Amino acid dipepetide frequency for Rhodovulum sulfidophilum (Rhodobacter sulfidophilus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.265AlaAla: 20.265 ± 0.245	1.244AlaCys: 1.244 ± 0.035	7.196AlaAsp: 7.196 ± 0.107	9.9AlaGlu: 9.9 ± 0.128	4.419AlaPhe: 4.419 ± 0.067	12.052AlaGly: 12.052 ± 0.129	2.349AlaHis: 2.349 ± 0.045	5.794AlaIle: 5.794 ± 0.072	2.892AlaLys: 2.892 ± 0.064	15.907AlaLeu: 15.907 ± 0.148	3.999AlaMet: 3.999 ± 0.066	2.27AlaAsn: 2.27 ± 0.037	7.221AlaPro: 7.221 ± 0.122	3.858AlaGln: 3.858 ± 0.06	11.442AlaArg: 11.442 ± 0.13	5.595AlaSer: 5.595 ± 0.07	6.108AlaThr: 6.108 ± 0.102	8.849AlaVal: 8.849 ± 0.084	1.617AlaTrp: 1.617 ± 0.038	2.355AlaTyr: 2.355 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.031	0.126CysCys: 0.126 ± 0.01	0.6CysAsp: 0.6 ± 0.021	0.49CysGlu: 0.49 ± 0.022	0.319CysPhe: 0.319 ± 0.017	0.997CysGly: 0.997 ± 0.03	0.299CysHis: 0.299 ± 0.017	0.39CysIle: 0.39 ± 0.017	0.18CysLys: 0.18 ± 0.013	1.005CysLeu: 1.005 ± 0.03	0.158CysMet: 0.158 ± 0.011	0.218CysAsn: 0.218 ± 0.012	0.64CysPro: 0.64 ± 0.023	0.237CysGln: 0.237 ± 0.014	0.749CysArg: 0.749 ± 0.029	0.439CysSer: 0.439 ± 0.017	0.402CysThr: 0.402 ± 0.018	0.538CysVal: 0.538 ± 0.019	0.12CysTrp: 0.12 ± 0.009	0.201CysTyr: 0.201 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.992AspAla: 6.992 ± 0.074	0.597AspCys: 0.597 ± 0.021	3.028AspAsp: 3.028 ± 0.076	3.427AspGlu: 3.427 ± 0.062	2.215AspPhe: 2.215 ± 0.049	5.383AspGly: 5.383 ± 0.109	1.189AspHis: 1.189 ± 0.028	2.837AspIle: 2.837 ± 0.048	1.306AspLys: 1.306 ± 0.039	6.836AspLeu: 6.836 ± 0.101	1.589AspMet: 1.589 ± 0.035	1.062AspAsn: 1.062 ± 0.032	4.245AspPro: 4.245 ± 0.069	1.483AspGln: 1.483 ± 0.043	5.179AspArg: 5.179 ± 0.068	2.206AspSer: 2.206 ± 0.062	2.607AspThr: 2.607 ± 0.063	3.394AspVal: 3.394 ± 0.058	1.259AspTrp: 1.259 ± 0.032	1.457AspTyr: 1.457 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	9.926GluAla: 9.926 ± 0.12	0.366GluCys: 0.366 ± 0.017	3.494GluAsp: 3.494 ± 0.061	3.437GluGlu: 3.437 ± 0.073	1.698GluPhe: 1.698 ± 0.039	5.209GluGly: 5.209 ± 0.081	1.038GluHis: 1.038 ± 0.031	3.905GluIle: 3.905 ± 0.057	1.805GluLys: 1.805 ± 0.044	5.317GluLeu: 5.317 ± 0.07	1.698GluMet: 1.698 ± 0.039	1.447GluAsn: 1.447 ± 0.036	2.741GluPro: 2.741 ± 0.054	1.628GluGln: 1.628 ± 0.044	4.853GluArg: 4.853 ± 0.07	1.968GluSer: 1.968 ± 0.04	4.397GluThr: 4.397 ± 0.064	4.063GluVal: 4.063 ± 0.074	0.618GluTrp: 0.618 ± 0.024	0.913GluTyr: 0.913 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.315PheAla: 4.315 ± 0.067	0.418PheCys: 0.418 ± 0.015	2.704PheAsp: 2.704 ± 0.047	2.214PheGlu: 2.214 ± 0.04	1.266PhePhe: 1.266 ± 0.038	3.773PheGly: 3.773 ± 0.056	0.741PheHis: 0.741 ± 0.028	1.35PheIle: 1.35 ± 0.033	0.656PheLys: 0.656 ± 0.027	3.434PheLeu: 3.434 ± 0.064	0.728PheMet: 0.728 ± 0.023	0.849PheAsn: 0.849 ± 0.026	1.493PhePro: 1.493 ± 0.034	0.863PheGln: 0.863 ± 0.025	2.495PheArg: 2.495 ± 0.041	2.058PheSer: 2.058 ± 0.043	1.825PheThr: 1.825 ± 0.037	2.473PheVal: 2.473 ± 0.052	0.518PheTrp: 0.518 ± 0.022	0.842PheTyr: 0.842 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.216GlyAla: 11.216 ± 0.138	0.917GlyCys: 0.917 ± 0.025	4.678GlyAsp: 4.678 ± 0.111	4.898GlyGlu: 4.898 ± 0.075	3.654GlyPhe: 3.654 ± 0.053	7.68GlyGly: 7.68 ± 0.136	1.951GlyHis: 1.951 ± 0.04	4.361GlyIle: 4.361 ± 0.07	2.718GlyLys: 2.718 ± 0.048	10.422GlyLeu: 10.422 ± 0.118	2.547GlyMet: 2.547 ± 0.046	1.845GlyAsn: 1.845 ± 0.043	4.43GlyPro: 4.43 ± 0.07	3.107GlyGln: 3.107 ± 0.052	7.475GlyArg: 7.475 ± 0.073	4.362GlySer: 4.362 ± 0.107	4.772GlyThr: 4.772 ± 0.089	6.01GlyVal: 6.01 ± 0.067	1.609GlyTrp: 1.609 ± 0.039	2.162GlyTyr: 2.162 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.417HisAla: 2.417 ± 0.042	0.233HisCys: 0.233 ± 0.012	1.281HisAsp: 1.281 ± 0.036	0.987HisGlu: 0.987 ± 0.027	0.723HisPhe: 0.723 ± 0.026	1.945HisGly: 1.945 ± 0.044	0.5HisHis: 0.5 ± 0.023	0.818HisIle: 0.818 ± 0.026	0.404HisLys: 0.404 ± 0.018	2.092HisLeu: 2.092 ± 0.044	0.495HisMet: 0.495 ± 0.022	0.367HisAsn: 0.367 ± 0.02	1.448HisPro: 1.448 ± 0.036	0.47HisGln: 0.47 ± 0.021	1.547HisArg: 1.547 ± 0.036	0.863HisSer: 0.863 ± 0.027	0.649HisThr: 0.649 ± 0.025	1.515HisVal: 1.515 ± 0.039	0.307HisTrp: 0.307 ± 0.015	0.492HisTyr: 0.492 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.927IleAla: 6.927 ± 0.084	0.611IleCys: 0.611 ± 0.022	3.249IleAsp: 3.249 ± 0.055	3.492IleGlu: 3.492 ± 0.058	1.545IlePhe: 1.545 ± 0.035	4.876IleGly: 4.876 ± 0.061	0.853IleHis: 0.853 ± 0.026	1.52IleIle: 1.52 ± 0.041	1.047IleLys: 1.047 ± 0.03	4.485IleLeu: 4.485 ± 0.074	0.931IleMet: 0.931 ± 0.027	1.012IleAsn: 1.012 ± 0.031	2.155IlePro: 2.155 ± 0.039	1.015IleGln: 1.015 ± 0.029	3.708IleArg: 3.708 ± 0.06	2.605IleSer: 2.605 ± 0.045	2.142IleThr: 2.142 ± 0.05	3.512IleVal: 3.512 ± 0.061	0.68IleTrp: 0.68 ± 0.025	1.017IleTyr: 1.017 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.537LysAla: 3.537 ± 0.064	0.15LysCys: 0.15 ± 0.013	1.387LysAsp: 1.387 ± 0.045	1.226LysGlu: 1.226 ± 0.039	0.688LysPhe: 0.688 ± 0.027	2.404LysGly: 2.404 ± 0.047	0.466LysHis: 0.466 ± 0.017	1.332LysIle: 1.332 ± 0.037	0.918LysLys: 0.918 ± 0.035	2.523LysLeu: 2.523 ± 0.048	0.652LysMet: 0.652 ± 0.023	0.541LysAsn: 0.541 ± 0.024	1.479LysPro: 1.479 ± 0.039	0.661LysGln: 0.661 ± 0.026	1.925LysArg: 1.925 ± 0.048	1.454LysSer: 1.454 ± 0.041	1.742LysThr: 1.742 ± 0.036	1.924LysVal: 1.924 ± 0.051	0.332LysTrp: 0.332 ± 0.016	0.492LysTyr: 0.492 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.269LeuAla: 15.269 ± 0.143	1.066LeuCys: 1.066 ± 0.029	6.487LeuAsp: 6.487 ± 0.083	5.599LeuGlu: 5.599 ± 0.089	3.423LeuPhe: 3.423 ± 0.06	9.473LeuGly: 9.473 ± 0.111	1.934LeuHis: 1.934 ± 0.044	5.058LeuIle: 5.058 ± 0.073	3.018LeuLys: 3.018 ± 0.055	9.441LeuLeu: 9.441 ± 0.144	2.504LeuMet: 2.504 ± 0.045	2.262LeuAsn: 2.262 ± 0.045	6.257LeuPro: 6.257 ± 0.086	2.507LeuGln: 2.507 ± 0.042	7.849LeuArg: 7.849 ± 0.087	6.807LeuSer: 6.807 ± 0.091	6.017LeuThr: 6.017 ± 0.116	7.016LeuVal: 7.016 ± 0.09	1.318LeuTrp: 1.318 ± 0.032	1.929LeuTyr: 1.929 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.625MetAla: 3.625 ± 0.053	0.164MetCys: 0.164 ± 0.01	1.211MetAsp: 1.211 ± 0.034	1.317MetGlu: 1.317 ± 0.031	0.683MetPhe: 0.683 ± 0.024	2.118MetGly: 2.118 ± 0.038	0.438MetHis: 0.438 ± 0.02	1.328MetIle: 1.328 ± 0.029	0.889MetLys: 0.889 ± 0.029	2.521MetLeu: 2.521 ± 0.047	0.672MetMet: 0.672 ± 0.023	0.712MetAsn: 0.712 ± 0.023	1.605MetPro: 1.605 ± 0.037	0.823MetGln: 0.823 ± 0.026	2.028MetArg: 2.028 ± 0.04	1.605MetSer: 1.605 ± 0.034	2.03MetThr: 2.03 ± 0.042	1.722MetVal: 1.722 ± 0.041	0.197MetTrp: 0.197 ± 0.012	0.276MetTyr: 0.276 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.827AsnAla: 2.827 ± 0.042	0.223AsnCys: 0.223 ± 0.012	1.163AsnAsp: 1.163 ± 0.042	0.969AsnGlu: 0.969 ± 0.03	0.761AsnPhe: 0.761 ± 0.028	1.964AsnGly: 1.964 ± 0.04	0.416AsnHis: 0.416 ± 0.019	1.08AsnIle: 1.08 ± 0.031	0.464AsnLys: 0.464 ± 0.018	2.1AsnLeu: 2.1 ± 0.042	0.544AsnMet: 0.544 ± 0.019	0.464AsnAsn: 0.464 ± 0.021	1.548AsnPro: 1.548 ± 0.035	0.511AsnGln: 0.511 ± 0.02	1.796AsnArg: 1.796 ± 0.037	0.977AsnSer: 0.977 ± 0.03	0.998AsnThr: 0.998 ± 0.025	1.49AsnVal: 1.49 ± 0.035	0.384AsnTrp: 0.384 ± 0.017	0.487AsnTyr: 0.487 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.204ProAla: 7.204 ± 0.114	0.461ProCys: 0.461 ± 0.02	4.212ProAsp: 4.212 ± 0.068	4.881ProGlu: 4.881 ± 0.075	1.972ProPhe: 1.972 ± 0.039	5.693ProGly: 5.693 ± 0.085	1.103ProHis: 1.103 ± 0.03	1.936ProIle: 1.936 ± 0.045	1.446ProLys: 1.446 ± 0.037	5.187ProLeu: 5.187 ± 0.074	1.291ProMet: 1.291 ± 0.029	1.052ProAsn: 1.052 ± 0.028	2.985ProPro: 2.985 ± 0.078	1.526ProGln: 1.526 ± 0.031	3.566ProArg: 3.566 ± 0.057	2.499ProSer: 2.499 ± 0.046	2.245ProThr: 2.245 ± 0.04	4.632ProVal: 4.632 ± 0.063	0.681ProTrp: 0.681 ± 0.024	1.096ProTyr: 1.096 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.957GlnAla: 3.957 ± 0.063	0.178GlnCys: 0.178 ± 0.012	1.421GlnAsp: 1.421 ± 0.032	1.403GlnGlu: 1.403 ± 0.03	0.88GlnPhe: 0.88 ± 0.028	2.373GlnGly: 2.373 ± 0.044	0.432GlnHis: 0.432 ± 0.019	1.792GlnIle: 1.792 ± 0.037	0.885GlnLys: 0.885 ± 0.028	2.384GlnLeu: 2.384 ± 0.047	0.912GlnMet: 0.912 ± 0.027	0.713GlnAsn: 0.713 ± 0.024	1.474GlnPro: 1.474 ± 0.033	0.848GlnGln: 0.848 ± 0.027	2.102GlnArg: 2.102 ± 0.045	1.554GlnSer: 1.554 ± 0.03	1.588GlnThr: 1.588 ± 0.036	2.002GlnVal: 2.002 ± 0.038	0.335GlnTrp: 0.335 ± 0.015	0.458GlnTyr: 0.458 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.183ArgAla: 10.183 ± 0.121	0.612ArgCys: 0.612 ± 0.021	4.504ArgAsp: 4.504 ± 0.059	4.23ArgGlu: 4.23 ± 0.066	3.028ArgPhe: 3.028 ± 0.041	5.57ArgGly: 5.57 ± 0.07	1.908ArgHis: 1.908 ± 0.042	4.424ArgIle: 4.424 ± 0.054	2.301ArgLys: 2.301 ± 0.045	9.056ArgLeu: 9.056 ± 0.092	2.185ArgMet: 2.185 ± 0.04	1.798ArgAsn: 1.798 ± 0.04	4.623ArgPro: 4.623 ± 0.071	2.585ArgGln: 2.585 ± 0.048	6.768ArgArg: 6.768 ± 0.098	3.591ArgSer: 3.591 ± 0.057	3.186ArgThr: 3.186 ± 0.052	5.067ArgVal: 5.067 ± 0.073	1.052ArgTrp: 1.052 ± 0.029	1.654ArgTyr: 1.654 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.11SerAla: 6.11 ± 0.093	0.43SerCys: 0.43 ± 0.017	2.99SerAsp: 2.99 ± 0.067	2.786SerGlu: 2.786 ± 0.049	2.095SerPhe: 2.095 ± 0.041	5.505SerGly: 5.505 ± 0.1	0.996SerHis: 0.996 ± 0.023	2.15SerIle: 2.15 ± 0.043	1.232SerLys: 1.232 ± 0.039	4.897SerLeu: 4.897 ± 0.075	1.214SerMet: 1.214 ± 0.032	1.068SerAsn: 1.068 ± 0.033	2.595SerPro: 2.595 ± 0.042	1.377SerGln: 1.377 ± 0.033	3.506SerArg: 3.506 ± 0.058	2.507SerSer: 2.507 ± 0.061	2.284SerThr: 2.284 ± 0.055	3.617SerVal: 3.617 ± 0.069	0.738SerTrp: 0.738 ± 0.031	1.164SerTyr: 1.164 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.488ThrAla: 6.488 ± 0.119	0.471ThrCys: 0.471 ± 0.018	3.032ThrAsp: 3.032 ± 0.059	3.058ThrGlu: 3.058 ± 0.047	1.647ThrPhe: 1.647 ± 0.035	5.678ThrGly: 5.678 ± 0.08	0.937ThrHis: 0.937 ± 0.033	2.259ThrIle: 2.259 ± 0.045	1.067ThrLys: 1.067 ± 0.031	6.04ThrLeu: 6.04 ± 0.132	1.164ThrMet: 1.164 ± 0.031	1.034ThrAsn: 1.034 ± 0.031	3.303ThrPro: 3.303 ± 0.059	1.182ThrGln: 1.182 ± 0.033	3.774ThrArg: 3.774 ± 0.057	2.296ThrSer: 2.296 ± 0.047	2.444ThrThr: 2.444 ± 0.053	4.134ThrVal: 4.134 ± 0.084	0.608ThrTrp: 0.608 ± 0.023	1.06ThrTyr: 1.06 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.134ValAla: 9.134 ± 0.1	0.581ValCys: 0.581 ± 0.024	3.534ValAsp: 3.534 ± 0.06	4.472ValGlu: 4.472 ± 0.059	2.706ValPhe: 2.706 ± 0.044	5.11ValGly: 5.11 ± 0.083	1.236ValHis: 1.236 ± 0.03	3.62ValIle: 3.62 ± 0.056	1.719ValLys: 1.719 ± 0.042	7.705ValLeu: 7.705 ± 0.1	1.871ValMet: 1.871 ± 0.041	1.648ValAsn: 1.648 ± 0.034	3.708ValPro: 3.708 ± 0.062	1.793ValGln: 1.793 ± 0.036	4.565ValArg: 4.565 ± 0.068	4.062ValSer: 4.062 ± 0.068	4.512ValThr: 4.512 ± 0.122	4.994ValVal: 4.994 ± 0.073	0.91ValTrp: 0.91 ± 0.03	1.311ValTyr: 1.311 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.455TrpAla: 1.455 ± 0.034	0.132TrpCys: 0.132 ± 0.009	0.7TrpAsp: 0.7 ± 0.027	0.598TrpGlu: 0.598 ± 0.023	0.534TrpPhe: 0.534 ± 0.021	1.005TrpGly: 1.005 ± 0.031	0.325TrpHis: 0.325 ± 0.015	0.682TrpIle: 0.682 ± 0.024	0.437TrpLys: 0.437 ± 0.017	1.692TrpLeu: 1.692 ± 0.038	0.378TrpMet: 0.378 ± 0.014	0.31TrpAsn: 0.31 ± 0.015	0.745TrpPro: 0.745 ± 0.024	0.649TrpGln: 0.649 ± 0.024	1.282TrpArg: 1.282 ± 0.033	0.794TrpSer: 0.794 ± 0.024	0.769TrpThr: 0.769 ± 0.032	0.84TrpVal: 0.84 ± 0.027	0.2TrpTrp: 0.2 ± 0.013	0.251TrpTyr: 0.251 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.406TyrAla: 2.406 ± 0.044	0.202TyrCys: 0.202 ± 0.012	1.422TyrAsp: 1.422 ± 0.035	1.138TyrGlu: 1.138 ± 0.034	0.759TyrPhe: 0.759 ± 0.025	2.006TyrGly: 2.006 ± 0.042	0.444TyrHis: 0.444 ± 0.019	0.746TyrIle: 0.746 ± 0.024	0.451TyrLys: 0.451 ± 0.019	2.187TyrLeu: 2.187 ± 0.043	0.433TyrMet: 0.433 ± 0.02	0.494TyrAsn: 0.494 ± 0.021	0.977TyrPro: 0.977 ± 0.029	0.568TyrGln: 0.568 ± 0.021	1.714TyrArg: 1.714 ± 0.036	1.02TyrSer: 1.02 ± 0.031	0.957TyrThr: 0.957 ± 0.026	1.399TyrVal: 1.399 ± 0.036	0.294TyrTrp: 0.294 ± 0.017	0.499TyrTyr: 0.499 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4359 proteins (1350422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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