Amino acid dipepetide frequency for Cesiribacter andamanensis AMV16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.692AlaAla: 8.692 ± 0.117	0.801AlaCys: 0.801 ± 0.023	4.692AlaAsp: 4.692 ± 0.071	5.456AlaGlu: 5.456 ± 0.066	3.705AlaPhe: 3.705 ± 0.055	7.21AlaGly: 7.21 ± 0.103	1.746AlaHis: 1.746 ± 0.039	4.537AlaIle: 4.537 ± 0.06	3.294AlaLys: 3.294 ± 0.051	10.132AlaLeu: 10.132 ± 0.1	1.84AlaMet: 1.84 ± 0.042	2.973AlaAsn: 2.973 ± 0.063	3.857AlaPro: 3.857 ± 0.076	4.132AlaGln: 4.132 ± 0.062	4.818AlaArg: 4.818 ± 0.065	5.197AlaSer: 5.197 ± 0.078	4.391AlaThr: 4.391 ± 0.078	5.18AlaVal: 5.18 ± 0.063	1.093AlaTrp: 1.093 ± 0.027	3.328AlaTyr: 3.328 ± 0.051	0.001AlaXaa: 0.001 ± 0.001
Cys	0.555CysAla: 0.555 ± 0.024	0.153CysCys: 0.153 ± 0.01	0.334CysAsp: 0.334 ± 0.017	0.344CysGlu: 0.344 ± 0.019	0.336CysPhe: 0.336 ± 0.016	0.634CysGly: 0.634 ± 0.026	0.188CysHis: 0.188 ± 0.013	0.399CysIle: 0.399 ± 0.017	0.256CysLys: 0.256 ± 0.015	0.887CysLeu: 0.887 ± 0.027	0.208CysMet: 0.208 ± 0.013	0.257CysAsn: 0.257 ± 0.014	0.386CysPro: 0.386 ± 0.019	0.376CysGln: 0.376 ± 0.016	0.479CysArg: 0.479 ± 0.022	0.599CysSer: 0.599 ± 0.025	0.453CysThr: 0.453 ± 0.024	0.36CysVal: 0.36 ± 0.016	0.107CysTrp: 0.107 ± 0.009	0.293CysTyr: 0.293 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.136AspAla: 4.136 ± 0.074	0.331AspCys: 0.331 ± 0.017	2.013AspAsp: 2.013 ± 0.045	3.029AspGlu: 3.029 ± 0.055	2.461AspPhe: 2.461 ± 0.046	3.453AspGly: 3.453 ± 0.099	0.904AspHis: 0.904 ± 0.03	2.868AspIle: 2.868 ± 0.05	2.5AspLys: 2.5 ± 0.051	4.774AspLeu: 4.774 ± 0.064	1.125AspMet: 1.125 ± 0.029	1.733AspAsn: 1.733 ± 0.045	2.457AspPro: 2.457 ± 0.048	1.853AspGln: 1.853 ± 0.038	2.655AspArg: 2.655 ± 0.051	2.695AspSer: 2.695 ± 0.061	2.419AspThr: 2.419 ± 0.048	2.966AspVal: 2.966 ± 0.048	0.763AspTrp: 0.763 ± 0.026	2.043AspTyr: 2.043 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.176GluAla: 6.176 ± 0.092	0.302GluCys: 0.302 ± 0.016	2.73GluAsp: 2.73 ± 0.05	5.113GluGlu: 5.113 ± 0.087	2.157GluPhe: 2.157 ± 0.043	5.107GluGly: 5.107 ± 0.067	1.342GluHis: 1.342 ± 0.034	3.482GluIle: 3.482 ± 0.068	3.798GluLys: 3.798 ± 0.059	7.091GluLeu: 7.091 ± 0.072	1.401GluMet: 1.401 ± 0.036	2.378GluAsn: 2.378 ± 0.046	2.228GluPro: 2.228 ± 0.042	3.806GluGln: 3.806 ± 0.057	3.726GluArg: 3.726 ± 0.058	2.802GluSer: 2.802 ± 0.047	2.672GluThr: 2.672 ± 0.046	4.515GluVal: 4.515 ± 0.062	0.812GluTrp: 0.812 ± 0.024	1.966GluTyr: 1.966 ± 0.042	0.001GluXaa: 0.001 ± 0.001
Phe	3.451PheAla: 3.451 ± 0.053	0.408PheCys: 0.408 ± 0.018	2.289PheAsp: 2.289 ± 0.042	2.459PheGlu: 2.459 ± 0.052	2.248PhePhe: 2.248 ± 0.049	3.348PheGly: 3.348 ± 0.059	0.76PheHis: 0.76 ± 0.023	2.417PheIle: 2.417 ± 0.052	1.8PheLys: 1.8 ± 0.04	4.293PheLeu: 4.293 ± 0.074	1.078PheMet: 1.078 ± 0.03	1.698PheAsn: 1.698 ± 0.045	1.543PhePro: 1.543 ± 0.034	1.475PheGln: 1.475 ± 0.033	2.362PheArg: 2.362 ± 0.044	3.436PheSer: 3.436 ± 0.064	2.728PheThr: 2.728 ± 0.048	2.73PheVal: 2.73 ± 0.045	0.695PheTrp: 0.695 ± 0.025	1.834PheTyr: 1.834 ± 0.036	0.001PheXaa: 0.001 ± 0.001
Gly	5.965GlyAla: 5.965 ± 0.083	0.74GlyCys: 0.74 ± 0.031	3.319GlyAsp: 3.319 ± 0.064	4.224GlyGlu: 4.224 ± 0.059	3.348GlyPhe: 3.348 ± 0.057	6.053GlyGly: 6.053 ± 0.095	1.461GlyHis: 1.461 ± 0.037	4.72GlyIle: 4.72 ± 0.066	3.782GlyLys: 3.782 ± 0.05	8.029GlyLeu: 8.029 ± 0.094	1.967GlyMet: 1.967 ± 0.041	2.913GlyAsn: 2.913 ± 0.058	2.271GlyPro: 2.271 ± 0.048	3.416GlyGln: 3.416 ± 0.057	4.099GlyArg: 4.099 ± 0.059	4.821GlySer: 4.821 ± 0.079	4.329GlyThr: 4.329 ± 0.091	4.872GlyVal: 4.872 ± 0.069	1.085GlyTrp: 1.085 ± 0.03	3.095GlyTyr: 3.095 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.543HisAla: 1.543 ± 0.034	0.205HisCys: 0.205 ± 0.012	0.801HisAsp: 0.801 ± 0.025	1.122HisGlu: 1.122 ± 0.032	1.179HisPhe: 1.179 ± 0.031	1.253HisGly: 1.253 ± 0.038	0.666HisHis: 0.666 ± 0.026	1.292HisIle: 1.292 ± 0.034	0.969HisLys: 0.969 ± 0.025	2.36HisLeu: 2.36 ± 0.045	0.49HisMet: 0.49 ± 0.018	0.812HisAsn: 0.812 ± 0.026	1.407HisPro: 1.407 ± 0.03	1.117HisGln: 1.117 ± 0.033	1.109HisArg: 1.109 ± 0.027	1.245HisSer: 1.245 ± 0.032	1.267HisThr: 1.267 ± 0.031	1.088HisVal: 1.088 ± 0.027	0.37HisTrp: 0.37 ± 0.018	1.097HisTyr: 1.097 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	4.689IleAla: 4.689 ± 0.07	0.544IleCys: 0.544 ± 0.021	2.9IleAsp: 2.9 ± 0.047	3.242IleGlu: 3.242 ± 0.053	2.284IlePhe: 2.284 ± 0.052	4.397IleGly: 4.397 ± 0.072	1.096IleHis: 1.096 ± 0.028	3.151IleIle: 3.151 ± 0.058	2.517IleLys: 2.517 ± 0.05	5.236IleLeu: 5.236 ± 0.092	1.121IleMet: 1.121 ± 0.031	2.401IleAsn: 2.401 ± 0.041	2.656IlePro: 2.656 ± 0.048	2.104IleGln: 2.104 ± 0.039	3.737IleArg: 3.737 ± 0.054	4.078IleSer: 4.078 ± 0.064	3.376IleThr: 3.376 ± 0.059	3.062IleVal: 3.062 ± 0.057	0.679IleTrp: 0.679 ± 0.024	1.846IleTyr: 1.846 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.353LysAla: 4.353 ± 0.065	0.214LysCys: 0.214 ± 0.013	2.3LysAsp: 2.3 ± 0.04	3.8LysGlu: 3.8 ± 0.064	1.381LysPhe: 1.381 ± 0.033	3.844LysGly: 3.844 ± 0.064	0.954LysHis: 0.954 ± 0.027	2.729LysIle: 2.729 ± 0.059	3.305LysLys: 3.305 ± 0.065	4.555LysLeu: 4.555 ± 0.072	1.152LysMet: 1.152 ± 0.034	1.975LysAsn: 1.975 ± 0.043	2.125LysPro: 2.125 ± 0.044	2.185LysGln: 2.185 ± 0.042	2.572LysArg: 2.572 ± 0.05	2.362LysSer: 2.362 ± 0.048	2.487LysThr: 2.487 ± 0.042	3.056LysVal: 3.056 ± 0.054	0.591LysTrp: 0.591 ± 0.021	1.372LysTyr: 1.372 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	9.797LeuAla: 9.797 ± 0.105	0.896LeuCys: 0.896 ± 0.029	5.092LeuAsp: 5.092 ± 0.072	7.249LeuGlu: 7.249 ± 0.087	4.804LeuPhe: 4.804 ± 0.079	7.239LeuGly: 7.239 ± 0.092	2.564LeuHis: 2.564 ± 0.048	5.66LeuIle: 5.66 ± 0.082	5.184LeuLys: 5.184 ± 0.066	14.602LeuLeu: 14.602 ± 0.174	2.603LeuMet: 2.603 ± 0.05	4.26LeuAsn: 4.26 ± 0.061	5.706LeuPro: 5.706 ± 0.07	6.972LeuGln: 6.972 ± 0.102	5.978LeuArg: 5.978 ± 0.071	7.584LeuSer: 7.584 ± 0.09	5.073LeuThr: 5.073 ± 0.074	6.9LeuVal: 6.9 ± 0.088	1.225LeuTrp: 1.225 ± 0.034	4.008LeuTyr: 4.008 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.195MetAla: 2.195 ± 0.042	0.125MetCys: 0.125 ± 0.01	1.02MetAsp: 1.02 ± 0.025	1.415MetGlu: 1.415 ± 0.04	0.693MetPhe: 0.693 ± 0.024	1.767MetGly: 1.767 ± 0.038	0.547MetHis: 0.547 ± 0.022	1.147MetIle: 1.147 ± 0.032	1.427MetLys: 1.427 ± 0.032	2.619MetLeu: 2.619 ± 0.051	0.541MetMet: 0.541 ± 0.021	0.931MetAsn: 0.931 ± 0.025	1.207MetPro: 1.207 ± 0.03	1.244MetGln: 1.244 ± 0.032	1.366MetArg: 1.366 ± 0.031	1.216MetSer: 1.216 ± 0.029	0.898MetThr: 0.898 ± 0.026	1.372MetVal: 1.372 ± 0.034	0.19MetTrp: 0.19 ± 0.013	0.622MetTyr: 0.622 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.024AsnAla: 3.024 ± 0.054	0.292AsnCys: 0.292 ± 0.017	1.641AsnAsp: 1.641 ± 0.049	2.142AsnGlu: 2.142 ± 0.042	1.682AsnPhe: 1.682 ± 0.04	2.836AsnGly: 2.836 ± 0.074	0.704AsnHis: 0.704 ± 0.023	2.211AsnIle: 2.211 ± 0.041	1.864AsnLys: 1.864 ± 0.037	4.056AsnLeu: 4.056 ± 0.057	0.916AsnMet: 0.916 ± 0.024	1.666AsnAsn: 1.666 ± 0.05	2.348AsnPro: 2.348 ± 0.047	1.71AsnGln: 1.71 ± 0.038	2.429AsnArg: 2.429 ± 0.047	2.353AsnSer: 2.353 ± 0.051	2.317AsnThr: 2.317 ± 0.046	2.057AsnVal: 2.057 ± 0.043	0.597AsnTrp: 0.597 ± 0.022	1.572AsnTyr: 1.572 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	4.813ProAla: 4.813 ± 0.079	0.27ProCys: 0.27 ± 0.015	2.771ProAsp: 2.771 ± 0.059	3.579ProGlu: 3.579 ± 0.051	2.091ProPhe: 2.091 ± 0.041	3.353ProGly: 3.353 ± 0.053	1.069ProHis: 1.069 ± 0.029	2.201ProIle: 2.201 ± 0.045	1.721ProLys: 1.721 ± 0.034	5.348ProLeu: 5.348 ± 0.078	0.973ProMet: 0.973 ± 0.029	1.636ProAsn: 1.636 ± 0.039	1.728ProPro: 1.728 ± 0.044	2.442ProGln: 2.442 ± 0.046	1.924ProArg: 1.924 ± 0.041	2.551ProSer: 2.551 ± 0.045	2.168ProThr: 2.168 ± 0.045	3.128ProVal: 3.128 ± 0.051	0.555ProTrp: 0.555 ± 0.022	1.839ProTyr: 1.839 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.814GlnAla: 4.814 ± 0.075	0.214GlnCys: 0.214 ± 0.013	2.22GlnAsp: 2.22 ± 0.043	4.05GlnGlu: 4.05 ± 0.062	1.651GlnPhe: 1.651 ± 0.04	3.4GlnGly: 3.4 ± 0.057	1.299GlnHis: 1.299 ± 0.033	2.275GlnIle: 2.275 ± 0.036	2.602GlnLys: 2.602 ± 0.045	6.354GlnLeu: 6.354 ± 0.086	1.011GlnMet: 1.011 ± 0.028	1.808GlnAsn: 1.808 ± 0.041	2.56GlnPro: 2.56 ± 0.056	4.36GlnGln: 4.36 ± 0.076	2.618GlnArg: 2.618 ± 0.05	2.15GlnSer: 2.15 ± 0.045	2.252GlnThr: 2.252 ± 0.043	3.08GlnVal: 3.08 ± 0.048	0.644GlnTrp: 0.644 ± 0.025	1.7GlnTyr: 1.7 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.701ArgAla: 3.701 ± 0.051	0.328ArgCys: 0.328 ± 0.018	2.24ArgAsp: 2.24 ± 0.042	3.566ArgGlu: 3.566 ± 0.06	2.644ArgPhe: 2.644 ± 0.045	3.342ArgGly: 3.342 ± 0.055	1.301ArgHis: 1.301 ± 0.031	3.447ArgIle: 3.447 ± 0.048	2.771ArgLys: 2.771 ± 0.054	6.767ArgLeu: 6.767 ± 0.087	1.511ArgMet: 1.511 ± 0.035	2.223ArgAsn: 2.223 ± 0.04	2.384ArgPro: 2.384 ± 0.051	3.665ArgGln: 3.665 ± 0.057	3.112ArgArg: 3.112 ± 0.061	3.294ArgSer: 3.294 ± 0.059	2.663ArgThr: 2.663 ± 0.045	3.023ArgVal: 3.023 ± 0.043	0.889ArgTrp: 0.889 ± 0.028	2.531ArgTyr: 2.531 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.778SerAla: 4.778 ± 0.07	0.601SerCys: 0.601 ± 0.023	2.645SerAsp: 2.645 ± 0.061	3.197SerGlu: 3.197 ± 0.051	2.937SerPhe: 2.937 ± 0.057	5.235SerGly: 5.235 ± 0.075	1.117SerHis: 1.117 ± 0.025	3.536SerIle: 3.536 ± 0.054	2.444SerLys: 2.444 ± 0.043	7.607SerLeu: 7.607 ± 0.088	1.393SerMet: 1.393 ± 0.03	2.162SerAsn: 2.162 ± 0.048	3.079SerPro: 3.079 ± 0.059	2.546SerGln: 2.546 ± 0.046	3.516SerArg: 3.516 ± 0.053	4.13SerSer: 4.13 ± 0.071	3.157SerThr: 3.157 ± 0.056	3.359SerVal: 3.359 ± 0.058	1.022SerTrp: 1.022 ± 0.033	2.324SerTyr: 2.324 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.889ThrAla: 4.889 ± 0.087	0.315ThrCys: 0.315 ± 0.017	2.89ThrAsp: 2.89 ± 0.058	2.879ThrGlu: 2.879 ± 0.048	2.273ThrPhe: 2.273 ± 0.039	4.232ThrGly: 4.232 ± 0.065	1.164ThrHis: 1.164 ± 0.028	3.195ThrIle: 3.195 ± 0.051	1.905ThrLys: 1.905 ± 0.038	5.59ThrLeu: 5.59 ± 0.073	0.733ThrMet: 0.733 ± 0.025	2.012ThrAsn: 2.012 ± 0.043	3.193ThrPro: 3.193 ± 0.056	1.836ThrGln: 1.836 ± 0.043	2.426ThrArg: 2.426 ± 0.044	3.154ThrSer: 3.154 ± 0.063	3.098ThrThr: 3.098 ± 0.066	3.322ThrVal: 3.322 ± 0.075	0.469ThrTrp: 0.469 ± 0.017	2.257ThrTyr: 2.257 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	5.582ValAla: 5.582 ± 0.069	0.488ValCys: 0.488 ± 0.021	2.89ValAsp: 2.89 ± 0.048	3.834ValGlu: 3.834 ± 0.057	2.732ValPhe: 2.732 ± 0.047	4.071ValGly: 4.071 ± 0.06	1.277ValHis: 1.277 ± 0.03	3.282ValIle: 3.282 ± 0.062	2.814ValLys: 2.814 ± 0.051	7.213ValLeu: 7.213 ± 0.094	1.34ValMet: 1.34 ± 0.034	2.433ValAsn: 2.433 ± 0.051	2.758ValPro: 2.758 ± 0.045	2.95ValGln: 2.95 ± 0.047	3.28ValArg: 3.28 ± 0.054	3.848ValSer: 3.848 ± 0.053	2.918ValThr: 2.918 ± 0.07	4.856ValVal: 4.856 ± 0.068	0.781ValTrp: 0.781 ± 0.027	2.432ValTyr: 2.432 ± 0.043	0.001ValXaa: 0.001 ± 0.001
Trp	1.058TrpAla: 1.058 ± 0.029	0.086TrpCys: 0.086 ± 0.009	0.616TrpAsp: 0.616 ± 0.027	0.831TrpGlu: 0.831 ± 0.025	0.511TrpPhe: 0.511 ± 0.02	1.299TrpGly: 1.299 ± 0.037	0.322TrpHis: 0.322 ± 0.017	0.693TrpIle: 0.693 ± 0.022	0.627TrpLys: 0.627 ± 0.021	1.505TrpLeu: 1.505 ± 0.04	0.366TrpMet: 0.366 ± 0.018	0.519TrpAsn: 0.519 ± 0.024	0.444TrpPro: 0.444 ± 0.021	0.879TrpGln: 0.879 ± 0.035	0.647TrpArg: 0.647 ± 0.023	0.727TrpSer: 0.727 ± 0.026	0.61TrpThr: 0.61 ± 0.022	0.895TrpVal: 0.895 ± 0.027	0.209TrpTrp: 0.209 ± 0.016	0.477TrpTyr: 0.477 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.865TyrAla: 2.865 ± 0.048	0.293TyrCys: 0.293 ± 0.015	1.776TyrAsp: 1.776 ± 0.042	2.073TyrGlu: 2.073 ± 0.042	1.935TyrPhe: 1.935 ± 0.045	2.436TyrGly: 2.436 ± 0.045	0.908TyrHis: 0.908 ± 0.028	1.873TyrIle: 1.873 ± 0.042	1.73TyrLys: 1.73 ± 0.038	4.377TyrLeu: 4.377 ± 0.07	0.774TyrMet: 0.774 ± 0.028	1.626TyrAsn: 1.626 ± 0.042	1.825TyrPro: 1.825 ± 0.04	1.995TyrGln: 1.995 ± 0.04	2.55TyrArg: 2.55 ± 0.046	2.545TyrSer: 2.545 ± 0.05	2.557TyrThr: 2.557 ± 0.06	1.955TyrVal: 1.955 ± 0.043	0.546TyrTrp: 0.546 ± 0.021	1.816TyrTyr: 1.816 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4225 proteins (1361372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---