Amino acid dipepetide frequency for Dyadobacter sp. UC 10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.998AlaAla: 6.998 ± 0.073
0.652AlaCys: 0.652 ± 0.018
4.443AlaAsp: 4.443 ± 0.052
4.682AlaGlu: 4.682 ± 0.06
3.855AlaPhe: 3.855 ± 0.046
6.53AlaGly: 6.53 ± 0.07
1.287AlaHis: 1.287 ± 0.027
4.934AlaIle: 4.934 ± 0.055
4.3AlaLys: 4.3 ± 0.047
7.249AlaLeu: 7.249 ± 0.071
1.716AlaMet: 1.716 ± 0.032
3.637AlaAsn: 3.637 ± 0.048
2.705AlaPro: 2.705 ± 0.037
2.938AlaGln: 2.938 ± 0.04
3.279AlaArg: 3.279 ± 0.039
4.98AlaSer: 4.98 ± 0.054
4.286AlaThr: 4.286 ± 0.051
5.117AlaVal: 5.117 ± 0.065
0.887AlaTrp: 0.887 ± 0.023
2.75AlaTyr: 2.75 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.502CysAla: 0.502 ± 0.018
0.132CysCys: 0.132 ± 0.008
0.385CysAsp: 0.385 ± 0.015
0.428CysGlu: 0.428 ± 0.017
0.389CysPhe: 0.389 ± 0.014
0.608CysGly: 0.608 ± 0.022
0.211CysHis: 0.211 ± 0.011
0.533CysIle: 0.533 ± 0.018
0.383CysLys: 0.383 ± 0.015
0.708CysLeu: 0.708 ± 0.018
0.174CysMet: 0.174 ± 0.008
0.324CysAsn: 0.324 ± 0.012
0.307CysPro: 0.307 ± 0.014
0.251CysGln: 0.251 ± 0.013
0.336CysArg: 0.336 ± 0.013
0.502CysSer: 0.502 ± 0.016
0.419CysThr: 0.419 ± 0.014
0.443CysVal: 0.443 ± 0.015
0.098CysTrp: 0.098 ± 0.007
0.287CysTyr: 0.287 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.925AspAla: 3.925 ± 0.043
0.357AspCys: 0.357 ± 0.013
2.413AspAsp: 2.413 ± 0.036
3.23AspGlu: 3.23 ± 0.037
3.169AspPhe: 3.169 ± 0.037
4.047AspGly: 4.047 ± 0.057
1.027AspHis: 1.027 ± 0.024
3.763AspIle: 3.763 ± 0.039
3.38AspLys: 3.38 ± 0.045
5.199AspLeu: 5.199 ± 0.047
1.205AspMet: 1.205 ± 0.025
2.435AspAsn: 2.435 ± 0.034
2.479AspPro: 2.479 ± 0.035
2.06AspGln: 2.06 ± 0.028
2.501AspArg: 2.501 ± 0.035
3.129AspSer: 3.129 ± 0.042
2.431AspThr: 2.431 ± 0.041
3.252AspVal: 3.252 ± 0.041
0.887AspTrp: 0.887 ± 0.024
2.271AspTyr: 2.271 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
4.502GluAla: 4.502 ± 0.046
0.333GluCys: 0.333 ± 0.013
2.745GluAsp: 2.745 ± 0.041
3.928GluGlu: 3.928 ± 0.052
2.453GluPhe: 2.453 ± 0.036
3.71GluGly: 3.71 ± 0.044
1.061GluHis: 1.061 ± 0.021
4.493GluIle: 4.493 ± 0.057
5.045GluLys: 5.045 ± 0.067
5.603GluLeu: 5.603 ± 0.058
1.639GluMet: 1.639 ± 0.029
3.532GluAsn: 3.532 ± 0.042
1.903GluPro: 1.903 ± 0.029
2.291GluGln: 2.291 ± 0.034
2.785GluArg: 2.785 ± 0.04
3.35GluSer: 3.35 ± 0.04
3.269GluThr: 3.269 ± 0.045
4.058GluVal: 4.058 ± 0.047
0.782GluTrp: 0.782 ± 0.019
2.115GluTyr: 2.115 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.478PheAla: 3.478 ± 0.038
0.448PheCys: 0.448 ± 0.016
3.018PheAsp: 3.018 ± 0.038
3.001PheGlu: 3.001 ± 0.039
2.407PhePhe: 2.407 ± 0.04
3.602PheGly: 3.602 ± 0.046
0.861PheHis: 0.861 ± 0.019
2.931PheIle: 2.931 ± 0.039
2.727PheLys: 2.727 ± 0.044
4.57PheLeu: 4.57 ± 0.054
1.073PheMet: 1.073 ± 0.024
2.567PheAsn: 2.567 ± 0.041
1.969PhePro: 1.969 ± 0.03
1.745PheGln: 1.745 ± 0.028
2.349PheArg: 2.349 ± 0.036
3.756PheSer: 3.756 ± 0.045
3.05PheThr: 3.05 ± 0.033
3.077PheVal: 3.077 ± 0.038
0.656PheTrp: 0.656 ± 0.02
1.934PheTyr: 1.934 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.102GlyAla: 5.102 ± 0.059
0.643GlyCys: 0.643 ± 0.02
3.597GlyAsp: 3.597 ± 0.045
3.754GlyGlu: 3.754 ± 0.043
3.764GlyPhe: 3.764 ± 0.043
5.356GlyGly: 5.356 ± 0.07
1.236GlyHis: 1.236 ± 0.03
5.313GlyIle: 5.313 ± 0.055
5.501GlyLys: 5.501 ± 0.052
6.505GlyLeu: 6.505 ± 0.054
1.82GlyMet: 1.82 ± 0.035
3.949GlyAsn: 3.949 ± 0.06
1.95GlyPro: 1.95 ± 0.037
2.601GlyGln: 2.601 ± 0.041
3.11GlyArg: 3.11 ± 0.037
4.971GlySer: 4.971 ± 0.063
4.457GlyThr: 4.457 ± 0.062
4.681GlyVal: 4.681 ± 0.052
1.053GlyTrp: 1.053 ± 0.022
3.159GlyTyr: 3.159 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.304HisAla: 1.304 ± 0.027
0.176HisCys: 0.176 ± 0.009
0.873HisAsp: 0.873 ± 0.022
1.02HisGlu: 1.02 ± 0.026
1.185HisPhe: 1.185 ± 0.026
1.149HisGly: 1.149 ± 0.027
0.46HisHis: 0.46 ± 0.017
1.37HisIle: 1.37 ± 0.028
0.873HisLys: 0.873 ± 0.026
1.773HisLeu: 1.773 ± 0.029
0.362HisMet: 0.362 ± 0.015
0.808HisAsn: 0.808 ± 0.02
0.948HisPro: 0.948 ± 0.024
0.696HisGln: 0.696 ± 0.02
0.856HisArg: 0.856 ± 0.022
1.137HisSer: 1.137 ± 0.023
0.955HisThr: 0.955 ± 0.019
1.04HisVal: 1.04 ± 0.023
0.288HisTrp: 0.288 ± 0.012
0.869HisTyr: 0.869 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.497IleAla: 5.497 ± 0.062
0.636IleCys: 0.636 ± 0.018
3.836IleAsp: 3.836 ± 0.038
4.107IleGlu: 4.107 ± 0.056
3.058IlePhe: 3.058 ± 0.043
4.823IleGly: 4.823 ± 0.05
1.21IleHis: 1.21 ± 0.024
3.966IleIle: 3.966 ± 0.053
3.707IleLys: 3.707 ± 0.047
6.03IleLeu: 6.03 ± 0.072
1.218IleMet: 1.218 ± 0.026
3.356IleAsn: 3.356 ± 0.043
3.11IlePro: 3.11 ± 0.041
2.234IleGln: 2.234 ± 0.031
3.506IleArg: 3.506 ± 0.041
5.079IleSer: 5.079 ± 0.051
3.917IleThr: 3.917 ± 0.044
4.31IleVal: 4.31 ± 0.057
0.75IleTrp: 0.75 ± 0.02
2.421IleTyr: 2.421 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.839LysAla: 4.839 ± 0.057
0.296LysCys: 0.296 ± 0.011
3.386LysAsp: 3.386 ± 0.045
4.159LysGlu: 4.159 ± 0.057
2.286LysPhe: 2.286 ± 0.041
4.357LysGly: 4.357 ± 0.052
1.064LysHis: 1.064 ± 0.024
4.392LysIle: 4.392 ± 0.062
4.59LysLys: 4.59 ± 0.06
5.491LysLeu: 5.491 ± 0.054
1.708LysMet: 1.708 ± 0.026
3.591LysAsn: 3.591 ± 0.047
2.778LysPro: 2.778 ± 0.047
2.232LysGln: 2.232 ± 0.037
2.756LysArg: 2.756 ± 0.039
4.161LysSer: 4.161 ± 0.052
3.811LysThr: 3.811 ± 0.05
4.121LysVal: 4.121 ± 0.052
0.898LysTrp: 0.898 ± 0.022
2.478LysTyr: 2.478 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
7.429LeuAla: 7.429 ± 0.067
0.712LeuCys: 0.712 ± 0.023
4.775LeuAsp: 4.775 ± 0.051
5.111LeuGlu: 5.111 ± 0.055
4.553LeuPhe: 4.553 ± 0.05
6.184LeuGly: 6.184 ± 0.053
1.753LeuHis: 1.753 ± 0.034
6.187LeuIle: 6.187 ± 0.069
6.241LeuLys: 6.241 ± 0.059
9.354LeuLeu: 9.354 ± 0.084
1.991LeuMet: 1.991 ± 0.032
4.886LeuAsn: 4.886 ± 0.055
4.438LeuPro: 4.438 ± 0.049
3.227LeuGln: 3.227 ± 0.045
4.379LeuArg: 4.379 ± 0.049
6.896LeuSer: 6.896 ± 0.061
5.715LeuThr: 5.715 ± 0.062
5.727LeuVal: 5.727 ± 0.062
1.036LeuTrp: 1.036 ± 0.025
3.127LeuTyr: 3.127 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
1.691MetAla: 1.691 ± 0.03
0.121MetCys: 0.121 ± 0.007
1.166MetAsp: 1.166 ± 0.024
1.362MetGlu: 1.362 ± 0.026
0.798MetPhe: 0.798 ± 0.022
1.504MetGly: 1.504 ± 0.032
0.474MetHis: 0.474 ± 0.016
1.429MetIle: 1.429 ± 0.028
1.867MetLys: 1.867 ± 0.029
2.247MetLeu: 2.247 ± 0.033
0.534MetMet: 0.534 ± 0.018
1.22MetAsn: 1.22 ± 0.022
1.05MetPro: 1.05 ± 0.025
0.974MetGln: 0.974 ± 0.023
1.095MetArg: 1.095 ± 0.025
1.39MetSer: 1.39 ± 0.025
1.184MetThr: 1.184 ± 0.024
1.448MetVal: 1.448 ± 0.029
0.208MetTrp: 0.208 ± 0.011
0.658MetTyr: 0.658 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
4.242AsnAla: 4.242 ± 0.054
0.339AsnCys: 0.339 ± 0.017
2.491AsnAsp: 2.491 ± 0.038
2.818AsnGlu: 2.818 ± 0.035
2.504AsnPhe: 2.504 ± 0.044
4.087AsnGly: 4.087 ± 0.058
0.912AsnHis: 0.912 ± 0.023
3.361AsnIle: 3.361 ± 0.043
2.717AsnLys: 2.717 ± 0.042
4.724AsnLeu: 4.724 ± 0.05
1.098AsnMet: 1.098 ± 0.021
2.668AsnAsn: 2.668 ± 0.047
2.855AsnPro: 2.855 ± 0.035
2.055AsnGln: 2.055 ± 0.03
2.505AsnArg: 2.505 ± 0.038
3.233AsnSer: 3.233 ± 0.049
2.961AsnThr: 2.961 ± 0.042
3.274AsnVal: 3.274 ± 0.045
0.75AsnTrp: 0.75 ± 0.02
2.241AsnTyr: 2.241 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
3.911ProAla: 3.911 ± 0.053
0.21ProCys: 0.21 ± 0.01
2.823ProAsp: 2.823 ± 0.033
3.302ProGlu: 3.302 ± 0.042
2.052ProPhe: 2.052 ± 0.034
3.383ProGly: 3.383 ± 0.047
0.714ProHis: 0.714 ± 0.019
2.257ProIle: 2.257 ± 0.037
2.219ProLys: 2.219 ± 0.039
3.413ProLeu: 3.413 ± 0.048
0.835ProMet: 0.835 ± 0.021
1.986ProAsn: 1.986 ± 0.031
1.149ProPro: 1.149 ± 0.025
1.415ProGln: 1.415 ± 0.026
1.401ProArg: 1.401 ± 0.027
2.455ProSer: 2.455 ± 0.032
2.008ProThr: 2.008 ± 0.035
3.631ProVal: 3.631 ± 0.042
0.478ProTrp: 0.478 ± 0.019
1.585ProTyr: 1.585 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
2.677GlnAla: 2.677 ± 0.034
0.23GlnCys: 0.23 ± 0.012
1.63GlnAsp: 1.63 ± 0.027
2.205GlnGlu: 2.205 ± 0.035
1.763GlnPhe: 1.763 ± 0.033
2.215GlnGly: 2.215 ± 0.039
0.702GlnHis: 0.702 ± 0.018
2.622GlnIle: 2.622 ± 0.044
2.661GlnLys: 2.661 ± 0.036
3.634GlnLeu: 3.634 ± 0.045
0.938GlnMet: 0.938 ± 0.024
2.089GlnAsn: 2.089 ± 0.038
1.583GlnPro: 1.583 ± 0.031
1.699GlnGln: 1.699 ± 0.033
1.632GlnArg: 1.632 ± 0.026
2.283GlnSer: 2.283 ± 0.033
2.146GlnThr: 2.146 ± 0.031
2.443GlnVal: 2.443 ± 0.037
0.5GlnTrp: 0.5 ± 0.018
1.46GlnTyr: 1.46 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.979ArgAla: 2.979 ± 0.034
0.25ArgCys: 0.25 ± 0.01
2.346ArgAsp: 2.346 ± 0.038
2.941ArgGlu: 2.941 ± 0.046
2.49ArgPhe: 2.49 ± 0.03
2.534ArgGly: 2.534 ± 0.039
0.836ArgHis: 0.836 ± 0.021
3.547ArgIle: 3.547 ± 0.043
3.143ArgLys: 3.143 ± 0.036
4.467ArgLeu: 4.467 ± 0.051
1.145ArgMet: 1.145 ± 0.023
2.655ArgAsn: 2.655 ± 0.036
1.71ArgPro: 1.71 ± 0.029
1.92ArgGln: 1.92 ± 0.035
2.112ArgArg: 2.112 ± 0.032
2.779ArgSer: 2.779 ± 0.036
2.44ArgThr: 2.44 ± 0.032
2.768ArgVal: 2.768 ± 0.041
0.644ArgTrp: 0.644 ± 0.017
2.034ArgTyr: 2.034 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
4.911SerAla: 4.911 ± 0.051
0.577SerCys: 0.577 ± 0.017
3.594SerAsp: 3.594 ± 0.042
3.869SerGlu: 3.869 ± 0.042
3.65SerPhe: 3.65 ± 0.044
5.604SerGly: 5.604 ± 0.06
1.124SerHis: 1.124 ± 0.028
4.292SerIle: 4.292 ± 0.052
3.819SerLys: 3.819 ± 0.053
6.364SerLeu: 6.364 ± 0.055
1.368SerMet: 1.368 ± 0.026
3.06SerAsn: 3.06 ± 0.046
2.673SerPro: 2.673 ± 0.04
2.319SerGln: 2.319 ± 0.036
3.025SerArg: 3.025 ± 0.041
4.252SerSer: 4.252 ± 0.058
3.485SerThr: 3.485 ± 0.052
4.583SerVal: 4.583 ± 0.048
0.907SerTrp: 0.907 ± 0.022
2.784SerTyr: 2.784 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.527ThrAla: 4.527 ± 0.054
0.349ThrCys: 0.349 ± 0.015
3.333ThrAsp: 3.333 ± 0.043
3.171ThrGlu: 3.171 ± 0.042
2.933ThrPhe: 2.933 ± 0.038
4.986ThrGly: 4.986 ± 0.054
1.015ThrHis: 1.015 ± 0.022
3.89ThrIle: 3.89 ± 0.042
2.874ThrLys: 2.874 ± 0.038
5.26ThrLeu: 5.26 ± 0.051
1.037ThrMet: 1.037 ± 0.027
2.773ThrAsn: 2.773 ± 0.042
2.65ThrPro: 2.65 ± 0.039
1.893ThrGln: 1.893 ± 0.033
2.322ThrArg: 2.322 ± 0.032
3.682ThrSer: 3.682 ± 0.046
3.255ThrThr: 3.255 ± 0.057
3.957ThrVal: 3.957 ± 0.052
0.704ThrTrp: 0.704 ± 0.018
2.273ThrTyr: 2.273 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.015ValAla: 5.015 ± 0.057
0.57ValCys: 0.57 ± 0.019
3.383ValAsp: 3.383 ± 0.045
3.616ValGlu: 3.616 ± 0.049
3.164ValPhe: 3.164 ± 0.036
4.16ValGly: 4.16 ± 0.055
1.085ValHis: 1.085 ± 0.027
4.47ValIle: 4.47 ± 0.061
4.163ValLys: 4.163 ± 0.048
6.011ValLeu: 6.011 ± 0.067
1.472ValMet: 1.472 ± 0.026
3.472ValAsn: 3.472 ± 0.046
2.805ValPro: 2.805 ± 0.04
2.148ValGln: 2.148 ± 0.031
3.169ValArg: 3.169 ± 0.045
4.891ValSer: 4.891 ± 0.057
4.23ValThr: 4.23 ± 0.054
4.413ValVal: 4.413 ± 0.058
0.765ValTrp: 0.765 ± 0.019
2.326ValTyr: 2.326 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
0.896TrpAla: 0.896 ± 0.024
0.089TrpCys: 0.089 ± 0.007
0.686TrpAsp: 0.686 ± 0.02
0.806TrpGlu: 0.806 ± 0.021
0.632TrpPhe: 0.632 ± 0.018
0.892TrpGly: 0.892 ± 0.02
0.28TrpHis: 0.28 ± 0.013
0.801TrpIle: 0.801 ± 0.024
0.941TrpLys: 0.941 ± 0.022
1.335TrpLeu: 1.335 ± 0.03
0.351TrpMet: 0.351 ± 0.014
0.728TrpAsn: 0.728 ± 0.021
0.424TrpPro: 0.424 ± 0.015
0.626TrpGln: 0.626 ± 0.019
0.599TrpArg: 0.599 ± 0.017
0.735TrpSer: 0.735 ± 0.023
0.711TrpThr: 0.711 ± 0.021
0.815TrpVal: 0.815 ± 0.02
0.21TrpTrp: 0.21 ± 0.01
0.493TrpTyr: 0.493 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.8TyrAla: 2.8 ± 0.037
0.3TyrCys: 0.3 ± 0.011
2.237TyrAsp: 2.237 ± 0.038
2.085TyrGlu: 2.085 ± 0.032
2.115TyrPhe: 2.115 ± 0.037
2.789TyrGly: 2.789 ± 0.043
0.831TyrHis: 0.831 ± 0.019
2.221TyrIle: 2.221 ± 0.035
2.245TyrLys: 2.245 ± 0.039
3.782TyrLeu: 3.782 ± 0.047
0.733TyrMet: 0.733 ± 0.02
2.101TyrAsn: 2.101 ± 0.036
1.74TyrPro: 1.74 ± 0.031
1.789TyrGln: 1.789 ± 0.028
2.021TyrArg: 2.021 ± 0.033
2.6TyrSer: 2.6 ± 0.04
2.157TyrThr: 2.157 ± 0.041
2.17TyrVal: 2.17 ± 0.035
0.55TyrTrp: 0.55 ± 0.017
1.715TyrTyr: 1.715 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5562 proteins (2061393 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski