Amino acid dipepetide frequency for Acholeplasma hippikon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.693AlaAla: 3.693 ± 0.11
0.365AlaCys: 0.365 ± 0.031
2.618AlaAsp: 2.618 ± 0.092
3.213AlaGlu: 3.213 ± 0.121
3.082AlaPhe: 3.082 ± 0.091
3.648AlaGly: 3.648 ± 0.126
1.048AlaHis: 1.048 ± 0.057
5.469AlaIle: 5.469 ± 0.135
5.075AlaLys: 5.075 ± 0.123
6.562AlaLeu: 6.562 ± 0.158
1.436AlaMet: 1.436 ± 0.059
3.073AlaAsn: 3.073 ± 0.09
1.474AlaPro: 1.474 ± 0.066
1.653AlaGln: 1.653 ± 0.075
1.961AlaArg: 1.961 ± 0.071
3.725AlaSer: 3.725 ± 0.106
3.394AlaThr: 3.394 ± 0.082
3.859AlaVal: 3.859 ± 0.109
0.433AlaTrp: 0.433 ± 0.038
2.91AlaTyr: 2.91 ± 0.098
0.0AlaXaa: 0.0 ± 0.0
Cys
0.272CysAla: 0.272 ± 0.029
0.038CysCys: 0.038 ± 0.009
0.285CysAsp: 0.285 ± 0.026
0.272CysGlu: 0.272 ± 0.025
0.186CysPhe: 0.186 ± 0.021
0.433CysGly: 0.433 ± 0.035
0.113CysHis: 0.113 ± 0.016
0.374CysIle: 0.374 ± 0.031
0.274CysLys: 0.274 ± 0.026
0.34CysLeu: 0.34 ± 0.027
0.113CysMet: 0.113 ± 0.014
0.222CysAsn: 0.222 ± 0.021
0.186CysPro: 0.186 ± 0.023
0.134CysGln: 0.134 ± 0.018
0.113CysArg: 0.113 ± 0.016
0.229CysSer: 0.229 ± 0.022
0.183CysThr: 0.183 ± 0.018
0.267CysVal: 0.267 ± 0.02
0.023CysTrp: 0.023 ± 0.007
0.192CysTyr: 0.192 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.365AspAla: 3.365 ± 0.097
0.197AspCys: 0.197 ± 0.02
2.966AspAsp: 2.966 ± 0.105
4.755AspGlu: 4.755 ± 0.096
3.336AspPhe: 3.336 ± 0.084
3.585AspGly: 3.585 ± 0.12
0.947AspHis: 0.947 ± 0.047
4.712AspIle: 4.712 ± 0.113
4.563AspLys: 4.563 ± 0.1
6.1AspLeu: 6.1 ± 0.131
1.155AspMet: 1.155 ± 0.051
2.568AspAsn: 2.568 ± 0.09
1.728AspPro: 1.728 ± 0.073
1.651AspGln: 1.651 ± 0.063
1.633AspArg: 1.633 ± 0.066
2.774AspSer: 2.774 ± 0.072
2.717AspThr: 2.717 ± 0.085
3.899AspVal: 3.899 ± 0.093
0.392AspTrp: 0.392 ± 0.034
2.937AspTyr: 2.937 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
4.536GluAla: 4.536 ± 0.115
0.24GluCys: 0.24 ± 0.026
3.351GluAsp: 3.351 ± 0.097
4.973GluGlu: 4.973 ± 0.128
2.985GluPhe: 2.985 ± 0.078
3.505GluGly: 3.505 ± 0.086
1.051GluHis: 1.051 ± 0.051
6.279GluIle: 6.279 ± 0.126
6.257GluLys: 6.257 ± 0.15
7.07GluLeu: 7.07 ± 0.143
1.841GluMet: 1.841 ± 0.066
4.472GluAsn: 4.472 ± 0.105
1.596GluPro: 1.596 ± 0.062
2.054GluGln: 2.054 ± 0.071
2.493GluArg: 2.493 ± 0.075
3.773GluSer: 3.773 ± 0.095
3.827GluThr: 3.827 ± 0.109
5.439GluVal: 5.439 ± 0.114
0.496GluTrp: 0.496 ± 0.032
2.52GluTyr: 2.52 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
2.561PheAla: 2.561 ± 0.09
0.211PheCys: 0.211 ± 0.023
3.422PheAsp: 3.422 ± 0.09
3.646PheGlu: 3.646 ± 0.092
2.244PhePhe: 2.244 ± 0.088
3.173PheGly: 3.173 ± 0.085
0.702PheHis: 0.702 ± 0.04
4.701PheIle: 4.701 ± 0.126
4.228PheLys: 4.228 ± 0.102
4.364PheLeu: 4.364 ± 0.135
1.365PheMet: 1.365 ± 0.063
3.227PheAsn: 3.227 ± 0.093
1.155PhePro: 1.155 ± 0.056
1.241PheGln: 1.241 ± 0.053
1.59PheArg: 1.59 ± 0.063
3.014PheSer: 3.014 ± 0.078
2.942PheThr: 2.942 ± 0.089
3.458PheVal: 3.458 ± 0.104
0.315PheTrp: 0.315 ± 0.028
2.199PheTyr: 2.199 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
3.702GlyAla: 3.702 ± 0.108
0.342GlyCys: 0.342 ± 0.027
2.79GlyAsp: 2.79 ± 0.098
3.367GlyGlu: 3.367 ± 0.09
3.399GlyPhe: 3.399 ± 0.094
3.705GlyGly: 3.705 ± 0.137
1.198GlyHis: 1.198 ± 0.053
5.679GlyIle: 5.679 ± 0.128
4.683GlyLys: 4.683 ± 0.12
5.935GlyLeu: 5.935 ± 0.131
1.51GlyMet: 1.51 ± 0.064
2.914GlyAsn: 2.914 ± 0.104
1.23GlyPro: 1.23 ± 0.058
1.71GlyGln: 1.71 ± 0.054
1.936GlyArg: 1.936 ± 0.073
3.376GlySer: 3.376 ± 0.097
3.553GlyThr: 3.553 ± 0.111
4.327GlyVal: 4.327 ± 0.115
0.62GlyTrp: 0.62 ± 0.041
3.281GlyTyr: 3.281 ± 0.1
0.0GlyXaa: 0.0 ± 0.0
His
1.148HisAla: 1.148 ± 0.048
0.079HisCys: 0.079 ± 0.013
1.055HisAsp: 1.055 ± 0.057
1.325HisGlu: 1.325 ± 0.06
0.897HisPhe: 0.897 ± 0.049
1.121HisGly: 1.121 ± 0.054
0.525HisHis: 0.525 ± 0.039
1.585HisIle: 1.585 ± 0.065
1.191HisLys: 1.191 ± 0.055
1.891HisLeu: 1.891 ± 0.076
0.403HisMet: 0.403 ± 0.031
0.827HisAsn: 0.827 ± 0.045
0.811HisPro: 0.811 ± 0.044
0.734HisGln: 0.734 ± 0.045
0.564HisArg: 0.564 ± 0.04
0.858HisSer: 0.858 ± 0.041
1.017HisThr: 1.017 ± 0.039
1.189HisVal: 1.189 ± 0.053
0.097HisTrp: 0.097 ± 0.014
0.806HisTyr: 0.806 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.272IleAla: 5.272 ± 0.128
0.423IleCys: 0.423 ± 0.035
5.446IleAsp: 5.446 ± 0.122
6.177IleGlu: 6.177 ± 0.129
4.067IlePhe: 4.067 ± 0.134
5.389IleGly: 5.389 ± 0.123
1.553IleHis: 1.553 ± 0.063
7.323IleIle: 7.323 ± 0.163
7.489IleLys: 7.489 ± 0.15
8.603IleLeu: 8.603 ± 0.19
1.886IleMet: 1.886 ± 0.077
5.177IleAsn: 5.177 ± 0.112
3.023IlePro: 3.023 ± 0.092
2.423IleGln: 2.423 ± 0.078
2.706IleArg: 2.706 ± 0.079
5.609IleSer: 5.609 ± 0.135
5.036IleThr: 5.036 ± 0.135
5.532IleVal: 5.532 ± 0.118
0.643IleTrp: 0.643 ± 0.044
4.182IleTyr: 4.182 ± 0.117
0.0IleXaa: 0.0 ± 0.0
Lys
4.377LysAla: 4.377 ± 0.125
0.206LysCys: 0.206 ± 0.022
5.392LysAsp: 5.392 ± 0.115
7.683LysGlu: 7.683 ± 0.173
3.274LysPhe: 3.274 ± 0.096
4.076LysGly: 4.076 ± 0.112
1.612LysHis: 1.612 ± 0.068
6.542LysIle: 6.542 ± 0.142
7.466LysLys: 7.466 ± 0.208
7.532LysLeu: 7.532 ± 0.132
2.271LysMet: 2.271 ± 0.075
5.161LysAsn: 5.161 ± 0.116
2.323LysPro: 2.323 ± 0.082
2.871LysGln: 2.871 ± 0.08
3.098LysArg: 3.098 ± 0.093
4.23LysSer: 4.23 ± 0.098
4.556LysThr: 4.556 ± 0.107
5.777LysVal: 5.777 ± 0.123
0.663LysTrp: 0.663 ± 0.042
4.076LysTyr: 4.076 ± 0.102
0.0LysXaa: 0.0 ± 0.0
Leu
6.297LeuAla: 6.297 ± 0.138
0.437LeuCys: 0.437 ± 0.032
6.003LeuAsp: 6.003 ± 0.149
6.279LeuGlu: 6.279 ± 0.124
4.819LeuPhe: 4.819 ± 0.139
6.193LeuGly: 6.193 ± 0.125
1.433LeuHis: 1.433 ± 0.057
8.788LeuIle: 8.788 ± 0.184
8.308LeuLys: 8.308 ± 0.152
9.006LeuLeu: 9.006 ± 0.183
2.409LeuMet: 2.409 ± 0.083
6.431LeuAsn: 6.431 ± 0.128
3.161LeuPro: 3.161 ± 0.075
2.532LeuGln: 2.532 ± 0.073
3.283LeuArg: 3.283 ± 0.099
6.902LeuSer: 6.902 ± 0.142
6.069LeuThr: 6.069 ± 0.122
6.843LeuVal: 6.843 ± 0.133
0.654LeuTrp: 0.654 ± 0.041
3.961LeuTyr: 3.961 ± 0.109
0.0LeuXaa: 0.0 ± 0.0
Met
1.49MetAla: 1.49 ± 0.066
0.068MetCys: 0.068 ± 0.012
1.264MetAsp: 1.264 ± 0.06
1.327MetGlu: 1.327 ± 0.062
1.125MetPhe: 1.125 ± 0.069
1.384MetGly: 1.384 ± 0.062
0.439MetHis: 0.439 ± 0.026
2.502MetIle: 2.502 ± 0.09
2.373MetLys: 2.373 ± 0.08
2.269MetLeu: 2.269 ± 0.072
0.734MetMet: 0.734 ± 0.047
1.524MetAsn: 1.524 ± 0.06
0.802MetPro: 0.802 ± 0.043
0.657MetGln: 0.657 ± 0.038
0.919MetArg: 0.919 ± 0.045
1.418MetSer: 1.418 ± 0.059
1.329MetThr: 1.329 ± 0.055
1.524MetVal: 1.524 ± 0.063
0.14MetTrp: 0.14 ± 0.02
0.926MetTyr: 0.926 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
3.052AsnAla: 3.052 ± 0.09
0.195AsnCys: 0.195 ± 0.022
3.297AsnAsp: 3.297 ± 0.08
4.69AsnGlu: 4.69 ± 0.126
2.772AsnPhe: 2.772 ± 0.087
3.462AsnGly: 3.462 ± 0.105
1.422AsnHis: 1.422 ± 0.062
4.638AsnIle: 4.638 ± 0.115
4.703AsnLys: 4.703 ± 0.108
5.976AsnLeu: 5.976 ± 0.156
1.288AsnMet: 1.288 ± 0.055
3.209AsnAsn: 3.209 ± 0.117
2.278AsnPro: 2.278 ± 0.081
2.321AsnGln: 2.321 ± 0.081
1.959AsnArg: 1.959 ± 0.073
2.579AsnSer: 2.579 ± 0.085
2.792AsnThr: 2.792 ± 0.114
3.512AsnVal: 3.512 ± 0.096
0.51AsnTrp: 0.51 ± 0.036
3.25AsnTyr: 3.25 ± 0.122
0.0AsnXaa: 0.0 ± 0.0
Pro
1.495ProAla: 1.495 ± 0.072
0.102ProCys: 0.102 ± 0.015
1.504ProAsp: 1.504 ± 0.056
2.04ProGlu: 2.04 ± 0.075
1.682ProPhe: 1.682 ± 0.066
1.594ProGly: 1.594 ± 0.073
0.573ProHis: 0.573 ± 0.031
2.48ProIle: 2.48 ± 0.071
2.296ProLys: 2.296 ± 0.076
2.785ProLeu: 2.785 ± 0.088
0.688ProMet: 0.688 ± 0.041
1.9ProAsn: 1.9 ± 0.071
0.439ProPro: 0.439 ± 0.028
0.851ProGln: 0.851 ± 0.043
0.915ProArg: 0.915 ± 0.052
1.855ProSer: 1.855 ± 0.071
1.88ProThr: 1.88 ± 0.075
2.244ProVal: 2.244 ± 0.079
0.265ProTrp: 0.265 ± 0.024
1.585ProTyr: 1.585 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.952GlnAla: 1.952 ± 0.075
0.072GlnCys: 0.072 ± 0.012
1.483GlnAsp: 1.483 ± 0.062
1.735GlnGlu: 1.735 ± 0.066
1.415GlnPhe: 1.415 ± 0.058
1.698GlnGly: 1.698 ± 0.068
0.414GlnHis: 0.414 ± 0.031
2.792GlnIle: 2.792 ± 0.087
2.552GlnLys: 2.552 ± 0.075
3.052GlnLeu: 3.052 ± 0.089
0.87GlnMet: 0.87 ± 0.043
1.771GlnAsn: 1.771 ± 0.057
0.833GlnPro: 0.833 ± 0.041
0.962GlnGln: 0.962 ± 0.053
1.15GlnArg: 1.15 ± 0.064
1.852GlnSer: 1.852 ± 0.071
1.956GlnThr: 1.956 ± 0.073
2.033GlnVal: 2.033 ± 0.074
0.229GlnTrp: 0.229 ± 0.022
1.359GlnTyr: 1.359 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
1.891ArgAla: 1.891 ± 0.066
0.12ArgCys: 0.12 ± 0.018
1.619ArgAsp: 1.619 ± 0.052
2.149ArgGlu: 2.149 ± 0.079
1.712ArgPhe: 1.712 ± 0.064
1.773ArgGly: 1.773 ± 0.069
0.632ArgHis: 0.632 ± 0.035
3.019ArgIle: 3.019 ± 0.096
2.903ArgLys: 2.903 ± 0.094
3.471ArgLeu: 3.471 ± 0.099
0.987ArgMet: 0.987 ± 0.045
1.938ArgAsn: 1.938 ± 0.065
0.965ArgPro: 0.965 ± 0.049
1.141ArgGln: 1.141 ± 0.055
1.359ArgArg: 1.359 ± 0.071
1.753ArgSer: 1.753 ± 0.063
1.782ArgThr: 1.782 ± 0.071
2.26ArgVal: 2.26 ± 0.077
0.292ArgTrp: 0.292 ± 0.031
1.673ArgTyr: 1.673 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
3.039SerAla: 3.039 ± 0.086
0.245SerCys: 0.245 ± 0.025
3.091SerAsp: 3.091 ± 0.085
3.286SerGlu: 3.286 ± 0.096
3.535SerPhe: 3.535 ± 0.094
3.766SerGly: 3.766 ± 0.114
1.028SerHis: 1.028 ± 0.041
5.478SerIle: 5.478 ± 0.131
4.71SerLys: 4.71 ± 0.103
6.042SerLeu: 6.042 ± 0.113
1.356SerMet: 1.356 ± 0.055
3.718SerAsn: 3.718 ± 0.117
1.436SerPro: 1.436 ± 0.048
1.762SerGln: 1.762 ± 0.061
1.859SerArg: 1.859 ± 0.067
3.546SerSer: 3.546 ± 0.123
3.179SerThr: 3.179 ± 0.1
3.768SerVal: 3.768 ± 0.093
0.487SerTrp: 0.487 ± 0.035
3.028SerTyr: 3.028 ± 0.104
0.0SerXaa: 0.0 ± 0.0
Thr
3.098ThrAla: 3.098 ± 0.105
0.242ThrCys: 0.242 ± 0.028
2.86ThrAsp: 2.86 ± 0.091
3.057ThrGlu: 3.057 ± 0.094
2.896ThrPhe: 2.896 ± 0.092
3.469ThrGly: 3.469 ± 0.096
1.209ThrHis: 1.209 ± 0.055
5.156ThrIle: 5.156 ± 0.133
4.574ThrLys: 4.574 ± 0.112
6.139ThrLeu: 6.139 ± 0.122
1.089ThrMet: 1.089 ± 0.047
3.071ThrAsn: 3.071 ± 0.11
2.063ThrPro: 2.063 ± 0.069
1.467ThrGln: 1.467 ± 0.063
1.685ThrArg: 1.685 ± 0.063
3.487ThrSer: 3.487 ± 0.11
3.259ThrThr: 3.259 ± 0.1
4.076ThrVal: 4.076 ± 0.14
0.566ThrTrp: 0.566 ± 0.041
3.084ThrTyr: 3.084 ± 0.121
0.0ThrXaa: 0.0 ± 0.0
Val
4.124ValAla: 4.124 ± 0.116
0.417ValCys: 0.417 ± 0.031
4.024ValAsp: 4.024 ± 0.107
4.624ValGlu: 4.624 ± 0.116
3.401ValPhe: 3.401 ± 0.104
4.264ValGly: 4.264 ± 0.123
0.976ValHis: 0.976 ± 0.046
6.087ValIle: 6.087 ± 0.132
5.498ValLys: 5.498 ± 0.107
6.859ValLeu: 6.859 ± 0.128
1.569ValMet: 1.569 ± 0.059
3.709ValAsn: 3.709 ± 0.098
2.004ValPro: 2.004 ± 0.068
1.569ValGln: 1.569 ± 0.066
2.154ValArg: 2.154 ± 0.077
4.631ValSer: 4.631 ± 0.114
4.237ValThr: 4.237 ± 0.144
5.091ValVal: 5.091 ± 0.124
0.516ValTrp: 0.516 ± 0.035
3.016ValTyr: 3.016 ± 0.098
0.0ValXaa: 0.0 ± 0.0
Trp
0.376TrpAla: 0.376 ± 0.031
0.043TrpCys: 0.043 ± 0.01
0.403TrpAsp: 0.403 ± 0.032
0.389TrpGlu: 0.389 ± 0.032
0.442TrpPhe: 0.442 ± 0.039
0.505TrpGly: 0.505 ± 0.035
0.172TrpHis: 0.172 ± 0.02
0.731TrpIle: 0.731 ± 0.042
0.546TrpLys: 0.546 ± 0.038
0.86TrpLeu: 0.86 ± 0.044
0.24TrpMet: 0.24 ± 0.022
0.507TrpAsn: 0.507 ± 0.033
0.192TrpPro: 0.192 ± 0.02
0.263TrpGln: 0.263 ± 0.028
0.245TrpArg: 0.245 ± 0.03
0.433TrpSer: 0.433 ± 0.031
0.36TrpThr: 0.36 ± 0.033
0.516TrpVal: 0.516 ± 0.031
0.104TrpTrp: 0.104 ± 0.016
0.435TrpTyr: 0.435 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.951TyrAla: 2.951 ± 0.095
0.206TyrCys: 0.206 ± 0.024
3.107TyrAsp: 3.107 ± 0.09
3.77TyrGlu: 3.77 ± 0.104
2.489TyrPhe: 2.489 ± 0.085
2.516TyrGly: 2.516 ± 0.08
1.073TyrHis: 1.073 ± 0.049
3.625TyrIle: 3.625 ± 0.106
3.499TyrLys: 3.499 ± 0.09
4.955TyrLeu: 4.955 ± 0.117
0.999TyrMet: 0.999 ± 0.05
2.486TyrAsn: 2.486 ± 0.106
1.474TyrPro: 1.474 ± 0.071
2.187TyrGln: 2.187 ± 0.078
1.818TyrArg: 1.818 ± 0.067
2.314TyrSer: 2.314 ± 0.079
2.48TyrThr: 2.48 ± 0.1
3.154TyrVal: 3.154 ± 0.094
0.317TyrTrp: 0.317 ± 0.028
2.457TyrTyr: 2.457 ± 0.101
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1335 proteins (441607 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski