Amino acid dipepetide frequency for Sphingomonas yabuuchiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.324AlaAla: 19.324 ± 0.218	0.976AlaCys: 0.976 ± 0.028	7.843AlaAsp: 7.843 ± 0.096	7.69AlaGlu: 7.69 ± 0.123	4.141AlaPhe: 4.141 ± 0.072	11.424AlaGly: 11.424 ± 0.12	2.383AlaHis: 2.383 ± 0.047	7.142AlaIle: 7.142 ± 0.102	4.195AlaLys: 4.195 ± 0.079	13.561AlaLeu: 13.561 ± 0.164	4.242AlaMet: 4.242 ± 0.068	3.296AlaAsn: 3.296 ± 0.072	6.493AlaPro: 6.493 ± 0.107	4.825AlaGln: 4.825 ± 0.067	9.886AlaArg: 9.886 ± 0.11	6.355AlaSer: 6.355 ± 0.092	7.423AlaThr: 7.423 ± 0.092	8.9AlaVal: 8.9 ± 0.104	1.637AlaTrp: 1.637 ± 0.049	2.645AlaTyr: 2.645 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.879CysAla: 0.879 ± 0.033	0.085CysCys: 0.085 ± 0.01	0.449CysAsp: 0.449 ± 0.021	0.32CysGlu: 0.32 ± 0.017	0.263CysPhe: 0.263 ± 0.016	0.773CysGly: 0.773 ± 0.028	0.193CysHis: 0.193 ± 0.013	0.306CysIle: 0.306 ± 0.016	0.117CysLys: 0.117 ± 0.011	0.599CysLeu: 0.599 ± 0.023	0.12CysMet: 0.12 ± 0.01	0.171CysAsn: 0.171 ± 0.013	0.416CysPro: 0.416 ± 0.021	0.178CysGln: 0.178 ± 0.012	0.539CysArg: 0.539 ± 0.023	0.369CysSer: 0.369 ± 0.015	0.378CysThr: 0.378 ± 0.018	0.499CysVal: 0.499 ± 0.021	0.101CysTrp: 0.101 ± 0.011	0.139CysTyr: 0.139 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.863AspAla: 7.863 ± 0.09	0.382AspCys: 0.382 ± 0.019	3.212AspAsp: 3.212 ± 0.06	3.25AspGlu: 3.25 ± 0.062	2.057AspPhe: 2.057 ± 0.043	5.851AspGly: 5.851 ± 0.089	1.391AspHis: 1.391 ± 0.037	2.733AspIle: 2.733 ± 0.052	1.578AspLys: 1.578 ± 0.044	5.729AspLeu: 5.729 ± 0.063	1.415AspMet: 1.415 ± 0.039	1.32AspAsn: 1.32 ± 0.04	3.895AspPro: 3.895 ± 0.064	2.034AspGln: 2.034 ± 0.041	5.362AspArg: 5.362 ± 0.082	2.248AspSer: 2.248 ± 0.041	2.993AspThr: 2.993 ± 0.06	4.162AspVal: 4.162 ± 0.068	1.185AspTrp: 1.185 ± 0.033	1.638AspTyr: 1.638 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.731GluAla: 7.731 ± 0.121	0.271GluCys: 0.271 ± 0.018	2.671GluAsp: 2.671 ± 0.053	2.63GluGlu: 2.63 ± 0.068	1.221GluPhe: 1.221 ± 0.034	4.463GluGly: 4.463 ± 0.078	1.025GluHis: 1.025 ± 0.034	2.45GluIle: 2.45 ± 0.053	1.655GluLys: 1.655 ± 0.046	4.571GluLeu: 4.571 ± 0.072	1.243GluMet: 1.243 ± 0.039	1.144GluAsn: 1.144 ± 0.033	2.504GluPro: 2.504 ± 0.051	2.112GluGln: 2.112 ± 0.042	4.945GluArg: 4.945 ± 0.087	1.963GluSer: 1.963 ± 0.042	3.039GluThr: 3.039 ± 0.06	3.406GluVal: 3.406 ± 0.063	0.813GluTrp: 0.813 ± 0.028	0.888GluTyr: 0.888 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.755PheAla: 4.755 ± 0.08	0.292PheCys: 0.292 ± 0.017	2.643PheAsp: 2.643 ± 0.05	1.718PheGlu: 1.718 ± 0.037	1.229PhePhe: 1.229 ± 0.037	3.425PheGly: 3.425 ± 0.067	0.74PheHis: 0.74 ± 0.026	1.275PheIle: 1.275 ± 0.04	0.742PheLys: 0.742 ± 0.026	3.035PheLeu: 3.035 ± 0.061	0.677PheMet: 0.677 ± 0.025	1.013PheAsn: 1.013 ± 0.038	1.453PhePro: 1.453 ± 0.035	0.964PheGln: 0.964 ± 0.03	2.28PheArg: 2.28 ± 0.046	1.758PheSer: 1.758 ± 0.043	2.013PheThr: 2.013 ± 0.043	2.596PheVal: 2.596 ± 0.048	0.483PheTrp: 0.483 ± 0.026	0.85PheTyr: 0.85 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.959GlyAla: 9.959 ± 0.092	0.769GlyCys: 0.769 ± 0.026	5.049GlyAsp: 5.049 ± 0.064	4.796GlyGlu: 4.796 ± 0.069	3.663GlyPhe: 3.663 ± 0.064	8.499GlyGly: 8.499 ± 0.123	1.913GlyHis: 1.913 ± 0.044	4.391GlyIle: 4.391 ± 0.08	2.954GlyLys: 2.954 ± 0.061	9.034GlyLeu: 9.034 ± 0.1	2.379GlyMet: 2.379 ± 0.047	2.332GlyAsn: 2.332 ± 0.064	3.706GlyPro: 3.706 ± 0.059	3.62GlyGln: 3.62 ± 0.064	7.116GlyArg: 7.116 ± 0.085	4.615GlySer: 4.615 ± 0.085	5.135GlyThr: 5.135 ± 0.118	6.682GlyVal: 6.682 ± 0.085	1.754GlyTrp: 1.754 ± 0.04	2.453GlyTyr: 2.453 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.386HisAla: 2.386 ± 0.051	0.197HisCys: 0.197 ± 0.014	1.3HisAsp: 1.3 ± 0.04	0.972HisGlu: 0.972 ± 0.03	0.78HisPhe: 0.78 ± 0.028	1.985HisGly: 1.985 ± 0.049	0.587HisHis: 0.587 ± 0.025	0.887HisIle: 0.887 ± 0.028	0.383HisLys: 0.383 ± 0.018	1.878HisLeu: 1.878 ± 0.05	0.438HisMet: 0.438 ± 0.02	0.42HisAsn: 0.42 ± 0.021	1.302HisPro: 1.302 ± 0.038	0.556HisGln: 0.556 ± 0.023	1.571HisArg: 1.571 ± 0.037	0.838HisSer: 0.838 ± 0.026	0.666HisThr: 0.666 ± 0.025	1.542HisVal: 1.542 ± 0.037	0.387HisTrp: 0.387 ± 0.019	0.547HisTyr: 0.547 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.011IleAla: 8.011 ± 0.105	0.363IleCys: 0.363 ± 0.019	3.949IleAsp: 3.949 ± 0.058	3.072IleGlu: 3.072 ± 0.061	1.347IlePhe: 1.347 ± 0.034	5.26IleGly: 5.26 ± 0.087	0.842IleHis: 0.842 ± 0.026	1.768IleIle: 1.768 ± 0.047	1.053IleLys: 1.053 ± 0.033	4.087IleLeu: 4.087 ± 0.077	0.778IleMet: 0.778 ± 0.026	1.178IleAsn: 1.178 ± 0.037	2.174IlePro: 2.174 ± 0.045	1.178IleGln: 1.178 ± 0.033	3.396IleArg: 3.396 ± 0.06	2.145IleSer: 2.145 ± 0.051	2.541IleThr: 2.541 ± 0.052	4.334IleVal: 4.334 ± 0.06	0.608IleTrp: 0.608 ± 0.023	0.899IleTyr: 0.899 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.856LysAla: 3.856 ± 0.078	0.107LysCys: 0.107 ± 0.011	1.413LysAsp: 1.413 ± 0.04	0.958LysGlu: 0.958 ± 0.037	0.692LysPhe: 0.692 ± 0.025	2.68LysGly: 2.68 ± 0.055	0.441LysHis: 0.441 ± 0.023	1.287LysIle: 1.287 ± 0.036	0.927LysLys: 0.927 ± 0.039	2.892LysLeu: 2.892 ± 0.055	0.714LysMet: 0.714 ± 0.03	0.639LysAsn: 0.639 ± 0.028	2.04LysPro: 2.04 ± 0.047	0.816LysGln: 0.816 ± 0.032	2.115LysArg: 2.115 ± 0.044	1.392LysSer: 1.392 ± 0.04	1.7LysThr: 1.7 ± 0.037	2.018LysVal: 2.018 ± 0.045	0.321LysTrp: 0.321 ± 0.016	0.524LysTyr: 0.524 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.922LeuAla: 13.922 ± 0.146	0.698LeuCys: 0.698 ± 0.025	6.091LeuAsp: 6.091 ± 0.079	4.179LeuGlu: 4.179 ± 0.069	3.518LeuPhe: 3.518 ± 0.062	8.476LeuGly: 8.476 ± 0.114	1.784LeuHis: 1.784 ± 0.051	4.852LeuIle: 4.852 ± 0.074	2.765LeuLys: 2.765 ± 0.064	8.833LeuLeu: 8.833 ± 0.121	2.077LeuMet: 2.077 ± 0.045	2.56LeuAsn: 2.56 ± 0.054	5.601LeuPro: 5.601 ± 0.076	2.326LeuGln: 2.326 ± 0.054	6.791LeuArg: 6.791 ± 0.096	6.113LeuSer: 6.113 ± 0.083	6.228LeuThr: 6.228 ± 0.075	7.196LeuVal: 7.196 ± 0.095	1.268LeuTrp: 1.268 ± 0.046	2.09LeuTyr: 2.09 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.56MetAla: 3.56 ± 0.068	0.128MetCys: 0.128 ± 0.012	1.06MetAsp: 1.06 ± 0.038	0.951MetGlu: 0.951 ± 0.029	0.594MetPhe: 0.594 ± 0.025	1.912MetGly: 1.912 ± 0.047	0.359MetHis: 0.359 ± 0.017	1.369MetIle: 1.369 ± 0.034	0.933MetLys: 0.933 ± 0.03	2.696MetLeu: 2.696 ± 0.059	0.672MetMet: 0.672 ± 0.027	0.664MetAsn: 0.664 ± 0.026	1.472MetPro: 1.472 ± 0.041	0.68MetGln: 0.68 ± 0.025	1.8MetArg: 1.8 ± 0.043	1.284MetSer: 1.284 ± 0.034	1.985MetThr: 1.985 ± 0.044	1.76MetVal: 1.76 ± 0.043	0.218MetTrp: 0.218 ± 0.014	0.268MetTyr: 0.268 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.293AsnAla: 3.293 ± 0.063	0.187AsnCys: 0.187 ± 0.014	1.458AsnAsp: 1.458 ± 0.041	1.048AsnGlu: 1.048 ± 0.03	0.95AsnPhe: 0.95 ± 0.039	2.584AsnGly: 2.584 ± 0.073	0.447AsnHis: 0.447 ± 0.021	1.273AsnIle: 1.273 ± 0.043	0.593AsnLys: 0.593 ± 0.021	2.375AsnLeu: 2.375 ± 0.059	0.513AsnMet: 0.513 ± 0.021	0.721AsnAsn: 0.721 ± 0.037	1.785AsnPro: 1.785 ± 0.049	0.804AsnGln: 0.804 ± 0.031	1.862AsnArg: 1.862 ± 0.04	1.194AsnSer: 1.194 ± 0.041	1.258AsnThr: 1.258 ± 0.046	1.815AsnVal: 1.815 ± 0.049	0.429AsnTrp: 0.429 ± 0.019	0.744AsnTyr: 0.744 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	7.194ProAla: 7.194 ± 0.094	0.318ProCys: 0.318 ± 0.016	3.903ProAsp: 3.903 ± 0.066	3.307ProGlu: 3.307 ± 0.059	1.919ProPhe: 1.919 ± 0.041	4.953ProGly: 4.953 ± 0.075	1.048ProHis: 1.048 ± 0.034	2.53ProIle: 2.53 ± 0.048	1.457ProLys: 1.457 ± 0.039	4.988ProLeu: 4.988 ± 0.081	1.339ProMet: 1.339 ± 0.037	1.384ProAsn: 1.384 ± 0.038	2.775ProPro: 2.775 ± 0.072	1.754ProGln: 1.754 ± 0.048	3.286ProArg: 3.286 ± 0.052	2.702ProSer: 2.702 ± 0.05	2.846ProThr: 2.846 ± 0.052	4.564ProVal: 4.564 ± 0.07	0.735ProTrp: 0.735 ± 0.03	1.17ProTyr: 1.17 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.714GlnAla: 4.714 ± 0.068	0.206GlnCys: 0.206 ± 0.013	1.546GlnAsp: 1.546 ± 0.039	1.18GlnGlu: 1.18 ± 0.036	1.092GlnPhe: 1.092 ± 0.034	2.856GlnGly: 2.856 ± 0.055	0.579GlnHis: 0.579 ± 0.025	1.667GlnIle: 1.667 ± 0.042	0.859GlnLys: 0.859 ± 0.028	2.988GlnLeu: 2.988 ± 0.055	0.851GlnMet: 0.851 ± 0.028	0.844GlnAsn: 0.844 ± 0.031	1.972GlnPro: 1.972 ± 0.044	1.259GlnGln: 1.259 ± 0.037	2.678GlnArg: 2.678 ± 0.051	1.681GlnSer: 1.681 ± 0.04	1.835GlnThr: 1.835 ± 0.048	2.495GlnVal: 2.495 ± 0.049	0.485GlnTrp: 0.485 ± 0.022	0.655GlnTyr: 0.655 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.051ArgAla: 9.051 ± 0.116	0.476ArgCys: 0.476 ± 0.021	4.676ArgAsp: 4.676 ± 0.069	3.94ArgGlu: 3.94 ± 0.073	3.286ArgPhe: 3.286 ± 0.058	5.492ArgGly: 5.492 ± 0.071	1.811ArgHis: 1.811 ± 0.042	4.289ArgIle: 4.289 ± 0.067	1.737ArgLys: 1.737 ± 0.05	8.368ArgLeu: 8.368 ± 0.108	2.104ArgMet: 2.104 ± 0.039	1.814ArgAsn: 1.814 ± 0.043	3.991ArgPro: 3.991 ± 0.075	2.667ArgGln: 2.667 ± 0.054	6.147ArgArg: 6.147 ± 0.093	3.592ArgSer: 3.592 ± 0.053	3.829ArgThr: 3.829 ± 0.058	5.308ArgVal: 5.308 ± 0.073	1.345ArgTrp: 1.345 ± 0.038	2.079ArgTyr: 2.079 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.069SerAla: 6.069 ± 0.08	0.339SerCys: 0.339 ± 0.021	2.881SerAsp: 2.881 ± 0.056	2.255SerGlu: 2.255 ± 0.044	1.988SerPhe: 1.988 ± 0.043	5.298SerGly: 5.298 ± 0.089	0.931SerHis: 0.931 ± 0.035	2.493SerIle: 2.493 ± 0.053	1.266SerLys: 1.266 ± 0.038	4.858SerLeu: 4.858 ± 0.073	1.098SerMet: 1.098 ± 0.033	1.327SerAsn: 1.327 ± 0.043	2.938SerPro: 2.938 ± 0.055	1.509SerGln: 1.509 ± 0.041	3.278SerArg: 3.278 ± 0.053	2.596SerSer: 2.596 ± 0.055	2.677SerThr: 2.677 ± 0.059	3.72SerVal: 3.72 ± 0.066	0.742SerTrp: 0.742 ± 0.03	1.34SerTyr: 1.34 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.991ThrAla: 6.991 ± 0.097	0.352ThrCys: 0.352 ± 0.02	3.153ThrAsp: 3.153 ± 0.052	2.331ThrGlu: 2.331 ± 0.052	1.717ThrPhe: 1.717 ± 0.045	5.789ThrGly: 5.789 ± 0.094	0.943ThrHis: 0.943 ± 0.031	3.218ThrIle: 3.218 ± 0.067	1.364ThrLys: 1.364 ± 0.04	6.452ThrLeu: 6.452 ± 0.081	1.255ThrMet: 1.255 ± 0.033	1.417ThrAsn: 1.417 ± 0.053	3.854ThrPro: 3.854 ± 0.071	1.613ThrGln: 1.613 ± 0.043	3.944ThrArg: 3.944 ± 0.05	2.637ThrSer: 2.637 ± 0.049	3.082ThrThr: 3.082 ± 0.075	4.649ThrVal: 4.649 ± 0.079	0.589ThrTrp: 0.589 ± 0.025	1.259ThrTyr: 1.259 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.424ValAla: 10.424 ± 0.113	0.431ValCys: 0.431 ± 0.021	4.524ValAsp: 4.524 ± 0.072	4.568ValGlu: 4.568 ± 0.079	2.108ValPhe: 2.108 ± 0.049	5.881ValGly: 5.881 ± 0.079	1.359ValHis: 1.359 ± 0.038	3.566ValIle: 3.566 ± 0.061	1.977ValLys: 1.977 ± 0.042	6.659ValLeu: 6.659 ± 0.081	1.705ValMet: 1.705 ± 0.041	1.986ValAsn: 1.986 ± 0.059	3.983ValPro: 3.983 ± 0.061	2.218ValGln: 2.218 ± 0.047	5.477ValArg: 5.477 ± 0.087	4.006ValSer: 4.006 ± 0.064	4.989ValThr: 4.989 ± 0.081	5.611ValVal: 5.611 ± 0.081	0.847ValTrp: 0.847 ± 0.033	1.396ValTyr: 1.396 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.495TrpAla: 1.495 ± 0.043	0.124TrpCys: 0.124 ± 0.01	0.757TrpAsp: 0.757 ± 0.027	0.522TrpGlu: 0.522 ± 0.023	0.562TrpPhe: 0.562 ± 0.021	1.011TrpGly: 1.011 ± 0.037	0.356TrpHis: 0.356 ± 0.018	0.648TrpIle: 0.648 ± 0.028	0.402TrpLys: 0.402 ± 0.021	1.69TrpLeu: 1.69 ± 0.049	0.352TrpMet: 0.352 ± 0.019	0.448TrpAsn: 0.448 ± 0.022	0.761TrpPro: 0.761 ± 0.03	0.614TrpGln: 0.614 ± 0.025	1.477TrpArg: 1.477 ± 0.047	0.942TrpSer: 0.942 ± 0.03	0.952TrpThr: 0.952 ± 0.031	0.885TrpVal: 0.885 ± 0.033	0.297TrpTrp: 0.297 ± 0.018	0.318TrpTyr: 0.318 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.904TyrAla: 2.904 ± 0.051	0.193TyrCys: 0.193 ± 0.012	1.719TyrAsp: 1.719 ± 0.044	1.061TyrGlu: 1.061 ± 0.034	0.815TyrPhe: 0.815 ± 0.028	2.205TyrGly: 2.205 ± 0.055	0.493TyrHis: 0.493 ± 0.023	0.84TyrIle: 0.84 ± 0.027	0.575TyrLys: 0.575 ± 0.024	2.075TyrLeu: 2.075 ± 0.046	0.39TyrMet: 0.39 ± 0.02	0.652TyrAsn: 0.652 ± 0.032	1.054TyrPro: 1.054 ± 0.03	0.714TyrGln: 0.714 ± 0.023	2.056TyrArg: 2.056 ± 0.047	1.175TyrSer: 1.175 ± 0.038	1.039TyrThr: 1.039 ± 0.035	1.571TyrVal: 1.571 ± 0.043	0.369TyrTrp: 0.369 ± 0.02	0.656TyrTyr: 0.656 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3411 proteins (1104473 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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