Amino acid dipepetide frequency for Hwanghaeicola aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.75AlaAla: 17.75 ± 0.173	1.137AlaCys: 1.137 ± 0.031	7.038AlaAsp: 7.038 ± 0.076	8.984AlaGlu: 8.984 ± 0.103	4.514AlaPhe: 4.514 ± 0.069	11.212AlaGly: 11.212 ± 0.102	2.257AlaHis: 2.257 ± 0.049	6.835AlaIle: 6.835 ± 0.077	2.807AlaLys: 2.807 ± 0.056	14.097AlaLeu: 14.097 ± 0.128	3.84AlaMet: 3.84 ± 0.06	2.428AlaAsn: 2.428 ± 0.045	6.182AlaPro: 6.182 ± 0.078	3.741AlaGln: 3.741 ± 0.059	10.219AlaArg: 10.219 ± 0.131	6.051AlaSer: 6.051 ± 0.076	6.45AlaThr: 6.45 ± 0.079	8.444AlaVal: 8.444 ± 0.084	1.642AlaTrp: 1.642 ± 0.037	2.442AlaTyr: 2.442 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.064CysAla: 1.064 ± 0.028	0.09CysCys: 0.09 ± 0.01	0.615CysAsp: 0.615 ± 0.024	0.422CysGlu: 0.422 ± 0.02	0.325CysPhe: 0.325 ± 0.014	0.896CysGly: 0.896 ± 0.031	0.244CysHis: 0.244 ± 0.013	0.391CysIle: 0.391 ± 0.017	0.133CysLys: 0.133 ± 0.009	0.949CysLeu: 0.949 ± 0.031	0.157CysMet: 0.157 ± 0.011	0.201CysAsn: 0.201 ± 0.013	0.487CysPro: 0.487 ± 0.021	0.171CysGln: 0.171 ± 0.011	0.672CysArg: 0.672 ± 0.021	0.402CysSer: 0.402 ± 0.015	0.414CysThr: 0.414 ± 0.019	0.6CysVal: 0.6 ± 0.02	0.115CysTrp: 0.115 ± 0.009	0.195CysTyr: 0.195 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.295AspAla: 8.295 ± 0.084	0.529AspCys: 0.529 ± 0.022	3.531AspAsp: 3.531 ± 0.066	3.706AspGlu: 3.706 ± 0.063	2.247AspPhe: 2.247 ± 0.041	6.153AspGly: 6.153 ± 0.089	1.31AspHis: 1.31 ± 0.034	2.915AspIle: 2.915 ± 0.048	1.019AspLys: 1.019 ± 0.03	6.784AspLeu: 6.784 ± 0.078	1.536AspMet: 1.536 ± 0.035	1.041AspAsn: 1.041 ± 0.03	4.295AspPro: 4.295 ± 0.067	1.525AspGln: 1.525 ± 0.037	5.331AspArg: 5.331 ± 0.07	1.797AspSer: 1.797 ± 0.038	2.919AspThr: 2.919 ± 0.057	4.338AspVal: 4.338 ± 0.061	1.222AspTrp: 1.222 ± 0.033	1.415AspTyr: 1.415 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.914GluAla: 8.914 ± 0.109	0.352GluCys: 0.352 ± 0.016	3.406GluAsp: 3.406 ± 0.051	4.188GluGlu: 4.188 ± 0.065	1.689GluPhe: 1.689 ± 0.039	5.331GluGly: 5.331 ± 0.081	1.112GluHis: 1.112 ± 0.027	4.258GluIle: 4.258 ± 0.059	1.706GluLys: 1.706 ± 0.042	4.998GluLeu: 4.998 ± 0.068	1.903GluMet: 1.903 ± 0.039	1.587GluAsn: 1.587 ± 0.037	2.85GluPro: 2.85 ± 0.048	1.712GluGln: 1.712 ± 0.038	5.316GluArg: 5.316 ± 0.072	2.257GluSer: 2.257 ± 0.044	4.386GluThr: 4.386 ± 0.061	4.231GluVal: 4.231 ± 0.055	0.754GluTrp: 0.754 ± 0.028	1.054GluTyr: 1.054 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.632PheAla: 4.632 ± 0.064	0.391PheCys: 0.391 ± 0.016	2.858PheAsp: 2.858 ± 0.051	2.212PheGlu: 2.212 ± 0.04	1.34PhePhe: 1.34 ± 0.042	3.664PheGly: 3.664 ± 0.054	0.729PheHis: 0.729 ± 0.021	1.357PheIle: 1.357 ± 0.037	0.592PheLys: 0.592 ± 0.025	3.591PheLeu: 3.591 ± 0.069	0.722PheMet: 0.722 ± 0.024	0.801PheAsn: 0.801 ± 0.026	1.574PhePro: 1.574 ± 0.035	0.898PheGln: 0.898 ± 0.026	2.29PheArg: 2.29 ± 0.04	2.018PheSer: 2.018 ± 0.038	2.032PheThr: 2.032 ± 0.037	2.919PheVal: 2.919 ± 0.04	0.564PheTrp: 0.564 ± 0.024	0.853PheTyr: 0.853 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.484GlyAla: 10.484 ± 0.087	0.842GlyCys: 0.842 ± 0.027	4.951GlyAsp: 4.951 ± 0.071	5.235GlyGlu: 5.235 ± 0.078	3.526GlyPhe: 3.526 ± 0.05	8.006GlyGly: 8.006 ± 0.107	1.939GlyHis: 1.939 ± 0.04	5.031GlyIle: 5.031 ± 0.062	2.421GlyLys: 2.421 ± 0.05	9.576GlyLeu: 9.576 ± 0.096	2.516GlyMet: 2.516 ± 0.046	1.933GlyAsn: 1.933 ± 0.044	4.147GlyPro: 4.147 ± 0.065	2.829GlyGln: 2.829 ± 0.05	7.174GlyArg: 7.174 ± 0.085	4.542GlySer: 4.542 ± 0.064	5.171GlyThr: 5.171 ± 0.074	6.144GlyVal: 6.144 ± 0.066	1.483GlyTrp: 1.483 ± 0.035	2.227GlyTyr: 2.227 ± 0.043	0.001GlyXaa: 0.001 ± 0.001
His	2.428HisAla: 2.428 ± 0.051	0.222HisCys: 0.222 ± 0.014	1.342HisAsp: 1.342 ± 0.034	1.113HisGlu: 1.113 ± 0.032	0.74HisPhe: 0.74 ± 0.021	1.932HisGly: 1.932 ± 0.044	0.556HisHis: 0.556 ± 0.024	0.804HisIle: 0.804 ± 0.025	0.34HisLys: 0.34 ± 0.016	2.109HisLeu: 2.109 ± 0.046	0.471HisMet: 0.471 ± 0.017	0.364HisAsn: 0.364 ± 0.017	1.381HisPro: 1.381 ± 0.035	0.463HisGln: 0.463 ± 0.02	1.48HisArg: 1.48 ± 0.037	0.823HisSer: 0.823 ± 0.025	0.739HisThr: 0.739 ± 0.024	1.589HisVal: 1.589 ± 0.037	0.322HisTrp: 0.322 ± 0.014	0.505HisTyr: 0.505 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.54IleAla: 7.54 ± 0.089	0.554IleCys: 0.554 ± 0.023	3.686IleAsp: 3.686 ± 0.06	3.586IleGlu: 3.586 ± 0.05	1.768IlePhe: 1.768 ± 0.04	5.07IleGly: 5.07 ± 0.069	0.909IleHis: 0.909 ± 0.026	1.766IleIle: 1.766 ± 0.046	0.91IleLys: 0.91 ± 0.029	5.101IleLeu: 5.101 ± 0.071	0.969IleMet: 0.969 ± 0.027	1.066IleAsn: 1.066 ± 0.03	2.394IlePro: 2.394 ± 0.046	0.981IleGln: 0.981 ± 0.03	3.577IleArg: 3.577 ± 0.053	2.732IleSer: 2.732 ± 0.048	2.663IleThr: 2.663 ± 0.047	4.54IleVal: 4.54 ± 0.061	0.683IleTrp: 0.683 ± 0.024	1.113IleTyr: 1.113 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.849LysAla: 2.849 ± 0.059	0.129LysCys: 0.129 ± 0.009	1.229LysAsp: 1.229 ± 0.032	1.177LysGlu: 1.177 ± 0.03	0.676LysPhe: 0.676 ± 0.024	1.933LysGly: 1.933 ± 0.048	0.396LysHis: 0.396 ± 0.018	1.251LysIle: 1.251 ± 0.035	0.784LysLys: 0.784 ± 0.03	2.262LysLeu: 2.262 ± 0.043	0.654LysMet: 0.654 ± 0.02	0.545LysAsn: 0.545 ± 0.021	1.28LysPro: 1.28 ± 0.033	0.594LysGln: 0.594 ± 0.024	1.914LysArg: 1.914 ± 0.04	1.446LysSer: 1.446 ± 0.036	1.422LysThr: 1.422 ± 0.034	1.735LysVal: 1.735 ± 0.042	0.259LysTrp: 0.259 ± 0.014	0.416LysTyr: 0.416 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.679LeuAla: 13.679 ± 0.12	0.948LeuCys: 0.948 ± 0.029	6.81LeuAsp: 6.81 ± 0.087	5.35LeuGlu: 5.35 ± 0.076	3.511LeuPhe: 3.511 ± 0.063	9.087LeuGly: 9.087 ± 0.085	1.913LeuHis: 1.913 ± 0.042	4.538LeuIle: 4.538 ± 0.064	2.418LeuLys: 2.418 ± 0.05	9.36LeuLeu: 9.36 ± 0.119	2.386LeuMet: 2.386 ± 0.05	2.264LeuAsn: 2.264 ± 0.046	5.66LeuPro: 5.66 ± 0.082	2.322LeuGln: 2.322 ± 0.044	7.525LeuArg: 7.525 ± 0.09	6.616LeuSer: 6.616 ± 0.067	5.532LeuThr: 5.532 ± 0.069	7.594LeuVal: 7.594 ± 0.084	1.292LeuTrp: 1.292 ± 0.035	2.05LeuTyr: 2.05 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.397MetAla: 3.397 ± 0.058	0.148MetCys: 0.148 ± 0.01	1.262MetAsp: 1.262 ± 0.03	1.395MetGlu: 1.395 ± 0.032	0.728MetPhe: 0.728 ± 0.021	2.223MetGly: 2.223 ± 0.043	0.422MetHis: 0.422 ± 0.015	1.47MetIle: 1.47 ± 0.033	0.847MetLys: 0.847 ± 0.027	2.33MetLeu: 2.33 ± 0.042	0.71MetMet: 0.71 ± 0.027	0.772MetAsn: 0.772 ± 0.025	1.568MetPro: 1.568 ± 0.031	0.787MetGln: 0.787 ± 0.025	2.056MetArg: 2.056 ± 0.04	1.798MetSer: 1.798 ± 0.037	1.973MetThr: 1.973 ± 0.039	1.668MetVal: 1.668 ± 0.038	0.231MetTrp: 0.231 ± 0.012	0.303MetTyr: 0.303 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.903AsnAla: 2.903 ± 0.053	0.219AsnCys: 0.219 ± 0.014	1.28AsnAsp: 1.28 ± 0.036	1.084AsnGlu: 1.084 ± 0.032	0.823AsnPhe: 0.823 ± 0.025	2.097AsnGly: 2.097 ± 0.044	0.414AsnHis: 0.414 ± 0.018	1.083AsnIle: 1.083 ± 0.034	0.395AsnLys: 0.395 ± 0.018	2.303AsnLeu: 2.303 ± 0.046	0.574AsnMet: 0.574 ± 0.02	0.501AsnAsn: 0.501 ± 0.021	1.607AsnPro: 1.607 ± 0.038	0.573AsnGln: 0.573 ± 0.022	1.63AsnArg: 1.63 ± 0.033	1.021AsnSer: 1.021 ± 0.03	1.069AsnThr: 1.069 ± 0.03	1.755AsnVal: 1.755 ± 0.044	0.372AsnTrp: 0.372 ± 0.018	0.545AsnTyr: 0.545 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.042ProAla: 6.042 ± 0.071	0.387ProCys: 0.387 ± 0.015	4.375ProAsp: 4.375 ± 0.068	4.323ProGlu: 4.323 ± 0.056	2.046ProPhe: 2.046 ± 0.04	5.127ProGly: 5.127 ± 0.057	1.095ProHis: 1.095 ± 0.03	2.343ProIle: 2.343 ± 0.046	1.233ProLys: 1.233 ± 0.033	4.708ProLeu: 4.708 ± 0.067	1.268ProMet: 1.268 ± 0.033	1.2ProAsn: 1.2 ± 0.037	2.702ProPro: 2.702 ± 0.058	1.373ProGln: 1.373 ± 0.034	3.324ProArg: 3.324 ± 0.059	2.762ProSer: 2.762 ± 0.051	2.469ProThr: 2.469 ± 0.05	4.295ProVal: 4.295 ± 0.059	0.715ProTrp: 0.715 ± 0.025	1.126ProTyr: 1.126 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.367GlnAla: 3.367 ± 0.064	0.155GlnCys: 0.155 ± 0.011	1.46GlnAsp: 1.46 ± 0.035	1.451GlnGlu: 1.451 ± 0.034	0.885GlnPhe: 0.885 ± 0.028	2.31GlnGly: 2.31 ± 0.044	0.448GlnHis: 0.448 ± 0.018	1.783GlnIle: 1.783 ± 0.035	0.777GlnLys: 0.777 ± 0.024	2.276GlnLeu: 2.276 ± 0.046	0.872GlnMet: 0.872 ± 0.024	0.78GlnAsn: 0.78 ± 0.028	1.263GlnPro: 1.263 ± 0.032	0.835GlnGln: 0.835 ± 0.036	2.009GlnArg: 2.009 ± 0.04	1.736GlnSer: 1.736 ± 0.044	1.608GlnThr: 1.608 ± 0.035	1.977GlnVal: 1.977 ± 0.037	0.322GlnTrp: 0.322 ± 0.014	0.51GlnTyr: 0.51 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.149ArgAla: 9.149 ± 0.114	0.586ArgCys: 0.586 ± 0.022	5.098ArgAsp: 5.098 ± 0.07	4.616ArgGlu: 4.616 ± 0.067	2.862ArgPhe: 2.862 ± 0.041	5.483ArgGly: 5.483 ± 0.064	1.811ArgHis: 1.811 ± 0.043	4.639ArgIle: 4.639 ± 0.064	1.907ArgLys: 1.907 ± 0.041	8.179ArgLeu: 8.179 ± 0.092	2.193ArgMet: 2.193 ± 0.036	1.721ArgAsn: 1.721 ± 0.042	4.025ArgPro: 4.025 ± 0.066	2.336ArgGln: 2.336 ± 0.042	6.643ArgArg: 6.643 ± 0.099	3.923ArgSer: 3.923 ± 0.061	3.702ArgThr: 3.702 ± 0.055	5.133ArgVal: 5.133 ± 0.073	0.977ArgTrp: 0.977 ± 0.029	1.635ArgTyr: 1.635 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.892SerAla: 5.892 ± 0.068	0.437SerCys: 0.437 ± 0.02	3.422SerAsp: 3.422 ± 0.06	3.145SerGlu: 3.145 ± 0.052	2.122SerPhe: 2.122 ± 0.04	5.485SerGly: 5.485 ± 0.066	1.036SerHis: 1.036 ± 0.029	2.539SerIle: 2.539 ± 0.047	1.198SerLys: 1.198 ± 0.037	4.994SerLeu: 4.994 ± 0.063	1.291SerMet: 1.291 ± 0.03	1.284SerAsn: 1.284 ± 0.034	2.538SerPro: 2.538 ± 0.041	1.42SerGln: 1.42 ± 0.038	3.712SerArg: 3.712 ± 0.053	2.702SerSer: 2.702 ± 0.051	2.512SerThr: 2.512 ± 0.038	3.817SerVal: 3.817 ± 0.051	0.727SerTrp: 0.727 ± 0.027	1.231SerTyr: 1.231 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.349ThrAla: 6.349 ± 0.086	0.459ThrCys: 0.459 ± 0.018	3.244ThrAsp: 3.244 ± 0.055	3.188ThrGlu: 3.188 ± 0.05	2.088ThrPhe: 2.088 ± 0.043	5.622ThrGly: 5.622 ± 0.072	1.061ThrHis: 1.061 ± 0.032	2.975ThrIle: 2.975 ± 0.052	1.126ThrLys: 1.126 ± 0.034	6.06ThrLeu: 6.06 ± 0.07	1.27ThrMet: 1.27 ± 0.031	1.163ThrAsn: 1.163 ± 0.03	3.245ThrPro: 3.245 ± 0.049	1.342ThrGln: 1.342 ± 0.035	3.834ThrArg: 3.834 ± 0.052	2.801ThrSer: 2.801 ± 0.045	2.723ThrThr: 2.723 ± 0.054	3.89ThrVal: 3.89 ± 0.062	0.689ThrTrp: 0.689 ± 0.023	1.185ThrTyr: 1.185 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.447ValAla: 9.447 ± 0.098	0.619ValCys: 0.619 ± 0.022	4.019ValAsp: 4.019 ± 0.048	4.931ValGlu: 4.931 ± 0.077	2.759ValPhe: 2.759 ± 0.057	5.486ValGly: 5.486 ± 0.071	1.327ValHis: 1.327 ± 0.034	4.018ValIle: 4.018 ± 0.063	1.575ValLys: 1.575 ± 0.04	7.375ValLeu: 7.375 ± 0.083	1.924ValMet: 1.924 ± 0.042	1.665ValAsn: 1.665 ± 0.04	3.926ValPro: 3.926 ± 0.053	1.778ValGln: 1.778 ± 0.037	4.953ValArg: 4.953 ± 0.066	4.145ValSer: 4.145 ± 0.05	4.656ValThr: 4.656 ± 0.078	5.757ValVal: 5.757 ± 0.077	0.957ValTrp: 0.957 ± 0.028	1.399ValTyr: 1.399 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.284TrpAla: 1.284 ± 0.036	0.136TrpCys: 0.136 ± 0.01	0.731TrpAsp: 0.731 ± 0.023	0.665TrpGlu: 0.665 ± 0.023	0.547TrpPhe: 0.547 ± 0.021	1.015TrpGly: 1.015 ± 0.026	0.301TrpHis: 0.301 ± 0.016	0.789TrpIle: 0.789 ± 0.025	0.363TrpLys: 0.363 ± 0.017	1.579TrpLeu: 1.579 ± 0.042	0.393TrpMet: 0.393 ± 0.014	0.423TrpAsn: 0.423 ± 0.017	0.719TrpPro: 0.719 ± 0.026	0.56TrpGln: 0.56 ± 0.017	1.273TrpArg: 1.273 ± 0.034	0.917TrpSer: 0.917 ± 0.028	0.854TrpThr: 0.854 ± 0.029	0.828TrpVal: 0.828 ± 0.028	0.227TrpTrp: 0.227 ± 0.013	0.276TrpTyr: 0.276 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.605TyrAla: 2.605 ± 0.049	0.201TyrCys: 0.201 ± 0.012	1.552TyrAsp: 1.552 ± 0.037	1.235TyrGlu: 1.235 ± 0.033	0.84TyrPhe: 0.84 ± 0.025	2.048TyrGly: 2.048 ± 0.039	0.444TyrHis: 0.444 ± 0.019	0.823TyrIle: 0.823 ± 0.025	0.401TyrLys: 0.401 ± 0.02	2.227TyrLeu: 2.227 ± 0.038	0.437TyrMet: 0.437 ± 0.02	0.51TyrAsn: 0.51 ± 0.019	1.069TyrPro: 1.069 ± 0.027	0.582TyrGln: 0.582 ± 0.024	1.683TyrArg: 1.683 ± 0.035	1.016TyrSer: 1.016 ± 0.033	1.018TyrThr: 1.018 ± 0.031	1.462TyrVal: 1.462 ± 0.03	0.328TyrTrp: 0.328 ± 0.019	0.521TyrTyr: 0.521 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4336 proteins (1340171 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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