Amino acid dipepetide frequency for Rhodoferax antarcticus ANT.BR

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.932AlaAla: 14.932 ± 0.16
1.414AlaCys: 1.414 ± 0.039
6.03AlaAsp: 6.03 ± 0.072
5.525AlaGlu: 5.525 ± 0.064
3.995AlaPhe: 3.995 ± 0.057
8.867AlaGly: 8.867 ± 0.102
2.678AlaHis: 2.678 ± 0.053
5.052AlaIle: 5.052 ± 0.075
4.735AlaLys: 4.735 ± 0.085
14.544AlaLeu: 14.544 ± 0.143
3.57AlaMet: 3.57 ± 0.063
3.479AlaAsn: 3.479 ± 0.061
5.332AlaPro: 5.332 ± 0.091
6.629AlaGln: 6.629 ± 0.102
7.259AlaArg: 7.259 ± 0.09
6.893AlaSer: 6.893 ± 0.084
6.102AlaThr: 6.102 ± 0.08
8.529AlaVal: 8.529 ± 0.102
1.76AlaTrp: 1.76 ± 0.043
2.457AlaTyr: 2.457 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.266CysAla: 1.266 ± 0.038
0.157CysCys: 0.157 ± 0.012
0.636CysAsp: 0.636 ± 0.021
0.54CysGlu: 0.54 ± 0.022
0.375CysPhe: 0.375 ± 0.019
1.026CysGly: 1.026 ± 0.032
0.324CysHis: 0.324 ± 0.018
0.476CysIle: 0.476 ± 0.021
0.364CysLys: 0.364 ± 0.019
0.998CysLeu: 0.998 ± 0.032
0.234CysMet: 0.234 ± 0.015
0.338CysAsn: 0.338 ± 0.019
0.595CysPro: 0.595 ± 0.026
0.424CysGln: 0.424 ± 0.021
0.575CysArg: 0.575 ± 0.019
0.58CysSer: 0.58 ± 0.024
0.535CysThr: 0.535 ± 0.023
0.777CysVal: 0.777 ± 0.029
0.155CysTrp: 0.155 ± 0.014
0.219CysTyr: 0.219 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.822AspAla: 6.822 ± 0.087
0.576AspCys: 0.576 ± 0.022
2.849AspAsp: 2.849 ± 0.053
2.963AspGlu: 2.963 ± 0.055
2.217AspPhe: 2.217 ± 0.044
3.915AspGly: 3.915 ± 0.059
1.114AspHis: 1.114 ± 0.034
2.717AspIle: 2.717 ± 0.046
2.192AspLys: 2.192 ± 0.056
5.652AspLeu: 5.652 ± 0.07
1.381AspMet: 1.381 ± 0.037
1.39AspAsn: 1.39 ± 0.034
2.533AspPro: 2.533 ± 0.046
1.986AspGln: 1.986 ± 0.039
2.751AspArg: 2.751 ± 0.055
2.63AspSer: 2.63 ± 0.048
2.689AspThr: 2.689 ± 0.047
3.985AspVal: 3.985 ± 0.065
0.955AspTrp: 0.955 ± 0.03
1.432AspTyr: 1.432 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
5.807GluAla: 5.807 ± 0.072
0.394GluCys: 0.394 ± 0.018
2.194GluAsp: 2.194 ± 0.046
2.104GluGlu: 2.104 ± 0.049
1.936GluPhe: 1.936 ± 0.044
3.181GluGly: 3.181 ± 0.058
1.265GluHis: 1.265 ± 0.036
2.644GluIle: 2.644 ± 0.058
2.177GluLys: 2.177 ± 0.053
5.824GluLeu: 5.824 ± 0.081
1.31GluMet: 1.31 ± 0.037
1.361GluAsn: 1.361 ± 0.038
2.396GluPro: 2.396 ± 0.059
2.496GluGln: 2.496 ± 0.049
3.791GluArg: 3.791 ± 0.057
2.704GluSer: 2.704 ± 0.049
2.406GluThr: 2.406 ± 0.043
4.117GluVal: 4.117 ± 0.061
0.598GluTrp: 0.598 ± 0.024
0.94GluTyr: 0.94 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.095PheAla: 4.095 ± 0.058
0.458PheCys: 0.458 ± 0.022
2.599PheAsp: 2.599 ± 0.049
2.333PheGlu: 2.333 ± 0.042
1.472PhePhe: 1.472 ± 0.038
3.263PheGly: 3.263 ± 0.056
0.696PheHis: 0.696 ± 0.022
1.583PheIle: 1.583 ± 0.039
1.643PheLys: 1.643 ± 0.041
3.13PheLeu: 3.13 ± 0.059
0.935PheMet: 0.935 ± 0.028
1.257PheAsn: 1.257 ± 0.033
1.385PhePro: 1.385 ± 0.033
1.164PheGln: 1.164 ± 0.029
1.622PheArg: 1.622 ± 0.037
2.455PheSer: 2.455 ± 0.049
1.951PheThr: 1.951 ± 0.044
2.793PheVal: 2.793 ± 0.054
0.563PheTrp: 0.563 ± 0.026
1.011PheTyr: 1.011 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.826GlyAla: 7.826 ± 0.096
0.954GlyCys: 0.954 ± 0.032
3.708GlyAsp: 3.708 ± 0.059
3.882GlyGlu: 3.882 ± 0.068
3.206GlyPhe: 3.206 ± 0.058
5.836GlyGly: 5.836 ± 0.094
1.813GlyHis: 1.813 ± 0.045
3.712GlyIle: 3.712 ± 0.064
3.603GlyLys: 3.603 ± 0.066
8.709GlyLeu: 8.709 ± 0.094
2.272GlyMet: 2.272 ± 0.048
2.198GlyAsn: 2.198 ± 0.055
2.536GlyPro: 2.536 ± 0.051
3.597GlyGln: 3.597 ± 0.055
4.295GlyArg: 4.295 ± 0.065
4.403GlySer: 4.403 ± 0.069
3.923GlyThr: 3.923 ± 0.065
6.389GlyVal: 6.389 ± 0.072
1.25GlyTrp: 1.25 ± 0.039
2.167GlyTyr: 2.167 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.53HisAla: 2.53 ± 0.048
0.339HisCys: 0.339 ± 0.02
1.165HisAsp: 1.165 ± 0.033
1.019HisGlu: 1.019 ± 0.029
0.922HisPhe: 0.922 ± 0.028
1.864HisGly: 1.864 ± 0.044
0.613HisHis: 0.613 ± 0.025
1.16HisIle: 1.16 ± 0.031
0.735HisLys: 0.735 ± 0.025
2.422HisLeu: 2.422 ± 0.049
0.531HisMet: 0.531 ± 0.022
0.586HisAsn: 0.586 ± 0.025
1.447HisPro: 1.447 ± 0.032
0.984HisGln: 0.984 ± 0.028
1.319HisArg: 1.319 ± 0.036
1.214HisSer: 1.214 ± 0.035
1.214HisThr: 1.214 ± 0.032
1.432HisVal: 1.432 ± 0.031
0.428HisTrp: 0.428 ± 0.02
0.657HisTyr: 0.657 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.683IleAla: 5.683 ± 0.081
0.527IleCys: 0.527 ± 0.024
3.099IleAsp: 3.099 ± 0.049
3.047IleGlu: 3.047 ± 0.058
1.551IlePhe: 1.551 ± 0.042
3.819IleGly: 3.819 ± 0.068
1.019IleHis: 1.019 ± 0.029
1.833IleIle: 1.833 ± 0.045
2.086IleLys: 2.086 ± 0.046
3.673IleLeu: 3.673 ± 0.059
0.918IleMet: 0.918 ± 0.028
1.774IleAsn: 1.774 ± 0.038
1.927IlePro: 1.927 ± 0.041
1.53IleGln: 1.53 ± 0.037
2.593IleArg: 2.593 ± 0.046
2.925IleSer: 2.925 ± 0.053
2.847IleThr: 2.847 ± 0.051
3.118IleVal: 3.118 ± 0.059
0.545IleTrp: 0.545 ± 0.025
1.067IleTyr: 1.067 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.547LysAla: 4.547 ± 0.068
0.271LysCys: 0.271 ± 0.017
2.019LysAsp: 2.019 ± 0.051
1.773LysGlu: 1.773 ± 0.047
1.222LysPhe: 1.222 ± 0.031
2.73LysGly: 2.73 ± 0.051
0.864LysHis: 0.864 ± 0.031
1.858LysIle: 1.858 ± 0.049
1.947LysLys: 1.947 ± 0.053
4.4LysLeu: 4.4 ± 0.072
1.049LysMet: 1.049 ± 0.031
1.368LysAsn: 1.368 ± 0.037
2.441LysPro: 2.441 ± 0.05
1.516LysGln: 1.516 ± 0.041
2.752LysArg: 2.752 ± 0.048
2.342LysSer: 2.342 ± 0.045
2.698LysThr: 2.698 ± 0.051
3.041LysVal: 3.041 ± 0.057
0.39LysTrp: 0.39 ± 0.018
0.772LysTyr: 0.772 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
14.439LeuAla: 14.439 ± 0.138
1.104LeuCys: 1.104 ± 0.034
5.937LeuAsp: 5.937 ± 0.073
5.233LeuGlu: 5.233 ± 0.079
3.509LeuPhe: 3.509 ± 0.064
8.407LeuGly: 8.407 ± 0.102
2.364LeuHis: 2.364 ± 0.055
4.819LeuIle: 4.819 ± 0.071
4.58LeuLys: 4.58 ± 0.068
11.734LeuLeu: 11.734 ± 0.132
2.976LeuMet: 2.976 ± 0.052
3.183LeuAsn: 3.183 ± 0.05
6.027LeuPro: 6.027 ± 0.081
5.152LeuGln: 5.152 ± 0.079
6.898LeuArg: 6.898 ± 0.088
6.829LeuSer: 6.829 ± 0.081
5.98LeuThr: 5.98 ± 0.073
7.818LeuVal: 7.818 ± 0.086
1.423LeuTrp: 1.423 ± 0.042
2.075LeuTyr: 2.075 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
3.359MetAla: 3.359 ± 0.061
0.211MetCys: 0.211 ± 0.014
1.281MetAsp: 1.281 ± 0.032
1.027MetGlu: 1.027 ± 0.032
0.77MetPhe: 0.77 ± 0.028
2.068MetGly: 2.068 ± 0.039
0.567MetHis: 0.567 ± 0.023
1.098MetIle: 1.098 ± 0.034
1.145MetLys: 1.145 ± 0.033
2.983MetLeu: 2.983 ± 0.055
0.69MetMet: 0.69 ± 0.027
0.92MetAsn: 0.92 ± 0.026
1.609MetPro: 1.609 ± 0.04
1.269MetGln: 1.269 ± 0.036
1.67MetArg: 1.67 ± 0.041
1.629MetSer: 1.629 ± 0.039
1.769MetThr: 1.769 ± 0.039
2.019MetVal: 2.019 ± 0.048
0.206MetTrp: 0.206 ± 0.014
0.402MetTyr: 0.402 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.618AsnAla: 3.618 ± 0.053
0.319AsnCys: 0.319 ± 0.019
1.495AsnAsp: 1.495 ± 0.038
1.307AsnGlu: 1.307 ± 0.039
1.108AsnPhe: 1.108 ± 0.035
2.183AsnGly: 2.183 ± 0.05
0.647AsnHis: 0.647 ± 0.025
1.476AsnIle: 1.476 ± 0.033
1.133AsnLys: 1.133 ± 0.03
3.112AsnLeu: 3.112 ± 0.051
0.762AsnMet: 0.762 ± 0.027
0.903AsnAsn: 0.903 ± 0.028
2.091AsnPro: 2.091 ± 0.041
1.292AsnGln: 1.292 ± 0.033
1.759AsnArg: 1.759 ± 0.041
1.502AsnSer: 1.502 ± 0.04
1.708AsnThr: 1.708 ± 0.044
2.035AsnVal: 2.035 ± 0.043
0.484AsnTrp: 0.484 ± 0.021
0.759AsnTyr: 0.759 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
5.894ProAla: 5.894 ± 0.08
0.44ProCys: 0.44 ± 0.021
3.142ProAsp: 3.142 ± 0.055
3.043ProGlu: 3.043 ± 0.055
1.706ProPhe: 1.706 ± 0.039
4.046ProGly: 4.046 ± 0.062
1.018ProHis: 1.018 ± 0.029
1.985ProIle: 1.985 ± 0.041
1.886ProLys: 1.886 ± 0.046
5.161ProLeu: 5.161 ± 0.07
1.374ProMet: 1.374 ± 0.034
1.465ProAsn: 1.465 ± 0.035
2.368ProPro: 2.368 ± 0.057
2.254ProGln: 2.254 ± 0.052
2.33ProArg: 2.33 ± 0.045
2.736ProSer: 2.736 ± 0.044
2.767ProThr: 2.767 ± 0.063
4.137ProVal: 4.137 ± 0.058
0.753ProTrp: 0.753 ± 0.027
1.101ProTyr: 1.101 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
6.463GlnAla: 6.463 ± 0.097
0.346GlnCys: 0.346 ± 0.015
1.952GlnAsp: 1.952 ± 0.044
1.801GlnGlu: 1.801 ± 0.038
1.467GlnPhe: 1.467 ± 0.032
3.264GlnGly: 3.264 ± 0.061
1.13GlnHis: 1.13 ± 0.033
2.164GlnIle: 2.164 ± 0.042
1.51GlnLys: 1.51 ± 0.038
4.743GlnLeu: 4.743 ± 0.072
1.149GlnMet: 1.149 ± 0.038
1.172GlnAsn: 1.172 ± 0.034
2.539GlnPro: 2.539 ± 0.054
2.198GlnGln: 2.198 ± 0.053
3.635GlnArg: 3.635 ± 0.059
2.453GlnSer: 2.453 ± 0.048
2.651GlnThr: 2.651 ± 0.039
3.43GlnVal: 3.43 ± 0.061
0.675GlnTrp: 0.675 ± 0.024
0.794GlnTyr: 0.794 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.586ArgAla: 6.586 ± 0.083
0.698ArgCys: 0.698 ± 0.024
3.178ArgAsp: 3.178 ± 0.054
3.375ArgGlu: 3.375 ± 0.056
2.502ArgPhe: 2.502 ± 0.039
3.814ArgGly: 3.814 ± 0.059
1.605ArgHis: 1.605 ± 0.04
3.038ArgIle: 3.038 ± 0.055
2.252ArgLys: 2.252 ± 0.053
7.174ArgLeu: 7.174 ± 0.096
1.719ArgMet: 1.719 ± 0.034
1.714ArgAsn: 1.714 ± 0.04
2.582ArgPro: 2.582 ± 0.048
3.096ArgGln: 3.096 ± 0.054
3.676ArgArg: 3.676 ± 0.065
3.221ArgSer: 3.221 ± 0.056
2.797ArgThr: 2.797 ± 0.043
4.693ArgVal: 4.693 ± 0.065
1.031ArgTrp: 1.031 ± 0.03
1.621ArgTyr: 1.621 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.891SerAla: 6.891 ± 0.092
0.545SerCys: 0.545 ± 0.025
2.951SerAsp: 2.951 ± 0.05
2.756SerGlu: 2.756 ± 0.045
2.243SerPhe: 2.243 ± 0.052
5.275SerGly: 5.275 ± 0.084
1.288SerHis: 1.288 ± 0.034
2.597SerIle: 2.597 ± 0.042
2.069SerLys: 2.069 ± 0.042
6.203SerLeu: 6.203 ± 0.076
1.518SerMet: 1.518 ± 0.038
1.714SerAsn: 1.714 ± 0.042
2.766SerPro: 2.766 ± 0.049
2.381SerGln: 2.381 ± 0.054
3.302SerArg: 3.302 ± 0.057
3.336SerSer: 3.336 ± 0.069
3.08SerThr: 3.08 ± 0.046
4.44SerVal: 4.44 ± 0.062
0.745SerTrp: 0.745 ± 0.026
1.361SerTyr: 1.361 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.021ThrAla: 6.021 ± 0.075
0.509ThrCys: 0.509 ± 0.023
2.799ThrAsp: 2.799 ± 0.048
2.699ThrGlu: 2.699 ± 0.044
1.786ThrPhe: 1.786 ± 0.042
4.519ThrGly: 4.519 ± 0.072
1.254ThrHis: 1.254 ± 0.031
2.215ThrIle: 2.215 ± 0.043
1.743ThrLys: 1.743 ± 0.042
6.763ThrLeu: 6.763 ± 0.08
1.174ThrMet: 1.174 ± 0.033
1.443ThrAsn: 1.443 ± 0.036
3.493ThrPro: 3.493 ± 0.066
2.569ThrGln: 2.569 ± 0.048
3.106ThrArg: 3.106 ± 0.052
3.049ThrSer: 3.049 ± 0.058
3.012ThrThr: 3.012 ± 0.071
4.02ThrVal: 4.02 ± 0.064
0.725ThrTrp: 0.725 ± 0.026
1.192ThrTyr: 1.192 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
9.14ValAla: 9.14 ± 0.093
0.847ValCys: 0.847 ± 0.026
4.008ValAsp: 4.008 ± 0.057
3.669ValGlu: 3.669 ± 0.067
2.854ValPhe: 2.854 ± 0.049
5.435ValGly: 5.435 ± 0.071
1.517ValHis: 1.517 ± 0.037
3.664ValIle: 3.664 ± 0.064
2.93ValLys: 2.93 ± 0.046
8.534ValLeu: 8.534 ± 0.103
2.246ValMet: 2.246 ± 0.048
2.429ValAsn: 2.429 ± 0.05
3.62ValPro: 3.62 ± 0.058
3.101ValGln: 3.101 ± 0.052
4.338ValArg: 4.338 ± 0.066
4.469ValSer: 4.469 ± 0.055
4.158ValThr: 4.158 ± 0.065
6.219ValVal: 6.219 ± 0.09
1.043ValTrp: 1.043 ± 0.028
1.503ValTyr: 1.503 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.347TrpAla: 1.347 ± 0.032
0.189TrpCys: 0.189 ± 0.013
0.594TrpAsp: 0.594 ± 0.024
0.528TrpGlu: 0.528 ± 0.021
0.554TrpPhe: 0.554 ± 0.021
0.905TrpGly: 0.905 ± 0.028
0.368TrpHis: 0.368 ± 0.017
0.612TrpIle: 0.612 ± 0.027
0.464TrpLys: 0.464 ± 0.02
2.161TrpLeu: 2.161 ± 0.049
0.423TrpMet: 0.423 ± 0.018
0.394TrpAsn: 0.394 ± 0.017
0.725TrpPro: 0.725 ± 0.027
0.881TrpGln: 0.881 ± 0.03
1.15TrpArg: 1.15 ± 0.03
0.775TrpSer: 0.775 ± 0.025
0.648TrpThr: 0.648 ± 0.024
1.133TrpVal: 1.133 ± 0.034
0.269TrpTrp: 0.269 ± 0.017
0.257TrpTyr: 0.257 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.514TyrAla: 2.514 ± 0.05
0.296TyrCys: 0.296 ± 0.016
1.113TyrAsp: 1.113 ± 0.036
1.02TyrGlu: 1.02 ± 0.029
1.012TyrPhe: 1.012 ± 0.031
1.858TyrGly: 1.858 ± 0.038
0.44TyrHis: 0.44 ± 0.019
0.877TyrIle: 0.877 ± 0.024
0.805TyrLys: 0.805 ± 0.024
2.571TyrLeu: 2.571 ± 0.053
0.461TyrMet: 0.461 ± 0.023
0.607TyrAsn: 0.607 ± 0.023
1.191TyrPro: 1.191 ± 0.037
1.018TyrGln: 1.018 ± 0.026
1.55TyrArg: 1.55 ± 0.032
1.314TyrSer: 1.314 ± 0.037
1.161TyrThr: 1.161 ± 0.036
1.602TyrVal: 1.602 ± 0.036
0.378TyrTrp: 0.378 ± 0.019
0.558TyrTyr: 0.558 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4231 proteins (1180028 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski