Amino acid dipepetide frequency for Aeropyrum pernix ovoid virus 1 (APOV1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.439AlaAla: 12.439 ± 2.751
0.488AlaCys: 0.488 ± 0.355
2.439AlaAsp: 2.439 ± 0.646
4.878AlaGlu: 4.878 ± 1.158
3.415AlaPhe: 3.415 ± 0.902
7.073AlaGly: 7.073 ± 1.255
0.976AlaHis: 0.976 ± 0.465
8.293AlaIle: 8.293 ± 1.856
3.902AlaLys: 3.902 ± 1.236
13.171AlaLeu: 13.171 ± 1.943
2.195AlaMet: 2.195 ± 0.737
1.22AlaAsn: 1.22 ± 0.622
4.39AlaPro: 4.39 ± 1.478
1.707AlaGln: 1.707 ± 0.579
9.756AlaArg: 9.756 ± 2.745
5.854AlaSer: 5.854 ± 1.352
2.927AlaThr: 2.927 ± 0.754
9.024AlaVal: 9.024 ± 1.832
2.439AlaTrp: 2.439 ± 0.711
3.902AlaTyr: 3.902 ± 1.001
0.0AlaXaa: 0.0 ± 0.0
Cys
0.244CysAla: 0.244 ± 0.196
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.732CysGlu: 0.732 ± 0.531
0.488CysPhe: 0.488 ± 0.357
0.244CysGly: 0.244 ± 0.196
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.488CysLys: 0.488 ± 0.395
1.463CysLeu: 1.463 ± 0.593
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.488CysPro: 0.488 ± 0.364
0.0CysGln: 0.0 ± 0.0
0.244CysArg: 0.244 ± 0.196
0.488CysSer: 0.488 ± 0.424
0.244CysThr: 0.244 ± 0.196
0.244CysVal: 0.244 ± 0.251
0.0CysTrp: 0.0 ± 0.0
0.732CysTyr: 0.732 ± 0.394
0.0CysXaa: 0.0 ± 0.0
Asp
3.902AspAla: 3.902 ± 1.077
0.976AspCys: 0.976 ± 0.394
1.463AspAsp: 1.463 ± 0.527
2.683AspGlu: 2.683 ± 0.546
1.707AspPhe: 1.707 ± 0.468
4.634AspGly: 4.634 ± 0.954
0.244AspHis: 0.244 ± 0.24
1.951AspIle: 1.951 ± 0.663
1.951AspLys: 1.951 ± 0.447
3.171AspLeu: 3.171 ± 0.838
0.732AspMet: 0.732 ± 0.403
0.976AspAsn: 0.976 ± 0.434
3.902AspPro: 3.902 ± 1.108
0.244AspGln: 0.244 ± 0.212
3.415AspArg: 3.415 ± 0.704
5.366AspSer: 5.366 ± 1.467
1.951AspThr: 1.951 ± 0.686
2.439AspVal: 2.439 ± 0.713
2.195AspTrp: 2.195 ± 0.937
3.902AspTyr: 3.902 ± 1.762
0.0AspXaa: 0.0 ± 0.0
Glu
8.293GluAla: 8.293 ± 1.594
0.488GluCys: 0.488 ± 0.276
3.415GluAsp: 3.415 ± 0.697
5.122GluGlu: 5.122 ± 1.381
2.195GluPhe: 2.195 ± 0.793
3.659GluGly: 3.659 ± 0.929
1.707GluHis: 1.707 ± 0.637
1.951GluIle: 1.951 ± 0.856
4.39GluLys: 4.39 ± 1.345
10.0GluLeu: 10.0 ± 1.734
0.488GluMet: 0.488 ± 0.348
0.488GluAsn: 0.488 ± 0.363
3.659GluPro: 3.659 ± 1.096
1.22GluGln: 1.22 ± 0.39
4.634GluArg: 4.634 ± 1.331
2.927GluSer: 2.927 ± 0.751
2.439GluThr: 2.439 ± 0.758
2.439GluVal: 2.439 ± 0.927
2.927GluTrp: 2.927 ± 0.589
2.927GluTyr: 2.927 ± 0.67
0.0GluXaa: 0.0 ± 0.0
Phe
1.707PheAla: 1.707 ± 0.485
0.488PheCys: 0.488 ± 0.299
1.22PheAsp: 1.22 ± 0.484
1.707PheGlu: 1.707 ± 0.535
0.976PhePhe: 0.976 ± 0.329
1.951PheGly: 1.951 ± 0.487
0.244PheHis: 0.244 ± 0.193
2.439PheIle: 2.439 ± 0.808
1.22PheLys: 1.22 ± 0.488
3.902PheLeu: 3.902 ± 0.949
0.732PheMet: 0.732 ± 0.386
1.22PheAsn: 1.22 ± 0.574
0.732PhePro: 0.732 ± 0.363
0.732PheGln: 0.732 ± 0.464
1.951PheArg: 1.951 ± 0.457
0.976PheSer: 0.976 ± 0.426
1.22PheThr: 1.22 ± 0.475
1.22PheVal: 1.22 ± 0.449
0.732PheTrp: 0.732 ± 0.467
1.951PheTyr: 1.951 ± 0.821
0.0PheXaa: 0.0 ± 0.0
Gly
4.878GlyAla: 4.878 ± 1.143
0.488GlyCys: 0.488 ± 0.321
4.146GlyAsp: 4.146 ± 1.072
3.659GlyGlu: 3.659 ± 0.85
1.22GlyPhe: 1.22 ± 0.395
4.878GlyGly: 4.878 ± 1.244
0.976GlyHis: 0.976 ± 0.367
3.171GlyIle: 3.171 ± 0.765
4.146GlyLys: 4.146 ± 0.97
9.024GlyLeu: 9.024 ± 1.073
1.707GlyMet: 1.707 ± 0.633
2.683GlyAsn: 2.683 ± 0.773
2.195GlyPro: 2.195 ± 0.568
1.22GlyGln: 1.22 ± 0.496
5.854GlyArg: 5.854 ± 1.045
5.366GlySer: 5.366 ± 0.912
2.439GlyThr: 2.439 ± 1.18
8.049GlyVal: 8.049 ± 1.174
2.927GlyTrp: 2.927 ± 0.901
4.39GlyTyr: 4.39 ± 1.188
0.0GlyXaa: 0.0 ± 0.0
His
0.488HisAla: 0.488 ± 0.388
0.0HisCys: 0.0 ± 0.0
0.732HisAsp: 0.732 ± 0.45
1.463HisGlu: 1.463 ± 0.546
0.244HisPhe: 0.244 ± 0.24
0.488HisGly: 0.488 ± 0.377
0.0HisHis: 0.0 ± 0.0
0.732HisIle: 0.732 ± 0.341
1.707HisLys: 1.707 ± 0.498
0.976HisLeu: 0.976 ± 0.501
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.732HisPro: 0.732 ± 0.362
0.732HisGln: 0.732 ± 0.38
0.732HisArg: 0.732 ± 0.54
0.488HisSer: 0.488 ± 0.386
1.22HisThr: 1.22 ± 0.626
1.22HisVal: 1.22 ± 0.43
0.488HisTrp: 0.488 ± 0.299
1.22HisTyr: 1.22 ± 0.619
0.0HisXaa: 0.0 ± 0.0
Ile
6.585IleAla: 6.585 ± 1.426
0.0IleCys: 0.0 ± 0.0
3.659IleAsp: 3.659 ± 1.421
3.902IleGlu: 3.902 ± 1.075
1.707IlePhe: 1.707 ± 0.703
2.683IleGly: 2.683 ± 0.808
0.732IleHis: 0.732 ± 0.439
2.439IleIle: 2.439 ± 0.833
2.927IleLys: 2.927 ± 0.902
5.122IleLeu: 5.122 ± 1.047
2.439IleMet: 2.439 ± 0.691
1.22IleAsn: 1.22 ± 0.651
2.195IlePro: 2.195 ± 0.713
0.976IleGln: 0.976 ± 0.426
2.439IleArg: 2.439 ± 0.494
1.707IleSer: 1.707 ± 0.426
1.707IleThr: 1.707 ± 0.881
4.878IleVal: 4.878 ± 1.341
0.976IleTrp: 0.976 ± 0.477
1.951IleTyr: 1.951 ± 0.757
0.0IleXaa: 0.0 ± 0.0
Lys
4.878LysAla: 4.878 ± 0.855
0.244LysCys: 0.244 ± 0.251
1.463LysAsp: 1.463 ± 0.383
3.171LysGlu: 3.171 ± 1.014
1.463LysPhe: 1.463 ± 0.521
3.171LysGly: 3.171 ± 0.97
1.707LysHis: 1.707 ± 0.651
1.951LysIle: 1.951 ± 0.693
1.22LysLys: 1.22 ± 0.501
5.854LysLeu: 5.854 ± 0.933
1.707LysMet: 1.707 ± 0.593
0.488LysAsn: 0.488 ± 0.356
3.659LysPro: 3.659 ± 0.997
1.951LysGln: 1.951 ± 0.725
5.366LysArg: 5.366 ± 1.625
3.415LysSer: 3.415 ± 0.848
3.171LysThr: 3.171 ± 0.9
2.439LysVal: 2.439 ± 0.813
0.488LysTrp: 0.488 ± 0.318
2.195LysTyr: 2.195 ± 0.686
0.0LysXaa: 0.0 ± 0.0
Leu
18.293LeuAla: 18.293 ± 2.2
0.244LeuCys: 0.244 ± 0.276
6.098LeuAsp: 6.098 ± 1.106
6.829LeuGlu: 6.829 ± 1.523
2.439LeuPhe: 2.439 ± 0.536
7.317LeuGly: 7.317 ± 1.217
1.951LeuHis: 1.951 ± 0.551
5.854LeuIle: 5.854 ± 1.025
5.366LeuLys: 5.366 ± 0.754
16.585LeuLeu: 16.585 ± 2.864
2.195LeuMet: 2.195 ± 0.729
2.683LeuAsn: 2.683 ± 0.679
4.39LeuPro: 4.39 ± 0.819
3.415LeuGln: 3.415 ± 0.924
9.512LeuArg: 9.512 ± 1.644
6.829LeuSer: 6.829 ± 1.215
5.61LeuThr: 5.61 ± 0.861
8.78LeuVal: 8.78 ± 1.06
1.951LeuTrp: 1.951 ± 0.655
5.122LeuTyr: 5.122 ± 0.989
0.0LeuXaa: 0.0 ± 0.0
Met
3.171MetAla: 3.171 ± 0.924
0.0MetCys: 0.0 ± 0.0
0.244MetAsp: 0.244 ± 0.281
1.22MetGlu: 1.22 ± 0.477
0.244MetPhe: 0.244 ± 0.242
0.976MetGly: 0.976 ± 0.448
0.244MetHis: 0.244 ± 0.193
1.463MetIle: 1.463 ± 0.575
1.22MetLys: 1.22 ± 0.552
1.707MetLeu: 1.707 ± 0.597
0.732MetMet: 0.732 ± 0.569
0.732MetAsn: 0.732 ± 0.436
1.707MetPro: 1.707 ± 0.506
0.244MetGln: 0.244 ± 0.248
1.707MetArg: 1.707 ± 0.441
0.732MetSer: 0.732 ± 0.498
0.976MetThr: 0.976 ± 0.469
2.683MetVal: 2.683 ± 0.688
0.732MetTrp: 0.732 ± 0.474
0.976MetTyr: 0.976 ± 0.669
0.0MetXaa: 0.0 ± 0.0
Asn
1.951AsnAla: 1.951 ± 0.729
0.0AsnCys: 0.0 ± 0.0
1.22AsnAsp: 1.22 ± 0.802
1.22AsnGlu: 1.22 ± 0.448
0.488AsnPhe: 0.488 ± 0.363
2.439AsnGly: 2.439 ± 0.702
0.244AsnHis: 0.244 ± 0.237
0.732AsnIle: 0.732 ± 0.633
0.732AsnLys: 0.732 ± 0.305
2.683AsnLeu: 2.683 ± 0.53
0.732AsnMet: 0.732 ± 0.356
0.976AsnAsn: 0.976 ± 0.549
0.976AsnPro: 0.976 ± 0.441
0.488AsnGln: 0.488 ± 0.338
0.732AsnArg: 0.732 ± 0.368
0.976AsnSer: 0.976 ± 0.394
1.22AsnThr: 1.22 ± 0.462
2.439AsnVal: 2.439 ± 0.763
0.488AsnTrp: 0.488 ± 0.354
0.976AsnTyr: 0.976 ± 0.364
0.0AsnXaa: 0.0 ± 0.0
Pro
4.146ProAla: 4.146 ± 1.35
0.244ProCys: 0.244 ± 0.281
2.195ProAsp: 2.195 ± 0.646
1.951ProGlu: 1.951 ± 0.646
1.22ProPhe: 1.22 ± 0.361
4.634ProGly: 4.634 ± 1.27
0.244ProHis: 0.244 ± 0.237
0.976ProIle: 0.976 ± 0.431
2.683ProLys: 2.683 ± 0.657
4.634ProLeu: 4.634 ± 0.868
0.976ProMet: 0.976 ± 0.55
0.488ProAsn: 0.488 ± 0.424
2.195ProPro: 2.195 ± 0.66
0.732ProGln: 0.732 ± 0.389
3.659ProArg: 3.659 ± 0.83
4.146ProSer: 4.146 ± 0.886
1.463ProThr: 1.463 ± 0.52
3.659ProVal: 3.659 ± 0.662
1.22ProTrp: 1.22 ± 0.442
2.683ProTyr: 2.683 ± 0.829
0.0ProXaa: 0.0 ± 0.0
Gln
3.902GlnAla: 3.902 ± 0.725
0.0GlnCys: 0.0 ± 0.0
1.22GlnAsp: 1.22 ± 0.355
1.22GlnGlu: 1.22 ± 0.499
0.732GlnPhe: 0.732 ± 0.342
3.415GlnGly: 3.415 ± 0.747
0.244GlnHis: 0.244 ± 0.251
1.22GlnIle: 1.22 ± 0.668
0.488GlnLys: 0.488 ± 0.363
2.927GlnLeu: 2.927 ± 0.554
0.244GlnMet: 0.244 ± 0.264
0.732GlnAsn: 0.732 ± 0.389
0.244GlnPro: 0.244 ± 0.193
0.0GlnGln: 0.0 ± 0.0
1.463GlnArg: 1.463 ± 0.56
0.732GlnSer: 0.732 ± 0.289
0.976GlnThr: 0.976 ± 0.461
2.439GlnVal: 2.439 ± 0.46
0.732GlnTrp: 0.732 ± 0.321
1.22GlnTyr: 1.22 ± 0.451
0.0GlnXaa: 0.0 ± 0.0
Arg
7.805ArgAla: 7.805 ± 1.912
0.244ArgCys: 0.244 ± 0.264
2.927ArgAsp: 2.927 ± 0.692
7.317ArgGlu: 7.317 ± 1.91
0.732ArgPhe: 0.732 ± 0.403
5.854ArgGly: 5.854 ± 1.294
0.976ArgHis: 0.976 ± 0.322
2.927ArgIle: 2.927 ± 0.788
4.146ArgLys: 4.146 ± 0.86
11.463ArgLeu: 11.463 ± 1.715
2.439ArgMet: 2.439 ± 0.902
1.951ArgAsn: 1.951 ± 0.499
2.683ArgPro: 2.683 ± 0.709
2.195ArgGln: 2.195 ± 0.658
8.537ArgArg: 8.537 ± 2.459
4.39ArgSer: 4.39 ± 1.085
2.683ArgThr: 2.683 ± 1.001
6.341ArgVal: 6.341 ± 1.059
0.732ArgTrp: 0.732 ± 0.363
2.927ArgTyr: 2.927 ± 0.844
0.0ArgXaa: 0.0 ± 0.0
Ser
3.415SerAla: 3.415 ± 0.751
0.732SerCys: 0.732 ± 0.48
1.707SerAsp: 1.707 ± 0.676
3.659SerGlu: 3.659 ± 0.687
2.683SerPhe: 2.683 ± 0.66
6.829SerGly: 6.829 ± 1.165
0.244SerHis: 0.244 ± 0.214
3.902SerIle: 3.902 ± 0.738
2.927SerLys: 2.927 ± 0.923
7.317SerLeu: 7.317 ± 1.254
0.976SerMet: 0.976 ± 0.407
0.244SerAsn: 0.244 ± 0.212
2.439SerPro: 2.439 ± 0.569
2.927SerGln: 2.927 ± 0.796
5.122SerArg: 5.122 ± 1.088
3.171SerSer: 3.171 ± 1.09
2.683SerThr: 2.683 ± 1.156
2.683SerVal: 2.683 ± 0.647
2.195SerTrp: 2.195 ± 0.601
2.683SerTyr: 2.683 ± 1.133
0.0SerXaa: 0.0 ± 0.0
Thr
2.195ThrAla: 2.195 ± 0.606
0.244ThrCys: 0.244 ± 0.196
2.195ThrAsp: 2.195 ± 0.609
1.707ThrGlu: 1.707 ± 0.737
1.463ThrPhe: 1.463 ± 0.499
3.659ThrGly: 3.659 ± 0.904
0.244ThrHis: 0.244 ± 0.237
2.439ThrIle: 2.439 ± 0.944
1.463ThrLys: 1.463 ± 0.565
6.585ThrLeu: 6.585 ± 0.871
0.732ThrMet: 0.732 ± 0.407
1.22ThrAsn: 1.22 ± 0.389
2.195ThrPro: 2.195 ± 0.482
0.488ThrGln: 0.488 ± 0.291
1.22ThrArg: 1.22 ± 0.424
1.951ThrSer: 1.951 ± 0.505
3.415ThrThr: 3.415 ± 1.016
3.659ThrVal: 3.659 ± 0.874
0.732ThrTrp: 0.732 ± 0.337
3.171ThrTyr: 3.171 ± 0.835
0.0ThrXaa: 0.0 ± 0.0
Val
6.585ValAla: 6.585 ± 1.367
0.488ValCys: 0.488 ± 0.326
4.39ValAsp: 4.39 ± 1.022
7.073ValGlu: 7.073 ± 1.639
3.171ValPhe: 3.171 ± 0.838
3.659ValGly: 3.659 ± 0.957
0.976ValHis: 0.976 ± 0.652
4.146ValIle: 4.146 ± 0.849
6.098ValLys: 6.098 ± 1.565
7.317ValLeu: 7.317 ± 1.102
1.22ValMet: 1.22 ± 0.515
1.707ValAsn: 1.707 ± 0.617
1.707ValPro: 1.707 ± 0.565
2.439ValGln: 2.439 ± 0.77
7.805ValArg: 7.805 ± 1.339
3.902ValSer: 3.902 ± 1.029
2.683ValThr: 2.683 ± 0.814
5.366ValVal: 5.366 ± 1.207
1.463ValTrp: 1.463 ± 0.612
3.902ValTyr: 3.902 ± 0.961
0.0ValXaa: 0.0 ± 0.0
Trp
1.707TrpAla: 1.707 ± 0.6
0.488TrpCys: 0.488 ± 0.278
2.439TrpAsp: 2.439 ± 0.525
2.195TrpGlu: 2.195 ± 0.669
0.0TrpPhe: 0.0 ± 0.0
2.683TrpGly: 2.683 ± 0.815
0.976TrpHis: 0.976 ± 0.586
0.732TrpIle: 0.732 ± 0.401
0.732TrpLys: 0.732 ± 0.335
2.927TrpLeu: 2.927 ± 0.89
0.0TrpMet: 0.0 ± 0.0
0.732TrpAsn: 0.732 ± 0.385
0.976TrpPro: 0.976 ± 0.509
0.488TrpGln: 0.488 ± 0.301
1.707TrpArg: 1.707 ± 0.531
1.951TrpSer: 1.951 ± 0.615
0.732TrpThr: 0.732 ± 0.508
2.195TrpVal: 2.195 ± 0.461
0.732TrpTrp: 0.732 ± 0.285
0.732TrpTyr: 0.732 ± 0.321
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.902TyrAla: 3.902 ± 0.808
0.244TyrCys: 0.244 ± 0.281
4.634TyrAsp: 4.634 ± 1.276
3.659TyrGlu: 3.659 ± 0.604
0.732TyrPhe: 0.732 ± 0.431
3.415TyrGly: 3.415 ± 1.601
0.732TyrHis: 0.732 ± 0.399
2.927TyrIle: 2.927 ± 0.724
2.195TyrLys: 2.195 ± 0.734
4.634TyrLeu: 4.634 ± 0.814
1.22TyrMet: 1.22 ± 0.463
1.951TyrAsn: 1.951 ± 0.547
2.683TyrPro: 2.683 ± 1.026
1.951TyrGln: 1.951 ± 0.514
3.415TyrArg: 3.415 ± 1.103
3.171TyrSer: 3.171 ± 0.7
1.22TyrThr: 1.22 ± 0.335
3.902TyrVal: 3.902 ± 1.245
0.976TyrTrp: 0.976 ± 0.508
4.878TyrTyr: 4.878 ± 1.544
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (4101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski