Amino acid dipepetide frequency for Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.243AlaAla: 14.243 ± 0.087	1.037AlaCys: 1.037 ± 0.018	5.491AlaAsp: 5.491 ± 0.038	5.662AlaGlu: 5.662 ± 0.055	3.087AlaPhe: 3.087 ± 0.03	7.192AlaGly: 7.192 ± 0.05	2.058AlaHis: 2.058 ± 0.023	4.089AlaIle: 4.089 ± 0.032	4.251AlaLys: 4.251 ± 0.043	8.031AlaLeu: 8.031 ± 0.046	2.182AlaMet: 2.182 ± 0.018	3.351AlaAsn: 3.351 ± 0.025	6.153AlaPro: 6.153 ± 0.065	3.742AlaGln: 3.742 ± 0.036	5.555AlaArg: 5.555 ± 0.046	9.629AlaSer: 9.629 ± 0.073	6.586AlaThr: 6.586 ± 0.041	6.531AlaVal: 6.531 ± 0.041	1.164AlaTrp: 1.164 ± 0.017	2.33AlaTyr: 2.33 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.902CysAla: 0.902 ± 0.014	0.216CysCys: 0.216 ± 0.008	0.588CysAsp: 0.588 ± 0.011	0.495CysGlu: 0.495 ± 0.01	0.466CysPhe: 0.466 ± 0.01	0.81CysGly: 0.81 ± 0.015	0.28CysHis: 0.28 ± 0.008	0.616CysIle: 0.616 ± 0.012	0.411CysLys: 0.411 ± 0.01	1.097CysLeu: 1.097 ± 0.015	0.244CysMet: 0.244 ± 0.007	0.364CysAsn: 0.364 ± 0.009	0.561CysPro: 0.561 ± 0.013	0.378CysGln: 0.378 ± 0.01	0.706CysArg: 0.706 ± 0.012	0.819CysSer: 0.819 ± 0.015	0.63CysThr: 0.63 ± 0.013	0.721CysVal: 0.721 ± 0.012	0.158CysTrp: 0.158 ± 0.006	0.326CysTyr: 0.326 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.827AspAla: 5.827 ± 0.04	0.563AspCys: 0.563 ± 0.012	5.717AspAsp: 5.717 ± 0.072	4.679AspGlu: 4.679 ± 0.053	2.008AspPhe: 2.008 ± 0.021	4.529AspGly: 4.529 ± 0.035	1.171AspHis: 1.171 ± 0.016	2.867AspIle: 2.867 ± 0.025	2.489AspLys: 2.489 ± 0.028	4.705AspLeu: 4.705 ± 0.029	1.332AspMet: 1.332 ± 0.017	2.072AspAsn: 2.072 ± 0.021	2.986AspPro: 2.986 ± 0.027	1.688AspGln: 1.688 ± 0.021	3.157AspArg: 3.157 ± 0.036	4.324AspSer: 4.324 ± 0.034	3.237AspThr: 3.237 ± 0.027	3.872AspVal: 3.872 ± 0.035	0.789AspTrp: 0.789 ± 0.013	1.592AspTyr: 1.592 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.957GluAla: 5.957 ± 0.057	0.523GluCys: 0.523 ± 0.01	4.135GluAsp: 4.135 ± 0.048	4.759GluGlu: 4.759 ± 0.069	1.625GluPhe: 1.625 ± 0.02	3.238GluGly: 3.238 ± 0.037	1.342GluHis: 1.342 ± 0.017	2.412GluIle: 2.412 ± 0.026	3.095GluLys: 3.095 ± 0.037	4.728GluLeu: 4.728 ± 0.043	1.306GluMet: 1.306 ± 0.017	1.855GluAsn: 1.855 ± 0.021	2.694GluPro: 2.694 ± 0.046	2.318GluGln: 2.318 ± 0.026	3.685GluArg: 3.685 ± 0.038	3.924GluSer: 3.924 ± 0.035	3.381GluThr: 3.381 ± 0.038	3.131GluVal: 3.131 ± 0.032	0.71GluTrp: 0.71 ± 0.013	1.493GluTyr: 1.493 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.067PheAla: 3.067 ± 0.026	0.486PheCys: 0.486 ± 0.011	2.172PheAsp: 2.172 ± 0.02	1.805PheGlu: 1.805 ± 0.021	1.471PhePhe: 1.471 ± 0.02	2.746PheGly: 2.746 ± 0.031	0.798PheHis: 0.798 ± 0.013	1.479PheIle: 1.479 ± 0.022	1.228PheLys: 1.228 ± 0.017	3.059PheLeu: 3.059 ± 0.031	0.751PheMet: 0.751 ± 0.013	1.241PheAsn: 1.241 ± 0.018	1.745PhePro: 1.745 ± 0.023	1.19PheGln: 1.19 ± 0.016	1.87PheArg: 1.87 ± 0.019	2.877PheSer: 2.877 ± 0.03	1.908PheThr: 1.908 ± 0.02	2.377PheVal: 2.377 ± 0.028	0.544PheTrp: 0.544 ± 0.012	1.038PheTyr: 1.038 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	6.509GlyAla: 6.509 ± 0.05	0.763GlyCys: 0.763 ± 0.013	4.008GlyAsp: 4.008 ± 0.031	3.329GlyGlu: 3.329 ± 0.034	2.592GlyPhe: 2.592 ± 0.027	7.116GlyGly: 7.116 ± 0.077	1.84GlyHis: 1.84 ± 0.024	3.249GlyIle: 3.249 ± 0.027	3.072GlyLys: 3.072 ± 0.028	5.932GlyLeu: 5.932 ± 0.047	1.602GlyMet: 1.602 ± 0.022	2.653GlyAsn: 2.653 ± 0.027	3.636GlyPro: 3.636 ± 0.036	2.567GlyGln: 2.567 ± 0.029	4.505GlyArg: 4.505 ± 0.038	6.716GlySer: 6.716 ± 0.053	4.286GlyThr: 4.286 ± 0.036	4.383GlyVal: 4.383 ± 0.032	1.019GlyTrp: 1.019 ± 0.016	1.991GlyTyr: 1.991 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	2.107HisAla: 2.107 ± 0.021	0.273HisCys: 0.273 ± 0.008	1.383HisAsp: 1.383 ± 0.018	1.209HisGlu: 1.209 ± 0.018	0.803HisPhe: 0.803 ± 0.014	1.849HisGly: 1.849 ± 0.023	0.992HisHis: 0.992 ± 0.019	1.135HisIle: 1.135 ± 0.016	0.876HisLys: 0.876 ± 0.014	2.032HisLeu: 2.032 ± 0.023	0.54HisMet: 0.54 ± 0.01	0.917HisAsn: 0.917 ± 0.014	1.546HisPro: 1.546 ± 0.022	1.098HisGln: 1.098 ± 0.021	1.57HisArg: 1.57 ± 0.02	1.92HisSer: 1.92 ± 0.028	1.354HisThr: 1.354 ± 0.017	1.426HisVal: 1.426 ± 0.019	0.286HisTrp: 0.286 ± 0.008	0.684HisTyr: 0.684 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.043IleAla: 4.043 ± 0.034	0.583IleCys: 0.583 ± 0.01	2.72IleAsp: 2.72 ± 0.026	2.486IleGlu: 2.486 ± 0.024	1.626IlePhe: 1.626 ± 0.023	2.976IleGly: 2.976 ± 0.032	0.978IleHis: 0.978 ± 0.015	2.018IleIle: 2.018 ± 0.026	1.839IleLys: 1.839 ± 0.021	3.767IleLeu: 3.767 ± 0.033	0.957IleMet: 0.957 ± 0.012	1.645IleAsn: 1.645 ± 0.018	2.637IlePro: 2.637 ± 0.022	1.563IleGln: 1.563 ± 0.021	2.459IleArg: 2.459 ± 0.022	3.301IleSer: 3.301 ± 0.033	2.531IleThr: 2.531 ± 0.025	3.14IleVal: 3.14 ± 0.034	0.564IleTrp: 0.564 ± 0.01	1.194IleTyr: 1.194 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.402LysAla: 4.402 ± 0.045	0.384LysCys: 0.384 ± 0.009	2.56LysAsp: 2.56 ± 0.03	2.804LysGlu: 2.804 ± 0.034	1.163LysPhe: 1.163 ± 0.016	2.518LysGly: 2.518 ± 0.028	0.976LysHis: 0.976 ± 0.016	1.834LysIle: 1.834 ± 0.018	3.174LysLys: 3.174 ± 0.056	3.495LysLeu: 3.495 ± 0.03	0.942LysMet: 0.942 ± 0.015	1.562LysAsn: 1.562 ± 0.022	2.507LysPro: 2.507 ± 0.029	1.736LysGln: 1.736 ± 0.021	3.055LysArg: 3.055 ± 0.032	3.101LysSer: 3.101 ± 0.031	2.864LysThr: 2.864 ± 0.028	2.359LysVal: 2.359 ± 0.028	0.522LysTrp: 0.522 ± 0.011	1.192LysTyr: 1.192 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.525LeuAla: 8.525 ± 0.056	1.059LeuCys: 1.059 ± 0.016	4.994LeuAsp: 4.994 ± 0.039	4.769LeuGlu: 4.769 ± 0.042	3.108LeuPhe: 3.108 ± 0.032	5.838LeuGly: 5.838 ± 0.038	2.077LeuHis: 2.077 ± 0.021	3.162LeuIle: 3.162 ± 0.03	3.434LeuLys: 3.434 ± 0.029	7.845LeuLeu: 7.845 ± 0.064	1.656LeuMet: 1.656 ± 0.021	2.68LeuAsn: 2.68 ± 0.028	5.529LeuPro: 5.529 ± 0.039	3.653LeuGln: 3.653 ± 0.031	5.579LeuArg: 5.579 ± 0.037	7.004LeuSer: 7.004 ± 0.041	4.45LeuThr: 4.45 ± 0.035	5.489LeuVal: 5.489 ± 0.047	1.075LeuTrp: 1.075 ± 0.019	2.186LeuTyr: 2.186 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.573MetAla: 2.573 ± 0.023	0.242MetCys: 0.242 ± 0.007	1.248MetAsp: 1.248 ± 0.016	1.091MetGlu: 1.091 ± 0.015	0.728MetPhe: 0.728 ± 0.012	1.461MetGly: 1.461 ± 0.018	0.538MetHis: 0.538 ± 0.009	0.841MetIle: 0.841 ± 0.015	0.752MetLys: 0.752 ± 0.014	1.855MetLeu: 1.855 ± 0.022	0.561MetMet: 0.561 ± 0.012	0.699MetAsn: 0.699 ± 0.012	1.478MetPro: 1.478 ± 0.019	0.891MetGln: 0.891 ± 0.013	1.322MetArg: 1.322 ± 0.017	1.993MetSer: 1.993 ± 0.021	1.29MetThr: 1.29 ± 0.015	1.248MetVal: 1.248 ± 0.015	0.243MetTrp: 0.243 ± 0.007	0.516MetTyr: 0.516 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.308AsnAla: 3.308 ± 0.029	0.358AsnCys: 0.358 ± 0.008	2.023AsnAsp: 2.023 ± 0.023	1.792AsnGlu: 1.792 ± 0.022	1.176AsnPhe: 1.176 ± 0.015	3.223AsnGly: 3.223 ± 0.036	0.769AsnHis: 0.769 ± 0.012	1.76AsnIle: 1.76 ± 0.022	1.47AsnLys: 1.47 ± 0.018	2.761AsnLeu: 2.761 ± 0.027	0.865AsnMet: 0.865 ± 0.014	1.7AsnAsn: 1.7 ± 0.027	2.037AsnPro: 2.037 ± 0.02	1.175AsnGln: 1.175 ± 0.018	1.833AsnArg: 1.833 ± 0.018	2.827AsnSer: 2.827 ± 0.034	2.278AsnThr: 2.278 ± 0.024	2.152AsnVal: 2.152 ± 0.025	0.466AsnTrp: 0.466 ± 0.011	0.975AsnTyr: 0.975 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.796ProAla: 6.796 ± 0.071	0.449ProCys: 0.449 ± 0.011	3.121ProAsp: 3.121 ± 0.023	3.393ProGlu: 3.393 ± 0.035	1.918ProPhe: 1.918 ± 0.022	4.249ProGly: 4.249 ± 0.041	1.362ProHis: 1.362 ± 0.022	2.337ProIle: 2.337 ± 0.026	2.334ProLys: 2.334 ± 0.027	4.739ProLeu: 4.739 ± 0.039	1.169ProMet: 1.169 ± 0.019	1.936ProAsn: 1.936 ± 0.023	5.814ProPro: 5.814 ± 0.098	2.545ProGln: 2.545 ± 0.035	3.51ProArg: 3.51 ± 0.036	6.477ProSer: 6.477 ± 0.061	4.219ProThr: 4.219 ± 0.041	3.941ProVal: 3.941 ± 0.037	0.637ProTrp: 0.637 ± 0.014	1.497ProTyr: 1.497 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.718GlnAla: 3.718 ± 0.032	0.379GlnCys: 0.379 ± 0.01	1.919GlnAsp: 1.919 ± 0.022	1.997GlnGlu: 1.997 ± 0.022	1.2GlnPhe: 1.2 ± 0.017	2.246GlnGly: 2.246 ± 0.023	1.31GlnHis: 1.31 ± 0.024	1.605GlnIle: 1.605 ± 0.018	1.71GlnLys: 1.71 ± 0.021	3.452GlnLeu: 3.452 ± 0.029	0.899GlnMet: 0.899 ± 0.015	1.39GlnAsn: 1.39 ± 0.02	2.796GlnPro: 2.796 ± 0.037	3.366GlnGln: 3.366 ± 0.076	2.737GlnArg: 2.737 ± 0.023	3.089GlnSer: 3.089 ± 0.035	2.302GlnThr: 2.302 ± 0.024	2.031GlnVal: 2.031 ± 0.02	0.521GlnTrp: 0.521 ± 0.011	1.114GlnTyr: 1.114 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.255ArgAla: 5.255 ± 0.036	0.675ArgCys: 0.675 ± 0.013	3.575ArgAsp: 3.575 ± 0.044	3.53ArgGlu: 3.53 ± 0.036	1.98ArgPhe: 1.98 ± 0.022	3.936ArgGly: 3.936 ± 0.038	1.662ArgHis: 1.662 ± 0.021	2.657ArgIle: 2.657 ± 0.022	3.079ArgLys: 3.079 ± 0.033	5.408ArgLeu: 5.408 ± 0.041	1.351ArgMet: 1.351 ± 0.016	2.124ArgAsn: 2.124 ± 0.021	3.795ArgPro: 3.795 ± 0.039	2.766ArgGln: 2.766 ± 0.026	5.579ArgArg: 5.579 ± 0.054	4.888ArgSer: 4.888 ± 0.045	3.34ArgThr: 3.34 ± 0.031	3.395ArgVal: 3.395 ± 0.03	0.857ArgTrp: 0.857 ± 0.014	1.592ArgTyr: 1.592 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	8.636SerAla: 8.636 ± 0.059	0.787SerCys: 0.787 ± 0.013	4.463SerAsp: 4.463 ± 0.043	3.752SerGlu: 3.752 ± 0.031	2.952SerPhe: 2.952 ± 0.03	6.382SerGly: 6.382 ± 0.05	2.051SerHis: 2.051 ± 0.028	3.757SerIle: 3.757 ± 0.032	3.384SerLys: 3.384 ± 0.032	7.029SerLeu: 7.029 ± 0.044	1.784SerMet: 1.784 ± 0.022	3.03SerAsn: 3.03 ± 0.036	5.856SerPro: 5.856 ± 0.065	3.214SerGln: 3.214 ± 0.031	5.167SerArg: 5.167 ± 0.047	11.022SerSer: 11.022 ± 0.145	6.359SerThr: 6.359 ± 0.054	5.025SerVal: 5.025 ± 0.042	0.985SerTrp: 0.985 ± 0.016	2.018SerTyr: 2.018 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	6.786ThrAla: 6.786 ± 0.047	0.657ThrCys: 0.657 ± 0.011	3.048ThrAsp: 3.048 ± 0.03	3.075ThrGlu: 3.075 ± 0.031	2.019ThrPhe: 2.019 ± 0.02	4.442ThrGly: 4.442 ± 0.042	1.299ThrHis: 1.299 ± 0.016	2.744ThrIle: 2.744 ± 0.027	2.523ThrLys: 2.523 ± 0.033	4.957ThrLeu: 4.957 ± 0.037	1.235ThrMet: 1.235 ± 0.015	2.083ThrAsn: 2.083 ± 0.022	4.85ThrPro: 4.85 ± 0.046	2.026ThrGln: 2.026 ± 0.023	3.149ThrArg: 3.149 ± 0.029	5.881ThrSer: 5.881 ± 0.049	4.992ThrThr: 4.992 ± 0.058	3.958ThrVal: 3.958 ± 0.039	0.725ThrTrp: 0.725 ± 0.012	1.521ThrTyr: 1.521 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	6.33ValAla: 6.33 ± 0.038	0.809ValCys: 0.809 ± 0.013	3.936ValAsp: 3.936 ± 0.033	3.568ValGlu: 3.568 ± 0.044	2.389ValPhe: 2.389 ± 0.029	4.109ValGly: 4.109 ± 0.036	1.47ValHis: 1.47 ± 0.016	2.622ValIle: 2.622 ± 0.03	2.43ValLys: 2.43 ± 0.026	5.658ValLeu: 5.658 ± 0.042	1.247ValMet: 1.247 ± 0.016	2.054ValAsn: 2.054 ± 0.021	3.939ValPro: 3.939 ± 0.035	2.324ValGln: 2.324 ± 0.028	3.597ValArg: 3.597 ± 0.031	4.957ValSer: 4.957 ± 0.038	3.531ValThr: 3.531 ± 0.032	4.631ValVal: 4.631 ± 0.037	0.834ValTrp: 0.834 ± 0.014	1.752ValTyr: 1.752 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.12TrpAla: 1.12 ± 0.014	0.175TrpCys: 0.175 ± 0.006	0.797TrpAsp: 0.797 ± 0.014	0.657TrpGlu: 0.657 ± 0.011	0.465TrpPhe: 0.465 ± 0.01	0.82TrpGly: 0.82 ± 0.015	0.33TrpHis: 0.33 ± 0.008	0.585TrpIle: 0.585 ± 0.012	0.607TrpLys: 0.607 ± 0.011	1.207TrpLeu: 1.207 ± 0.017	0.328TrpMet: 0.328 ± 0.009	0.504TrpAsn: 0.504 ± 0.012	0.578TrpPro: 0.578 ± 0.012	0.541TrpGln: 0.541 ± 0.01	0.867TrpArg: 0.867 ± 0.014	0.918TrpSer: 0.918 ± 0.015	0.849TrpThr: 0.849 ± 0.013	0.777TrpVal: 0.777 ± 0.013	0.237TrpTrp: 0.237 ± 0.007	0.361TrpTyr: 0.361 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.261TyrAla: 2.261 ± 0.025	0.37TyrCys: 0.37 ± 0.009	1.703TyrAsp: 1.703 ± 0.021	1.459TyrGlu: 1.459 ± 0.019	1.077TyrPhe: 1.077 ± 0.016	2.088TyrGly: 2.088 ± 0.023	0.698TyrHis: 0.698 ± 0.013	1.258TyrIle: 1.258 ± 0.016	0.996TyrLys: 0.996 ± 0.015	2.351TyrLeu: 2.351 ± 0.025	0.621TyrMet: 0.621 ± 0.012	1.088TyrAsn: 1.088 ± 0.015	1.307TyrPro: 1.307 ± 0.019	0.999TyrGln: 0.999 ± 0.015	1.539TyrArg: 1.539 ± 0.019	1.987TyrSer: 1.987 ± 0.027	1.583TyrThr: 1.583 ± 0.02	1.599TyrVal: 1.599 ± 0.02	0.386TyrTrp: 0.386 ± 0.009	0.929TyrTyr: 0.929 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8878 proteins (4937363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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