Amino acid dipepetide frequency for Marinitoga camini virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.357AlaAla: 2.357 ± 0.567
0.135AlaCys: 0.135 ± 0.082
3.031AlaAsp: 3.031 ± 0.665
4.31AlaGlu: 4.31 ± 0.629
2.222AlaPhe: 2.222 ± 0.406
3.367AlaGly: 3.367 ± 0.891
0.471AlaHis: 0.471 ± 0.178
4.916AlaIle: 4.916 ± 1.472
6.398AlaLys: 6.398 ± 0.645
5.118AlaLeu: 5.118 ± 0.711
0.741AlaMet: 0.741 ± 0.223
3.367AlaAsn: 3.367 ± 0.62
0.875AlaPro: 0.875 ± 0.208
1.28AlaGln: 1.28 ± 0.393
1.751AlaArg: 1.751 ± 0.325
2.357AlaSer: 2.357 ± 0.323
3.569AlaThr: 3.569 ± 1.034
2.963AlaVal: 2.963 ± 0.496
0.539AlaTrp: 0.539 ± 0.181
1.886AlaTyr: 1.886 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.337CysAsp: 0.337 ± 0.161
0.269CysGlu: 0.269 ± 0.133
0.067CysPhe: 0.067 ± 0.069
0.269CysGly: 0.269 ± 0.115
0.202CysHis: 0.202 ± 0.119
0.202CysIle: 0.202 ± 0.112
0.202CysLys: 0.202 ± 0.114
0.202CysLeu: 0.202 ± 0.143
0.067CysMet: 0.067 ± 0.064
0.337CysAsn: 0.337 ± 0.162
0.269CysPro: 0.269 ± 0.182
0.202CysGln: 0.202 ± 0.11
0.0CysArg: 0.0 ± 0.0
0.337CysSer: 0.337 ± 0.151
0.0CysThr: 0.0 ± 0.0
0.404CysVal: 0.404 ± 0.181
0.0CysTrp: 0.0 ± 0.0
0.067CysTyr: 0.067 ± 0.067
0.0CysXaa: 0.0 ± 0.0
Asp
3.3AspAla: 3.3 ± 0.464
0.202AspCys: 0.202 ± 0.112
2.963AspAsp: 2.963 ± 0.425
4.714AspGlu: 4.714 ± 0.472
3.704AspPhe: 3.704 ± 0.487
2.828AspGly: 2.828 ± 0.468
0.606AspHis: 0.606 ± 0.216
4.916AspIle: 4.916 ± 0.584
5.59AspLys: 5.59 ± 0.798
5.926AspLeu: 5.926 ± 0.65
1.145AspMet: 1.145 ± 0.246
4.31AspAsn: 4.31 ± 0.625
1.684AspPro: 1.684 ± 0.33
1.01AspGln: 1.01 ± 0.322
1.751AspArg: 1.751 ± 0.338
2.963AspSer: 2.963 ± 0.415
2.492AspThr: 2.492 ± 0.419
3.233AspVal: 3.233 ± 0.465
0.943AspTrp: 0.943 ± 0.241
3.165AspTyr: 3.165 ± 0.434
0.0AspXaa: 0.0 ± 0.0
Glu
2.828GluAla: 2.828 ± 0.676
0.337GluCys: 0.337 ± 0.165
4.579GluAsp: 4.579 ± 0.436
5.926GluGlu: 5.926 ± 1.089
3.502GluPhe: 3.502 ± 0.517
2.896GluGly: 2.896 ± 0.405
0.741GluHis: 0.741 ± 0.224
9.967GluIle: 9.967 ± 0.933
11.247GluLys: 11.247 ± 1.411
7.677GluLeu: 7.677 ± 0.8
2.088GluMet: 2.088 ± 0.331
7.341GluAsn: 7.341 ± 0.836
1.886GluPro: 1.886 ± 0.505
2.626GluGln: 2.626 ± 0.464
1.953GluArg: 1.953 ± 0.394
4.108GluSer: 4.108 ± 0.513
3.569GluThr: 3.569 ± 0.522
3.704GluVal: 3.704 ± 0.48
1.01GluTrp: 1.01 ± 0.227
4.108GluTyr: 4.108 ± 0.453
0.0GluXaa: 0.0 ± 0.0
Phe
2.492PheAla: 2.492 ± 0.494
0.067PheCys: 0.067 ± 0.061
3.569PheAsp: 3.569 ± 0.45
3.973PheGlu: 3.973 ± 0.438
2.828PhePhe: 2.828 ± 0.698
3.637PheGly: 3.637 ± 0.742
0.673PheHis: 0.673 ± 0.189
3.367PheIle: 3.367 ± 0.517
5.388PheLys: 5.388 ± 0.783
3.839PheLeu: 3.839 ± 0.542
0.808PheMet: 0.808 ± 0.248
2.626PheAsn: 2.626 ± 0.521
1.212PhePro: 1.212 ± 0.299
1.145PheGln: 1.145 ± 0.264
1.347PheArg: 1.347 ± 0.315
3.165PheSer: 3.165 ± 0.556
1.751PheThr: 1.751 ± 0.3
2.492PheVal: 2.492 ± 0.399
0.808PheTrp: 0.808 ± 0.252
1.953PheTyr: 1.953 ± 0.394
0.0PheXaa: 0.0 ± 0.0
Gly
3.3GlyAla: 3.3 ± 0.974
0.135GlyCys: 0.135 ± 0.096
2.828GlyAsp: 2.828 ± 0.377
3.906GlyGlu: 3.906 ± 0.486
1.549GlyPhe: 1.549 ± 0.35
2.357GlyGly: 2.357 ± 0.444
0.606GlyHis: 0.606 ± 0.219
6.061GlyIle: 6.061 ± 0.448
5.994GlyLys: 5.994 ± 0.649
4.041GlyLeu: 4.041 ± 0.499
1.145GlyMet: 1.145 ± 0.297
3.906GlyAsn: 3.906 ± 0.45
1.212GlyPro: 1.212 ± 0.317
1.482GlyGln: 1.482 ± 0.316
1.616GlyArg: 1.616 ± 0.274
2.828GlySer: 2.828 ± 0.553
3.637GlyThr: 3.637 ± 0.687
2.963GlyVal: 2.963 ± 0.418
0.471GlyTrp: 0.471 ± 0.16
2.492GlyTyr: 2.492 ± 0.358
0.0GlyXaa: 0.0 ± 0.0
His
0.673HisAla: 0.673 ± 0.159
0.202HisCys: 0.202 ± 0.143
0.943HisAsp: 0.943 ± 0.201
0.539HisGlu: 0.539 ± 0.206
0.875HisPhe: 0.875 ± 0.282
0.606HisGly: 0.606 ± 0.16
0.269HisHis: 0.269 ± 0.133
1.28HisIle: 1.28 ± 0.252
0.875HisLys: 0.875 ± 0.211
0.539HisLeu: 0.539 ± 0.233
0.202HisMet: 0.202 ± 0.109
0.337HisAsn: 0.337 ± 0.156
0.539HisPro: 0.539 ± 0.182
0.404HisGln: 0.404 ± 0.156
0.404HisArg: 0.404 ± 0.159
1.078HisSer: 1.078 ± 0.436
1.01HisThr: 1.01 ± 0.304
0.606HisVal: 0.606 ± 0.184
0.269HisTrp: 0.269 ± 0.131
0.741HisTyr: 0.741 ± 0.198
0.0HisXaa: 0.0 ± 0.0
Ile
6.196IleAla: 6.196 ± 1.199
0.269IleCys: 0.269 ± 0.18
6.196IleAsp: 6.196 ± 0.664
9.361IleGlu: 9.361 ± 1.073
4.445IlePhe: 4.445 ± 0.712
5.32IleGly: 5.32 ± 0.665
0.875IleHis: 0.875 ± 0.251
9.294IleIle: 9.294 ± 1.012
11.247IleLys: 11.247 ± 0.965
8.889IleLeu: 8.889 ± 0.951
1.886IleMet: 1.886 ± 0.36
6.061IleAsn: 6.061 ± 0.672
3.973IlePro: 3.973 ± 0.629
2.626IleGln: 2.626 ± 0.495
3.165IleArg: 3.165 ± 0.452
6.734IleSer: 6.734 ± 0.701
5.792IleThr: 5.792 ± 1.346
4.175IleVal: 4.175 ± 0.545
0.539IleTrp: 0.539 ± 0.226
3.502IleTyr: 3.502 ± 0.434
0.0IleXaa: 0.0 ± 0.0
Lys
4.243LysAla: 4.243 ± 0.442
0.471LysCys: 0.471 ± 0.196
6.061LysAsp: 6.061 ± 0.661
10.438LysGlu: 10.438 ± 1.295
3.973LysPhe: 3.973 ± 0.455
4.849LysGly: 4.849 ± 0.563
1.751LysHis: 1.751 ± 0.351
15.624LysIle: 15.624 ± 1.114
14.008LysLys: 14.008 ± 1.932
8.62LysLeu: 8.62 ± 0.827
2.492LysMet: 2.492 ± 0.553
8.687LysAsn: 8.687 ± 1.029
1.684LysPro: 1.684 ± 0.322
2.828LysGln: 2.828 ± 0.422
4.108LysArg: 4.108 ± 0.67
5.724LysSer: 5.724 ± 0.806
5.32LysThr: 5.32 ± 0.576
6.128LysVal: 6.128 ± 0.566
1.212LysTrp: 1.212 ± 0.293
5.253LysTyr: 5.253 ± 0.718
0.0LysXaa: 0.0 ± 0.0
Leu
4.512LeuAla: 4.512 ± 0.742
0.471LeuCys: 0.471 ± 0.165
5.253LeuAsp: 5.253 ± 0.567
7.341LeuGlu: 7.341 ± 0.95
3.233LeuPhe: 3.233 ± 0.55
5.455LeuGly: 5.455 ± 0.768
0.943LeuHis: 0.943 ± 0.377
6.532LeuIle: 6.532 ± 0.708
11.651LeuLys: 11.651 ± 1.12
6.532LeuLeu: 6.532 ± 0.768
1.751LeuMet: 1.751 ± 0.349
7.273LeuAsn: 7.273 ± 0.736
2.424LeuPro: 2.424 ± 0.389
2.963LeuGln: 2.963 ± 0.493
2.896LeuArg: 2.896 ± 0.58
6.061LeuSer: 6.061 ± 0.624
4.849LeuThr: 4.849 ± 0.503
4.041LeuVal: 4.041 ± 0.448
0.539LeuTrp: 0.539 ± 0.222
3.098LeuTyr: 3.098 ± 0.502
0.0LeuXaa: 0.0 ± 0.0
Met
1.549MetAla: 1.549 ± 0.379
0.067MetCys: 0.067 ± 0.064
0.741MetAsp: 0.741 ± 0.21
1.684MetGlu: 1.684 ± 0.343
0.943MetPhe: 0.943 ± 0.219
1.212MetGly: 1.212 ± 0.282
0.337MetHis: 0.337 ± 0.172
1.818MetIle: 1.818 ± 0.413
2.626MetLys: 2.626 ± 0.515
1.482MetLeu: 1.482 ± 0.372
0.269MetMet: 0.269 ± 0.144
1.347MetAsn: 1.347 ± 0.283
0.606MetPro: 0.606 ± 0.236
0.808MetGln: 0.808 ± 0.248
0.673MetArg: 0.673 ± 0.207
1.347MetSer: 1.347 ± 0.291
1.145MetThr: 1.145 ± 0.255
0.808MetVal: 0.808 ± 0.201
0.067MetTrp: 0.067 ± 0.076
0.808MetTyr: 0.808 ± 0.259
0.0MetXaa: 0.0 ± 0.0
Asn
3.569AsnAla: 3.569 ± 0.714
0.337AsnCys: 0.337 ± 0.178
3.569AsnAsp: 3.569 ± 0.478
4.984AsnGlu: 4.984 ± 0.546
3.569AsnPhe: 3.569 ± 0.515
3.839AsnGly: 3.839 ± 0.467
0.875AsnHis: 0.875 ± 0.237
6.465AsnIle: 6.465 ± 0.684
7.677AsnLys: 7.677 ± 0.734
7.408AsnLeu: 7.408 ± 0.65
1.145AsnMet: 1.145 ± 0.279
5.724AsnAsn: 5.724 ± 0.906
2.088AsnPro: 2.088 ± 0.389
2.02AsnGln: 2.02 ± 0.348
1.616AsnArg: 1.616 ± 0.297
3.839AsnSer: 3.839 ± 0.453
3.098AsnThr: 3.098 ± 0.459
3.906AsnVal: 3.906 ± 0.453
0.741AsnTrp: 0.741 ± 0.235
3.098AsnTyr: 3.098 ± 0.462
0.0AsnXaa: 0.0 ± 0.0
Pro
1.414ProAla: 1.414 ± 0.355
0.0ProCys: 0.0 ± 0.0
1.953ProAsp: 1.953 ± 0.432
2.424ProGlu: 2.424 ± 0.341
1.549ProPhe: 1.549 ± 0.375
0.673ProGly: 0.673 ± 0.213
0.135ProHis: 0.135 ± 0.105
2.492ProIle: 2.492 ± 0.391
2.492ProLys: 2.492 ± 0.514
1.616ProLeu: 1.616 ± 0.273
0.337ProMet: 0.337 ± 0.15
1.751ProAsn: 1.751 ± 0.395
0.539ProPro: 0.539 ± 0.201
0.808ProGln: 0.808 ± 0.201
0.673ProArg: 0.673 ± 0.224
1.886ProSer: 1.886 ± 0.346
1.818ProThr: 1.818 ± 0.49
1.684ProVal: 1.684 ± 0.348
0.202ProTrp: 0.202 ± 0.112
1.347ProTyr: 1.347 ± 0.305
0.0ProXaa: 0.0 ± 0.0
Gln
1.347GlnAla: 1.347 ± 0.346
0.067GlnCys: 0.067 ± 0.065
1.078GlnAsp: 1.078 ± 0.241
2.492GlnGlu: 2.492 ± 0.32
1.078GlnPhe: 1.078 ± 0.269
1.078GlnGly: 1.078 ± 0.245
0.404GlnHis: 0.404 ± 0.18
3.165GlnIle: 3.165 ± 0.469
3.973GlnLys: 3.973 ± 0.58
3.165GlnLeu: 3.165 ± 0.428
0.471GlnMet: 0.471 ± 0.145
2.02GlnAsn: 2.02 ± 0.336
0.673GlnPro: 0.673 ± 0.216
1.145GlnGln: 1.145 ± 0.276
1.212GlnArg: 1.212 ± 0.22
1.347GlnSer: 1.347 ± 0.282
1.616GlnThr: 1.616 ± 0.366
1.616GlnVal: 1.616 ± 0.318
0.269GlnTrp: 0.269 ± 0.142
1.078GlnTyr: 1.078 ± 0.285
0.0GlnXaa: 0.0 ± 0.0
Arg
1.684ArgAla: 1.684 ± 0.381
0.135ArgCys: 0.135 ± 0.089
1.414ArgAsp: 1.414 ± 0.419
2.155ArgGlu: 2.155 ± 0.578
1.616ArgPhe: 1.616 ± 0.375
1.684ArgGly: 1.684 ± 0.361
0.606ArgHis: 0.606 ± 0.208
3.569ArgIle: 3.569 ± 0.624
3.637ArgLys: 3.637 ± 0.675
2.088ArgLeu: 2.088 ± 0.325
1.616ArgMet: 1.616 ± 0.365
2.02ArgAsn: 2.02 ± 0.517
0.808ArgPro: 0.808 ± 0.255
0.943ArgGln: 0.943 ± 0.248
1.347ArgArg: 1.347 ± 0.393
1.482ArgSer: 1.482 ± 0.365
1.886ArgThr: 1.886 ± 0.388
1.347ArgVal: 1.347 ± 0.296
0.202ArgTrp: 0.202 ± 0.098
1.28ArgTyr: 1.28 ± 0.384
0.0ArgXaa: 0.0 ± 0.0
Ser
3.839SerAla: 3.839 ± 0.955
0.067SerCys: 0.067 ± 0.059
3.3SerAsp: 3.3 ± 0.532
5.051SerGlu: 5.051 ± 0.589
3.367SerPhe: 3.367 ± 0.589
3.637SerGly: 3.637 ± 0.564
1.01SerHis: 1.01 ± 0.34
5.186SerIle: 5.186 ± 0.785
5.657SerLys: 5.657 ± 0.715
6.128SerLeu: 6.128 ± 0.657
1.01SerMet: 1.01 ± 0.303
3.3SerAsn: 3.3 ± 0.558
1.28SerPro: 1.28 ± 0.328
1.616SerGln: 1.616 ± 0.265
1.212SerArg: 1.212 ± 0.303
3.435SerSer: 3.435 ± 0.498
3.233SerThr: 3.233 ± 0.467
2.424SerVal: 2.424 ± 0.389
0.673SerTrp: 0.673 ± 0.178
3.098SerTyr: 3.098 ± 0.421
0.0SerXaa: 0.0 ± 0.0
Thr
4.243ThrAla: 4.243 ± 0.986
0.067ThrCys: 0.067 ± 0.069
3.031ThrAsp: 3.031 ± 0.519
3.569ThrGlu: 3.569 ± 0.562
2.424ThrPhe: 2.424 ± 0.338
3.502ThrGly: 3.502 ± 0.683
0.943ThrHis: 0.943 ± 0.297
4.916ThrIle: 4.916 ± 0.579
4.243ThrLys: 4.243 ± 0.485
4.647ThrLeu: 4.647 ± 0.681
1.078ThrMet: 1.078 ± 0.277
2.29ThrAsn: 2.29 ± 0.657
1.953ThrPro: 1.953 ± 0.338
1.886ThrGln: 1.886 ± 0.451
1.482ThrArg: 1.482 ± 0.321
3.367ThrSer: 3.367 ± 0.702
3.839ThrThr: 3.839 ± 0.959
3.233ThrVal: 3.233 ± 0.632
0.808ThrTrp: 0.808 ± 0.234
1.684ThrTyr: 1.684 ± 0.343
0.0ThrXaa: 0.0 ± 0.0
Val
2.357ValAla: 2.357 ± 0.529
0.202ValCys: 0.202 ± 0.124
3.233ValAsp: 3.233 ± 0.491
4.377ValGlu: 4.377 ± 0.505
2.761ValPhe: 2.761 ± 0.43
2.626ValGly: 2.626 ± 0.423
0.404ValHis: 0.404 ± 0.173
5.522ValIle: 5.522 ± 0.566
4.243ValLys: 4.243 ± 0.602
4.512ValLeu: 4.512 ± 0.601
0.875ValMet: 0.875 ± 0.214
3.569ValAsn: 3.569 ± 0.455
1.212ValPro: 1.212 ± 0.337
1.953ValGln: 1.953 ± 0.325
2.29ValArg: 2.29 ± 0.375
3.502ValSer: 3.502 ± 0.555
1.684ValThr: 1.684 ± 0.34
2.155ValVal: 2.155 ± 0.386
0.741ValTrp: 0.741 ± 0.232
1.751ValTyr: 1.751 ± 0.314
0.0ValXaa: 0.0 ± 0.0
Trp
0.337TrpAla: 0.337 ± 0.17
0.135TrpCys: 0.135 ± 0.103
0.741TrpAsp: 0.741 ± 0.254
1.145TrpGlu: 1.145 ± 0.224
0.539TrpPhe: 0.539 ± 0.219
0.471TrpGly: 0.471 ± 0.198
0.0TrpHis: 0.0 ± 0.0
0.875TrpIle: 0.875 ± 0.219
1.28TrpLys: 1.28 ± 0.343
1.01TrpLeu: 1.01 ± 0.246
0.269TrpMet: 0.269 ± 0.139
0.741TrpAsn: 0.741 ± 0.204
0.067TrpPro: 0.067 ± 0.084
0.269TrpGln: 0.269 ± 0.107
0.471TrpArg: 0.471 ± 0.165
0.741TrpSer: 0.741 ± 0.218
0.606TrpThr: 0.606 ± 0.159
0.471TrpVal: 0.471 ± 0.182
0.0TrpTrp: 0.0 ± 0.0
0.337TrpTyr: 0.337 ± 0.123
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.414TyrAla: 1.414 ± 0.418
0.067TyrCys: 0.067 ± 0.063
2.626TyrAsp: 2.626 ± 0.338
3.435TyrGlu: 3.435 ± 0.641
2.896TyrPhe: 2.896 ± 0.468
2.222TyrGly: 2.222 ± 0.424
0.539TyrHis: 0.539 ± 0.18
4.377TyrIle: 4.377 ± 0.621
5.051TyrLys: 5.051 ± 0.845
4.377TyrLeu: 4.377 ± 0.61
0.875TyrMet: 0.875 ± 0.244
2.559TyrAsn: 2.559 ± 0.407
0.808TyrPro: 0.808 ± 0.222
1.28TyrGln: 1.28 ± 0.207
1.616TyrArg: 1.616 ± 0.334
2.222TyrSer: 2.222 ± 0.414
2.29TyrThr: 2.29 ± 0.38
1.616TyrVal: 1.616 ± 0.287
0.471TyrTrp: 0.471 ± 0.207
2.02TyrTyr: 2.02 ± 0.345
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (14850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski