Amino acid dipepetide frequency for Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.659AlaAla: 17.659 ± 0.236
1.268AlaCys: 1.268 ± 0.034
7.637AlaAsp: 7.637 ± 0.086
8.078AlaGlu: 8.078 ± 0.106
3.947AlaPhe: 3.947 ± 0.061
10.559AlaGly: 10.559 ± 0.118
2.517AlaHis: 2.517 ± 0.046
6.03AlaIle: 6.03 ± 0.081
4.602AlaLys: 4.602 ± 0.08
13.795AlaLeu: 13.795 ± 0.15
3.662AlaMet: 3.662 ± 0.06
3.175AlaAsn: 3.175 ± 0.072
5.379AlaPro: 5.379 ± 0.093
4.769AlaGln: 4.769 ± 0.071
8.031AlaArg: 8.031 ± 0.099
5.727AlaSer: 5.727 ± 0.09
5.591AlaThr: 5.591 ± 0.122
9.316AlaVal: 9.316 ± 0.102
1.636AlaTrp: 1.636 ± 0.038
2.219AlaTyr: 2.219 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.052CysAla: 1.052 ± 0.028
0.152CysCys: 0.152 ± 0.011
0.59CysAsp: 0.59 ± 0.02
0.423CysGlu: 0.423 ± 0.018
0.308CysPhe: 0.308 ± 0.016
1.03CysGly: 1.03 ± 0.033
0.32CysHis: 0.32 ± 0.019
0.379CysIle: 0.379 ± 0.018
0.279CysLys: 0.279 ± 0.014
0.959CysLeu: 0.959 ± 0.027
0.175CysMet: 0.175 ± 0.012
0.22CysAsn: 0.22 ± 0.014
0.601CysPro: 0.601 ± 0.029
0.299CysGln: 0.299 ± 0.014
0.813CysArg: 0.813 ± 0.029
0.478CysSer: 0.478 ± 0.022
0.48CysThr: 0.48 ± 0.02
0.653CysVal: 0.653 ± 0.025
0.141CysTrp: 0.141 ± 0.01
0.196CysTyr: 0.196 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.429AspAla: 6.429 ± 0.09
0.572AspCys: 0.572 ± 0.022
3.786AspAsp: 3.786 ± 0.088
3.453AspGlu: 3.453 ± 0.075
2.274AspPhe: 2.274 ± 0.044
6.128AspGly: 6.128 ± 0.094
1.533AspHis: 1.533 ± 0.038
3.215AspIle: 3.215 ± 0.058
2.054AspLys: 2.054 ± 0.044
6.382AspLeu: 6.382 ± 0.075
1.587AspMet: 1.587 ± 0.034
1.556AspAsn: 1.556 ± 0.046
3.107AspPro: 3.107 ± 0.056
2.171AspGln: 2.171 ± 0.04
4.192AspArg: 4.192 ± 0.069
2.769AspSer: 2.769 ± 0.054
2.813AspThr: 2.813 ± 0.067
4.085AspVal: 4.085 ± 0.081
0.969AspTrp: 0.969 ± 0.032
1.355AspTyr: 1.355 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.111GluAla: 7.111 ± 0.084
0.481GluCys: 0.481 ± 0.021
2.731GluAsp: 2.731 ± 0.056
2.824GluGlu: 2.824 ± 0.067
1.642GluPhe: 1.642 ± 0.037
3.646GluGly: 3.646 ± 0.057
1.133GluHis: 1.133 ± 0.032
3.201GluIle: 3.201 ± 0.056
2.173GluLys: 2.173 ± 0.048
5.021GluLeu: 5.021 ± 0.084
1.706GluMet: 1.706 ± 0.038
1.457GluAsn: 1.457 ± 0.033
2.256GluPro: 2.256 ± 0.046
2.25GluGln: 2.25 ± 0.05
4.47GluArg: 4.47 ± 0.068
2.412GluSer: 2.412 ± 0.045
3.124GluThr: 3.124 ± 0.044
3.971GluVal: 3.971 ± 0.063
0.671GluTrp: 0.671 ± 0.023
1.029GluTyr: 1.029 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.321PheAla: 4.321 ± 0.061
0.428PheCys: 0.428 ± 0.017
2.5PheAsp: 2.5 ± 0.047
1.624PheGlu: 1.624 ± 0.038
1.294PhePhe: 1.294 ± 0.036
3.137PheGly: 3.137 ± 0.058
0.784PheHis: 0.784 ± 0.029
1.622PheIle: 1.622 ± 0.04
1.076PheLys: 1.076 ± 0.031
3.265PheLeu: 3.265 ± 0.057
0.757PheMet: 0.757 ± 0.024
1.011PheAsn: 1.011 ± 0.035
1.419PhePro: 1.419 ± 0.033
1.114PheGln: 1.114 ± 0.028
2.064PheArg: 2.064 ± 0.041
2.02PheSer: 2.02 ± 0.041
2.056PheThr: 2.056 ± 0.047
2.468PheVal: 2.468 ± 0.049
0.465PheTrp: 0.465 ± 0.021
0.738PheTyr: 0.738 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
8.748GlyAla: 8.748 ± 0.1
0.957GlyCys: 0.957 ± 0.032
4.917GlyAsp: 4.917 ± 0.084
4.366GlyGlu: 4.366 ± 0.066
3.26GlyPhe: 3.26 ± 0.046
7.529GlyGly: 7.529 ± 0.121
2.071GlyHis: 2.071 ± 0.046
4.824GlyIle: 4.824 ± 0.07
3.557GlyLys: 3.557 ± 0.07
9.202GlyLeu: 9.202 ± 0.106
2.492GlyMet: 2.492 ± 0.04
2.293GlyAsn: 2.293 ± 0.072
3.207GlyPro: 3.207 ± 0.059
3.437GlyGln: 3.437 ± 0.059
5.91GlyArg: 5.91 ± 0.075
4.308GlySer: 4.308 ± 0.098
4.675GlyThr: 4.675 ± 0.143
5.617GlyVal: 5.617 ± 0.072
1.41GlyTrp: 1.41 ± 0.032
2.078GlyTyr: 2.078 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.338HisAla: 2.338 ± 0.044
0.293HisCys: 0.293 ± 0.017
1.459HisAsp: 1.459 ± 0.034
1.005HisGlu: 1.005 ± 0.03
0.942HisPhe: 0.942 ± 0.025
2.134HisGly: 2.134 ± 0.044
0.734HisHis: 0.734 ± 0.026
0.929HisIle: 0.929 ± 0.028
0.581HisLys: 0.581 ± 0.023
2.454HisLeu: 2.454 ± 0.05
0.574HisMet: 0.574 ± 0.022
0.508HisAsn: 0.508 ± 0.023
1.479HisPro: 1.479 ± 0.035
0.775HisGln: 0.775 ± 0.027
1.531HisArg: 1.531 ± 0.036
1.081HisSer: 1.081 ± 0.029
0.937HisThr: 0.937 ± 0.026
1.668HisVal: 1.668 ± 0.035
0.408HisTrp: 0.408 ± 0.015
0.569HisTyr: 0.569 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.594IleAla: 6.594 ± 0.075
0.486IleCys: 0.486 ± 0.021
3.565IleAsp: 3.565 ± 0.06
2.95IleGlu: 2.95 ± 0.057
1.4IlePhe: 1.4 ± 0.041
4.591IleGly: 4.591 ± 0.072
1.048IleHis: 1.048 ± 0.026
2.469IleIle: 2.469 ± 0.049
1.762IleLys: 1.762 ± 0.044
4.408IleLeu: 4.408 ± 0.068
0.978IleMet: 0.978 ± 0.031
1.565IleAsn: 1.565 ± 0.043
2.245IlePro: 2.245 ± 0.042
1.387IleGln: 1.387 ± 0.037
3.263IleArg: 3.263 ± 0.047
2.813IleSer: 2.813 ± 0.044
2.991IleThr: 2.991 ± 0.078
3.48IleVal: 3.48 ± 0.057
0.523IleTrp: 0.523 ± 0.023
0.896IleTyr: 0.896 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.645LysAla: 4.645 ± 0.071
0.223LysCys: 0.223 ± 0.012
1.89LysAsp: 1.89 ± 0.043
1.541LysGlu: 1.541 ± 0.042
0.974LysPhe: 0.974 ± 0.029
2.907LysGly: 2.907 ± 0.059
0.632LysHis: 0.632 ± 0.028
1.631LysIle: 1.631 ± 0.04
1.428LysLys: 1.428 ± 0.046
3.55LysLeu: 3.55 ± 0.06
0.908LysMet: 0.908 ± 0.024
0.904LysAsn: 0.904 ± 0.025
2.149LysPro: 2.149 ± 0.055
1.066LysGln: 1.066 ± 0.028
2.379LysArg: 2.379 ± 0.048
1.927LysSer: 1.927 ± 0.042
1.96LysThr: 1.96 ± 0.043
2.916LysVal: 2.916 ± 0.053
0.375LysTrp: 0.375 ± 0.017
0.676LysTyr: 0.676 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.277LeuAla: 15.277 ± 0.159
0.927LeuCys: 0.927 ± 0.025
6.632LeuAsp: 6.632 ± 0.092
5.266LeuGlu: 5.266 ± 0.074
3.456LeuPhe: 3.456 ± 0.061
8.59LeuGly: 8.59 ± 0.108
2.133LeuHis: 2.133 ± 0.041
4.723LeuIle: 4.723 ± 0.066
3.765LeuLys: 3.765 ± 0.061
10.209LeuLeu: 10.209 ± 0.152
2.481LeuMet: 2.481 ± 0.048
2.61LeuAsn: 2.61 ± 0.048
5.765LeuPro: 5.765 ± 0.099
2.54LeuGln: 2.54 ± 0.044
7.087LeuArg: 7.087 ± 0.105
6.574LeuSer: 6.574 ± 0.077
5.918LeuThr: 5.918 ± 0.078
7.859LeuVal: 7.859 ± 0.094
1.304LeuTrp: 1.304 ± 0.034
2.022LeuTyr: 2.022 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.662MetAla: 3.662 ± 0.052
0.171MetCys: 0.171 ± 0.013
1.542MetAsp: 1.542 ± 0.033
1.325MetGlu: 1.325 ± 0.036
0.728MetPhe: 0.728 ± 0.026
2.143MetGly: 2.143 ± 0.05
0.434MetHis: 0.434 ± 0.018
1.275MetIle: 1.275 ± 0.03
0.959MetLys: 0.959 ± 0.03
2.528MetLeu: 2.528 ± 0.053
0.705MetMet: 0.705 ± 0.021
0.814MetAsn: 0.814 ± 0.025
1.441MetPro: 1.441 ± 0.037
0.728MetGln: 0.728 ± 0.021
1.803MetArg: 1.803 ± 0.041
1.631MetSer: 1.631 ± 0.038
1.794MetThr: 1.794 ± 0.036
2.318MetVal: 2.318 ± 0.039
0.217MetTrp: 0.217 ± 0.013
0.296MetTyr: 0.296 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.368AsnAla: 3.368 ± 0.082
0.258AsnCys: 0.258 ± 0.016
1.585AsnAsp: 1.585 ± 0.056
1.129AsnGlu: 1.129 ± 0.03
0.823AsnPhe: 0.823 ± 0.025
2.419AsnGly: 2.419 ± 0.089
0.581AsnHis: 0.581 ± 0.017
1.282AsnIle: 1.282 ± 0.03
0.728AsnLys: 0.728 ± 0.025
2.767AsnLeu: 2.767 ± 0.057
0.66AsnMet: 0.66 ± 0.022
0.717AsnAsn: 0.717 ± 0.03
1.793AsnPro: 1.793 ± 0.037
0.925AsnGln: 0.925 ± 0.025
1.848AsnArg: 1.848 ± 0.039
1.27AsnSer: 1.27 ± 0.038
1.349AsnThr: 1.349 ± 0.05
1.912AsnVal: 1.912 ± 0.052
0.356AsnTrp: 0.356 ± 0.018
0.531AsnTyr: 0.531 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.098ProAla: 6.098 ± 0.091
0.394ProCys: 0.394 ± 0.015
3.353ProAsp: 3.353 ± 0.051
3.196ProGlu: 3.196 ± 0.056
1.781ProPhe: 1.781 ± 0.037
4.217ProGly: 4.217 ± 0.058
1.13ProHis: 1.13 ± 0.03
2.016ProIle: 2.016 ± 0.046
1.66ProLys: 1.66 ± 0.043
5.002ProLeu: 5.002 ± 0.082
1.3ProMet: 1.3 ± 0.035
1.217ProAsn: 1.217 ± 0.03
3.199ProPro: 3.199 ± 0.09
1.7ProGln: 1.7 ± 0.043
2.776ProArg: 2.776 ± 0.059
2.591ProSer: 2.591 ± 0.049
2.336ProThr: 2.336 ± 0.049
4.431ProVal: 4.431 ± 0.08
0.745ProTrp: 0.745 ± 0.026
1.001ProTyr: 1.001 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
5.275GlnAla: 5.275 ± 0.067
0.289GlnCys: 0.289 ± 0.015
1.606GlnAsp: 1.606 ± 0.034
1.526GlnGlu: 1.526 ± 0.036
0.99GlnPhe: 0.99 ± 0.025
3.082GlnGly: 3.082 ± 0.047
0.71GlnHis: 0.71 ± 0.023
1.603GlnIle: 1.603 ± 0.04
1.008GlnLys: 1.008 ± 0.03
3.076GlnLeu: 3.076 ± 0.053
0.978GlnMet: 0.978 ± 0.033
0.812GlnAsn: 0.812 ± 0.023
1.903GlnPro: 1.903 ± 0.047
1.294GlnGln: 1.294 ± 0.035
2.404GlnArg: 2.404 ± 0.042
1.956GlnSer: 1.956 ± 0.043
1.864GlnThr: 1.864 ± 0.047
3.093GlnVal: 3.093 ± 0.051
0.542GlnTrp: 0.542 ± 0.019
0.662GlnTyr: 0.662 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
7.51ArgAla: 7.51 ± 0.102
0.567ArgCys: 0.567 ± 0.022
4.116ArgAsp: 4.116 ± 0.058
3.382ArgGlu: 3.382 ± 0.067
2.633ArgPhe: 2.633 ± 0.044
4.159ArgGly: 4.159 ± 0.065
2.046ArgHis: 2.046 ± 0.047
3.616ArgIle: 3.616 ± 0.065
2.303ArgLys: 2.303 ± 0.051
8.76ArgLeu: 8.76 ± 0.122
2.058ArgMet: 2.058 ± 0.044
1.733ArgAsn: 1.733 ± 0.036
3.432ArgPro: 3.432 ± 0.066
3.138ArgGln: 3.138 ± 0.055
5.687ArgArg: 5.687 ± 0.084
3.183ArgSer: 3.183 ± 0.048
2.995ArgThr: 2.995 ± 0.054
4.638ArgVal: 4.638 ± 0.06
1.02ArgTrp: 1.02 ± 0.029
1.429ArgTyr: 1.429 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.117SerAla: 6.117 ± 0.092
0.494SerCys: 0.494 ± 0.022
2.814SerAsp: 2.814 ± 0.064
2.435SerGlu: 2.435 ± 0.047
2.002SerPhe: 2.002 ± 0.045
5.29SerGly: 5.29 ± 0.098
1.251SerHis: 1.251 ± 0.029
2.42SerIle: 2.42 ± 0.046
1.526SerLys: 1.526 ± 0.035
5.715SerLeu: 5.715 ± 0.068
1.381SerMet: 1.381 ± 0.034
1.296SerAsn: 1.296 ± 0.034
2.679SerPro: 2.679 ± 0.046
1.78SerGln: 1.78 ± 0.043
3.552SerArg: 3.552 ± 0.058
2.824SerSer: 2.824 ± 0.065
2.64SerThr: 2.64 ± 0.066
4.048SerVal: 4.048 ± 0.066
0.763SerTrp: 0.763 ± 0.026
1.131SerTyr: 1.131 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.197ThrAla: 6.197 ± 0.121
0.468ThrCys: 0.468 ± 0.02
3.035ThrAsp: 3.035 ± 0.064
2.666ThrGlu: 2.666 ± 0.049
1.858ThrPhe: 1.858 ± 0.046
4.945ThrGly: 4.945 ± 0.117
1.033ThrHis: 1.033 ± 0.028
2.98ThrIle: 2.98 ± 0.069
1.554ThrLys: 1.554 ± 0.034
5.936ThrLeu: 5.936 ± 0.095
1.269ThrMet: 1.269 ± 0.033
1.408ThrAsn: 1.408 ± 0.061
2.876ThrPro: 2.876 ± 0.052
1.7ThrGln: 1.7 ± 0.041
3.005ThrArg: 3.005 ± 0.046
2.541ThrSer: 2.541 ± 0.082
2.808ThrThr: 2.808 ± 0.084
4.313ThrVal: 4.313 ± 0.089
0.68ThrTrp: 0.68 ± 0.028
1.172ThrTyr: 1.172 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
9.69ValAla: 9.69 ± 0.096
0.709ValCys: 0.709 ± 0.021
4.576ValAsp: 4.576 ± 0.079
4.63ValGlu: 4.63 ± 0.064
2.596ValPhe: 2.596 ± 0.045
5.478ValGly: 5.478 ± 0.06
1.451ValHis: 1.451 ± 0.038
3.891ValIle: 3.891 ± 0.061
2.563ValLys: 2.563 ± 0.054
8.258ValLeu: 8.258 ± 0.104
2.026ValMet: 2.026 ± 0.041
2.027ValAsn: 2.027 ± 0.044
3.592ValPro: 3.592 ± 0.066
2.212ValGln: 2.212 ± 0.041
4.648ValArg: 4.648 ± 0.061
4.192ValSer: 4.192 ± 0.071
4.457ValThr: 4.457 ± 0.098
6.761ValVal: 6.761 ± 0.096
0.908ValTrp: 0.908 ± 0.031
1.362ValTyr: 1.362 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.382TrpAla: 1.382 ± 0.039
0.168TrpCys: 0.168 ± 0.012
0.721TrpAsp: 0.721 ± 0.025
0.53TrpGlu: 0.53 ± 0.021
0.45TrpPhe: 0.45 ± 0.02
0.984TrpGly: 0.984 ± 0.029
0.344TrpHis: 0.344 ± 0.018
0.554TrpIle: 0.554 ± 0.021
0.49TrpLys: 0.49 ± 0.02
1.783TrpLeu: 1.783 ± 0.042
0.387TrpMet: 0.387 ± 0.019
0.436TrpAsn: 0.436 ± 0.017
0.7TrpPro: 0.7 ± 0.023
0.62TrpGln: 0.62 ± 0.023
1.333TrpArg: 1.333 ± 0.034
0.729TrpSer: 0.729 ± 0.024
0.636TrpThr: 0.636 ± 0.028
0.907TrpVal: 0.907 ± 0.029
0.23TrpTrp: 0.23 ± 0.016
0.277TrpTyr: 0.277 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.127TyrAla: 2.127 ± 0.041
0.242TyrCys: 0.242 ± 0.014
1.375TyrAsp: 1.375 ± 0.037
0.958TyrGlu: 0.958 ± 0.031
0.807TyrPhe: 0.807 ± 0.031
1.891TyrGly: 1.891 ± 0.037
0.514TyrHis: 0.514 ± 0.02
0.754TyrIle: 0.754 ± 0.022
0.613TyrLys: 0.613 ± 0.027
2.068TyrLeu: 2.068 ± 0.04
0.429TyrMet: 0.429 ± 0.019
0.544TyrAsn: 0.544 ± 0.025
0.92TyrPro: 0.92 ± 0.03
0.768TyrGln: 0.768 ± 0.023
1.612TyrArg: 1.612 ± 0.039
1.13TyrSer: 1.13 ± 0.032
1.017TyrThr: 1.017 ± 0.036
1.572TyrVal: 1.572 ± 0.034
0.297TyrTrp: 0.297 ± 0.014
0.501TyrTyr: 0.501 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4155 proteins (1329743 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski