Amino acid dipepetide frequency for Erwinia sp. CPCC 100877

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.434AlaAla: 8.434 ± 0.103
0.906AlaCys: 0.906 ± 0.025
4.523AlaAsp: 4.523 ± 0.056
5.435AlaGlu: 5.435 ± 0.065
3.359AlaPhe: 3.359 ± 0.047
6.628AlaGly: 6.628 ± 0.078
1.502AlaHis: 1.502 ± 0.03
5.681AlaIle: 5.681 ± 0.071
4.168AlaLys: 4.168 ± 0.058
9.855AlaLeu: 9.855 ± 0.11
2.424AlaMet: 2.424 ± 0.042
2.921AlaAsn: 2.921 ± 0.046
3.104AlaPro: 3.104 ± 0.052
3.624AlaGln: 3.624 ± 0.057
4.722AlaArg: 4.722 ± 0.072
4.864AlaSer: 4.864 ± 0.056
4.38AlaThr: 4.38 ± 0.048
6.043AlaVal: 6.043 ± 0.064
1.191AlaTrp: 1.191 ± 0.035
2.12AlaTyr: 2.12 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.696CysAla: 0.696 ± 0.019
0.13CysCys: 0.13 ± 0.009
0.513CysAsp: 0.513 ± 0.018
0.53CysGlu: 0.53 ± 0.019
0.4CysPhe: 0.4 ± 0.014
0.888CysGly: 0.888 ± 0.025
0.26CysHis: 0.26 ± 0.012
0.491CysIle: 0.491 ± 0.017
0.299CysLys: 0.299 ± 0.013
0.913CysLeu: 0.913 ± 0.024
0.202CysMet: 0.202 ± 0.011
0.264CysAsn: 0.264 ± 0.012
0.414CysPro: 0.414 ± 0.02
0.37CysGln: 0.37 ± 0.015
0.526CysArg: 0.526 ± 0.02
0.559CysSer: 0.559 ± 0.019
0.435CysThr: 0.435 ± 0.015
0.583CysVal: 0.583 ± 0.017
0.135CysTrp: 0.135 ± 0.01
0.326CysTyr: 0.326 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.269AspAla: 4.269 ± 0.054
0.44AspCys: 0.44 ± 0.018
2.873AspAsp: 2.873 ± 0.05
3.959AspGlu: 3.959 ± 0.056
2.471AspPhe: 2.471 ± 0.044
3.75AspGly: 3.75 ± 0.059
0.991AspHis: 0.991 ± 0.024
3.639AspIle: 3.639 ± 0.05
2.799AspLys: 2.799 ± 0.049
4.81AspLeu: 4.81 ± 0.053
1.338AspMet: 1.338 ± 0.027
2.133AspAsn: 2.133 ± 0.038
2.145AspPro: 2.145 ± 0.034
1.93AspGln: 1.93 ± 0.039
2.551AspArg: 2.551 ± 0.04
3.382AspSer: 3.382 ± 0.326
2.633AspThr: 2.633 ± 0.041
3.587AspVal: 3.587 ± 0.051
0.743AspTrp: 0.743 ± 0.021
2.16AspTyr: 2.16 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.84GluAla: 5.84 ± 0.062
0.455GluCys: 0.455 ± 0.016
2.872GluAsp: 2.872 ± 0.042
4.803GluGlu: 4.803 ± 0.07
2.14GluPhe: 2.14 ± 0.036
3.77GluGly: 3.77 ± 0.056
1.273GluHis: 1.273 ± 0.029
4.375GluIle: 4.375 ± 0.059
4.917GluLys: 4.917 ± 0.066
6.753GluLeu: 6.753 ± 0.084
1.996GluMet: 1.996 ± 0.035
2.998GluAsn: 2.998 ± 0.041
2.066GluPro: 2.066 ± 0.037
3.784GluGln: 3.784 ± 0.054
3.743GluArg: 3.743 ± 0.06
3.205GluSer: 3.205 ± 0.04
3.55GluThr: 3.55 ± 0.045
4.51GluVal: 4.51 ± 0.062
0.71GluTrp: 0.71 ± 0.021
1.886GluTyr: 1.886 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.243PheAla: 3.243 ± 0.044
0.447PheCys: 0.447 ± 0.017
2.46PheAsp: 2.46 ± 0.044
2.308PheGlu: 2.308 ± 0.036
2.052PhePhe: 2.052 ± 0.041
3.115PheGly: 3.115 ± 0.046
0.795PheHis: 0.795 ± 0.024
2.93PheIle: 2.93 ± 0.048
1.781PheLys: 1.781 ± 0.038
3.935PheLeu: 3.935 ± 0.058
1.01PheMet: 1.01 ± 0.027
1.763PheAsn: 1.763 ± 0.032
1.555PhePro: 1.555 ± 0.03
1.357PheGln: 1.357 ± 0.03
1.781PheArg: 1.781 ± 0.029
3.248PheSer: 3.248 ± 0.049
2.425PheThr: 2.425 ± 0.041
2.797PheVal: 2.797 ± 0.043
0.565PheTrp: 0.565 ± 0.021
1.497PheTyr: 1.497 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.584GlyAla: 5.584 ± 0.08
0.806GlyCys: 0.806 ± 0.026
3.515GlyAsp: 3.515 ± 0.053
4.573GlyGlu: 4.573 ± 0.057
3.188GlyPhe: 3.188 ± 0.048
5.203GlyGly: 5.203 ± 0.07
1.504GlyHis: 1.504 ± 0.032
5.228GlyIle: 5.228 ± 0.062
4.282GlyLys: 4.282 ± 0.051
7.089GlyLeu: 7.089 ± 0.079
2.16GlyMet: 2.16 ± 0.041
2.861GlyAsn: 2.861 ± 0.055
1.8GlyPro: 1.8 ± 0.034
2.806GlyGln: 2.806 ± 0.044
3.474GlyArg: 3.474 ± 0.048
4.249GlySer: 4.249 ± 0.065
3.969GlyThr: 3.969 ± 0.054
5.255GlyVal: 5.255 ± 0.054
1.015GlyTrp: 1.015 ± 0.026
2.621GlyTyr: 2.621 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.455HisAla: 1.455 ± 0.034
0.24HisCys: 0.24 ± 0.012
1.008HisAsp: 1.008 ± 0.027
1.154HisGlu: 1.154 ± 0.025
1.026HisPhe: 1.026 ± 0.027
1.513HisGly: 1.513 ± 0.032
0.631HisHis: 0.631 ± 0.021
1.212HisIle: 1.212 ± 0.025
0.755HisLys: 0.755 ± 0.02
2.087HisLeu: 2.087 ± 0.04
0.487HisMet: 0.487 ± 0.015
0.734HisAsn: 0.734 ± 0.022
1.129HisPro: 1.129 ± 0.03
1.05HisGln: 1.05 ± 0.024
1.076HisArg: 1.076 ± 0.028
1.174HisSer: 1.174 ± 0.029
0.982HisThr: 0.982 ± 0.023
1.115HisVal: 1.115 ± 0.026
0.31HisTrp: 0.31 ± 0.014
0.881HisTyr: 0.881 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.941IleAla: 5.941 ± 0.074
0.656IleCys: 0.656 ± 0.019
3.96IleAsp: 3.96 ± 0.048
4.245IleGlu: 4.245 ± 0.059
2.622IlePhe: 2.622 ± 0.048
4.946IleGly: 4.946 ± 0.067
1.329IleHis: 1.329 ± 0.026
4.339IleIle: 4.339 ± 0.072
3.327IleLys: 3.327 ± 0.049
5.942IleLeu: 5.942 ± 0.075
1.416IleMet: 1.416 ± 0.028
2.93IleAsn: 2.93 ± 0.045
2.838IlePro: 2.838 ± 0.039
2.413IleGln: 2.413 ± 0.041
3.108IleArg: 3.108 ± 0.044
4.252IleSer: 4.252 ± 0.051
3.868IleThr: 3.868 ± 0.05
4.509IleVal: 4.509 ± 0.059
0.61IleTrp: 0.61 ± 0.019
1.997IleTyr: 1.997 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.484LysAla: 4.484 ± 0.063
0.262LysCys: 0.262 ± 0.013
2.721LysAsp: 2.721 ± 0.052
4.728LysGlu: 4.728 ± 0.071
1.51LysPhe: 1.51 ± 0.032
3.374LysGly: 3.374 ± 0.05
0.882LysHis: 0.882 ± 0.023
3.73LysIle: 3.73 ± 0.052
4.325LysLys: 4.325 ± 0.069
4.759LysLeu: 4.759 ± 0.063
1.646LysMet: 1.646 ± 0.032
2.746LysAsn: 2.746 ± 0.052
1.919LysPro: 1.919 ± 0.037
2.634LysGln: 2.634 ± 0.043
2.9LysArg: 2.9 ± 0.044
2.732LysSer: 2.732 ± 0.042
3.097LysThr: 3.097 ± 0.053
3.625LysVal: 3.625 ± 0.054
0.495LysTrp: 0.495 ± 0.016
1.69LysTyr: 1.69 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
10.001LeuAla: 10.001 ± 0.085
0.956LeuCys: 0.956 ± 0.024
5.272LeuAsp: 5.272 ± 0.066
6.258LeuGlu: 6.258 ± 0.08
4.629LeuPhe: 4.629 ± 0.063
6.942LeuGly: 6.942 ± 0.069
1.951LeuHis: 1.951 ± 0.034
6.327LeuIle: 6.327 ± 0.07
5.589LeuLys: 5.589 ± 0.066
11.489LeuLeu: 11.489 ± 0.119
2.835LeuMet: 2.835 ± 0.04
4.47LeuAsn: 4.47 ± 0.053
4.877LeuPro: 4.877 ± 0.061
3.676LeuGln: 3.676 ± 0.053
5.169LeuArg: 5.169 ± 0.075
7.137LeuSer: 7.137 ± 0.072
6.331LeuThr: 6.331 ± 0.062
6.875LeuVal: 6.875 ± 0.07
1.217LeuTrp: 1.217 ± 0.032
2.838LeuTyr: 2.838 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.461MetAla: 2.461 ± 0.042
0.187MetCys: 0.187 ± 0.009
1.325MetAsp: 1.325 ± 0.027
1.557MetGlu: 1.557 ± 0.03
0.842MetPhe: 0.842 ± 0.022
1.792MetGly: 1.792 ± 0.033
0.433MetHis: 0.433 ± 0.017
1.754MetIle: 1.754 ± 0.037
1.813MetLys: 1.813 ± 0.032
2.787MetLeu: 2.787 ± 0.047
0.851MetMet: 0.851 ± 0.024
1.29MetAsn: 1.29 ± 0.025
1.201MetPro: 1.201 ± 0.026
1.04MetGln: 1.04 ± 0.023
1.276MetArg: 1.276 ± 0.023
1.666MetSer: 1.666 ± 0.033
1.727MetThr: 1.727 ± 0.033
1.849MetVal: 1.849 ± 0.035
0.192MetTrp: 0.192 ± 0.011
0.599MetTyr: 0.599 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.154AsnAla: 3.154 ± 0.046
0.324AsnCys: 0.324 ± 0.013
2.186AsnAsp: 2.186 ± 0.031
2.644AsnGlu: 2.644 ± 0.046
1.615AsnPhe: 1.615 ± 0.031
3.198AsnGly: 3.198 ± 0.053
0.894AsnHis: 0.894 ± 0.025
2.782AsnIle: 2.782 ± 0.04
2.196AsnLys: 2.196 ± 0.039
3.774AsnLeu: 3.774 ± 0.046
0.974AsnMet: 0.974 ± 0.024
1.825AsnAsn: 1.825 ± 0.039
1.997AsnPro: 1.997 ± 0.035
2.053AsnGln: 2.053 ± 0.04
2.071AsnArg: 2.071 ± 0.041
2.249AsnSer: 2.249 ± 0.041
2.077AsnThr: 2.077 ± 0.041
2.639AsnVal: 2.639 ± 0.042
0.535AsnTrp: 0.535 ± 0.018
1.579AsnTyr: 1.579 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.505ProAla: 3.505 ± 0.052
0.306ProCys: 0.306 ± 0.014
2.434ProAsp: 2.434 ± 0.042
3.387ProGlu: 3.387 ± 0.042
1.753ProPhe: 1.753 ± 0.031
2.931ProGly: 2.931 ± 0.04
0.842ProHis: 0.842 ± 0.025
2.138ProIle: 2.138 ± 0.035
1.866ProLys: 1.866 ± 0.031
4.398ProLeu: 4.398 ± 0.061
0.952ProMet: 0.952 ± 0.024
1.405ProAsn: 1.405 ± 0.029
1.274ProPro: 1.274 ± 0.033
1.83ProGln: 1.83 ± 0.034
1.659ProArg: 1.659 ± 0.032
1.961ProSer: 1.961 ± 0.029
2.113ProThr: 2.113 ± 0.038
3.418ProVal: 3.418 ± 0.051
0.583ProTrp: 0.583 ± 0.021
1.199ProTyr: 1.199 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.192GlnAla: 4.192 ± 0.056
0.272GlnCys: 0.272 ± 0.012
1.743GlnAsp: 1.743 ± 0.03
2.857GlnGlu: 2.857 ± 0.047
1.448GlnPhe: 1.448 ± 0.032
2.738GlnGly: 2.738 ± 0.041
0.932GlnHis: 0.932 ± 0.026
2.57GlnIle: 2.57 ± 0.042
2.536GlnLys: 2.536 ± 0.046
5.021GlnLeu: 5.021 ± 0.066
1.23GlnMet: 1.23 ± 0.025
1.613GlnAsn: 1.613 ± 0.033
1.892GlnPro: 1.892 ± 0.041
2.751GlnGln: 2.751 ± 0.06
2.516GlnArg: 2.516 ± 0.048
2.204GlnSer: 2.204 ± 0.038
2.36GlnThr: 2.36 ± 0.037
2.978GlnVal: 2.978 ± 0.041
0.511GlnTrp: 0.511 ± 0.019
1.222GlnTyr: 1.222 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.834ArgAla: 3.834 ± 0.061
0.488ArgCys: 0.488 ± 0.022
2.579ArgAsp: 2.579 ± 0.041
3.515ArgGlu: 3.515 ± 0.055
2.317ArgPhe: 2.317 ± 0.041
3.059ArgGly: 3.059 ± 0.049
1.278ArgHis: 1.278 ± 0.027
3.331ArgIle: 3.331 ± 0.046
2.707ArgLys: 2.707 ± 0.041
5.915ArgLeu: 5.915 ± 0.076
1.475ArgMet: 1.475 ± 0.027
1.978ArgAsn: 1.978 ± 0.033
2.014ArgPro: 2.014 ± 0.039
2.724ArgGln: 2.724 ± 0.045
3.23ArgArg: 3.23 ± 0.06
2.569ArgSer: 2.569 ± 0.045
2.327ArgThr: 2.327 ± 0.039
3.345ArgVal: 3.345 ± 0.048
0.743ArgTrp: 0.743 ± 0.026
2.051ArgTyr: 2.051 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
4.826SerAla: 4.826 ± 0.059
0.479SerCys: 0.479 ± 0.019
3.61SerAsp: 3.61 ± 0.322
3.713SerGlu: 3.713 ± 0.053
2.677SerPhe: 2.677 ± 0.041
5.098SerGly: 5.098 ± 0.066
1.198SerHis: 1.198 ± 0.028
3.623SerIle: 3.623 ± 0.051
2.73SerLys: 2.73 ± 0.042
6.454SerLeu: 6.454 ± 0.061
1.483SerMet: 1.483 ± 0.029
2.185SerAsn: 2.185 ± 0.037
2.19SerPro: 2.19 ± 0.036
2.47SerGln: 2.47 ± 0.039
3.081SerArg: 3.081 ± 0.051
3.705SerSer: 3.705 ± 0.059
2.978SerThr: 2.978 ± 0.042
4.18SerVal: 4.18 ± 0.052
0.834SerTrp: 0.834 ± 0.023
2.016SerTyr: 2.016 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.648ThrAla: 4.648 ± 0.06
0.411ThrCys: 0.411 ± 0.016
2.823ThrAsp: 2.823 ± 0.046
3.17ThrGlu: 3.17 ± 0.048
2.273ThrPhe: 2.273 ± 0.04
4.389ThrGly: 4.389 ± 0.05
1.08ThrHis: 1.08 ± 0.024
3.932ThrIle: 3.932 ± 0.055
2.484ThrLys: 2.484 ± 0.047
6.543ThrLeu: 6.543 ± 0.066
1.225ThrMet: 1.225 ± 0.028
2.056ThrAsn: 2.056 ± 0.039
2.828ThrPro: 2.828 ± 0.049
1.949ThrGln: 1.949 ± 0.034
2.669ThrArg: 2.669 ± 0.045
3.122ThrSer: 3.122 ± 0.048
3.138ThrThr: 3.138 ± 0.046
3.982ThrVal: 3.982 ± 0.061
0.681ThrTrp: 0.681 ± 0.021
1.501ThrTyr: 1.501 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
6.217ValAla: 6.217 ± 0.072
0.679ValCys: 0.679 ± 0.024
3.775ValAsp: 3.775 ± 0.052
4.372ValGlu: 4.372 ± 0.056
2.623ValPhe: 2.623 ± 0.038
4.75ValGly: 4.75 ± 0.068
1.167ValHis: 1.167 ± 0.026
4.729ValIle: 4.729 ± 0.061
3.761ValLys: 3.761 ± 0.057
6.967ValLeu: 6.967 ± 0.068
1.947ValMet: 1.947 ± 0.035
2.835ValAsn: 2.835 ± 0.039
2.889ValPro: 2.889 ± 0.041
2.348ValGln: 2.348 ± 0.04
3.28ValArg: 3.28 ± 0.048
4.519ValSer: 4.519 ± 0.05
4.339ValThr: 4.339 ± 0.058
5.388ValVal: 5.388 ± 0.056
0.774ValTrp: 0.774 ± 0.023
1.943ValTyr: 1.943 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.756TrpAla: 0.756 ± 0.021
0.137TrpCys: 0.137 ± 0.009
0.541TrpAsp: 0.541 ± 0.019
0.573TrpGlu: 0.573 ± 0.019
0.584TrpPhe: 0.584 ± 0.018
0.774TrpGly: 0.774 ± 0.022
0.332TrpHis: 0.332 ± 0.016
0.667TrpIle: 0.667 ± 0.021
0.507TrpLys: 0.507 ± 0.015
1.884TrpLeu: 1.884 ± 0.043
0.339TrpMet: 0.339 ± 0.014
0.497TrpAsn: 0.497 ± 0.02
0.457TrpPro: 0.457 ± 0.019
0.932TrpGln: 0.932 ± 0.026
0.886TrpArg: 0.886 ± 0.03
0.747TrpSer: 0.747 ± 0.023
0.499TrpThr: 0.499 ± 0.019
0.717TrpVal: 0.717 ± 0.021
0.17TrpTrp: 0.17 ± 0.011
0.406TrpTyr: 0.406 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.342TyrAla: 2.342 ± 0.039
0.355TyrCys: 0.355 ± 0.014
1.871TyrAsp: 1.871 ± 0.034
1.865TyrGlu: 1.865 ± 0.039
1.539TyrPhe: 1.539 ± 0.036
2.321TyrGly: 2.321 ± 0.042
0.744TyrHis: 0.744 ± 0.021
1.769TyrIle: 1.769 ± 0.032
1.418TyrLys: 1.418 ± 0.029
3.467TyrLeu: 3.467 ± 0.049
0.652TyrMet: 0.652 ± 0.021
1.265TyrAsn: 1.265 ± 0.032
1.364TyrPro: 1.364 ± 0.028
1.843TyrGln: 1.843 ± 0.035
1.76TyrArg: 1.76 ± 0.038
1.984TyrSer: 1.984 ± 0.041
1.677TyrThr: 1.677 ± 0.035
1.905TyrVal: 1.905 ± 0.034
0.391TyrTrp: 0.391 ± 0.016
1.23TyrTyr: 1.23 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5690 proteins (1778439 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski