Amino acid dipepetide frequency for Influenza A virus (strain A/little yellow-shouldered bat/Guatemala/153/2009(H17N10))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.618AlaAla: 3.618 ± 1.315
1.357AlaCys: 1.357 ± 0.484
1.357AlaAsp: 1.357 ± 0.635
2.714AlaGlu: 2.714 ± 0.574
2.261AlaPhe: 2.261 ± 1.06
3.392AlaGly: 3.392 ± 0.786
1.357AlaHis: 1.357 ± 0.395
3.844AlaIle: 3.844 ± 0.882
2.261AlaLys: 2.261 ± 0.76
5.201AlaLeu: 5.201 ± 1.318
2.488AlaMet: 2.488 ± 0.855
3.618AlaAsn: 3.618 ± 0.31
2.261AlaPro: 2.261 ± 0.364
3.392AlaGln: 3.392 ± 0.77
2.714AlaArg: 2.714 ± 0.89
4.297AlaSer: 4.297 ± 1.23
3.618AlaThr: 3.618 ± 0.734
4.523AlaVal: 4.523 ± 1.014
0.452AlaTrp: 0.452 ± 0.275
1.583AlaTyr: 1.583 ± 0.534
0.0AlaXaa: 0.0 ± 0.0
Cys
0.452CysAla: 0.452 ± 0.313
0.678CysCys: 0.678 ± 0.343
0.452CysAsp: 0.452 ± 0.297
0.905CysGlu: 0.905 ± 0.534
1.809CysPhe: 1.809 ± 0.956
0.452CysGly: 0.452 ± 0.315
0.678CysHis: 0.678 ± 0.264
1.131CysIle: 1.131 ± 0.564
1.583CysLys: 1.583 ± 0.362
0.905CysLeu: 0.905 ± 0.379
0.452CysMet: 0.452 ± 0.367
1.131CysAsn: 1.131 ± 0.405
0.452CysPro: 0.452 ± 0.483
1.131CysGln: 1.131 ± 0.495
1.131CysArg: 1.131 ± 0.618
0.678CysSer: 0.678 ± 0.51
0.905CysThr: 0.905 ± 0.396
0.678CysVal: 0.678 ± 0.286
0.226CysTrp: 0.226 ± 0.183
0.452CysTyr: 0.452 ± 0.397
0.0CysXaa: 0.0 ± 0.0
Asp
3.392AspAla: 3.392 ± 0.853
0.905AspCys: 0.905 ± 0.335
2.261AspAsp: 2.261 ± 0.699
3.844AspGlu: 3.844 ± 0.845
1.809AspPhe: 1.809 ± 0.438
2.94AspGly: 2.94 ± 0.383
0.226AspHis: 0.226 ± 0.183
2.488AspIle: 2.488 ± 0.584
1.809AspLys: 1.809 ± 0.56
5.427AspLeu: 5.427 ± 0.582
0.905AspMet: 0.905 ± 0.399
1.809AspAsn: 1.809 ± 0.575
3.166AspPro: 3.166 ± 1.039
1.131AspGln: 1.131 ± 0.387
2.035AspArg: 2.035 ± 0.646
2.488AspSer: 2.488 ± 0.602
2.261AspThr: 2.261 ± 0.552
1.809AspVal: 1.809 ± 0.521
0.452AspTrp: 0.452 ± 0.223
2.488AspTyr: 2.488 ± 0.863
0.0AspXaa: 0.0 ± 0.0
Glu
2.488GluAla: 2.488 ± 0.754
0.452GluCys: 0.452 ± 0.275
3.392GluAsp: 3.392 ± 0.754
6.558GluGlu: 6.558 ± 1.34
2.488GluPhe: 2.488 ± 0.703
6.558GluGly: 6.558 ± 1.693
0.905GluHis: 0.905 ± 0.422
5.201GluIle: 5.201 ± 0.652
7.915GluLys: 7.915 ± 1.271
5.88GluLeu: 5.88 ± 0.944
2.488GluMet: 2.488 ± 0.827
4.749GluAsn: 4.749 ± 0.998
2.035GluPro: 2.035 ± 0.763
2.488GluGln: 2.488 ± 0.444
4.071GluArg: 4.071 ± 0.983
6.332GluSer: 6.332 ± 0.809
2.94GluThr: 2.94 ± 0.859
5.88GluVal: 5.88 ± 1.16
1.357GluTrp: 1.357 ± 0.522
1.809GluTyr: 1.809 ± 0.637
0.0GluXaa: 0.0 ± 0.0
Phe
0.452PheAla: 0.452 ± 0.223
0.226PheCys: 0.226 ± 0.231
2.261PheAsp: 2.261 ± 0.904
4.749PheGlu: 4.749 ± 1.023
1.583PhePhe: 1.583 ± 0.517
1.809PheGly: 1.809 ± 0.508
0.678PheHis: 0.678 ± 0.362
2.94PheIle: 2.94 ± 0.962
1.809PheLys: 1.809 ± 0.562
3.392PheLeu: 3.392 ± 0.489
0.226PheMet: 0.226 ± 0.186
2.94PheAsn: 2.94 ± 0.973
1.357PhePro: 1.357 ± 0.449
2.714PheGln: 2.714 ± 0.675
1.583PheArg: 1.583 ± 0.539
3.844PheSer: 3.844 ± 0.786
2.035PheThr: 2.035 ± 0.588
2.94PheVal: 2.94 ± 0.639
0.678PheTrp: 0.678 ± 0.334
1.809PheTyr: 1.809 ± 0.474
0.0PheXaa: 0.0 ± 0.0
Gly
3.392GlyAla: 3.392 ± 0.883
0.678GlyCys: 0.678 ± 0.49
2.714GlyAsp: 2.714 ± 0.52
5.201GlyGlu: 5.201 ± 1.395
3.392GlyPhe: 3.392 ± 0.661
2.94GlyGly: 2.94 ± 0.695
0.905GlyHis: 0.905 ± 0.457
4.071GlyIle: 4.071 ± 0.939
4.071GlyLys: 4.071 ± 1.143
5.427GlyLeu: 5.427 ± 1.352
2.261GlyMet: 2.261 ± 0.676
4.975GlyAsn: 4.975 ± 1.46
2.94GlyPro: 2.94 ± 0.892
2.261GlyGln: 2.261 ± 0.467
4.975GlyArg: 4.975 ± 0.999
3.392GlySer: 3.392 ± 1.065
5.427GlyThr: 5.427 ± 0.983
3.392GlyVal: 3.392 ± 0.786
1.131GlyTrp: 1.131 ± 0.68
2.261GlyTyr: 2.261 ± 0.697
0.0GlyXaa: 0.0 ± 0.0
His
0.226HisAla: 0.226 ± 0.234
0.0HisCys: 0.0 ± 0.0
0.452HisAsp: 0.452 ± 0.265
0.905HisGlu: 0.905 ± 0.443
1.131HisPhe: 1.131 ± 0.529
0.905HisGly: 0.905 ± 0.428
0.452HisHis: 0.452 ± 0.265
1.357HisIle: 1.357 ± 0.412
1.357HisLys: 1.357 ± 0.395
2.035HisLeu: 2.035 ± 0.406
0.905HisMet: 0.905 ± 0.334
0.452HisAsn: 0.452 ± 0.483
0.905HisPro: 0.905 ± 0.304
0.678HisGln: 0.678 ± 0.472
1.131HisArg: 1.131 ± 0.478
0.452HisSer: 0.452 ± 0.272
0.905HisThr: 0.905 ± 0.406
0.0HisVal: 0.0 ± 0.0
0.452HisTrp: 0.452 ± 0.26
0.452HisTyr: 0.452 ± 0.243
0.0HisXaa: 0.0 ± 0.0
Ile
4.071IleAla: 4.071 ± 0.871
1.583IleCys: 1.583 ± 0.458
3.844IleAsp: 3.844 ± 1.195
5.427IleGlu: 5.427 ± 1.324
1.583IlePhe: 1.583 ± 0.445
4.523IleGly: 4.523 ± 0.497
0.678IleHis: 0.678 ± 0.39
4.071IleIle: 4.071 ± 0.898
5.427IleLys: 5.427 ± 0.538
7.237IleLeu: 7.237 ± 1.392
3.844IleMet: 3.844 ± 0.8
4.297IleAsn: 4.297 ± 1.187
2.035IlePro: 2.035 ± 0.439
4.523IleGln: 4.523 ± 0.777
5.427IleArg: 5.427 ± 1.24
4.523IleSer: 4.523 ± 0.622
3.844IleThr: 3.844 ± 0.913
2.488IleVal: 2.488 ± 0.538
1.131IleTrp: 1.131 ± 0.46
1.357IleTyr: 1.357 ± 0.504
0.0IleXaa: 0.0 ± 0.0
Lys
7.01LysAla: 7.01 ± 1.099
1.357LysCys: 1.357 ± 0.469
3.392LysAsp: 3.392 ± 0.633
4.975LysGlu: 4.975 ± 1.051
2.488LysPhe: 2.488 ± 0.73
5.201LysGly: 5.201 ± 1.151
0.452LysHis: 0.452 ± 0.373
2.714LysIle: 2.714 ± 0.758
4.523LysLys: 4.523 ± 1.638
5.654LysLeu: 5.654 ± 0.807
2.94LysMet: 2.94 ± 0.366
2.488LysAsn: 2.488 ± 0.92
0.905LysPro: 0.905 ± 0.396
0.905LysGln: 0.905 ± 0.439
4.523LysArg: 4.523 ± 1.142
3.618LysSer: 3.618 ± 0.693
3.392LysThr: 3.392 ± 0.913
2.488LysVal: 2.488 ± 0.672
1.809LysTrp: 1.809 ± 0.516
2.261LysTyr: 2.261 ± 0.632
0.0LysXaa: 0.0 ± 0.0
Leu
4.975LeuAla: 4.975 ± 1.2
0.905LeuCys: 0.905 ± 0.488
4.071LeuAsp: 4.071 ± 0.768
7.689LeuGlu: 7.689 ± 0.859
2.488LeuPhe: 2.488 ± 0.464
4.749LeuGly: 4.749 ± 0.77
1.131LeuHis: 1.131 ± 0.386
7.237LeuIle: 7.237 ± 1.046
6.558LeuLys: 6.558 ± 1.014
10.629LeuLeu: 10.629 ± 2.682
3.392LeuMet: 3.392 ± 0.67
6.106LeuAsn: 6.106 ± 0.845
4.523LeuPro: 4.523 ± 0.577
2.94LeuGln: 2.94 ± 0.54
5.201LeuArg: 5.201 ± 0.77
5.88LeuSer: 5.88 ± 1.265
6.106LeuThr: 6.106 ± 1.755
3.166LeuVal: 3.166 ± 0.759
2.035LeuTrp: 2.035 ± 0.514
2.261LeuTyr: 2.261 ± 0.846
0.0LeuXaa: 0.0 ± 0.0
Met
3.392MetAla: 3.392 ± 1.056
0.905MetCys: 0.905 ± 0.466
2.261MetAsp: 2.261 ± 0.585
5.427MetGlu: 5.427 ± 0.62
0.678MetPhe: 0.678 ± 0.539
1.583MetGly: 1.583 ± 0.72
0.226MetHis: 0.226 ± 0.18
4.071MetIle: 4.071 ± 0.804
2.488MetLys: 2.488 ± 1.119
1.809MetLeu: 1.809 ± 0.68
1.357MetMet: 1.357 ± 0.555
0.678MetAsn: 0.678 ± 0.407
0.905MetPro: 0.905 ± 0.396
0.678MetGln: 0.678 ± 0.343
1.583MetArg: 1.583 ± 0.608
1.809MetSer: 1.809 ± 0.488
2.488MetThr: 2.488 ± 0.604
1.583MetVal: 1.583 ± 0.609
0.226MetTrp: 0.226 ± 0.183
0.678MetTyr: 0.678 ± 0.402
0.0MetXaa: 0.0 ± 0.0
Asn
2.035AsnAla: 2.035 ± 0.531
0.678AsnCys: 0.678 ± 0.479
2.714AsnAsp: 2.714 ± 0.735
4.071AsnGlu: 4.071 ± 0.837
3.392AsnPhe: 3.392 ± 0.74
4.297AsnGly: 4.297 ± 1.573
0.905AsnHis: 0.905 ± 0.354
3.392AsnIle: 3.392 ± 0.638
2.261AsnLys: 2.261 ± 0.381
5.654AsnLeu: 5.654 ± 0.966
1.131AsnMet: 1.131 ± 0.563
3.392AsnAsn: 3.392 ± 1.206
6.106AsnPro: 6.106 ± 1.059
2.94AsnGln: 2.94 ± 0.753
2.714AsnArg: 2.714 ± 0.858
6.558AsnSer: 6.558 ± 1.099
3.844AsnThr: 3.844 ± 0.69
2.488AsnVal: 2.488 ± 0.859
1.583AsnTrp: 1.583 ± 0.529
1.131AsnTyr: 1.131 ± 0.393
0.0AsnXaa: 0.0 ± 0.0
Pro
2.035ProAla: 2.035 ± 0.524
0.452ProCys: 0.452 ± 0.326
1.357ProAsp: 1.357 ± 0.41
3.166ProGlu: 3.166 ± 0.699
2.261ProPhe: 2.261 ± 0.514
2.261ProGly: 2.261 ± 0.408
0.0ProHis: 0.0 ± 0.0
3.844ProIle: 3.844 ± 0.652
1.809ProLys: 1.809 ± 0.653
3.166ProLeu: 3.166 ± 0.922
0.905ProMet: 0.905 ± 0.394
2.488ProAsn: 2.488 ± 0.959
2.035ProPro: 2.035 ± 0.485
1.583ProGln: 1.583 ± 0.634
2.261ProArg: 2.261 ± 0.697
2.035ProSer: 2.035 ± 0.48
2.94ProThr: 2.94 ± 0.705
1.809ProVal: 1.809 ± 0.497
0.452ProTrp: 0.452 ± 0.275
1.131ProTyr: 1.131 ± 0.538
0.0ProXaa: 0.0 ± 0.0
Gln
2.261GlnAla: 2.261 ± 0.949
0.452GlnCys: 0.452 ± 0.266
1.131GlnAsp: 1.131 ± 0.571
2.94GlnGlu: 2.94 ± 0.778
0.678GlnPhe: 0.678 ± 0.286
2.94GlnGly: 2.94 ± 0.605
0.452GlnHis: 0.452 ± 0.297
2.94GlnIle: 2.94 ± 1.097
2.714GlnLys: 2.714 ± 0.966
2.94GlnLeu: 2.94 ± 0.804
2.714GlnMet: 2.714 ± 0.931
3.166GlnAsn: 3.166 ± 0.954
1.131GlnPro: 1.131 ± 0.486
2.488GlnGln: 2.488 ± 0.511
3.844GlnArg: 3.844 ± 0.174
2.94GlnSer: 2.94 ± 0.699
3.618GlnThr: 3.618 ± 0.96
1.583GlnVal: 1.583 ± 0.604
0.226GlnTrp: 0.226 ± 0.183
0.678GlnTyr: 0.678 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
3.844ArgAla: 3.844 ± 0.664
0.452ArgCys: 0.452 ± 0.223
2.261ArgAsp: 2.261 ± 0.328
3.392ArgGlu: 3.392 ± 0.932
1.357ArgPhe: 1.357 ± 0.474
5.427ArgGly: 5.427 ± 1.39
0.678ArgHis: 0.678 ± 0.306
4.523ArgIle: 4.523 ± 0.77
2.714ArgLys: 2.714 ± 0.61
5.427ArgLeu: 5.427 ± 1.466
2.488ArgMet: 2.488 ± 1.017
4.975ArgAsn: 4.975 ± 0.452
0.905ArgPro: 0.905 ± 0.39
1.583ArgGln: 1.583 ± 0.577
4.297ArgArg: 4.297 ± 1.031
3.844ArgSer: 3.844 ± 0.872
6.332ArgThr: 6.332 ± 1.36
2.261ArgVal: 2.261 ± 1.048
0.452ArgTrp: 0.452 ± 0.326
0.905ArgTyr: 0.905 ± 0.537
0.0ArgXaa: 0.0 ± 0.0
Ser
4.297SerAla: 4.297 ± 0.895
2.035SerCys: 2.035 ± 1.122
2.488SerAsp: 2.488 ± 0.326
3.844SerGlu: 3.844 ± 0.904
3.844SerPhe: 3.844 ± 0.782
4.523SerGly: 4.523 ± 0.824
1.809SerHis: 1.809 ± 0.601
5.201SerIle: 5.201 ± 0.796
3.166SerLys: 3.166 ± 0.612
5.427SerLeu: 5.427 ± 1.012
3.166SerMet: 3.166 ± 1.239
2.261SerAsn: 2.261 ± 0.482
2.035SerPro: 2.035 ± 0.729
3.844SerGln: 3.844 ± 0.702
2.94SerArg: 2.94 ± 0.631
6.332SerSer: 6.332 ± 1.742
6.106SerThr: 6.106 ± 1.094
2.035SerVal: 2.035 ± 0.283
0.678SerTrp: 0.678 ± 0.37
2.488SerTyr: 2.488 ± 0.703
0.0SerXaa: 0.0 ± 0.0
Thr
4.297ThrAla: 4.297 ± 1.202
1.809ThrCys: 1.809 ± 0.576
2.94ThrAsp: 2.94 ± 0.503
3.844ThrGlu: 3.844 ± 1.146
3.392ThrPhe: 3.392 ± 0.584
4.523ThrGly: 4.523 ± 1.176
1.583ThrHis: 1.583 ± 0.51
5.88ThrIle: 5.88 ± 1.106
3.392ThrLys: 3.392 ± 0.948
6.558ThrLeu: 6.558 ± 1.679
0.905ThrMet: 0.905 ± 0.378
6.106ThrAsn: 6.106 ± 0.994
1.583ThrPro: 1.583 ± 0.479
2.94ThrGln: 2.94 ± 0.795
2.714ThrArg: 2.714 ± 0.999
4.071ThrSer: 4.071 ± 1.188
4.297ThrThr: 4.297 ± 0.972
3.618ThrVal: 3.618 ± 0.88
0.226ThrTrp: 0.226 ± 0.183
2.261ThrTyr: 2.261 ± 0.735
0.0ThrXaa: 0.0 ± 0.0
Val
3.166ValAla: 3.166 ± 0.984
1.131ValCys: 1.131 ± 0.451
2.714ValAsp: 2.714 ± 0.832
3.166ValGlu: 3.166 ± 0.783
2.035ValPhe: 2.035 ± 0.573
2.488ValGly: 2.488 ± 0.824
0.905ValHis: 0.905 ± 0.27
3.618ValIle: 3.618 ± 0.873
4.297ValLys: 4.297 ± 1.139
6.784ValLeu: 6.784 ± 1.463
0.678ValMet: 0.678 ± 0.357
2.94ValAsn: 2.94 ± 0.806
1.583ValPro: 1.583 ± 0.478
1.583ValGln: 1.583 ± 0.523
1.809ValArg: 1.809 ± 1.043
2.261ValSer: 2.261 ± 0.896
2.035ValThr: 2.035 ± 0.641
1.357ValVal: 1.357 ± 0.391
0.226ValTrp: 0.226 ± 0.234
1.357ValTyr: 1.357 ± 0.54
0.0ValXaa: 0.0 ± 0.0
Trp
0.226TrpAla: 0.226 ± 0.234
0.0TrpCys: 0.0 ± 0.0
0.905TrpAsp: 0.905 ± 0.357
1.809TrpGlu: 1.809 ± 0.595
0.452TrpPhe: 0.452 ± 0.223
1.809TrpGly: 1.809 ± 0.731
0.452TrpHis: 0.452 ± 0.373
1.131TrpIle: 1.131 ± 0.443
1.131TrpLys: 1.131 ± 0.474
0.905TrpLeu: 0.905 ± 0.458
0.678TrpMet: 0.678 ± 0.361
0.905TrpAsn: 0.905 ± 0.396
0.226TrpPro: 0.226 ± 0.186
0.226TrpGln: 0.226 ± 0.241
0.452TrpArg: 0.452 ± 0.413
0.452TrpSer: 0.452 ± 0.483
1.809TrpThr: 1.809 ± 0.701
0.905TrpVal: 0.905 ± 0.466
0.452TrpTrp: 0.452 ± 0.24
0.226TrpTyr: 0.226 ± 0.241
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.678TyrAla: 0.678 ± 0.256
0.226TyrCys: 0.226 ± 0.186
0.678TyrAsp: 0.678 ± 0.36
1.583TyrGlu: 1.583 ± 0.585
0.905TyrPhe: 0.905 ± 0.38
2.488TyrGly: 2.488 ± 0.544
0.678TyrHis: 0.678 ± 0.286
2.261TyrIle: 2.261 ± 0.829
1.809TyrLys: 1.809 ± 0.529
1.583TyrLeu: 1.583 ± 0.513
0.678TyrMet: 0.678 ± 0.277
1.809TyrAsn: 1.809 ± 0.861
0.905TyrPro: 0.905 ± 0.4
1.809TyrGln: 1.809 ± 0.312
2.714TyrArg: 2.714 ± 1.119
2.714TyrSer: 2.714 ± 0.636
2.035TyrThr: 2.035 ± 0.691
1.131TyrVal: 1.131 ± 0.349
0.905TyrTrp: 0.905 ± 0.312
1.357TyrTyr: 1.357 ± 0.723
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (4423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski