Amino acid dipepetide frequency for Wenzhou picorna-like virus 35

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.933AlaAla: 6.933 ± 0.913
1.981AlaCys: 1.981 ± 1.082
2.971AlaAsp: 2.971 ± 0.675
3.632AlaGlu: 3.632 ± 0.834
3.962AlaPhe: 3.962 ± 0.44
7.263AlaGly: 7.263 ± 1.094
2.641AlaHis: 2.641 ± 0.293
5.943AlaIle: 5.943 ± 1.351
7.263AlaLys: 7.263 ± 2.242
5.612AlaLeu: 5.612 ± 1.341
0.99AlaMet: 0.99 ± 0.541
2.971AlaAsn: 2.971 ± 0.675
2.971AlaPro: 2.971 ± 0.675
3.962AlaGln: 3.962 ± 0.44
5.943AlaArg: 5.943 ± 0.947
6.603AlaSer: 6.603 ± 1.565
5.282AlaThr: 5.282 ± 0.563
3.301AlaVal: 3.301 ± 0.079
0.33AlaTrp: 0.33 ± 0.394
1.981AlaTyr: 1.981 ± 0.642
0.0AlaXaa: 0.0 ± 0.0
Cys
2.311CysAla: 2.311 ± 1.262
0.33CysCys: 0.33 ± 0.18
1.981CysAsp: 1.981 ± 1.082
1.321CysGlu: 1.321 ± 0.721
1.651CysPhe: 1.651 ± 0.327
1.651CysGly: 1.651 ± 0.327
0.66CysHis: 0.66 ± 0.214
0.99CysIle: 0.99 ± 0.034
2.311CysLys: 2.311 ± 0.113
0.99CysLeu: 0.99 ± 0.034
0.33CysMet: 0.33 ± 0.18
1.321CysAsn: 1.321 ± 0.721
0.66CysPro: 0.66 ± 0.361
0.33CysGln: 0.33 ± 0.18
2.311CysArg: 2.311 ± 1.262
0.66CysSer: 0.66 ± 0.214
0.99CysThr: 0.99 ± 0.608
1.651CysVal: 1.651 ± 0.327
0.0CysTrp: 0.0 ± 0.0
1.321CysTyr: 1.321 ± 0.147
0.0CysXaa: 0.0 ± 0.0
Asp
5.612AspAla: 5.612 ± 0.382
1.981AspCys: 1.981 ± 0.507
4.292AspAsp: 4.292 ± 1.678
3.962AspGlu: 3.962 ± 0.709
2.641AspPhe: 2.641 ± 1.43
3.962AspGly: 3.962 ± 0.135
0.33AspHis: 0.33 ± 0.394
2.971AspIle: 2.971 ± 0.101
2.641AspLys: 2.641 ± 1.442
4.622AspLeu: 4.622 ± 0.226
1.981AspMet: 1.981 ± 1.082
3.301AspAsn: 3.301 ± 1.644
1.981AspPro: 1.981 ± 0.067
0.66AspGln: 0.66 ± 0.788
1.981AspArg: 1.981 ± 0.642
7.263AspSer: 7.263 ± 0.055
3.632AspThr: 3.632 ± 0.315
4.952AspVal: 4.952 ± 0.168
0.33AspTrp: 0.33 ± 0.18
2.311AspTyr: 2.311 ± 0.462
0.0AspXaa: 0.0 ± 0.0
Glu
4.952GluAla: 4.952 ± 1.555
1.321GluCys: 1.321 ± 0.721
3.301GluAsp: 3.301 ± 0.079
6.603GluGlu: 6.603 ± 3.605
2.971GluPhe: 2.971 ± 0.473
2.311GluGly: 2.311 ± 1.036
0.66GluHis: 0.66 ± 0.361
6.273GluIle: 6.273 ± 1.127
4.622GluLys: 4.622 ± 0.8
3.632GluLeu: 3.632 ± 0.26
0.99GluMet: 0.99 ± 0.034
0.99GluAsn: 0.99 ± 0.541
0.99GluPro: 0.99 ± 0.541
1.651GluGln: 1.651 ± 0.901
1.981GluArg: 1.981 ± 1.082
2.641GluSer: 2.641 ± 0.293
3.962GluThr: 3.962 ± 1.014
3.632GluVal: 3.632 ± 0.315
1.651GluTrp: 1.651 ± 0.822
3.301GluTyr: 3.301 ± 1.07
0.0GluXaa: 0.0 ± 0.0
Phe
4.292PheAla: 4.292 ± 1.195
2.971PheCys: 2.971 ± 0.101
2.311PheAsp: 2.311 ± 0.462
2.641PheGlu: 2.641 ± 0.856
2.641PhePhe: 2.641 ± 0.293
2.641PheGly: 2.641 ± 0.856
0.33PheHis: 0.33 ± 0.18
1.321PheIle: 1.321 ± 0.147
1.321PheLys: 1.321 ± 0.147
3.301PheLeu: 3.301 ± 0.495
1.321PheMet: 1.321 ± 0.721
2.641PheAsn: 2.641 ± 0.868
1.321PhePro: 1.321 ± 1.002
2.311PheGln: 2.311 ± 0.462
1.651PheArg: 1.651 ± 0.327
2.641PheSer: 2.641 ± 0.293
3.301PheThr: 3.301 ± 0.079
2.641PheVal: 2.641 ± 1.442
0.33PheTrp: 0.33 ± 0.18
1.321PheTyr: 1.321 ± 0.147
0.0PheXaa: 0.0 ± 0.0
Gly
3.301GlyAla: 3.301 ± 1.644
0.66GlyCys: 0.66 ± 0.361
4.622GlyAsp: 4.622 ± 1.498
3.301GlyGlu: 3.301 ± 0.495
2.311GlyPhe: 2.311 ± 1.262
1.981GlyGly: 1.981 ± 0.067
0.66GlyHis: 0.66 ± 0.361
3.962GlyIle: 3.962 ± 1.014
4.622GlyLys: 4.622 ± 0.923
3.632GlyLeu: 3.632 ± 0.315
1.651GlyMet: 1.651 ± 0.822
3.632GlyAsn: 3.632 ± 0.315
2.641GlyPro: 2.641 ± 0.281
2.311GlyGln: 2.311 ± 0.113
2.971GlyArg: 2.971 ± 0.675
5.282GlySer: 5.282 ± 0.586
1.981GlyThr: 1.981 ± 0.067
4.292GlyVal: 4.292 ± 0.046
0.66GlyTrp: 0.66 ± 0.361
2.641GlyTyr: 2.641 ± 0.293
0.0GlyXaa: 0.0 ± 0.0
His
0.99HisAla: 0.99 ± 0.034
0.0HisCys: 0.0 ± 0.0
0.99HisAsp: 0.99 ± 0.541
0.0HisGlu: 0.0 ± 0.0
1.321HisPhe: 1.321 ± 0.721
1.321HisGly: 1.321 ± 0.428
0.99HisHis: 0.99 ± 0.034
1.981HisIle: 1.981 ± 0.642
1.981HisLys: 1.981 ± 1.082
1.981HisLeu: 1.981 ± 1.082
0.66HisMet: 0.66 ± 0.361
0.99HisAsn: 0.99 ± 0.541
0.33HisPro: 0.33 ± 0.394
0.0HisGln: 0.0 ± 0.0
0.66HisArg: 0.66 ± 0.361
0.99HisSer: 0.99 ± 0.034
1.651HisThr: 1.651 ± 0.248
0.99HisVal: 0.99 ± 0.034
0.66HisTrp: 0.66 ± 0.361
0.99HisTyr: 0.99 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.603IleAla: 6.603 ± 1.565
0.66IleCys: 0.66 ± 0.214
3.962IleAsp: 3.962 ± 0.44
2.641IleGlu: 2.641 ± 0.293
2.971IlePhe: 2.971 ± 1.25
3.632IleGly: 3.632 ± 0.889
0.33IleHis: 0.33 ± 0.18
2.641IleIle: 2.641 ± 0.868
2.971IleLys: 2.971 ± 0.473
3.962IleLeu: 3.962 ± 1.284
1.321IleMet: 1.321 ± 0.434
3.301IleAsn: 3.301 ± 0.079
3.962IlePro: 3.962 ± 2.433
1.321IleGln: 1.321 ± 0.721
2.971IleArg: 2.971 ± 1.622
4.292IleSer: 4.292 ± 1.195
6.603IleThr: 6.603 ± 0.733
4.292IleVal: 4.292 ± 0.529
0.66IleTrp: 0.66 ± 0.361
2.641IleTyr: 2.641 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
4.952LysAla: 4.952 ± 1.555
1.321LysCys: 1.321 ± 0.721
4.622LysAsp: 4.622 ± 0.226
4.952LysGlu: 4.952 ± 1.555
1.981LysPhe: 1.981 ± 0.067
3.632LysGly: 3.632 ± 0.834
2.311LysHis: 2.311 ± 1.262
3.962LysIle: 3.962 ± 1.014
1.651LysLys: 1.651 ± 0.327
3.301LysLeu: 3.301 ± 0.654
0.99LysMet: 0.99 ± 0.034
1.651LysAsn: 1.651 ± 0.327
2.641LysPro: 2.641 ± 0.281
3.632LysGln: 3.632 ± 0.834
2.311LysArg: 2.311 ± 0.462
2.971LysSer: 2.971 ± 0.675
5.612LysThr: 5.612 ± 1.916
4.952LysVal: 4.952 ± 0.981
0.66LysTrp: 0.66 ± 0.361
2.971LysTyr: 2.971 ± 0.101
0.0LysXaa: 0.0 ± 0.0
Leu
7.923LeuAla: 7.923 ± 0.305
2.311LeuCys: 2.311 ± 1.262
2.641LeuAsp: 2.641 ± 0.293
2.971LeuGlu: 2.971 ± 0.101
1.651LeuPhe: 1.651 ± 0.901
3.301LeuGly: 3.301 ± 1.228
2.641LeuHis: 2.641 ± 0.293
3.632LeuIle: 3.632 ± 0.834
4.292LeuLys: 4.292 ± 1.769
4.952LeuLeu: 4.952 ± 0.406
1.651LeuMet: 1.651 ± 0.248
2.971LeuAsn: 2.971 ± 1.25
2.311LeuPro: 2.311 ± 0.462
2.641LeuGln: 2.641 ± 0.281
5.943LeuArg: 5.943 ± 0.372
8.914LeuSer: 8.914 ± 2.026
5.943LeuThr: 5.943 ± 0.202
3.632LeuVal: 3.632 ± 0.26
0.33LeuTrp: 0.33 ± 0.18
1.981LeuTyr: 1.981 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
4.292MetAla: 4.292 ± 0.62
1.651MetCys: 1.651 ± 0.327
0.66MetAsp: 0.66 ± 0.361
0.99MetGlu: 0.99 ± 0.608
0.66MetPhe: 0.66 ± 0.361
0.33MetGly: 0.33 ± 0.18
1.321MetHis: 1.321 ± 0.147
1.981MetIle: 1.981 ± 0.642
0.0MetLys: 0.0 ± 0.0
1.651MetLeu: 1.651 ± 0.248
0.66MetMet: 0.66 ± 0.361
0.0MetAsn: 0.0 ± 0.0
1.321MetPro: 1.321 ± 0.428
0.33MetGln: 0.33 ± 0.18
1.651MetArg: 1.651 ± 0.327
0.99MetSer: 0.99 ± 0.541
1.651MetThr: 1.651 ± 0.327
0.99MetVal: 0.99 ± 0.541
0.33MetTrp: 0.33 ± 0.18
0.99MetTyr: 0.99 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.311AsnAla: 2.311 ± 0.113
1.651AsnCys: 1.651 ± 0.248
1.651AsnAsp: 1.651 ± 0.901
2.641AsnGlu: 2.641 ± 0.293
2.971AsnPhe: 2.971 ± 0.101
1.321AsnGly: 1.321 ± 0.147
0.0AsnHis: 0.0 ± 0.0
1.981AsnIle: 1.981 ± 0.067
2.641AsnLys: 2.641 ± 0.281
4.952AsnLeu: 4.952 ± 1.317
1.981AsnMet: 1.981 ± 0.067
0.0AsnAsn: 0.0 ± 0.0
2.641AsnPro: 2.641 ± 1.43
1.651AsnGln: 1.651 ± 1.397
0.99AsnArg: 0.99 ± 0.541
4.292AsnSer: 4.292 ± 0.046
1.981AsnThr: 1.981 ± 0.642
3.962AsnVal: 3.962 ± 1.284
0.99AsnTrp: 0.99 ± 1.183
0.99AsnTyr: 0.99 ± 0.541
0.0AsnXaa: 0.0 ± 0.0
Pro
3.301ProAla: 3.301 ± 0.654
0.0ProCys: 0.0 ± 0.0
2.311ProAsp: 2.311 ± 2.185
2.311ProGlu: 2.311 ± 0.113
2.311ProPhe: 2.311 ± 0.462
1.981ProGly: 1.981 ± 1.216
0.33ProHis: 0.33 ± 0.18
1.981ProIle: 1.981 ± 0.642
1.321ProLys: 1.321 ± 0.147
2.641ProLeu: 2.641 ± 0.293
1.651ProMet: 1.651 ± 0.248
1.651ProAsn: 1.651 ± 0.248
1.981ProPro: 1.981 ± 0.642
0.66ProGln: 0.66 ± 0.214
0.99ProArg: 0.99 ± 0.608
4.952ProSer: 4.952 ± 1.892
1.321ProThr: 1.321 ± 0.147
4.292ProVal: 4.292 ± 1.103
0.33ProTrp: 0.33 ± 0.18
3.962ProTyr: 3.962 ± 2.433
0.0ProXaa: 0.0 ± 0.0
Gln
2.971GlnAla: 2.971 ± 0.473
0.66GlnCys: 0.66 ± 0.361
1.651GlnAsp: 1.651 ± 0.822
1.321GlnGlu: 1.321 ± 0.721
0.99GlnPhe: 0.99 ± 0.034
3.962GlnGly: 3.962 ± 0.709
0.33GlnHis: 0.33 ± 0.18
2.311GlnIle: 2.311 ± 1.262
1.981GlnLys: 1.981 ± 0.067
4.292GlnLeu: 4.292 ± 0.62
0.99GlnMet: 0.99 ± 0.608
2.641GlnAsn: 2.641 ± 0.868
1.651GlnPro: 1.651 ± 0.248
1.651GlnGln: 1.651 ± 0.822
0.33GlnArg: 0.33 ± 0.18
2.641GlnSer: 2.641 ± 0.868
2.311GlnThr: 2.311 ± 0.113
1.981GlnVal: 1.981 ± 1.791
0.66GlnTrp: 0.66 ± 0.214
1.981GlnTyr: 1.981 ± 1.791
0.0GlnXaa: 0.0 ± 0.0
Arg
2.641ArgAla: 2.641 ± 0.281
1.321ArgCys: 1.321 ± 0.721
1.981ArgAsp: 1.981 ± 0.507
3.632ArgGlu: 3.632 ± 1.408
1.981ArgPhe: 1.981 ± 1.216
1.981ArgGly: 1.981 ± 1.082
1.651ArgHis: 1.651 ± 0.327
2.641ArgIle: 2.641 ± 0.856
3.632ArgLys: 3.632 ± 0.26
2.971ArgLeu: 2.971 ± 0.473
1.651ArgMet: 1.651 ± 0.822
1.651ArgAsn: 1.651 ± 0.327
1.981ArgPro: 1.981 ± 0.067
2.971ArgGln: 2.971 ± 0.473
1.321ArgArg: 1.321 ± 0.721
3.632ArgSer: 3.632 ± 0.26
3.632ArgThr: 3.632 ± 0.834
1.651ArgVal: 1.651 ± 0.822
1.321ArgTrp: 1.321 ± 0.721
1.321ArgTyr: 1.321 ± 1.002
0.0ArgXaa: 0.0 ± 0.0
Ser
4.622SerAla: 4.622 ± 0.226
1.321SerCys: 1.321 ± 0.147
7.923SerAsp: 7.923 ± 0.844
3.962SerGlu: 3.962 ± 2.163
1.981SerPhe: 1.981 ± 0.507
4.952SerGly: 4.952 ± 0.168
0.66SerHis: 0.66 ± 0.214
5.282SerIle: 5.282 ± 0.012
5.282SerLys: 5.282 ± 0.586
7.263SerLeu: 7.263 ± 0.055
1.321SerMet: 1.321 ± 0.721
2.641SerAsn: 2.641 ± 1.43
2.641SerPro: 2.641 ± 0.868
3.632SerGln: 3.632 ± 0.26
3.962SerArg: 3.962 ± 0.709
10.565SerSer: 10.565 ± 1.125
7.593SerThr: 7.593 ± 1.599
4.292SerVal: 4.292 ± 1.678
0.66SerTrp: 0.66 ± 0.361
3.632SerTyr: 3.632 ± 2.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.952ThrAla: 4.952 ± 1.317
0.33ThrCys: 0.33 ± 0.18
4.952ThrAsp: 4.952 ± 0.168
2.971ThrGlu: 2.971 ± 0.101
2.971ThrPhe: 2.971 ± 0.101
3.632ThrGly: 3.632 ± 0.315
0.99ThrHis: 0.99 ± 0.034
4.622ThrIle: 4.622 ± 0.923
5.943ThrLys: 5.943 ± 1.521
5.282ThrLeu: 5.282 ± 0.012
0.66ThrMet: 0.66 ± 0.361
3.301ThrAsn: 3.301 ± 0.495
2.311ThrPro: 2.311 ± 0.113
4.952ThrGln: 4.952 ± 1.317
3.632ThrArg: 3.632 ± 0.26
4.622ThrSer: 4.622 ± 0.8
5.943ThrThr: 5.943 ± 0.372
3.632ThrVal: 3.632 ± 0.315
0.99ThrTrp: 0.99 ± 0.608
2.641ThrTyr: 2.641 ± 1.442
0.0ThrXaa: 0.0 ± 0.0
Val
7.593ValAla: 7.593 ± 0.45
1.651ValCys: 1.651 ± 0.248
3.962ValAsp: 3.962 ± 1.284
2.971ValGlu: 2.971 ± 0.473
1.651ValPhe: 1.651 ± 0.901
4.292ValGly: 4.292 ± 1.678
0.99ValHis: 0.99 ± 0.034
2.641ValIle: 2.641 ± 0.293
4.952ValLys: 4.952 ± 0.981
5.282ValLeu: 5.282 ± 1.161
0.33ValMet: 0.33 ± 0.18
2.971ValAsn: 2.971 ± 1.824
4.292ValPro: 4.292 ± 2.252
1.321ValGln: 1.321 ± 0.428
1.651ValArg: 1.651 ± 0.327
5.943ValSer: 5.943 ± 0.947
4.292ValThr: 4.292 ± 1.678
4.622ValVal: 4.622 ± 0.923
0.0ValTrp: 0.0 ± 0.0
2.641ValTyr: 2.641 ± 0.281
0.0ValXaa: 0.0 ± 0.0
Trp
0.66TrpAla: 0.66 ± 0.214
0.66TrpCys: 0.66 ± 0.361
0.99TrpAsp: 0.99 ± 0.541
1.651TrpGlu: 1.651 ± 0.248
1.321TrpPhe: 1.321 ± 0.721
0.0TrpGly: 0.0 ± 0.0
0.33TrpHis: 0.33 ± 0.18
0.66TrpIle: 0.66 ± 0.361
0.0TrpLys: 0.0 ± 0.0
0.66TrpLeu: 0.66 ± 0.361
0.0TrpMet: 0.0 ± 0.0
0.33TrpAsn: 0.33 ± 0.394
0.33TrpPro: 0.33 ± 0.394
0.66TrpGln: 0.66 ± 0.361
0.66TrpArg: 0.66 ± 0.788
1.321TrpSer: 1.321 ± 1.002
0.66TrpThr: 0.66 ± 0.214
0.99TrpVal: 0.99 ± 0.034
0.0TrpTrp: 0.0 ± 0.0
0.33TrpTyr: 0.33 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.321TyrAla: 1.321 ± 0.721
0.99TyrCys: 0.99 ± 0.034
3.632TyrAsp: 3.632 ± 0.889
3.962TyrGlu: 3.962 ± 1.014
2.311TyrPhe: 2.311 ± 0.462
2.971TyrGly: 2.971 ± 0.101
1.321TyrHis: 1.321 ± 0.147
4.292TyrIle: 4.292 ± 2.827
1.651TyrLys: 1.651 ± 0.327
1.651TyrLeu: 1.651 ± 0.327
0.99TyrMet: 0.99 ± 0.541
2.641TyrAsn: 2.641 ± 1.43
1.321TyrPro: 1.321 ± 1.002
0.66TyrGln: 0.66 ± 0.214
1.651TyrArg: 1.651 ± 1.397
2.971TyrSer: 2.971 ± 1.25
0.99TyrThr: 0.99 ± 0.034
3.301TyrVal: 3.301 ± 0.495
1.321TyrTrp: 1.321 ± 0.428
1.651TyrTyr: 1.651 ± 0.248
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski