Amino acid dipepetide frequency for Streptococcus hyointestinalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.199AlaAla: 5.199 ± 0.139
0.576AlaCys: 0.576 ± 0.032
4.132AlaAsp: 4.132 ± 0.097
4.706AlaGlu: 4.706 ± 0.151
3.597AlaPhe: 3.597 ± 0.086
4.711AlaGly: 4.711 ± 0.123
1.339AlaHis: 1.339 ± 0.046
6.005AlaIle: 6.005 ± 0.106
5.713AlaLys: 5.713 ± 0.122
7.392AlaLeu: 7.392 ± 0.137
1.859AlaMet: 1.859 ± 0.047
3.175AlaAsn: 3.175 ± 0.091
2.029AlaPro: 2.029 ± 0.07
3.245AlaGln: 3.245 ± 0.11
3.121AlaArg: 3.121 ± 0.093
4.946AlaSer: 4.946 ± 0.096
4.701AlaThr: 4.701 ± 0.128
5.161AlaVal: 5.161 ± 0.11
0.583AlaTrp: 0.583 ± 0.027
3.111AlaTyr: 3.111 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.353CysAla: 0.353 ± 0.022
0.063CysCys: 0.063 ± 0.01
0.371CysAsp: 0.371 ± 0.024
0.363CysGlu: 0.363 ± 0.025
0.282CysPhe: 0.282 ± 0.019
0.551CysGly: 0.551 ± 0.033
0.245CysHis: 0.245 ± 0.023
0.406CysIle: 0.406 ± 0.024
0.299CysLys: 0.299 ± 0.022
0.601CysLeu: 0.601 ± 0.028
0.121CysMet: 0.121 ± 0.012
0.263CysAsn: 0.263 ± 0.021
0.359CysPro: 0.359 ± 0.025
0.389CysGln: 0.389 ± 0.022
0.266CysArg: 0.266 ± 0.021
0.434CysSer: 0.434 ± 0.026
0.242CysThr: 0.242 ± 0.021
0.312CysVal: 0.312 ± 0.021
0.046CysTrp: 0.046 ± 0.008
0.234CysTyr: 0.234 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.484AspAla: 3.484 ± 0.078
0.342AspCys: 0.342 ± 0.022
3.27AspAsp: 3.27 ± 0.083
4.364AspGlu: 4.364 ± 0.097
3.306AspPhe: 3.306 ± 0.073
3.779AspGly: 3.779 ± 0.134
0.801AspHis: 0.801 ± 0.032
4.371AspIle: 4.371 ± 0.091
4.805AspLys: 4.805 ± 0.099
5.552AspLeu: 5.552 ± 0.103
1.631AspMet: 1.631 ± 0.05
2.983AspAsn: 2.983 ± 0.079
1.53AspPro: 1.53 ± 0.072
1.423AspGln: 1.423 ± 0.047
1.964AspArg: 1.964 ± 0.056
6.068AspSer: 6.068 ± 1.883
4.249AspThr: 4.249 ± 0.83
4.075AspVal: 4.075 ± 0.081
0.63AspTrp: 0.63 ± 0.031
3.06AspTyr: 3.06 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
5.605GluAla: 5.605 ± 0.162
0.293GluCys: 0.293 ± 0.022
3.766GluAsp: 3.766 ± 0.094
5.502GluGlu: 5.502 ± 0.129
2.277GluPhe: 2.277 ± 0.069
3.182GluGly: 3.182 ± 0.082
1.43GluHis: 1.43 ± 0.046
5.075GluIle: 5.075 ± 0.414
5.605GluLys: 5.605 ± 0.1
7.093GluLeu: 7.093 ± 0.109
1.819GluMet: 1.819 ± 0.058
3.37GluAsn: 3.37 ± 0.078
1.552GluPro: 1.552 ± 0.066
2.868GluGln: 2.868 ± 0.072
3.779GluArg: 3.779 ± 0.113
3.284GluSer: 3.284 ± 0.119
4.662GluThr: 4.662 ± 0.319
4.659GluVal: 4.659 ± 0.096
0.538GluTrp: 0.538 ± 0.026
1.801GluTyr: 1.801 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.183PheAla: 3.183 ± 0.074
0.344PheCys: 0.344 ± 0.027
2.925PheAsp: 2.925 ± 0.07
2.986PheGlu: 2.986 ± 0.074
1.996PhePhe: 1.996 ± 0.06
3.054PheGly: 3.054 ± 0.075
0.816PheHis: 0.816 ± 0.037
2.971PheIle: 2.971 ± 0.077
2.686PheLys: 2.686 ± 0.067
4.153PheLeu: 4.153 ± 0.097
0.962PheMet: 0.962 ± 0.04
1.883PheAsn: 1.883 ± 0.053
1.591PhePro: 1.591 ± 0.054
1.369PheGln: 1.369 ± 0.045
1.623PheArg: 1.623 ± 0.047
3.25PheSer: 3.25 ± 0.07
2.503PheThr: 2.503 ± 0.059
2.98PheVal: 2.98 ± 0.072
0.389PheTrp: 0.389 ± 0.025
1.903PheTyr: 1.903 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.114GlyAla: 4.114 ± 0.109
0.37GlyCys: 0.37 ± 0.028
3.227GlyAsp: 3.227 ± 0.086
3.705GlyGlu: 3.705 ± 0.073
2.996GlyPhe: 2.996 ± 0.071
3.598GlyGly: 3.598 ± 0.103
1.323GlyHis: 1.323 ± 0.047
4.652GlyIle: 4.652 ± 0.101
4.659GlyLys: 4.659 ± 0.106
5.912GlyLeu: 5.912 ± 0.109
1.579GlyMet: 1.579 ± 0.056
2.562GlyAsn: 2.562 ± 0.087
0.976GlyPro: 0.976 ± 0.041
2.524GlyGln: 2.524 ± 0.063
2.709GlyArg: 2.709 ± 0.075
3.505GlySer: 3.505 ± 0.088
3.711GlyThr: 3.711 ± 0.122
4.488GlyVal: 4.488 ± 0.096
0.562GlyTrp: 0.562 ± 0.028
2.61GlyTyr: 2.61 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.113HisAla: 1.113 ± 0.045
0.185HisCys: 0.185 ± 0.015
1.0HisAsp: 1.0 ± 0.041
1.149HisGlu: 1.149 ± 0.048
1.182HisPhe: 1.182 ± 0.037
1.114HisGly: 1.114 ± 0.047
0.554HisHis: 0.554 ± 0.031
1.432HisIle: 1.432 ± 0.049
1.204HisLys: 1.204 ± 0.041
2.266HisLeu: 2.266 ± 0.068
0.433HisMet: 0.433 ± 0.025
0.809HisAsn: 0.809 ± 0.032
0.982HisPro: 0.982 ± 0.042
0.851HisGln: 0.851 ± 0.04
0.93HisArg: 0.93 ± 0.037
1.09HisSer: 1.09 ± 0.046
0.978HisThr: 0.978 ± 0.042
1.184HisVal: 1.184 ± 0.044
0.234HisTrp: 0.234 ± 0.018
1.115HisTyr: 1.115 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.181IleAla: 6.181 ± 0.101
0.535IleCys: 0.535 ± 0.029
4.869IleAsp: 4.869 ± 0.4
4.619IleGlu: 4.619 ± 0.095
2.848IlePhe: 2.848 ± 0.071
4.444IleGly: 4.444 ± 0.093
1.195IleHis: 1.195 ± 0.043
4.648IleIle: 4.648 ± 0.102
4.766IleLys: 4.766 ± 0.104
6.492IleLeu: 6.492 ± 0.129
1.435IleMet: 1.435 ± 0.048
2.939IleAsn: 2.939 ± 0.084
2.563IlePro: 2.563 ± 0.066
2.152IleGln: 2.152 ± 0.071
2.787IleArg: 2.787 ± 0.067
4.723IleSer: 4.723 ± 0.107
4.227IleThr: 4.227 ± 0.097
4.702IleVal: 4.702 ± 0.105
0.534IleTrp: 0.534 ± 0.031
2.41IleTyr: 2.41 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
6.151LysAla: 6.151 ± 0.15
0.305LysCys: 0.305 ± 0.024
4.342LysAsp: 4.342 ± 0.086
6.036LysGlu: 6.036 ± 0.1
1.701LysPhe: 1.701 ± 0.05
4.022LysGly: 4.022 ± 0.092
1.549LysHis: 1.549 ± 0.053
4.228LysIle: 4.228 ± 0.087
5.495LysLys: 5.495 ± 0.125
6.15LysLeu: 6.15 ± 0.11
1.832LysMet: 1.832 ± 0.064
3.391LysAsn: 3.391 ± 0.072
2.211LysPro: 2.211 ± 0.08
3.056LysGln: 3.056 ± 0.084
3.944LysArg: 3.944 ± 0.095
4.064LysSer: 4.064 ± 0.081
4.87LysThr: 4.87 ± 0.098
4.617LysVal: 4.617 ± 0.09
0.633LysTrp: 0.633 ± 0.031
2.214LysTyr: 2.214 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
8.495LeuAla: 8.495 ± 0.148
0.569LeuCys: 0.569 ± 0.032
6.044LeuAsp: 6.044 ± 0.102
6.893LeuGlu: 6.893 ± 0.126
4.265LeuPhe: 4.265 ± 0.102
6.208LeuGly: 6.208 ± 0.111
1.617LeuHis: 1.617 ± 0.048
6.185LeuIle: 6.185 ± 0.142
6.452LeuLys: 6.452 ± 0.123
9.944LeuLeu: 9.944 ± 0.181
2.209LeuMet: 2.209 ± 0.07
3.944LeuAsn: 3.944 ± 0.088
3.69LeuPro: 3.69 ± 0.071
3.071LeuGln: 3.071 ± 0.072
3.957LeuArg: 3.957 ± 0.088
7.606LeuSer: 7.606 ± 0.139
6.569LeuThr: 6.569 ± 0.18
6.674LeuVal: 6.674 ± 0.116
0.701LeuTrp: 0.701 ± 0.034
3.211LeuTyr: 3.211 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
1.935MetAla: 1.935 ± 0.059
0.125MetCys: 0.125 ± 0.013
1.419MetAsp: 1.419 ± 0.058
1.263MetGlu: 1.263 ± 0.043
0.77MetPhe: 0.77 ± 0.034
1.459MetGly: 1.459 ± 0.051
0.342MetHis: 0.342 ± 0.022
1.655MetIle: 1.655 ± 0.054
1.743MetLys: 1.743 ± 0.051
2.126MetLeu: 2.126 ± 0.063
0.68MetMet: 0.68 ± 0.036
1.038MetAsn: 1.038 ± 0.043
0.702MetPro: 0.702 ± 0.031
0.825MetGln: 0.825 ± 0.032
0.968MetArg: 0.968 ± 0.036
1.727MetSer: 1.727 ± 0.052
2.259MetThr: 2.259 ± 0.061
1.559MetVal: 1.559 ± 0.046
0.166MetTrp: 0.166 ± 0.015
0.58MetTyr: 0.58 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.131AsnAla: 3.131 ± 0.091
0.323AsnCys: 0.323 ± 0.024
2.467AsnAsp: 2.467 ± 0.069
2.282AsnGlu: 2.282 ± 0.065
1.891AsnPhe: 1.891 ± 0.055
3.158AsnGly: 3.158 ± 0.09
1.236AsnHis: 1.236 ± 0.051
2.946AsnIle: 2.946 ± 0.077
2.843AsnLys: 2.843 ± 0.073
4.082AsnLeu: 4.082 ± 0.073
1.022AsnMet: 1.022 ± 0.043
1.925AsnAsn: 1.925 ± 0.063
2.057AsnPro: 2.057 ± 0.057
2.057AsnGln: 2.057 ± 0.068
2.193AsnArg: 2.193 ± 0.056
2.636AsnSer: 2.636 ± 0.071
2.403AsnThr: 2.403 ± 0.079
2.569AsnVal: 2.569 ± 0.079
0.453AsnTrp: 0.453 ± 0.027
1.894AsnTyr: 1.894 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.147ProAla: 2.147 ± 0.08
0.197ProCys: 0.197 ± 0.02
1.933ProAsp: 1.933 ± 0.059
2.602ProGlu: 2.602 ± 0.067
1.524ProPhe: 1.524 ± 0.048
1.345ProGly: 1.345 ± 0.053
0.712ProHis: 0.712 ± 0.034
2.446ProIle: 2.446 ± 0.065
2.637ProLys: 2.637 ± 0.071
2.801ProLeu: 2.801 ± 0.067
0.643ProMet: 0.643 ± 0.026
1.534ProAsn: 1.534 ± 0.051
0.502ProPro: 0.502 ± 0.031
1.21ProGln: 1.21 ± 0.046
1.207ProArg: 1.207 ± 0.042
2.154ProSer: 2.154 ± 0.068
2.056ProThr: 2.056 ± 0.112
2.352ProVal: 2.352 ± 0.074
0.245ProTrp: 0.245 ± 0.017
1.46ProTyr: 1.46 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.617GlnAla: 3.617 ± 0.116
0.159GlnCys: 0.159 ± 0.015
1.9GlnAsp: 1.9 ± 0.051
2.916GlnGlu: 2.916 ± 0.099
1.62GlnPhe: 1.62 ± 0.048
1.982GlnGly: 1.982 ± 0.059
0.723GlnHis: 0.723 ± 0.031
2.375GlnIle: 2.375 ± 0.064
3.33GlnLys: 3.33 ± 0.099
4.277GlnLeu: 4.277 ± 0.113
1.006GlnMet: 1.006 ± 0.043
1.733GlnAsn: 1.733 ± 0.055
1.236GlnPro: 1.236 ± 0.047
1.444GlnGln: 1.444 ± 0.06
1.566GlnArg: 1.566 ± 0.054
2.267GlnSer: 2.267 ± 0.066
2.648GlnThr: 2.648 ± 0.066
2.928GlnVal: 2.928 ± 0.075
0.286GlnTrp: 0.286 ± 0.02
1.216GlnTyr: 1.216 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.693ArgAla: 2.693 ± 0.072
0.266ArgCys: 0.266 ± 0.022
2.381ArgAsp: 2.381 ± 0.055
3.106ArgGlu: 3.106 ± 0.074
2.207ArgPhe: 2.207 ± 0.065
2.302ArgGly: 2.302 ± 0.057
1.011ArgHis: 1.011 ± 0.041
2.82ArgIle: 2.82 ± 0.066
3.133ArgLys: 3.133 ± 0.076
4.779ArgLeu: 4.779 ± 0.095
1.063ArgMet: 1.063 ± 0.041
1.722ArgAsn: 1.722 ± 0.058
1.357ArgPro: 1.357 ± 0.05
2.431ArgGln: 2.431 ± 0.139
2.37ArgArg: 2.37 ± 0.071
2.385ArgSer: 2.385 ± 0.064
2.146ArgThr: 2.146 ± 0.06
2.898ArgVal: 2.898 ± 0.071
0.345ArgTrp: 0.345 ± 0.022
2.054ArgTyr: 2.054 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
4.395SerAla: 4.395 ± 0.107
0.342SerCys: 0.342 ± 0.026
5.176SerAsp: 5.176 ± 0.849
5.149SerGlu: 5.149 ± 0.789
3.007SerPhe: 3.007 ± 0.074
4.114SerGly: 4.114 ± 0.096
1.483SerHis: 1.483 ± 0.048
4.2SerIle: 4.2 ± 0.093
4.05SerLys: 4.05 ± 0.084
6.706SerLeu: 6.706 ± 0.173
1.33SerMet: 1.33 ± 0.048
2.541SerAsn: 2.541 ± 0.077
1.976SerPro: 1.976 ± 0.057
3.161SerGln: 3.161 ± 0.094
2.973SerArg: 2.973 ± 0.071
4.737SerSer: 4.737 ± 0.156
3.937SerThr: 3.937 ± 0.098
4.192SerVal: 4.192 ± 0.093
0.587SerTrp: 0.587 ± 0.03
2.855SerTyr: 2.855 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.534ThrAla: 4.534 ± 0.135
0.334ThrCys: 0.334 ± 0.023
5.289ThrAsp: 5.289 ± 1.365
3.331ThrGlu: 3.331 ± 0.106
2.916ThrPhe: 2.916 ± 0.062
4.019ThrGly: 4.019 ± 0.102
1.131ThrHis: 1.131 ± 0.038
4.681ThrIle: 4.681 ± 0.101
4.232ThrLys: 4.232 ± 0.09
6.158ThrLeu: 6.158 ± 0.104
1.174ThrMet: 1.174 ± 0.04
2.816ThrAsn: 2.816 ± 0.08
2.638ThrPro: 2.638 ± 0.097
2.25ThrGln: 2.25 ± 0.078
2.132ThrArg: 2.132 ± 0.059
4.272ThrSer: 4.272 ± 0.111
4.108ThrThr: 4.108 ± 0.18
4.58ThrVal: 4.58 ± 0.138
0.495ThrTrp: 0.495 ± 0.023
2.587ThrTyr: 2.587 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
5.641ValAla: 5.641 ± 0.114
0.501ValCys: 0.501 ± 0.03
4.023ValAsp: 4.023 ± 0.09
4.339ValGlu: 4.339 ± 0.1
2.855ValPhe: 2.855 ± 0.075
3.951ValGly: 3.951 ± 0.094
1.101ValHis: 1.101 ± 0.044
5.001ValIle: 5.001 ± 0.1
4.392ValLys: 4.392 ± 0.088
6.683ValLeu: 6.683 ± 0.105
1.611ValMet: 1.611 ± 0.056
2.839ValAsn: 2.839 ± 0.068
2.254ValPro: 2.254 ± 0.072
2.142ValGln: 2.142 ± 0.061
2.709ValArg: 2.709 ± 0.058
4.829ValSer: 4.829 ± 0.111
4.79ValThr: 4.79 ± 0.13
4.94ValVal: 4.94 ± 0.115
0.517ValTrp: 0.517 ± 0.03
2.624ValTyr: 2.624 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.544TrpAla: 0.544 ± 0.027
0.063TrpCys: 0.063 ± 0.008
0.515TrpAsp: 0.515 ± 0.026
0.527TrpGlu: 0.527 ± 0.029
0.407TrpPhe: 0.407 ± 0.023
0.505TrpGly: 0.505 ± 0.031
0.191TrpHis: 0.191 ± 0.017
0.53TrpIle: 0.53 ± 0.029
0.491TrpLys: 0.491 ± 0.027
1.021TrpLeu: 1.021 ± 0.039
0.217TrpMet: 0.217 ± 0.019
0.455TrpAsn: 0.455 ± 0.026
0.099TrpPro: 0.099 ± 0.012
0.466TrpGln: 0.466 ± 0.025
0.37TrpArg: 0.37 ± 0.025
0.567TrpSer: 0.567 ± 0.03
0.46TrpThr: 0.46 ± 0.024
0.49TrpVal: 0.49 ± 0.026
0.1TrpTrp: 0.1 ± 0.013
0.391TrpTyr: 0.391 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.787TyrAla: 2.787 ± 0.072
0.309TyrCys: 0.309 ± 0.023
2.637TyrAsp: 2.637 ± 0.067
2.321TyrGlu: 2.321 ± 0.073
1.918TyrPhe: 1.918 ± 0.053
2.284TyrGly: 2.284 ± 0.057
1.006TyrHis: 1.006 ± 0.037
2.439TyrIle: 2.439 ± 0.063
2.277TyrLys: 2.277 ± 0.069
4.117TyrLeu: 4.117 ± 0.099
0.715TyrMet: 0.715 ± 0.034
1.648TyrAsn: 1.648 ± 0.059
1.402TyrPro: 1.402 ± 0.051
2.298TyrGln: 2.298 ± 0.071
1.9TyrArg: 1.9 ± 0.054
2.367TyrSer: 2.367 ± 0.067
2.161TyrThr: 2.161 ± 0.081
2.384TyrVal: 2.384 ± 0.082
0.363TyrTrp: 0.363 ± 0.02
1.935TyrTyr: 1.935 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2417 proteins (719027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski