307 ± 0.062	2.577ValPro: 2.577 ± 0.049	2.133ValGln: 2.133 ± 0.046	2.366ValArg: 2.366 ± 0.051	4.46ValSer: 4.46 ± 0.06	4.074ValThr: 4.074 ± 0.074	4.788ValVal: 4.788 ± 0.086	0.556ValTrp: 0.556 ± 0.023	2.196ValTyr: 2.196 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.599TrpAla: 0.599 ± 0.028	0.072TrpCys: 0.072 ± 0.009	0.516TrpAsp: 0.516 ± 0.022	0.706TrpGlu: 0.706 ± 0.028	0.502TrpPhe: 0.502 ± 0.021	0.654TrpGly: 0.654 ± 0.028	0.189TrpHis: 0.189 ± 0.015	0.91TrpIle: 0.91 ± 0.034	0.67TrpLys: 0.67 ± 0.025	1.033TrpLeu: 1.033 ± 0.032	0.337TrpMet: 0.337 ± 0.019	0.539TrpAsn: 0.539 ± 0.025	0.267TrpPro: 0.267 ± 0.016	0.398TrpGln: 0.398 ± 0.02	0.366TrpArg: 0.366 ± 0.018	0.538TrpSer: 0.538 ± 0.027	0.479TrpThr: 0.479 ± 0.019	0.633TrpVal: 0.633 ± 0.024	0.137TrpTrp: 0.137 ± 0.012	0.351TrpTyr: 0.351 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.129TyrAla: 2.129 ± 0.043	0.255TyrCys: 0.255 ± 0.015	2.009TyrAsp: 2.009 ± 0.043	2.614TyrGlu: 2.614 ± 0.051	1.899TyrPhe: 1.899 ± 0.042	2.503TyrGly: 2.503 ± 0.05	0.887TyrHis: 0.887 ± 0.032	2.635TyrIle: 2.635 ± 0.055	1.918TyrLys: 1.918 ± 0.038	3.627TyrLeu: 3.627 ± 0.059	0.874TyrMet: 0.874 ± 0.03	1.703TyrAsn: 1.703 ± 0.043	1.417TyrPro: 1.417 ± 0.032	1.594TyrGln: 1.594 ± 0.041	1.596TyrArg: 1.596 ± 0.04	2.092TyrSer: 2.092 ± 0.05	1.835TyrThr: 1.835 ± 0.045	2.156TyrVal: 2.156 ± 0.039	0.393TyrTrp: 0.393 ± 0.02	1.52TyrTyr: 1.52 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3747 proteins (1080641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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