Amino acid dipepetide frequency for Adhaeribacter pallidiroseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.345AlaAla: 7.345 ± 0.087
0.661AlaCys: 0.661 ± 0.02
4.138AlaAsp: 4.138 ± 0.049
4.673AlaGlu: 4.673 ± 0.059
3.652AlaPhe: 3.652 ± 0.046
6.196AlaGly: 6.196 ± 0.072
1.377AlaHis: 1.377 ± 0.031
5.101AlaIle: 5.101 ± 0.064
4.254AlaLys: 4.254 ± 0.053
7.907AlaLeu: 7.907 ± 0.089
1.602AlaMet: 1.602 ± 0.031
3.924AlaAsn: 3.924 ± 0.06
3.11AlaPro: 3.11 ± 0.049
3.802AlaGln: 3.802 ± 0.046
2.993AlaArg: 2.993 ± 0.045
4.702AlaSer: 4.702 ± 0.066
5.135AlaThr: 5.135 ± 0.089
5.058AlaVal: 5.058 ± 0.065
0.901AlaTrp: 0.901 ± 0.022
2.97AlaTyr: 2.97 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.48CysAla: 0.48 ± 0.018
0.124CysCys: 0.124 ± 0.008
0.312CysAsp: 0.312 ± 0.013
0.353CysGlu: 0.353 ± 0.014
0.396CysPhe: 0.396 ± 0.015
0.539CysGly: 0.539 ± 0.02
0.194CysHis: 0.194 ± 0.01
0.439CysIle: 0.439 ± 0.016
0.326CysLys: 0.326 ± 0.015
0.799CysLeu: 0.799 ± 0.025
0.124CysMet: 0.124 ± 0.009
0.319CysAsn: 0.319 ± 0.014
0.32CysPro: 0.32 ± 0.015
0.37CysGln: 0.37 ± 0.015
0.322CysArg: 0.322 ± 0.014
0.476CysSer: 0.476 ± 0.019
0.406CysThr: 0.406 ± 0.017
0.383CysVal: 0.383 ± 0.016
0.101CysTrp: 0.101 ± 0.007
0.283CysTyr: 0.283 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.549AspAla: 3.549 ± 0.057
0.328AspCys: 0.328 ± 0.015
1.974AspAsp: 1.974 ± 0.043
2.713AspGlu: 2.713 ± 0.041
2.933AspPhe: 2.933 ± 0.045
3.401AspGly: 3.401 ± 0.067
0.825AspHis: 0.825 ± 0.027
3.187AspIle: 3.187 ± 0.051
3.753AspLys: 3.753 ± 0.08
5.024AspLeu: 5.024 ± 0.059
0.894AspMet: 0.894 ± 0.024
2.428AspAsn: 2.428 ± 0.044
2.137AspPro: 2.137 ± 0.039
2.048AspGln: 2.048 ± 0.038
2.007AspArg: 2.007 ± 0.038
2.638AspSer: 2.638 ± 0.045
2.393AspThr: 2.393 ± 0.041
2.947AspVal: 2.947 ± 0.038
0.754AspTrp: 0.754 ± 0.021
2.645AspTyr: 2.645 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.798GluAla: 4.798 ± 0.059
0.28GluCys: 0.28 ± 0.013
2.436GluAsp: 2.436 ± 0.04
3.757GluGlu: 3.757 ± 0.06
2.305GluPhe: 2.305 ± 0.035
3.018GluGly: 3.018 ± 0.047
1.031GluHis: 1.031 ± 0.025
4.03GluIle: 4.03 ± 0.057
4.356GluLys: 4.356 ± 0.064
5.555GluLeu: 5.555 ± 0.068
1.311GluMet: 1.311 ± 0.027
3.259GluAsn: 3.259 ± 0.048
2.103GluPro: 2.103 ± 0.04
2.816GluGln: 2.816 ± 0.042
2.336GluArg: 2.336 ± 0.04
2.745GluSer: 2.745 ± 0.037
3.056GluThr: 3.056 ± 0.047
4.24GluVal: 4.24 ± 0.057
0.689GluTrp: 0.689 ± 0.023
2.071GluTyr: 2.071 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.46PheAla: 3.46 ± 0.045
0.421PheCys: 0.421 ± 0.017
2.439PheAsp: 2.439 ± 0.038
2.358PheGlu: 2.358 ± 0.037
2.389PhePhe: 2.389 ± 0.049
3.29PheGly: 3.29 ± 0.048
0.788PheHis: 0.788 ± 0.02
3.2PheIle: 3.2 ± 0.051
2.93PheLys: 2.93 ± 0.049
4.874PheLeu: 4.874 ± 0.072
0.989PheMet: 0.989 ± 0.025
2.722PheAsn: 2.722 ± 0.042
1.805PhePro: 1.805 ± 0.033
1.727PheGln: 1.727 ± 0.033
2.144PheArg: 2.144 ± 0.04
3.408PheSer: 3.408 ± 0.045
3.59PheThr: 3.59 ± 0.051
2.825PheVal: 2.825 ± 0.04
0.641PheTrp: 0.641 ± 0.019
2.044PheTyr: 2.044 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
4.697GlyAla: 4.697 ± 0.061
0.571GlyCys: 0.571 ± 0.02
3.114GlyAsp: 3.114 ± 0.058
3.436GlyGlu: 3.436 ± 0.041
3.417GlyPhe: 3.417 ± 0.047
5.599GlyGly: 5.599 ± 0.136
1.222GlyHis: 1.222 ± 0.027
4.676GlyIle: 4.676 ± 0.047
4.843GlyLys: 4.843 ± 0.054
6.523GlyLeu: 6.523 ± 0.065
1.466GlyMet: 1.466 ± 0.03
3.787GlyAsn: 3.787 ± 0.074
1.99GlyPro: 1.99 ± 0.042
2.859GlyGln: 2.859 ± 0.041
2.724GlyArg: 2.724 ± 0.041
4.548GlySer: 4.548 ± 0.07
4.701GlyThr: 4.701 ± 0.105
4.256GlyVal: 4.256 ± 0.049
0.975GlyTrp: 0.975 ± 0.025
3.098GlyTyr: 3.098 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
1.198HisAla: 1.198 ± 0.032
0.17HisCys: 0.17 ± 0.009
0.883HisAsp: 0.883 ± 0.022
0.996HisGlu: 0.996 ± 0.026
1.09HisPhe: 1.09 ± 0.025
1.121HisGly: 1.121 ± 0.026
0.498HisHis: 0.498 ± 0.018
1.125HisIle: 1.125 ± 0.027
0.824HisLys: 0.824 ± 0.021
2.176HisLeu: 2.176 ± 0.041
0.315HisMet: 0.315 ± 0.013
0.834HisAsn: 0.834 ± 0.023
1.125HisPro: 1.125 ± 0.025
1.058HisGln: 1.058 ± 0.026
0.826HisArg: 0.826 ± 0.023
1.021HisSer: 1.021 ± 0.028
1.024HisThr: 1.024 ± 0.024
1.077HisVal: 1.077 ± 0.024
0.28HisTrp: 0.28 ± 0.014
0.925HisTyr: 0.925 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.266IleAla: 5.266 ± 0.056
0.581IleCys: 0.581 ± 0.02
3.123IleAsp: 3.123 ± 0.039
3.191IleGlu: 3.191 ± 0.052
2.872IlePhe: 2.872 ± 0.047
4.381IleGly: 4.381 ± 0.051
1.116IleHis: 1.116 ± 0.024
4.407IleIle: 4.407 ± 0.057
4.104IleLys: 4.104 ± 0.057
6.208IleLeu: 6.208 ± 0.065
1.224IleMet: 1.224 ± 0.028
3.758IleAsn: 3.758 ± 0.049
2.995IlePro: 2.995 ± 0.041
2.569IleGln: 2.569 ± 0.034
2.965IleArg: 2.965 ± 0.043
4.434IleSer: 4.434 ± 0.059
4.66IleThr: 4.66 ± 0.054
3.594IleVal: 3.594 ± 0.055
0.751IleTrp: 0.751 ± 0.021
2.425IleTyr: 2.425 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.923LysAla: 4.923 ± 0.052
0.247LysCys: 0.247 ± 0.012
2.974LysAsp: 2.974 ± 0.048
4.051LysGlu: 4.051 ± 0.064
2.362LysPhe: 2.362 ± 0.043
3.663LysGly: 3.663 ± 0.049
1.064LysHis: 1.064 ± 0.026
4.589LysIle: 4.589 ± 0.055
4.674LysLys: 4.674 ± 0.067
5.863LysLeu: 5.863 ± 0.06
1.509LysMet: 1.509 ± 0.031
3.944LysAsn: 3.944 ± 0.055
2.9LysPro: 2.9 ± 0.051
2.826LysGln: 2.826 ± 0.045
2.422LysArg: 2.422 ± 0.037
3.544LysSer: 3.544 ± 0.06
3.963LysThr: 3.963 ± 0.058
4.201LysVal: 4.201 ± 0.05
0.712LysTrp: 0.712 ± 0.022
2.386LysTyr: 2.386 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
8.459LeuAla: 8.459 ± 0.084
0.679LeuCys: 0.679 ± 0.02
4.792LeuAsp: 4.792 ± 0.056
5.477LeuGlu: 5.477 ± 0.06
4.803LeuPhe: 4.803 ± 0.069
6.227LeuGly: 6.227 ± 0.072
1.917LeuHis: 1.917 ± 0.04
6.204LeuIle: 6.204 ± 0.066
6.547LeuLys: 6.547 ± 0.068
10.654LeuLeu: 10.654 ± 0.11
1.86LeuMet: 1.86 ± 0.036
5.325LeuAsn: 5.325 ± 0.057
5.05LeuPro: 5.05 ± 0.071
4.911LeuGln: 4.911 ± 0.06
4.245LeuArg: 4.245 ± 0.052
6.097LeuSer: 6.097 ± 0.05
6.231LeuThr: 6.231 ± 0.061
6.533LeuVal: 6.533 ± 0.059
1.01LeuTrp: 1.01 ± 0.024
3.37LeuTyr: 3.37 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
1.885MetAla: 1.885 ± 0.035
0.103MetCys: 0.103 ± 0.008
0.916MetAsp: 0.916 ± 0.025
1.138MetGlu: 1.138 ± 0.03
0.67MetPhe: 0.67 ± 0.022
1.361MetGly: 1.361 ± 0.026
0.456MetHis: 0.456 ± 0.016
1.034MetIle: 1.034 ± 0.026
1.433MetLys: 1.433 ± 0.035
2.01MetLeu: 2.01 ± 0.036
0.451MetMet: 0.451 ± 0.017
1.006MetAsn: 1.006 ± 0.024
1.016MetPro: 1.016 ± 0.024
1.106MetGln: 1.106 ± 0.025
1.015MetArg: 1.015 ± 0.025
0.979MetSer: 0.979 ± 0.024
0.891MetThr: 0.891 ± 0.022
1.418MetVal: 1.418 ± 0.028
0.165MetTrp: 0.165 ± 0.009
0.598MetTyr: 0.598 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.93AsnAla: 3.93 ± 0.054
0.366AsnCys: 0.366 ± 0.014
2.271AsnAsp: 2.271 ± 0.039
2.489AsnGlu: 2.489 ± 0.04
2.77AsnPhe: 2.77 ± 0.05
3.821AsnGly: 3.821 ± 0.062
0.951AsnHis: 0.951 ± 0.024
3.35AsnIle: 3.35 ± 0.043
3.362AsnLys: 3.362 ± 0.044
5.674AsnLeu: 5.674 ± 0.066
0.966AsnMet: 0.966 ± 0.025
3.291AsnAsn: 3.291 ± 0.061
3.064AsnPro: 3.064 ± 0.047
2.865AsnGln: 2.865 ± 0.049
2.516AsnArg: 2.516 ± 0.036
3.301AsnSer: 3.301 ± 0.047
3.317AsnThr: 3.317 ± 0.053
2.958AsnVal: 2.958 ± 0.052
0.84AsnTrp: 0.84 ± 0.025
2.437AsnTyr: 2.437 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
4.193ProAla: 4.193 ± 0.058
0.224ProCys: 0.224 ± 0.014
3.132ProAsp: 3.132 ± 0.048
3.673ProGlu: 3.673 ± 0.051
1.969ProPhe: 1.969 ± 0.036
3.129ProGly: 3.129 ± 0.05
0.812ProHis: 0.812 ± 0.022
2.427ProIle: 2.427 ± 0.038
2.178ProLys: 2.178 ± 0.039
3.833ProLeu: 3.833 ± 0.051
0.694ProMet: 0.694 ± 0.021
2.341ProAsn: 2.341 ± 0.036
1.4ProPro: 1.4 ± 0.036
1.748ProGln: 1.748 ± 0.037
1.38ProArg: 1.38 ± 0.031
2.113ProSer: 2.113 ± 0.04
2.625ProThr: 2.625 ± 0.049
3.775ProVal: 3.775 ± 0.052
0.467ProTrp: 0.467 ± 0.015
1.653ProTyr: 1.653 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.015GlnAla: 4.015 ± 0.057
0.195GlnCys: 0.195 ± 0.011
2.121GlnAsp: 2.121 ± 0.037
2.986GlnGlu: 2.986 ± 0.042
1.902GlnPhe: 1.902 ± 0.037
2.629GlnGly: 2.629 ± 0.043
1.031GlnHis: 1.031 ± 0.024
2.926GlnIle: 2.926 ± 0.051
3.075GlnLys: 3.075 ± 0.056
4.56GlnLeu: 4.56 ± 0.059
0.884GlnMet: 0.884 ± 0.024
2.59GlnAsn: 2.59 ± 0.041
2.125GlnPro: 2.125 ± 0.037
2.784GlnGln: 2.784 ± 0.057
1.759GlnArg: 1.759 ± 0.035
2.247GlnSer: 2.247 ± 0.035
2.873GlnThr: 2.873 ± 0.041
3.433GlnVal: 3.433 ± 0.05
0.528GlnTrp: 0.528 ± 0.017
1.648GlnTyr: 1.648 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.834ArgAla: 2.834 ± 0.044
0.24ArgCys: 0.24 ± 0.012
1.95ArgAsp: 1.95 ± 0.035
2.508ArgGlu: 2.508 ± 0.046
2.176ArgPhe: 2.176 ± 0.038
2.34ArgGly: 2.34 ± 0.037
0.855ArgHis: 0.855 ± 0.024
2.938ArgIle: 2.938 ± 0.045
2.692ArgLys: 2.692 ± 0.039
4.433ArgLeu: 4.433 ± 0.059
1.016ArgMet: 1.016 ± 0.025
2.385ArgAsn: 2.385 ± 0.039
1.636ArgPro: 1.636 ± 0.034
2.122ArgGln: 2.122 ± 0.039
1.942ArgArg: 1.942 ± 0.037
2.316ArgSer: 2.316 ± 0.036
2.422ArgThr: 2.422 ± 0.032
2.733ArgVal: 2.733 ± 0.039
0.573ArgTrp: 0.573 ± 0.02
1.868ArgTyr: 1.868 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
4.363SerAla: 4.363 ± 0.057
0.547SerCys: 0.547 ± 0.021
2.788SerAsp: 2.788 ± 0.043
3.089SerGlu: 3.089 ± 0.046
3.406SerPhe: 3.406 ± 0.051
5.078SerGly: 5.078 ± 0.089
1.005SerHis: 1.005 ± 0.024
3.718SerIle: 3.718 ± 0.049
3.323SerLys: 3.323 ± 0.053
6.087SerLeu: 6.087 ± 0.066
1.139SerMet: 1.139 ± 0.026
2.992SerAsn: 2.992 ± 0.053
2.565SerPro: 2.565 ± 0.041
2.373SerGln: 2.373 ± 0.042
2.71SerArg: 2.71 ± 0.045
3.903SerSer: 3.903 ± 0.067
3.54SerThr: 3.54 ± 0.057
3.736SerVal: 3.736 ± 0.051
0.775SerTrp: 0.775 ± 0.022
2.46SerTyr: 2.46 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.083ThrAla: 5.083 ± 0.082
0.381ThrCys: 0.381 ± 0.013
3.295ThrAsp: 3.295 ± 0.048
3.263ThrGlu: 3.263 ± 0.047
3.055ThrPhe: 3.055 ± 0.045
5.148ThrGly: 5.148 ± 0.077
1.101ThrHis: 1.101 ± 0.027
4.106ThrIle: 4.106 ± 0.066
3.131ThrLys: 3.131 ± 0.043
5.985ThrLeu: 5.985 ± 0.059
0.965ThrMet: 0.965 ± 0.026
3.235ThrAsn: 3.235 ± 0.061
3.235ThrPro: 3.235 ± 0.051
2.528ThrGln: 2.528 ± 0.041
2.313ThrArg: 2.313 ± 0.036
3.845ThrSer: 3.845 ± 0.069
4.139ThrThr: 4.139 ± 0.099
4.018ThrVal: 4.018 ± 0.062
0.786ThrTrp: 0.786 ± 0.025
2.61ThrTyr: 2.61 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.373ValAla: 5.373 ± 0.066
0.543ValCys: 0.543 ± 0.018
3.057ValAsp: 3.057 ± 0.041
3.341ValGlu: 3.341 ± 0.051
3.003ValPhe: 3.003 ± 0.047
4.094ValGly: 4.094 ± 0.052
1.123ValHis: 1.123 ± 0.023
4.336ValIle: 4.336 ± 0.048
4.325ValLys: 4.325 ± 0.06
6.3ValLeu: 6.3 ± 0.065
1.322ValMet: 1.322 ± 0.03
3.539ValAsn: 3.539 ± 0.052
2.989ValPro: 2.989 ± 0.046
2.689ValGln: 2.689 ± 0.041
2.686ValArg: 2.686 ± 0.041
4.104ValSer: 4.104 ± 0.05
4.23ValThr: 4.23 ± 0.064
4.542ValVal: 4.542 ± 0.059
0.742ValTrp: 0.742 ± 0.022
2.437ValTyr: 2.437 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.818TrpAla: 0.818 ± 0.024
0.092TrpCys: 0.092 ± 0.007
0.804TrpAsp: 0.804 ± 0.043
0.706TrpGlu: 0.706 ± 0.021
0.59TrpPhe: 0.59 ± 0.021
0.773TrpGly: 0.773 ± 0.024
0.302TrpHis: 0.302 ± 0.014
0.713TrpIle: 0.713 ± 0.023
0.63TrpLys: 0.63 ± 0.019
1.484TrpLeu: 1.484 ± 0.034
0.309TrpMet: 0.309 ± 0.014
0.664TrpAsn: 0.664 ± 0.022
0.461TrpPro: 0.461 ± 0.018
0.868TrpGln: 0.868 ± 0.026
0.603TrpArg: 0.603 ± 0.019
0.662TrpSer: 0.662 ± 0.023
0.62TrpThr: 0.62 ± 0.021
0.887TrpVal: 0.887 ± 0.025
0.201TrpTrp: 0.201 ± 0.011
0.471TrpTyr: 0.471 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.831TyrAla: 2.831 ± 0.044
0.313TyrCys: 0.313 ± 0.014
2.061TyrAsp: 2.061 ± 0.037
1.994TyrGlu: 1.994 ± 0.039
2.284TyrPhe: 2.284 ± 0.038
2.692TyrGly: 2.692 ± 0.055
0.899TyrHis: 0.899 ± 0.024
2.119TyrIle: 2.119 ± 0.033
2.058TyrLys: 2.058 ± 0.035
4.442TyrLeu: 4.442 ± 0.066
0.612TyrMet: 0.612 ± 0.019
2.194TyrAsn: 2.194 ± 0.045
1.739TyrPro: 1.739 ± 0.029
2.244TyrGln: 2.244 ± 0.04
2.071TyrArg: 2.071 ± 0.041
2.514TyrSer: 2.514 ± 0.042
2.403TyrThr: 2.403 ± 0.043
2.164TyrVal: 2.164 ± 0.037
0.765TyrTrp: 0.765 ± 0.04
1.815TyrTyr: 1.815 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5268 proteins (1761654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski