Amino acid dipepetide frequency for Pantoea phage vB_PagS_MED16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.57AlaAla: 13.57 ± 1.159
0.535AlaCys: 0.535 ± 0.214
5.615AlaAsp: 5.615 ± 0.576
5.95AlaGlu: 5.95 ± 0.881
3.744AlaPhe: 3.744 ± 0.519
9.225AlaGly: 9.225 ± 0.723
1.738AlaHis: 1.738 ± 0.288
5.415AlaIle: 5.415 ± 0.559
5.081AlaLys: 5.081 ± 0.799
8.423AlaLeu: 8.423 ± 0.891
3.142AlaMet: 3.142 ± 0.42
2.941AlaAsn: 2.941 ± 0.439
3.008AlaPro: 3.008 ± 0.512
3.677AlaGln: 3.677 ± 0.577
5.081AlaArg: 5.081 ± 0.573
5.816AlaSer: 5.816 ± 0.614
5.348AlaThr: 5.348 ± 0.774
6.819AlaVal: 6.819 ± 0.583
2.206AlaTrp: 2.206 ± 0.434
2.674AlaTyr: 2.674 ± 0.311
0.0AlaXaa: 0.0 ± 0.0
Cys
0.936CysAla: 0.936 ± 0.238
0.201CysCys: 0.201 ± 0.105
0.936CysAsp: 0.936 ± 0.252
1.136CysGlu: 1.136 ± 0.306
0.334CysPhe: 0.334 ± 0.133
0.869CysGly: 0.869 ± 0.225
0.201CysHis: 0.201 ± 0.11
0.468CysIle: 0.468 ± 0.169
0.468CysLys: 0.468 ± 0.193
0.802CysLeu: 0.802 ± 0.24
0.334CysMet: 0.334 ± 0.207
0.668CysAsn: 0.668 ± 0.244
0.468CysPro: 0.468 ± 0.181
0.468CysGln: 0.468 ± 0.17
0.869CysArg: 0.869 ± 0.213
0.802CysSer: 0.802 ± 0.254
0.602CysThr: 0.602 ± 0.209
1.136CysVal: 1.136 ± 0.314
0.267CysTrp: 0.267 ± 0.164
0.201CysTyr: 0.201 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
5.749AspAla: 5.749 ± 0.64
0.602AspCys: 0.602 ± 0.209
3.543AspAsp: 3.543 ± 0.433
3.61AspGlu: 3.61 ± 0.445
2.072AspPhe: 2.072 ± 0.332
5.214AspGly: 5.214 ± 0.681
0.735AspHis: 0.735 ± 0.216
3.075AspIle: 3.075 ± 0.51
2.875AspLys: 2.875 ± 0.438
4.88AspLeu: 4.88 ± 0.557
1.671AspMet: 1.671 ± 0.313
2.875AspAsn: 2.875 ± 0.428
3.008AspPro: 3.008 ± 0.479
3.142AspGln: 3.142 ± 0.507
3.61AspArg: 3.61 ± 0.499
3.409AspSer: 3.409 ± 0.546
3.342AspThr: 3.342 ± 0.447
3.744AspVal: 3.744 ± 0.564
0.936AspTrp: 0.936 ± 0.248
1.805AspTyr: 1.805 ± 0.38
0.0AspXaa: 0.0 ± 0.0
Glu
6.484GluAla: 6.484 ± 0.864
0.735GluCys: 0.735 ± 0.263
3.075GluAsp: 3.075 ± 0.527
3.075GluGlu: 3.075 ± 0.527
2.473GluPhe: 2.473 ± 0.471
3.677GluGly: 3.677 ± 0.561
0.802GluHis: 0.802 ± 0.273
2.808GluIle: 2.808 ± 0.34
3.677GluLys: 3.677 ± 0.697
5.214GluLeu: 5.214 ± 0.611
1.939GluMet: 1.939 ± 0.316
2.206GluAsn: 2.206 ± 0.419
1.872GluPro: 1.872 ± 0.503
2.473GluGln: 2.473 ± 0.557
3.877GluArg: 3.877 ± 0.474
3.342GluSer: 3.342 ± 0.524
3.075GluThr: 3.075 ± 0.328
3.744GluVal: 3.744 ± 0.422
0.802GluTrp: 0.802 ± 0.27
1.471GluTyr: 1.471 ± 0.305
0.0GluXaa: 0.0 ± 0.0
Phe
2.674PheAla: 2.674 ± 0.365
0.401PheCys: 0.401 ± 0.155
2.34PheAsp: 2.34 ± 0.4
1.07PheGlu: 1.07 ± 0.27
0.869PhePhe: 0.869 ± 0.231
2.808PheGly: 2.808 ± 0.467
0.535PheHis: 0.535 ± 0.183
2.741PheIle: 2.741 ± 0.477
1.003PheLys: 1.003 ± 0.226
1.939PheLeu: 1.939 ± 0.336
1.003PheMet: 1.003 ± 0.287
1.872PheAsn: 1.872 ± 0.318
1.07PhePro: 1.07 ± 0.232
1.538PheGln: 1.538 ± 0.332
1.27PheArg: 1.27 ± 0.279
2.875PheSer: 2.875 ± 0.409
2.941PheThr: 2.941 ± 0.5
1.939PheVal: 1.939 ± 0.29
0.869PheTrp: 0.869 ± 0.312
0.869PheTyr: 0.869 ± 0.219
0.0PheXaa: 0.0 ± 0.0
Gly
7.42GlyAla: 7.42 ± 0.763
0.869GlyCys: 0.869 ± 0.252
4.345GlyAsp: 4.345 ± 0.546
5.615GlyGlu: 5.615 ± 0.435
2.741GlyPhe: 2.741 ± 0.457
6.819GlyGly: 6.819 ± 1.024
0.735GlyHis: 0.735 ± 0.239
4.546GlyIle: 4.546 ± 0.573
5.147GlyLys: 5.147 ± 0.746
5.081GlyLeu: 5.081 ± 0.564
2.607GlyMet: 2.607 ± 0.459
3.276GlyAsn: 3.276 ± 0.611
2.206GlyPro: 2.206 ± 0.497
3.677GlyGln: 3.677 ± 0.771
3.877GlyArg: 3.877 ± 0.465
4.813GlySer: 4.813 ± 0.599
6.15GlyThr: 6.15 ± 0.679
5.749GlyVal: 5.749 ± 0.674
1.538GlyTrp: 1.538 ± 0.292
2.206GlyTyr: 2.206 ± 0.331
0.0GlyXaa: 0.0 ± 0.0
His
1.203HisAla: 1.203 ± 0.276
0.201HisCys: 0.201 ± 0.118
1.337HisAsp: 1.337 ± 0.341
0.869HisGlu: 0.869 ± 0.226
0.869HisPhe: 0.869 ± 0.239
1.337HisGly: 1.337 ± 0.277
0.668HisHis: 0.668 ± 0.227
1.203HisIle: 1.203 ± 0.315
0.602HisLys: 0.602 ± 0.162
1.671HisLeu: 1.671 ± 0.239
0.535HisMet: 0.535 ± 0.178
0.602HisAsn: 0.602 ± 0.211
0.735HisPro: 0.735 ± 0.226
0.468HisGln: 0.468 ± 0.156
1.604HisArg: 1.604 ± 0.341
1.27HisSer: 1.27 ± 0.244
0.668HisThr: 0.668 ± 0.202
1.538HisVal: 1.538 ± 0.285
0.201HisTrp: 0.201 ± 0.149
1.003HisTyr: 1.003 ± 0.245
0.0HisXaa: 0.0 ± 0.0
Ile
4.746IleAla: 4.746 ± 0.548
0.535IleCys: 0.535 ± 0.157
3.276IleAsp: 3.276 ± 0.534
3.142IleGlu: 3.142 ± 0.379
1.738IlePhe: 1.738 ± 0.384
4.479IleGly: 4.479 ± 0.644
1.738IleHis: 1.738 ± 0.302
3.476IleIle: 3.476 ± 0.47
2.34IleLys: 2.34 ± 0.432
4.011IleLeu: 4.011 ± 0.455
1.738IleMet: 1.738 ± 0.378
2.941IleAsn: 2.941 ± 0.35
2.407IlePro: 2.407 ± 0.424
2.473IleGln: 2.473 ± 0.463
2.875IleArg: 2.875 ± 0.312
4.078IleSer: 4.078 ± 0.437
3.61IleThr: 3.61 ± 0.5
3.142IleVal: 3.142 ± 0.552
1.003IleTrp: 1.003 ± 0.231
1.671IleTyr: 1.671 ± 0.366
0.0IleXaa: 0.0 ± 0.0
Lys
6.752LysAla: 6.752 ± 0.821
0.535LysCys: 0.535 ± 0.217
2.875LysAsp: 2.875 ± 0.587
3.276LysGlu: 3.276 ± 0.473
1.404LysPhe: 1.404 ± 0.353
3.61LysGly: 3.61 ± 0.669
1.136LysHis: 1.136 ± 0.345
1.538LysIle: 1.538 ± 0.261
2.674LysLys: 2.674 ± 0.527
5.014LysLeu: 5.014 ± 0.691
2.273LysMet: 2.273 ± 0.417
1.939LysAsn: 1.939 ± 0.363
2.674LysPro: 2.674 ± 0.517
2.407LysGln: 2.407 ± 0.392
2.741LysArg: 2.741 ± 0.366
3.342LysSer: 3.342 ± 0.54
2.741LysThr: 2.741 ± 0.4
3.409LysVal: 3.409 ± 0.479
1.203LysTrp: 1.203 ± 0.242
2.005LysTyr: 2.005 ± 0.332
0.0LysXaa: 0.0 ± 0.0
Leu
8.222LeuAla: 8.222 ± 0.854
1.337LeuCys: 1.337 ± 0.266
5.014LeuAsp: 5.014 ± 0.569
3.476LeuGlu: 3.476 ± 0.447
2.005LeuPhe: 2.005 ± 0.406
5.415LeuGly: 5.415 ± 0.552
1.538LeuHis: 1.538 ± 0.365
4.88LeuIle: 4.88 ± 0.518
4.613LeuLys: 4.613 ± 0.619
5.081LeuLeu: 5.081 ± 0.524
1.604LeuMet: 1.604 ± 0.326
3.476LeuAsn: 3.476 ± 0.508
3.075LeuPro: 3.075 ± 0.501
3.209LeuGln: 3.209 ± 0.506
4.145LeuArg: 4.145 ± 0.556
5.014LeuSer: 5.014 ± 0.613
6.016LeuThr: 6.016 ± 0.554
4.546LeuVal: 4.546 ± 0.641
0.802LeuTrp: 0.802 ± 0.267
2.206LeuTyr: 2.206 ± 0.39
0.0LeuXaa: 0.0 ± 0.0
Met
2.741MetAla: 2.741 ± 0.411
0.334MetCys: 0.334 ± 0.144
1.136MetAsp: 1.136 ± 0.257
1.939MetGlu: 1.939 ± 0.38
0.468MetPhe: 0.468 ± 0.174
2.273MetGly: 2.273 ± 0.431
0.201MetHis: 0.201 ± 0.114
2.34MetIle: 2.34 ± 0.396
2.473MetLys: 2.473 ± 0.333
1.805MetLeu: 1.805 ± 0.291
1.203MetMet: 1.203 ± 0.368
1.136MetAsn: 1.136 ± 0.27
1.07MetPro: 1.07 ± 0.257
1.738MetGln: 1.738 ± 0.221
1.872MetArg: 1.872 ± 0.337
2.875MetSer: 2.875 ± 0.387
1.805MetThr: 1.805 ± 0.301
2.54MetVal: 2.54 ± 0.451
0.201MetTrp: 0.201 ± 0.124
0.735MetTyr: 0.735 ± 0.23
0.0MetXaa: 0.0 ± 0.0
Asn
4.479AsnAla: 4.479 ± 0.509
0.802AsnCys: 0.802 ± 0.199
3.008AsnAsp: 3.008 ± 0.384
2.741AsnGlu: 2.741 ± 0.429
1.136AsnPhe: 1.136 ± 0.271
5.348AsnGly: 5.348 ± 0.681
1.136AsnHis: 1.136 ± 0.257
1.939AsnIle: 1.939 ± 0.393
1.805AsnLys: 1.805 ± 0.308
2.808AsnLeu: 2.808 ± 0.42
1.27AsnMet: 1.27 ± 0.292
3.276AsnAsn: 3.276 ± 0.466
2.473AsnPro: 2.473 ± 0.351
1.872AsnGln: 1.872 ± 0.338
2.005AsnArg: 2.005 ± 0.366
1.872AsnSer: 1.872 ± 0.427
2.072AsnThr: 2.072 ± 0.343
2.808AsnVal: 2.808 ± 0.403
0.602AsnTrp: 0.602 ± 0.19
1.27AsnTyr: 1.27 ± 0.337
0.0AsnXaa: 0.0 ± 0.0
Pro
4.746ProAla: 4.746 ± 0.671
0.468ProCys: 0.468 ± 0.177
2.941ProAsp: 2.941 ± 0.453
3.543ProGlu: 3.543 ± 0.822
1.471ProPhe: 1.471 ± 0.349
2.607ProGly: 2.607 ± 0.376
0.802ProHis: 0.802 ± 0.203
1.538ProIle: 1.538 ± 0.291
2.607ProLys: 2.607 ± 0.399
2.741ProLeu: 2.741 ± 0.389
1.07ProMet: 1.07 ± 0.22
1.939ProAsn: 1.939 ± 0.413
1.738ProPro: 1.738 ± 0.378
1.07ProGln: 1.07 ± 0.278
1.471ProArg: 1.471 ± 0.379
2.34ProSer: 2.34 ± 0.442
2.34ProThr: 2.34 ± 0.428
3.944ProVal: 3.944 ± 0.548
1.337ProTrp: 1.337 ± 0.296
1.136ProTyr: 1.136 ± 0.293
0.0ProXaa: 0.0 ± 0.0
Gln
3.744GlnAla: 3.744 ± 0.43
0.468GlnCys: 0.468 ± 0.152
2.674GlnAsp: 2.674 ± 0.401
2.473GlnGlu: 2.473 ± 0.633
1.671GlnPhe: 1.671 ± 0.35
2.741GlnGly: 2.741 ± 0.434
0.535GlnHis: 0.535 ± 0.17
3.008GlnIle: 3.008 ± 0.539
2.005GlnLys: 2.005 ± 0.396
3.944GlnLeu: 3.944 ± 0.519
1.805GlnMet: 1.805 ± 0.419
1.203GlnAsn: 1.203 ± 0.278
1.738GlnPro: 1.738 ± 0.422
3.008GlnGln: 3.008 ± 0.83
3.409GlnArg: 3.409 ± 0.488
2.674GlnSer: 2.674 ± 0.53
2.607GlnThr: 2.607 ± 0.504
3.142GlnVal: 3.142 ± 0.424
1.003GlnTrp: 1.003 ± 0.23
1.471GlnTyr: 1.471 ± 0.27
0.0GlnXaa: 0.0 ± 0.0
Arg
4.613ArgAla: 4.613 ± 0.461
1.003ArgCys: 1.003 ± 0.3
2.54ArgAsp: 2.54 ± 0.407
3.209ArgGlu: 3.209 ± 0.571
2.139ArgPhe: 2.139 ± 0.366
3.342ArgGly: 3.342 ± 0.444
0.936ArgHis: 0.936 ± 0.242
3.677ArgIle: 3.677 ± 0.561
4.011ArgLys: 4.011 ± 0.72
4.88ArgLeu: 4.88 ± 0.558
2.072ArgMet: 2.072 ± 0.331
2.808ArgAsn: 2.808 ± 0.422
2.607ArgPro: 2.607 ± 0.517
2.808ArgGln: 2.808 ± 0.438
3.476ArgArg: 3.476 ± 0.569
2.674ArgSer: 2.674 ± 0.465
2.072ArgThr: 2.072 ± 0.333
3.744ArgVal: 3.744 ± 0.52
0.936ArgTrp: 0.936 ± 0.239
2.005ArgTyr: 2.005 ± 0.395
0.0ArgXaa: 0.0 ± 0.0
Ser
5.615SerAla: 5.615 ± 0.613
0.735SerCys: 0.735 ± 0.258
4.011SerAsp: 4.011 ± 0.457
3.543SerGlu: 3.543 ± 0.519
1.671SerPhe: 1.671 ± 0.298
6.15SerGly: 6.15 ± 0.569
1.203SerHis: 1.203 ± 0.26
3.476SerIle: 3.476 ± 0.512
3.008SerLys: 3.008 ± 0.425
4.412SerLeu: 4.412 ± 0.518
1.872SerMet: 1.872 ± 0.336
2.808SerAsn: 2.808 ± 0.626
2.54SerPro: 2.54 ± 0.401
2.139SerGln: 2.139 ± 0.408
2.808SerArg: 2.808 ± 0.444
3.209SerSer: 3.209 ± 0.503
3.944SerThr: 3.944 ± 0.474
4.679SerVal: 4.679 ± 0.614
1.136SerTrp: 1.136 ± 0.275
2.139SerTyr: 2.139 ± 0.299
0.0SerXaa: 0.0 ± 0.0
Thr
6.083ThrAla: 6.083 ± 0.659
0.802ThrCys: 0.802 ± 0.23
3.744ThrAsp: 3.744 ± 0.518
2.674ThrGlu: 2.674 ± 0.373
1.471ThrPhe: 1.471 ± 0.287
6.083ThrGly: 6.083 ± 0.721
1.136ThrHis: 1.136 ± 0.23
3.944ThrIle: 3.944 ± 0.477
2.941ThrLys: 2.941 ± 0.418
4.546ThrLeu: 4.546 ± 0.477
1.404ThrMet: 1.404 ± 0.294
3.142ThrAsn: 3.142 ± 0.52
3.075ThrPro: 3.075 ± 0.348
3.342ThrGln: 3.342 ± 0.494
3.142ThrArg: 3.142 ± 0.426
3.342ThrSer: 3.342 ± 0.535
3.543ThrThr: 3.543 ± 0.473
3.677ThrVal: 3.677 ± 0.548
0.869ThrTrp: 0.869 ± 0.223
1.738ThrTyr: 1.738 ± 0.318
0.0ThrXaa: 0.0 ± 0.0
Val
6.418ValAla: 6.418 ± 0.631
0.869ValCys: 0.869 ± 0.22
3.944ValAsp: 3.944 ± 0.864
3.476ValGlu: 3.476 ± 0.458
2.875ValPhe: 2.875 ± 0.485
3.944ValGly: 3.944 ± 0.501
1.07ValHis: 1.07 ± 0.267
3.276ValIle: 3.276 ± 0.552
3.944ValLys: 3.944 ± 0.606
4.613ValLeu: 4.613 ± 0.497
2.407ValMet: 2.407 ± 0.389
3.476ValAsn: 3.476 ± 0.514
3.276ValPro: 3.276 ± 0.454
3.075ValGln: 3.075 ± 0.424
4.011ValArg: 4.011 ± 0.671
4.412ValSer: 4.412 ± 0.443
5.348ValThr: 5.348 ± 0.635
5.548ValVal: 5.548 ± 0.747
0.802ValTrp: 0.802 ± 0.262
1.671ValTyr: 1.671 ± 0.286
0.0ValXaa: 0.0 ± 0.0
Trp
1.538TrpAla: 1.538 ± 0.389
0.134TrpCys: 0.134 ± 0.097
0.936TrpAsp: 0.936 ± 0.209
0.869TrpGlu: 0.869 ± 0.266
0.401TrpPhe: 0.401 ± 0.147
1.203TrpGly: 1.203 ± 0.255
0.936TrpHis: 0.936 ± 0.276
1.003TrpIle: 1.003 ± 0.262
1.203TrpLys: 1.203 ± 0.306
1.604TrpLeu: 1.604 ± 0.395
0.468TrpMet: 0.468 ± 0.159
0.602TrpAsn: 0.602 ± 0.174
1.136TrpPro: 1.136 ± 0.303
1.203TrpGln: 1.203 ± 0.315
1.136TrpArg: 1.136 ± 0.24
0.735TrpSer: 0.735 ± 0.201
0.802TrpThr: 0.802 ± 0.238
1.136TrpVal: 1.136 ± 0.282
0.334TrpTrp: 0.334 ± 0.153
0.267TrpTyr: 0.267 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.273TyrAla: 2.273 ± 0.391
0.602TyrCys: 0.602 ± 0.223
2.607TyrAsp: 2.607 ± 0.431
1.136TyrGlu: 1.136 ± 0.277
1.07TyrPhe: 1.07 ± 0.28
2.273TyrGly: 2.273 ± 0.318
0.802TyrHis: 0.802 ± 0.252
1.07TyrIle: 1.07 ± 0.258
1.07TyrLys: 1.07 ± 0.301
2.206TyrLeu: 2.206 ± 0.357
0.401TyrMet: 0.401 ± 0.162
1.538TyrAsn: 1.538 ± 0.327
1.738TyrPro: 1.738 ± 0.41
1.538TyrGln: 1.538 ± 0.274
2.273TyrArg: 2.273 ± 0.461
2.206TyrSer: 2.206 ± 0.359
1.671TyrThr: 1.671 ± 0.305
1.471TyrVal: 1.471 ± 0.283
0.602TyrTrp: 0.602 ± 0.232
1.07TyrTyr: 1.07 ± 0.284
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (14960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski