Amino acid dipepetide frequency for Streptococcus phage Javan173

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.497AlaAla: 4.497 ± 1.103
0.61AlaCys: 0.61 ± 0.272
5.031AlaAsp: 5.031 ± 0.535
6.555AlaGlu: 6.555 ± 0.84
2.592AlaPhe: 2.592 ± 0.623
6.327AlaGly: 6.327 ± 0.88
1.372AlaHis: 1.372 ± 0.414
6.937AlaIle: 6.937 ± 0.971
6.708AlaLys: 6.708 ± 0.608
7.013AlaLeu: 7.013 ± 1.048
2.744AlaMet: 2.744 ± 0.652
5.564AlaAsn: 5.564 ± 1.062
1.677AlaPro: 1.677 ± 0.36
4.192AlaGln: 4.192 ± 0.803
3.125AlaArg: 3.125 ± 0.395
4.955AlaSer: 4.955 ± 0.837
5.488AlaThr: 5.488 ± 0.701
5.717AlaVal: 5.717 ± 0.809
1.372AlaTrp: 1.372 ± 0.307
1.525AlaTyr: 1.525 ± 0.283
0.0AlaXaa: 0.0 ± 0.0
Cys
0.305CysAla: 0.305 ± 0.141
0.076CysCys: 0.076 ± 0.087
0.152CysAsp: 0.152 ± 0.108
0.152CysGlu: 0.152 ± 0.157
0.229CysPhe: 0.229 ± 0.129
0.61CysGly: 0.61 ± 0.274
0.229CysHis: 0.229 ± 0.126
0.152CysIle: 0.152 ± 0.111
0.229CysLys: 0.229 ± 0.14
0.534CysLeu: 0.534 ± 0.23
0.076CysMet: 0.076 ± 0.095
0.534CysAsn: 0.534 ± 0.156
0.229CysPro: 0.229 ± 0.158
0.305CysGln: 0.305 ± 0.13
0.229CysArg: 0.229 ± 0.159
0.152CysSer: 0.152 ± 0.111
0.229CysThr: 0.229 ± 0.124
0.152CysVal: 0.152 ± 0.115
0.076CysTrp: 0.076 ± 0.067
0.076CysTyr: 0.076 ± 0.074
0.0CysXaa: 0.0 ± 0.0
Asp
2.744AspAla: 2.744 ± 0.472
0.61AspCys: 0.61 ± 0.236
3.887AspAsp: 3.887 ± 0.557
4.878AspGlu: 4.878 ± 0.639
2.744AspPhe: 2.744 ± 0.491
5.183AspGly: 5.183 ± 0.655
0.61AspHis: 0.61 ± 0.217
4.421AspIle: 4.421 ± 0.547
4.955AspLys: 4.955 ± 0.661
5.336AspLeu: 5.336 ± 0.577
1.448AspMet: 1.448 ± 0.371
2.973AspAsn: 2.973 ± 0.48
1.372AspPro: 1.372 ± 0.334
2.134AspGln: 2.134 ± 0.36
2.592AspArg: 2.592 ± 0.695
3.125AspSer: 3.125 ± 0.573
3.43AspThr: 3.43 ± 0.485
3.964AspVal: 3.964 ± 0.601
0.991AspTrp: 0.991 ± 0.302
3.887AspTyr: 3.887 ± 0.548
0.0AspXaa: 0.0 ± 0.0
Glu
5.946GluAla: 5.946 ± 0.849
0.457GluCys: 0.457 ± 0.215
3.278GluAsp: 3.278 ± 0.518
4.955GluGlu: 4.955 ± 0.762
2.439GluPhe: 2.439 ± 0.404
3.278GluGly: 3.278 ± 0.59
1.143GluHis: 1.143 ± 0.29
4.65GluIle: 4.65 ± 0.479
5.031GluLys: 5.031 ± 0.775
8.69GluLeu: 8.69 ± 1.35
1.982GluMet: 1.982 ± 0.615
3.583GluAsn: 3.583 ± 0.479
1.906GluPro: 1.906 ± 0.324
3.735GluGln: 3.735 ± 0.533
3.811GluArg: 3.811 ± 0.585
3.049GluSer: 3.049 ± 0.458
4.116GluThr: 4.116 ± 0.685
5.26GluVal: 5.26 ± 0.658
1.372GluTrp: 1.372 ± 0.292
2.211GluTyr: 2.211 ± 0.401
0.0GluXaa: 0.0 ± 0.0
Phe
4.04PheAla: 4.04 ± 0.719
0.076PheCys: 0.076 ± 0.067
4.04PheAsp: 4.04 ± 0.48
2.973PheGlu: 2.973 ± 0.508
1.601PhePhe: 1.601 ± 0.334
3.354PheGly: 3.354 ± 0.489
0.61PheHis: 0.61 ± 0.203
1.601PheIle: 1.601 ± 0.309
2.82PheLys: 2.82 ± 0.491
2.515PheLeu: 2.515 ± 0.419
1.143PheMet: 1.143 ± 0.278
1.982PheAsn: 1.982 ± 0.408
1.448PhePro: 1.448 ± 0.338
1.22PheGln: 1.22 ± 0.344
1.753PheArg: 1.753 ± 0.382
2.363PheSer: 2.363 ± 0.347
2.592PheThr: 2.592 ± 0.436
2.439PheVal: 2.439 ± 0.44
0.457PheTrp: 0.457 ± 0.2
0.838PheTyr: 0.838 ± 0.282
0.0PheXaa: 0.0 ± 0.0
Gly
5.641GlyAla: 5.641 ± 1.071
0.305GlyCys: 0.305 ± 0.168
3.583GlyAsp: 3.583 ± 0.536
3.887GlyGlu: 3.887 ± 0.562
3.049GlyPhe: 3.049 ± 0.608
3.735GlyGly: 3.735 ± 0.777
1.525GlyHis: 1.525 ± 0.322
3.887GlyIle: 3.887 ± 0.702
6.479GlyLys: 6.479 ± 0.729
5.107GlyLeu: 5.107 ± 0.838
1.677GlyMet: 1.677 ± 0.44
2.973GlyAsn: 2.973 ± 0.457
0.915GlyPro: 0.915 ± 0.296
3.43GlyGln: 3.43 ± 0.558
3.354GlyArg: 3.354 ± 0.599
4.04GlySer: 4.04 ± 0.667
4.497GlyThr: 4.497 ± 0.639
5.183GlyVal: 5.183 ± 0.888
1.067GlyTrp: 1.067 ± 0.287
2.668GlyTyr: 2.668 ± 0.431
0.0GlyXaa: 0.0 ± 0.0
His
0.762HisAla: 0.762 ± 0.198
0.076HisCys: 0.076 ± 0.082
0.686HisAsp: 0.686 ± 0.271
0.991HisGlu: 0.991 ± 0.344
0.915HisPhe: 0.915 ± 0.315
0.61HisGly: 0.61 ± 0.195
0.61HisHis: 0.61 ± 0.22
1.143HisIle: 1.143 ± 0.328
0.686HisLys: 0.686 ± 0.282
1.067HisLeu: 1.067 ± 0.264
0.229HisMet: 0.229 ± 0.186
0.686HisAsn: 0.686 ± 0.175
0.61HisPro: 0.61 ± 0.238
0.762HisGln: 0.762 ± 0.341
0.381HisArg: 0.381 ± 0.18
1.601HisSer: 1.601 ± 0.415
1.22HisThr: 1.22 ± 0.401
0.762HisVal: 0.762 ± 0.24
0.152HisTrp: 0.152 ± 0.093
0.838HisTyr: 0.838 ± 0.261
0.0HisXaa: 0.0 ± 0.0
Ile
6.022IleAla: 6.022 ± 0.712
0.381IleCys: 0.381 ± 0.153
4.497IleAsp: 4.497 ± 0.575
5.488IleGlu: 5.488 ± 0.613
2.744IlePhe: 2.744 ± 0.438
3.43IleGly: 3.43 ± 0.579
0.915IleHis: 0.915 ± 0.306
3.278IleIle: 3.278 ± 0.53
4.421IleLys: 4.421 ± 0.494
5.183IleLeu: 5.183 ± 0.791
0.762IleMet: 0.762 ± 0.234
2.897IleAsn: 2.897 ± 0.489
2.363IlePro: 2.363 ± 0.377
2.973IleGln: 2.973 ± 0.663
2.363IleArg: 2.363 ± 0.381
4.345IleSer: 4.345 ± 0.927
4.192IleThr: 4.192 ± 0.558
3.506IleVal: 3.506 ± 0.516
0.381IleTrp: 0.381 ± 0.211
2.287IleTyr: 2.287 ± 0.579
0.0IleXaa: 0.0 ± 0.0
Lys
6.784LysAla: 6.784 ± 0.55
0.457LysCys: 0.457 ± 0.184
3.43LysAsp: 3.43 ± 0.505
5.26LysGlu: 5.26 ± 0.959
2.973LysPhe: 2.973 ± 0.395
5.183LysGly: 5.183 ± 0.565
1.143LysHis: 1.143 ± 0.262
5.031LysIle: 5.031 ± 0.574
5.412LysLys: 5.412 ± 0.947
5.869LysLeu: 5.869 ± 0.778
1.906LysMet: 1.906 ± 0.38
4.04LysAsn: 4.04 ± 0.457
2.287LysPro: 2.287 ± 0.435
3.735LysGln: 3.735 ± 0.64
3.43LysArg: 3.43 ± 0.664
4.65LysSer: 4.65 ± 0.498
4.116LysThr: 4.116 ± 0.635
4.345LysVal: 4.345 ± 0.61
0.762LysTrp: 0.762 ± 0.217
2.439LysTyr: 2.439 ± 0.598
0.0LysXaa: 0.0 ± 0.0
Leu
7.623LeuAla: 7.623 ± 0.805
0.305LeuCys: 0.305 ± 0.189
5.412LeuAsp: 5.412 ± 0.54
7.318LeuGlu: 7.318 ± 1.169
2.897LeuPhe: 2.897 ± 0.58
4.878LeuGly: 4.878 ± 0.965
0.838LeuHis: 0.838 ± 0.188
5.107LeuIle: 5.107 ± 0.874
5.793LeuLys: 5.793 ± 0.748
6.174LeuLeu: 6.174 ± 0.883
1.982LeuMet: 1.982 ± 0.386
3.887LeuAsn: 3.887 ± 0.483
3.278LeuPro: 3.278 ± 0.433
3.964LeuGln: 3.964 ± 0.655
4.269LeuArg: 4.269 ± 0.552
6.098LeuSer: 6.098 ± 0.982
4.574LeuThr: 4.574 ± 0.549
6.327LeuVal: 6.327 ± 0.548
0.686LeuTrp: 0.686 ± 0.218
2.058LeuTyr: 2.058 ± 0.371
0.0LeuXaa: 0.0 ± 0.0
Met
3.354MetAla: 3.354 ± 0.74
0.0MetCys: 0.0 ± 0.0
1.448MetAsp: 1.448 ± 0.438
1.296MetGlu: 1.296 ± 0.318
0.534MetPhe: 0.534 ± 0.218
1.372MetGly: 1.372 ± 0.279
0.229MetHis: 0.229 ± 0.124
1.448MetIle: 1.448 ± 0.328
1.296MetLys: 1.296 ± 0.341
1.372MetLeu: 1.372 ± 0.349
0.305MetMet: 0.305 ± 0.139
1.829MetAsn: 1.829 ± 0.572
0.534MetPro: 0.534 ± 0.167
1.296MetGln: 1.296 ± 0.251
1.296MetArg: 1.296 ± 0.319
1.296MetSer: 1.296 ± 0.273
2.897MetThr: 2.897 ± 0.396
2.287MetVal: 2.287 ± 0.33
0.152MetTrp: 0.152 ± 0.106
0.381MetTyr: 0.381 ± 0.168
0.0MetXaa: 0.0 ± 0.0
Asn
4.574AsnAla: 4.574 ± 0.697
0.152AsnCys: 0.152 ± 0.114
2.973AsnAsp: 2.973 ± 0.388
2.744AsnGlu: 2.744 ± 0.452
2.058AsnPhe: 2.058 ± 0.372
5.26AsnGly: 5.26 ± 0.732
0.61AsnHis: 0.61 ± 0.245
3.506AsnIle: 3.506 ± 0.439
2.973AsnLys: 2.973 ± 0.563
5.412AsnLeu: 5.412 ± 0.59
1.677AsnMet: 1.677 ± 0.409
2.668AsnAsn: 2.668 ± 0.385
1.753AsnPro: 1.753 ± 0.51
2.287AsnGln: 2.287 ± 0.442
2.287AsnArg: 2.287 ± 0.433
3.125AsnSer: 3.125 ± 0.717
2.515AsnThr: 2.515 ± 0.513
2.439AsnVal: 2.439 ± 0.371
0.762AsnTrp: 0.762 ± 0.314
1.753AsnTyr: 1.753 ± 0.431
0.0AsnXaa: 0.0 ± 0.0
Pro
2.134ProAla: 2.134 ± 0.434
0.076ProCys: 0.076 ± 0.099
2.515ProAsp: 2.515 ± 0.413
1.829ProGlu: 1.829 ± 0.414
1.22ProPhe: 1.22 ± 0.347
1.448ProGly: 1.448 ± 0.497
0.305ProHis: 0.305 ± 0.167
1.448ProIle: 1.448 ± 0.431
2.515ProLys: 2.515 ± 0.433
2.134ProLeu: 2.134 ± 0.396
0.457ProMet: 0.457 ± 0.16
2.058ProAsn: 2.058 ± 0.383
0.915ProPro: 0.915 ± 0.248
1.753ProGln: 1.753 ± 0.394
0.762ProArg: 0.762 ± 0.253
1.906ProSer: 1.906 ± 0.356
2.439ProThr: 2.439 ± 0.369
1.829ProVal: 1.829 ± 0.439
0.229ProTrp: 0.229 ± 0.164
0.61ProTyr: 0.61 ± 0.221
0.0ProXaa: 0.0 ± 0.0
Gln
4.269GlnAla: 4.269 ± 0.614
0.076GlnCys: 0.076 ± 0.075
1.829GlnAsp: 1.829 ± 0.382
3.278GlnGlu: 3.278 ± 0.614
2.592GlnPhe: 2.592 ± 0.394
2.592GlnGly: 2.592 ± 0.438
0.915GlnHis: 0.915 ± 0.339
2.973GlnIle: 2.973 ± 0.541
3.201GlnLys: 3.201 ± 0.486
3.887GlnLeu: 3.887 ± 0.614
1.753GlnMet: 1.753 ± 0.303
2.058GlnAsn: 2.058 ± 0.323
1.906GlnPro: 1.906 ± 0.603
2.744GlnGln: 2.744 ± 0.636
2.287GlnArg: 2.287 ± 0.406
3.735GlnSer: 3.735 ± 0.564
4.04GlnThr: 4.04 ± 0.689
2.592GlnVal: 2.592 ± 0.39
0.457GlnTrp: 0.457 ± 0.21
0.838GlnTyr: 0.838 ± 0.237
0.0GlnXaa: 0.0 ± 0.0
Arg
4.269ArgAla: 4.269 ± 0.48
0.305ArgCys: 0.305 ± 0.17
1.677ArgAsp: 1.677 ± 0.314
3.354ArgGlu: 3.354 ± 0.483
1.753ArgPhe: 1.753 ± 0.384
2.363ArgGly: 2.363 ± 0.414
0.838ArgHis: 0.838 ± 0.236
2.439ArgIle: 2.439 ± 0.454
3.583ArgLys: 3.583 ± 0.653
4.65ArgLeu: 4.65 ± 0.643
1.296ArgMet: 1.296 ± 0.333
1.296ArgAsn: 1.296 ± 0.299
0.991ArgPro: 0.991 ± 0.39
1.982ArgGln: 1.982 ± 0.319
2.134ArgArg: 2.134 ± 0.475
2.363ArgSer: 2.363 ± 0.462
2.744ArgThr: 2.744 ± 0.567
3.049ArgVal: 3.049 ± 0.495
0.229ArgTrp: 0.229 ± 0.152
2.058ArgTyr: 2.058 ± 0.482
0.0ArgXaa: 0.0 ± 0.0
Ser
6.555SerAla: 6.555 ± 1.815
0.0SerCys: 0.0 ± 0.0
3.735SerAsp: 3.735 ± 0.624
3.506SerGlu: 3.506 ± 0.506
2.439SerPhe: 2.439 ± 0.397
5.641SerGly: 5.641 ± 0.865
0.838SerHis: 0.838 ± 0.31
4.269SerIle: 4.269 ± 0.541
4.345SerLys: 4.345 ± 0.561
4.802SerLeu: 4.802 ± 0.775
1.525SerMet: 1.525 ± 0.277
2.439SerAsn: 2.439 ± 0.478
1.601SerPro: 1.601 ± 0.406
3.735SerGln: 3.735 ± 0.598
2.211SerArg: 2.211 ± 0.507
3.735SerSer: 3.735 ± 0.884
4.269SerThr: 4.269 ± 0.729
5.564SerVal: 5.564 ± 0.981
0.457SerTrp: 0.457 ± 0.18
2.134SerTyr: 2.134 ± 0.496
0.0SerXaa: 0.0 ± 0.0
Thr
6.86ThrAla: 6.86 ± 0.752
0.305ThrCys: 0.305 ± 0.137
4.574ThrAsp: 4.574 ± 0.562
4.04ThrGlu: 4.04 ± 0.612
2.744ThrPhe: 2.744 ± 0.582
5.26ThrGly: 5.26 ± 0.749
0.762ThrHis: 0.762 ± 0.247
4.878ThrIle: 4.878 ± 0.555
4.192ThrLys: 4.192 ± 0.63
4.04ThrLeu: 4.04 ± 0.452
1.372ThrMet: 1.372 ± 0.387
3.049ThrAsn: 3.049 ± 0.402
2.363ThrPro: 2.363 ± 0.463
2.363ThrGln: 2.363 ± 0.376
1.982ThrArg: 1.982 ± 0.453
4.574ThrSer: 4.574 ± 0.759
4.802ThrThr: 4.802 ± 0.625
5.641ThrVal: 5.641 ± 0.669
0.457ThrTrp: 0.457 ± 0.213
2.211ThrTyr: 2.211 ± 0.594
0.0ThrXaa: 0.0 ± 0.0
Val
4.269ValAla: 4.269 ± 0.547
0.305ValCys: 0.305 ± 0.182
5.336ValAsp: 5.336 ± 0.784
5.717ValGlu: 5.717 ± 0.767
2.592ValPhe: 2.592 ± 0.469
3.735ValGly: 3.735 ± 0.702
0.762ValHis: 0.762 ± 0.235
3.43ValIle: 3.43 ± 0.582
5.107ValLys: 5.107 ± 0.56
5.412ValLeu: 5.412 ± 0.754
1.143ValMet: 1.143 ± 0.331
4.878ValAsn: 4.878 ± 0.82
1.296ValPro: 1.296 ± 0.262
2.82ValGln: 2.82 ± 0.457
2.973ValArg: 2.973 ± 0.533
5.412ValSer: 5.412 ± 0.781
6.022ValThr: 6.022 ± 0.775
4.421ValVal: 4.421 ± 0.673
0.534ValTrp: 0.534 ± 0.173
2.058ValTyr: 2.058 ± 0.463
0.0ValXaa: 0.0 ± 0.0
Trp
1.067TrpAla: 1.067 ± 0.29
0.0TrpCys: 0.0 ± 0.0
0.915TrpAsp: 0.915 ± 0.329
0.686TrpGlu: 0.686 ± 0.218
0.457TrpPhe: 0.457 ± 0.178
0.61TrpGly: 0.61 ± 0.272
0.152TrpHis: 0.152 ± 0.102
0.381TrpIle: 0.381 ± 0.232
0.457TrpLys: 0.457 ± 0.163
1.372TrpLeu: 1.372 ± 0.289
0.229TrpMet: 0.229 ± 0.124
0.838TrpAsn: 0.838 ± 0.25
0.076TrpPro: 0.076 ± 0.073
0.305TrpGln: 0.305 ± 0.145
0.686TrpArg: 0.686 ± 0.255
1.22TrpSer: 1.22 ± 0.347
0.381TrpThr: 0.381 ± 0.169
0.838TrpVal: 0.838 ± 0.222
0.0TrpTrp: 0.0 ± 0.0
0.229TrpTyr: 0.229 ± 0.122
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.287TyrAla: 2.287 ± 0.504
0.152TyrCys: 0.152 ± 0.087
2.287TyrAsp: 2.287 ± 0.514
1.982TyrGlu: 1.982 ± 0.384
1.296TyrPhe: 1.296 ± 0.299
2.134TyrGly: 2.134 ± 0.387
0.381TyrHis: 0.381 ± 0.171
1.448TyrIle: 1.448 ± 0.313
3.049TyrLys: 3.049 ± 0.64
2.897TyrLeu: 2.897 ± 0.462
0.838TyrMet: 0.838 ± 0.239
1.296TyrAsn: 1.296 ± 0.325
1.067TyrPro: 1.067 ± 0.347
2.287TyrGln: 2.287 ± 0.646
1.448TyrArg: 1.448 ± 0.351
2.058TyrSer: 2.058 ± 0.366
1.906TyrThr: 1.906 ± 0.486
1.982TyrVal: 1.982 ± 0.401
0.305TyrTrp: 0.305 ± 0.138
1.677TyrTyr: 1.677 ± 0.359
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (13120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski