Amino acid dipepetide frequency for Paracoccus sphaerophysae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.327AlaAla: 23.327 ± 0.291	1.121AlaCys: 1.121 ± 0.041	8.319AlaAsp: 8.319 ± 0.111	9.062AlaGlu: 9.062 ± 0.119	4.062AlaPhe: 4.062 ± 0.086	12.82AlaGly: 12.82 ± 0.153	2.454AlaHis: 2.454 ± 0.053	6.149AlaIle: 6.149 ± 0.09	2.956AlaLys: 2.956 ± 0.067	15.441AlaLeu: 15.441 ± 0.161	4.223AlaMet: 4.223 ± 0.084	2.462AlaAsn: 2.462 ± 0.056	7.029AlaPro: 7.029 ± 0.118	4.665AlaGln: 4.665 ± 0.077	11.24AlaArg: 11.24 ± 0.129	5.255AlaSer: 5.255 ± 0.076	6.675AlaThr: 6.675 ± 0.097	9.668AlaVal: 9.668 ± 0.154	1.778AlaTrp: 1.778 ± 0.048	2.349AlaTyr: 2.349 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.03CysAla: 1.03 ± 0.034	0.093CysCys: 0.093 ± 0.01	0.582CysAsp: 0.582 ± 0.03	0.353CysGlu: 0.353 ± 0.024	0.291CysPhe: 0.291 ± 0.018	0.878CysGly: 0.878 ± 0.036	0.25CysHis: 0.25 ± 0.019	0.374CysIle: 0.374 ± 0.023	0.143CysLys: 0.143 ± 0.015	0.78CysLeu: 0.78 ± 0.033	0.14CysMet: 0.14 ± 0.013	0.162CysAsn: 0.162 ± 0.014	0.524CysPro: 0.524 ± 0.025	0.2CysGln: 0.2 ± 0.016	0.582CysArg: 0.582 ± 0.027	0.345CysSer: 0.345 ± 0.022	0.368CysThr: 0.368 ± 0.022	0.562CysVal: 0.562 ± 0.026	0.124CysTrp: 0.124 ± 0.014	0.154CysTyr: 0.154 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.05AspAla: 8.05 ± 0.096	0.491AspCys: 0.491 ± 0.029	3.484AspAsp: 3.484 ± 0.081	3.578AspGlu: 3.578 ± 0.079	2.208AspPhe: 2.208 ± 0.053	5.873AspGly: 5.873 ± 0.1	1.396AspHis: 1.396 ± 0.043	2.546AspIle: 2.546 ± 0.06	1.44AspLys: 1.44 ± 0.042	6.46AspLeu: 6.46 ± 0.103	1.46AspMet: 1.46 ± 0.041	1.136AspAsn: 1.136 ± 0.039	4.232AspPro: 4.232 ± 0.076	1.945AspGln: 1.945 ± 0.049	5.604AspArg: 5.604 ± 0.095	2.227AspSer: 2.227 ± 0.049	2.702AspThr: 2.702 ± 0.058	3.752AspVal: 3.752 ± 0.071	1.267AspTrp: 1.267 ± 0.046	1.461AspTyr: 1.461 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.884GluAla: 7.884 ± 0.127	0.298GluCys: 0.298 ± 0.021	2.863GluAsp: 2.863 ± 0.065	2.437GluGlu: 2.437 ± 0.073	1.593GluPhe: 1.593 ± 0.044	4.8GluGly: 4.8 ± 0.092	0.945GluHis: 0.945 ± 0.04	3.323GluIle: 3.323 ± 0.068	1.616GluLys: 1.616 ± 0.049	5.025GluLeu: 5.025 ± 0.08	1.598GluMet: 1.598 ± 0.048	1.355GluAsn: 1.355 ± 0.042	2.593GluPro: 2.593 ± 0.064	1.636GluGln: 1.636 ± 0.048	4.249GluArg: 4.249 ± 0.077	2.029GluSer: 2.029 ± 0.056	3.375GluThr: 3.375 ± 0.067	4.0GluVal: 4.0 ± 0.072	0.643GluTrp: 0.643 ± 0.031	0.896GluTyr: 0.896 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.559PheAla: 4.559 ± 0.075	0.359PheCys: 0.359 ± 0.022	2.604PheAsp: 2.604 ± 0.061	1.678PheGlu: 1.678 ± 0.053	1.165PhePhe: 1.165 ± 0.048	3.465PheGly: 3.465 ± 0.071	0.682PheHis: 0.682 ± 0.031	1.327PheIle: 1.327 ± 0.04	0.688PheLys: 0.688 ± 0.028	3.166PheLeu: 3.166 ± 0.073	0.744PheMet: 0.744 ± 0.029	0.802PheAsn: 0.802 ± 0.033	1.459PhePro: 1.459 ± 0.043	0.939PheGln: 0.939 ± 0.035	2.335PheArg: 2.335 ± 0.06	1.723PheSer: 1.723 ± 0.043	1.825PheThr: 1.825 ± 0.044	2.482PheVal: 2.482 ± 0.058	0.559PheTrp: 0.559 ± 0.029	0.768PheTyr: 0.768 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.391GlyAla: 11.391 ± 0.159	0.831GlyCys: 0.831 ± 0.035	5.151GlyAsp: 5.151 ± 0.088	4.738GlyGlu: 4.738 ± 0.087	3.58GlyPhe: 3.58 ± 0.071	8.133GlyGly: 8.133 ± 0.131	1.963GlyHis: 1.963 ± 0.054	4.509GlyIle: 4.509 ± 0.086	2.957GlyLys: 2.957 ± 0.069	9.593GlyLeu: 9.593 ± 0.117	2.781GlyMet: 2.781 ± 0.054	2.052GlyAsn: 2.052 ± 0.053	4.125GlyPro: 4.125 ± 0.076	3.23GlyGln: 3.23 ± 0.075	7.264GlyArg: 7.264 ± 0.106	4.191GlySer: 4.191 ± 0.077	4.987GlyThr: 4.987 ± 0.088	6.767GlyVal: 6.767 ± 0.095	1.719GlyTrp: 1.719 ± 0.053	2.12GlyTyr: 2.12 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.522HisAla: 2.522 ± 0.062	0.2HisCys: 0.2 ± 0.016	1.385HisAsp: 1.385 ± 0.042	0.979HisGlu: 0.979 ± 0.034	0.748HisPhe: 0.748 ± 0.029	2.139HisGly: 2.139 ± 0.052	0.563HisHis: 0.563 ± 0.028	0.76HisIle: 0.76 ± 0.029	0.401HisLys: 0.401 ± 0.022	2.085HisLeu: 2.085 ± 0.049	0.51HisMet: 0.51 ± 0.021	0.379HisAsn: 0.379 ± 0.022	1.481HisPro: 1.481 ± 0.041	0.517HisGln: 0.517 ± 0.028	1.478HisArg: 1.478 ± 0.048	0.715HisSer: 0.715 ± 0.03	0.713HisThr: 0.713 ± 0.03	1.559HisVal: 1.559 ± 0.046	0.346HisTrp: 0.346 ± 0.019	0.498HisTyr: 0.498 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.358IleAla: 7.358 ± 0.105	0.47IleCys: 0.47 ± 0.021	3.401IleAsp: 3.401 ± 0.064	3.118IleGlu: 3.118 ± 0.06	1.43IlePhe: 1.43 ± 0.046	4.711IleGly: 4.711 ± 0.096	0.924IleHis: 0.924 ± 0.035	1.84IleIle: 1.84 ± 0.059	1.072IleLys: 1.072 ± 0.04	4.38IleLeu: 4.38 ± 0.077	0.969IleMet: 0.969 ± 0.039	1.097IleAsn: 1.097 ± 0.036	2.386IlePro: 2.386 ± 0.055	0.996IleGln: 0.996 ± 0.032	3.668IleArg: 3.668 ± 0.073	2.337IleSer: 2.337 ± 0.053	2.543IleThr: 2.543 ± 0.058	3.721IleVal: 3.721 ± 0.076	0.627IleTrp: 0.627 ± 0.03	0.908IleTyr: 0.908 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.386LysAla: 3.386 ± 0.083	0.128LysCys: 0.128 ± 0.012	1.417LysAsp: 1.417 ± 0.051	1.078LysGlu: 1.078 ± 0.041	0.713LysPhe: 0.713 ± 0.027	2.335LysGly: 2.335 ± 0.066	0.455LysHis: 0.455 ± 0.025	1.177LysIle: 1.177 ± 0.044	0.839LysLys: 0.839 ± 0.039	2.428LysLeu: 2.428 ± 0.057	0.643LysMet: 0.643 ± 0.029	0.581LysAsn: 0.581 ± 0.03	1.494LysPro: 1.494 ± 0.046	0.672LysGln: 0.672 ± 0.03	1.708LysArg: 1.708 ± 0.052	1.374LysSer: 1.374 ± 0.046	1.47LysThr: 1.47 ± 0.043	1.903LysVal: 1.903 ± 0.055	0.322LysTrp: 0.322 ± 0.018	0.517LysTyr: 0.517 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	15.291LeuAla: 15.291 ± 0.174	0.786LeuCys: 0.786 ± 0.031	6.512LeuAsp: 6.512 ± 0.094	4.155LeuGlu: 4.155 ± 0.068	3.187LeuPhe: 3.187 ± 0.066	8.969LeuGly: 8.969 ± 0.102	1.81LeuHis: 1.81 ± 0.047	5.272LeuIle: 5.272 ± 0.085	2.487LeuLys: 2.487 ± 0.067	8.563LeuLeu: 8.563 ± 0.154	2.674LeuMet: 2.674 ± 0.063	2.368LeuAsn: 2.368 ± 0.053	6.078LeuPro: 6.078 ± 0.091	2.35LeuGln: 2.35 ± 0.062	7.721LeuArg: 7.721 ± 0.101	5.974LeuSer: 5.974 ± 0.083	6.418LeuThr: 6.418 ± 0.094	7.212LeuVal: 7.212 ± 0.121	1.335LeuTrp: 1.335 ± 0.044	1.806LeuTyr: 1.806 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.75MetAla: 3.75 ± 0.068	0.136MetCys: 0.136 ± 0.013	1.42MetAsp: 1.42 ± 0.043	1.157MetGlu: 1.157 ± 0.04	0.801MetPhe: 0.801 ± 0.034	2.316MetGly: 2.316 ± 0.058	0.428MetHis: 0.428 ± 0.024	1.383MetIle: 1.383 ± 0.041	0.843MetLys: 0.843 ± 0.033	2.663MetLeu: 2.663 ± 0.052	0.721MetMet: 0.721 ± 0.028	0.803MetAsn: 0.803 ± 0.032	1.607MetPro: 1.607 ± 0.047	0.961MetGln: 0.961 ± 0.031	2.012MetArg: 2.012 ± 0.047	1.558MetSer: 1.558 ± 0.048	2.068MetThr: 2.068 ± 0.051	1.828MetVal: 1.828 ± 0.052	0.235MetTrp: 0.235 ± 0.017	0.311MetTyr: 0.311 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.898AsnAla: 2.898 ± 0.068	0.235AsnCys: 0.235 ± 0.018	1.237AsnAsp: 1.237 ± 0.046	0.893AsnGlu: 0.893 ± 0.032	0.727AsnPhe: 0.727 ± 0.029	2.073AsnGly: 2.073 ± 0.055	0.433AsnHis: 0.433 ± 0.026	1.131AsnIle: 1.131 ± 0.045	0.497AsnLys: 0.497 ± 0.024	2.267AsnLeu: 2.267 ± 0.056	0.579AsnMet: 0.579 ± 0.029	0.475AsnAsn: 0.475 ± 0.027	1.733AsnPro: 1.733 ± 0.047	0.58AsnGln: 0.58 ± 0.029	1.74AsnArg: 1.74 ± 0.041	0.936AsnSer: 0.936 ± 0.04	1.008AsnThr: 1.008 ± 0.033	1.588AsnVal: 1.588 ± 0.046	0.371AsnTrp: 0.371 ± 0.022	0.528AsnTyr: 0.528 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.191ProAla: 8.191 ± 0.13	0.374ProCys: 0.374 ± 0.021	4.296ProAsp: 4.296 ± 0.075	3.902ProGlu: 3.902 ± 0.071	1.784ProPhe: 1.784 ± 0.05	5.453ProGly: 5.453 ± 0.096	1.074ProHis: 1.074 ± 0.038	2.099ProIle: 2.099 ± 0.055	1.213ProLys: 1.213 ± 0.039	4.829ProLeu: 4.829 ± 0.078	1.38ProMet: 1.38 ± 0.039	1.122ProAsn: 1.122 ± 0.038	2.9ProPro: 2.9 ± 0.086	1.956ProGln: 1.956 ± 0.057	3.641ProArg: 3.641 ± 0.068	2.217ProSer: 2.217 ± 0.053	2.425ProThr: 2.425 ± 0.054	4.732ProVal: 4.732 ± 0.075	0.772ProTrp: 0.772 ± 0.037	1.033ProTyr: 1.033 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.261GlnAla: 4.261 ± 0.076	0.184GlnCys: 0.184 ± 0.016	1.552GlnAsp: 1.552 ± 0.042	1.066GlnGlu: 1.066 ± 0.044	0.981GlnPhe: 0.981 ± 0.039	2.965GlnGly: 2.965 ± 0.061	0.549GlnHis: 0.549 ± 0.026	1.822GlnIle: 1.822 ± 0.048	0.827GlnLys: 0.827 ± 0.036	2.791GlnLeu: 2.791 ± 0.054	1.032GlnMet: 1.032 ± 0.037	0.735GlnAsn: 0.735 ± 0.03	1.919GlnPro: 1.919 ± 0.053	1.038GlnGln: 1.038 ± 0.044	2.288GlnArg: 2.288 ± 0.057	1.413GlnSer: 1.413 ± 0.048	1.653GlnThr: 1.653 ± 0.041	2.487GlnVal: 2.487 ± 0.06	0.379GlnTrp: 0.379 ± 0.022	0.438GlnTyr: 0.438 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	10.128ArgAla: 10.128 ± 0.142	0.47ArgCys: 0.47 ± 0.027	4.847ArgAsp: 4.847 ± 0.082	3.969ArgGlu: 3.969 ± 0.076	2.754ArgPhe: 2.754 ± 0.061	5.837ArgGly: 5.837 ± 0.085	1.866ArgHis: 1.866 ± 0.051	4.456ArgIle: 4.456 ± 0.081	1.871ArgLys: 1.871 ± 0.05	8.857ArgLeu: 8.857 ± 0.122	2.296ArgMet: 2.296 ± 0.057	1.629ArgAsn: 1.629 ± 0.046	4.26ArgPro: 4.26 ± 0.076	2.56ArgGln: 2.56 ± 0.056	6.398ArgArg: 6.398 ± 0.106	3.246ArgSer: 3.246 ± 0.063	3.259ArgThr: 3.259 ± 0.066	5.441ArgVal: 5.441 ± 0.082	1.268ArgTrp: 1.268 ± 0.038	1.467ArgTyr: 1.467 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.799SerAla: 5.799 ± 0.086	0.386SerCys: 0.386 ± 0.025	2.743SerAsp: 2.743 ± 0.054	2.176SerGlu: 2.176 ± 0.055	1.905SerPhe: 1.905 ± 0.045	5.108SerGly: 5.108 ± 0.091	0.939SerHis: 0.939 ± 0.037	1.995SerIle: 1.995 ± 0.056	1.007SerLys: 1.007 ± 0.038	4.362SerLeu: 4.362 ± 0.079	1.179SerMet: 1.179 ± 0.039	0.978SerAsn: 0.978 ± 0.037	2.407SerPro: 2.407 ± 0.058	1.284SerGln: 1.284 ± 0.041	3.361SerArg: 3.361 ± 0.073	1.924SerSer: 1.924 ± 0.053	2.175SerThr: 2.175 ± 0.05	3.412SerVal: 3.412 ± 0.072	0.707SerTrp: 0.707 ± 0.031	1.042SerTyr: 1.042 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.927ThrAla: 6.927 ± 0.113	0.447ThrCys: 0.447 ± 0.025	3.228ThrAsp: 3.228 ± 0.061	2.827ThrGlu: 2.827 ± 0.065	1.563ThrPhe: 1.563 ± 0.042	5.64ThrGly: 5.64 ± 0.091	1.039ThrHis: 1.039 ± 0.032	2.44ThrIle: 2.44 ± 0.06	1.02ThrLys: 1.02 ± 0.039	5.927ThrLeu: 5.927 ± 0.106	1.178ThrMet: 1.178 ± 0.042	1.132ThrAsn: 1.132 ± 0.039	3.461ThrPro: 3.461 ± 0.062	1.466ThrGln: 1.466 ± 0.042	3.941ThrArg: 3.941 ± 0.076	2.18ThrSer: 2.18 ± 0.051	2.831ThrThr: 2.831 ± 0.067	4.298ThrVal: 4.298 ± 0.08	0.629ThrTrp: 0.629 ± 0.027	0.986ThrTyr: 0.986 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	10.254ValAla: 10.254 ± 0.105	0.581ValCys: 0.581 ± 0.032	4.01ValAsp: 4.01 ± 0.072	4.391ValGlu: 4.391 ± 0.073	2.63ValPhe: 2.63 ± 0.063	5.529ValGly: 5.529 ± 0.095	1.378ValHis: 1.378 ± 0.038	4.021ValIle: 4.021 ± 0.078	1.866ValLys: 1.866 ± 0.058	7.462ValLeu: 7.462 ± 0.107	2.114ValMet: 2.114 ± 0.048	1.865ValAsn: 1.865 ± 0.051	3.908ValPro: 3.908 ± 0.073	2.06ValGln: 2.06 ± 0.052	4.808ValArg: 4.808 ± 0.069	3.575ValSer: 3.575 ± 0.069	4.929ValThr: 4.929 ± 0.083	6.008ValVal: 6.008 ± 0.096	1.091ValTrp: 1.091 ± 0.04	1.353ValTyr: 1.353 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.523TrpAla: 1.523 ± 0.047	0.125TrpCys: 0.125 ± 0.014	0.843TrpAsp: 0.843 ± 0.035	0.561TrpGlu: 0.561 ± 0.03	0.545TrpPhe: 0.545 ± 0.03	1.115TrpGly: 1.115 ± 0.039	0.354TrpHis: 0.354 ± 0.023	0.65TrpIle: 0.65 ± 0.026	0.42TrpLys: 0.42 ± 0.022	1.886TrpLeu: 1.886 ± 0.054	0.388TrpMet: 0.388 ± 0.021	0.359TrpAsn: 0.359 ± 0.02	0.785TrpPro: 0.785 ± 0.029	0.687TrpGln: 0.687 ± 0.026	1.318TrpArg: 1.318 ± 0.04	0.799TrpSer: 0.799 ± 0.029	0.904TrpThr: 0.904 ± 0.032	0.972TrpVal: 0.972 ± 0.036	0.28TrpTrp: 0.28 ± 0.019	0.245TrpTyr: 0.245 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.059	0.218TyrCys: 0.218 ± 0.016	1.418TyrAsp: 1.418 ± 0.041	1.038TyrGlu: 1.038 ± 0.039	0.669TyrPhe: 0.669 ± 0.028	1.925TyrGly: 1.925 ± 0.049	0.475TyrHis: 0.475 ± 0.022	0.68TyrIle: 0.68 ± 0.029	0.474TyrLys: 0.474 ± 0.025	2.003TyrLeu: 2.003 ± 0.048	0.391TyrMet: 0.391 ± 0.02	0.435TyrAsn: 0.435 ± 0.022	1.014TyrPro: 1.014 ± 0.031	0.639TyrGln: 0.639 ± 0.027	1.519TyrArg: 1.519 ± 0.043	0.872TyrSer: 0.872 ± 0.033	0.837TyrThr: 0.837 ± 0.035	1.44TyrVal: 1.44 ± 0.045	0.306TyrTrp: 0.306 ± 0.021	0.492TyrTyr: 0.492 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2819 proteins (829420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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