Amino acid dipepetide frequency for Scytonema hofmannii PCC 7110

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.247AlaAla: 6.247 ± 0.054	0.808AlaCys: 0.808 ± 0.02	3.547AlaAsp: 3.547 ± 0.036	4.789AlaGlu: 4.789 ± 0.043	3.045AlaPhe: 3.045 ± 0.034	4.864AlaGly: 4.864 ± 0.054	1.233AlaHis: 1.233 ± 0.022	6.549AlaIle: 6.549 ± 0.054	4.024AlaLys: 4.024 ± 0.037	8.389AlaLeu: 8.389 ± 0.066	1.509AlaMet: 1.509 ± 0.022	3.366AlaAsn: 3.366 ± 0.045	2.683AlaPro: 2.683 ± 0.036	3.888AlaGln: 3.888 ± 0.043	3.685AlaArg: 3.685 ± 0.037	5.049AlaSer: 5.049 ± 0.06	4.559AlaThr: 4.559 ± 0.041	5.314AlaVal: 5.314 ± 0.043	0.97AlaTrp: 0.97 ± 0.022	2.327AlaTyr: 2.327 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.629CysAla: 0.629 ± 0.015	0.169CysCys: 0.169 ± 0.008	0.545CysAsp: 0.545 ± 0.014	0.541CysGlu: 0.541 ± 0.014	0.429CysPhe: 0.429 ± 0.012	0.703CysGly: 0.703 ± 0.017	0.28CysHis: 0.28 ± 0.011	0.611CysIle: 0.611 ± 0.014	0.416CysLys: 0.416 ± 0.012	1.17CysLeu: 1.17 ± 0.021	0.162CysMet: 0.162 ± 0.007	0.413CysAsn: 0.413 ± 0.011	0.498CysPro: 0.498 ± 0.014	0.591CysGln: 0.591 ± 0.013	0.523CysArg: 0.523 ± 0.013	0.645CysSer: 0.645 ± 0.016	0.472CysThr: 0.472 ± 0.013	0.613CysVal: 0.613 ± 0.014	0.154CysTrp: 0.154 ± 0.006	0.38CysTyr: 0.38 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.66AspAla: 3.66 ± 0.042	0.539AspCys: 0.539 ± 0.014	2.262AspAsp: 2.262 ± 0.034	3.112AspGlu: 3.112 ± 0.039	2.327AspPhe: 2.327 ± 0.027	3.438AspGly: 3.438 ± 0.057	0.526AspHis: 0.526 ± 0.014	3.404AspIle: 3.404 ± 0.041	2.579AspLys: 2.579 ± 0.033	5.443AspLeu: 5.443 ± 0.046	0.726AspMet: 0.726 ± 0.016	2.167AspAsn: 2.167 ± 0.031	2.182AspPro: 2.182 ± 0.029	1.316AspGln: 1.316 ± 0.024	3.338AspArg: 3.338 ± 0.032	3.122AspSer: 3.122 ± 0.037	2.636AspThr: 2.636 ± 0.046	3.05AspVal: 3.05 ± 0.034	0.906AspTrp: 0.906 ± 0.018	1.802AspTyr: 1.802 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.203GluAla: 5.203 ± 0.048	0.528GluCys: 0.528 ± 0.015	2.848GluAsp: 2.848 ± 0.031	4.54GluGlu: 4.54 ± 0.051	2.602GluPhe: 2.602 ± 0.031	3.329GluGly: 3.329 ± 0.035	1.079GluHis: 1.079 ± 0.021	4.986GluIle: 4.986 ± 0.044	3.868GluLys: 3.868 ± 0.042	7.235GluLeu: 7.235 ± 0.057	1.34GluMet: 1.34 ± 0.02	2.958GluAsn: 2.958 ± 0.033	2.424GluPro: 2.424 ± 0.029	3.828GluGln: 3.828 ± 0.049	3.717GluArg: 3.717 ± 0.04	3.58GluSer: 3.58 ± 0.03	3.611GluThr: 3.611 ± 0.039	4.467GluVal: 4.467 ± 0.042	0.838GluTrp: 0.838 ± 0.019	1.977GluTyr: 1.977 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.045PheAla: 3.045 ± 0.036	0.531PheCys: 0.531 ± 0.014	2.27PheAsp: 2.27 ± 0.03	2.411PheGlu: 2.411 ± 0.032	1.795PhePhe: 1.795 ± 0.023	2.875PheGly: 2.875 ± 0.034	0.787PheHis: 0.787 ± 0.016	2.38PheIle: 2.38 ± 0.027	1.703PheLys: 1.703 ± 0.025	4.235PheLeu: 4.235 ± 0.043	0.658PheMet: 0.658 ± 0.017	1.874PheAsn: 1.874 ± 0.026	1.821PhePro: 1.821 ± 0.029	1.895PheGln: 1.895 ± 0.024	1.849PheArg: 1.849 ± 0.028	3.142PheSer: 3.142 ± 0.04	2.319PheThr: 2.319 ± 0.031	2.545PheVal: 2.545 ± 0.032	0.687PheTrp: 0.687 ± 0.015	1.411PheTyr: 1.411 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	4.432GlyAla: 4.432 ± 0.05	0.743GlyCys: 0.743 ± 0.018	3.241GlyAsp: 3.241 ± 0.043	4.107GlyGlu: 4.107 ± 0.038	2.837GlyPhe: 2.837 ± 0.034	4.622GlyGly: 4.622 ± 0.068	1.274GlyHis: 1.274 ± 0.03	4.775GlyIle: 4.775 ± 0.043	4.07GlyLys: 4.07 ± 0.043	6.48GlyLeu: 6.48 ± 0.048	1.377GlyMet: 1.377 ± 0.023	3.315GlyAsn: 3.315 ± 0.073	1.135GlyPro: 1.135 ± 0.023	2.911GlyGln: 2.911 ± 0.037	3.278GlyArg: 3.278 ± 0.037	4.26GlySer: 4.26 ± 0.053	3.866GlyThr: 3.866 ± 0.046	4.593GlyVal: 4.593 ± 0.047	1.029GlyTrp: 1.029 ± 0.02	2.311GlyTyr: 2.311 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.002HisAla: 1.002 ± 0.019	0.244HisCys: 0.244 ± 0.009	0.745HisAsp: 0.745 ± 0.017	0.97HisGlu: 0.97 ± 0.016	0.842HisPhe: 0.842 ± 0.017	1.072HisGly: 1.072 ± 0.021	0.543HisHis: 0.543 ± 0.017	1.157HisIle: 1.157 ± 0.018	0.846HisLys: 0.846 ± 0.018	2.239HisLeu: 2.239 ± 0.03	0.256HisMet: 0.256 ± 0.009	0.764HisAsn: 0.764 ± 0.016	1.182HisPro: 1.182 ± 0.02	1.105HisGln: 1.105 ± 0.023	1.049HisArg: 1.049 ± 0.023	1.328HisSer: 1.328 ± 0.021	0.924HisThr: 0.924 ± 0.02	0.814HisVal: 0.814 ± 0.016	0.35HisTrp: 0.35 ± 0.012	0.676HisTyr: 0.676 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.73IleAla: 6.73 ± 0.051	0.758IleCys: 0.758 ± 0.016	3.637IleAsp: 3.637 ± 0.036	4.45IleGlu: 4.45 ± 0.037	2.552IlePhe: 2.552 ± 0.029	4.33IleGly: 4.33 ± 0.046	1.255IleHis: 1.255 ± 0.02	3.637IleIle: 3.637 ± 0.037	3.194IleLys: 3.194 ± 0.04	6.65IleLeu: 6.65 ± 0.054	0.831IleMet: 0.831 ± 0.015	3.097IleAsn: 3.097 ± 0.037	3.479IlePro: 3.479 ± 0.037	3.137IleGln: 3.137 ± 0.035	3.132IleArg: 3.132 ± 0.033	4.535IleSer: 4.535 ± 0.043	3.575IleThr: 3.575 ± 0.038	4.428IleVal: 4.428 ± 0.037	0.858IleTrp: 0.858 ± 0.017	1.973IleTyr: 1.973 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.025LysAla: 4.025 ± 0.044	0.365LysCys: 0.365 ± 0.012	2.427LysAsp: 2.427 ± 0.036	3.255LysGlu: 3.255 ± 0.042	1.915LysPhe: 1.915 ± 0.025	2.851LysGly: 2.851 ± 0.035	0.903LysHis: 0.903 ± 0.019	3.652LysIle: 3.652 ± 0.038	2.73LysLys: 2.73 ± 0.04	5.666LysLeu: 5.666 ± 0.053	0.95LysMet: 0.95 ± 0.018	2.357LysAsn: 2.357 ± 0.034	2.491LysPro: 2.491 ± 0.029	2.942LysGln: 2.942 ± 0.032	2.557LysArg: 2.557 ± 0.028	3.259LysSer: 3.259 ± 0.034	3.183LysThr: 3.183 ± 0.04	3.448LysVal: 3.448 ± 0.036	0.559LysTrp: 0.559 ± 0.014	1.587LysTyr: 1.587 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	9.012LeuAla: 9.012 ± 0.062	1.075LeuCys: 1.075 ± 0.02	5.243LeuAsp: 5.243 ± 0.041	7.563LeuGlu: 7.563 ± 0.054	3.852LeuPhe: 3.852 ± 0.044	7.209LeuGly: 7.209 ± 0.058	1.919LeuHis: 1.919 ± 0.025	6.403LeuIle: 6.403 ± 0.053	5.875LeuLys: 5.875 ± 0.051	11.416LeuLeu: 11.416 ± 0.075	1.951LeuMet: 1.951 ± 0.027	4.792LeuAsn: 4.792 ± 0.044	5.535LeuPro: 5.535 ± 0.056	5.799LeuGln: 5.799 ± 0.051	5.722LeuArg: 5.722 ± 0.049	7.89LeuSer: 7.89 ± 0.054	6.521LeuThr: 6.521 ± 0.057	7.169LeuVal: 7.169 ± 0.062	1.528LeuTrp: 1.528 ± 0.032	2.774LeuTyr: 2.774 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.498MetAla: 1.498 ± 0.028	0.117MetCys: 0.117 ± 0.006	0.681MetAsp: 0.681 ± 0.013	0.984MetGlu: 0.984 ± 0.018	0.553MetPhe: 0.553 ± 0.014	1.206MetGly: 1.206 ± 0.02	0.305MetHis: 0.305 ± 0.011	0.988MetIle: 0.988 ± 0.019	0.982MetLys: 0.982 ± 0.019	1.872MetLeu: 1.872 ± 0.026	0.39MetMet: 0.39 ± 0.012	0.85MetAsn: 0.85 ± 0.016	0.864MetPro: 0.864 ± 0.018	0.871MetGln: 0.871 ± 0.018	0.951MetArg: 0.951 ± 0.017	1.312MetSer: 1.312 ± 0.02	1.312MetThr: 1.312 ± 0.023	1.216MetVal: 1.216 ± 0.023	0.163MetTrp: 0.163 ± 0.008	0.364MetTyr: 0.364 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.232AsnAla: 3.232 ± 0.038	0.458AsnCys: 0.458 ± 0.012	1.886AsnAsp: 1.886 ± 0.044	2.113AsnGlu: 2.113 ± 0.027	2.059AsnPhe: 2.059 ± 0.027	2.935AsnGly: 2.935 ± 0.049	0.817AsnHis: 0.817 ± 0.016	3.015AsnIle: 3.015 ± 0.046	1.957AsnLys: 1.957 ± 0.029	5.618AsnLeu: 5.618 ± 0.054	0.596AsnMet: 0.596 ± 0.014	2.238AsnAsn: 2.238 ± 0.04	2.885AsnPro: 2.885 ± 0.037	2.698AsnGln: 2.698 ± 0.034	2.48AsnArg: 2.48 ± 0.029	3.318AsnSer: 3.318 ± 0.043	2.552AsnThr: 2.552 ± 0.039	2.457AsnVal: 2.457 ± 0.04	0.765AsnTrp: 0.765 ± 0.018	1.559AsnTyr: 1.559 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	2.629ProAla: 2.629 ± 0.033	0.331ProCys: 0.331 ± 0.011	2.815ProAsp: 2.815 ± 0.034	3.718ProGlu: 3.718 ± 0.034	1.779ProPhe: 1.779 ± 0.026	2.73ProGly: 2.73 ± 0.032	0.845ProHis: 0.845 ± 0.017	3.004ProIle: 3.004 ± 0.034	2.303ProLys: 2.303 ± 0.03	4.468ProLeu: 4.468 ± 0.042	0.715ProMet: 0.715 ± 0.015	2.394ProAsn: 2.394 ± 0.033	2.207ProPro: 2.207 ± 0.039	2.392ProGln: 2.392 ± 0.033	1.696ProArg: 1.696 ± 0.022	3.129ProSer: 3.129 ± 0.033	2.926ProThr: 2.926 ± 0.041	3.229ProVal: 3.229 ± 0.033	0.568ProTrp: 0.568 ± 0.012	1.294ProTyr: 1.294 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.5GlnAla: 4.5 ± 0.046	0.384GlnCys: 0.384 ± 0.011	2.119GlnAsp: 2.119 ± 0.026	3.821GlnGlu: 3.821 ± 0.04	1.823GlnPhe: 1.823 ± 0.027	3.031GlnGly: 3.031 ± 0.034	0.91GlnHis: 0.91 ± 0.019	3.575GlnIle: 3.575 ± 0.038	2.931GlnLys: 2.931 ± 0.032	6.041GlnLeu: 6.041 ± 0.058	1.112GlnMet: 1.112 ± 0.019	2.239GlnAsn: 2.239 ± 0.028	2.475GlnPro: 2.475 ± 0.035	3.839GlnGln: 3.839 ± 0.06	2.828GlnArg: 2.828 ± 0.037	3.024GlnSer: 3.024 ± 0.033	2.897GlnThr: 2.897 ± 0.035	3.671GlnVal: 3.671 ± 0.04	0.657GlnTrp: 0.657 ± 0.016	1.301GlnTyr: 1.301 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	3.34ArgAla: 3.34 ± 0.032	0.508ArgCys: 0.508 ± 0.012	2.547ArgAsp: 2.547 ± 0.035	3.557ArgGlu: 3.557 ± 0.041	2.225ArgPhe: 2.225 ± 0.028	3.032ArgGly: 3.032 ± 0.038	0.983ArgHis: 0.983 ± 0.02	3.435ArgIle: 3.435 ± 0.037	2.491ArgLys: 2.491 ± 0.03	6.078ArgLeu: 6.078 ± 0.045	0.999ArgMet: 0.999 ± 0.018	2.292ArgAsn: 2.292 ± 0.026	1.944ArgPro: 1.944 ± 0.027	3.12ArgGln: 3.12 ± 0.036	3.034ArgArg: 3.034 ± 0.039	3.407ArgSer: 3.407 ± 0.036	2.659ArgThr: 2.659 ± 0.028	3.512ArgVal: 3.512 ± 0.038	0.802ArgTrp: 0.802 ± 0.02	1.929ArgTyr: 1.929 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	4.505SerAla: 4.505 ± 0.049	0.676SerCys: 0.676 ± 0.015	3.477SerAsp: 3.477 ± 0.037	4.067SerGlu: 4.067 ± 0.035	2.811SerPhe: 2.811 ± 0.036	4.823SerGly: 4.823 ± 0.055	1.387SerHis: 1.387 ± 0.023	4.035SerIle: 4.035 ± 0.037	3.059SerLys: 3.059 ± 0.036	7.651SerLeu: 7.651 ± 0.047	1.112SerMet: 1.112 ± 0.019	2.986SerAsn: 2.986 ± 0.039	3.421SerPro: 3.421 ± 0.04	3.811SerGln: 3.811 ± 0.04	3.292SerArg: 3.292 ± 0.036	4.881SerSer: 4.881 ± 0.046	3.847SerThr: 3.847 ± 0.044	4.513SerVal: 4.513 ± 0.05	0.929SerTrp: 0.929 ± 0.022	1.937SerTyr: 1.937 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	4.585ThrAla: 4.585 ± 0.046	0.452ThrCys: 0.452 ± 0.014	2.71ThrAsp: 2.71 ± 0.038	3.405ThrGlu: 3.405 ± 0.032	2.261ThrPhe: 2.261 ± 0.024	4.302ThrGly: 4.302 ± 0.055	1.049ThrHis: 1.049 ± 0.017	3.901ThrIle: 3.901 ± 0.04	2.439ThrLys: 2.439 ± 0.034	6.389ThrLeu: 6.389 ± 0.062	0.748ThrMet: 0.748 ± 0.015	2.513ThrAsn: 2.513 ± 0.034	3.354ThrPro: 3.354 ± 0.041	3.02ThrGln: 3.02 ± 0.037	2.483ThrArg: 2.483 ± 0.032	3.845ThrSer: 3.845 ± 0.044	3.531ThrThr: 3.531 ± 0.047	4.349ThrVal: 4.349 ± 0.049	0.706ThrTrp: 0.706 ± 0.015	1.687ThrTyr: 1.687 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	5.684ValAla: 5.684 ± 0.054	0.703ValCys: 0.703 ± 0.015	3.349ValAsp: 3.349 ± 0.033	4.743ValGlu: 4.743 ± 0.041	2.592ValPhe: 2.592 ± 0.03	4.46ValGly: 4.46 ± 0.039	1.003ValHis: 1.003 ± 0.022	4.108ValIle: 4.108 ± 0.034	3.507ValLys: 3.507 ± 0.037	6.838ValLeu: 6.838 ± 0.052	1.334ValMet: 1.334 ± 0.022	3.008ValAsn: 3.008 ± 0.038	2.848ValPro: 2.848 ± 0.043	2.971ValGln: 2.971 ± 0.031	3.455ValArg: 3.455 ± 0.042	4.557ValSer: 4.557 ± 0.042	4.121ValThr: 4.121 ± 0.045	4.876ValVal: 4.876 ± 0.053	0.857ValTrp: 0.857 ± 0.017	1.906ValTyr: 1.906 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.826TrpAla: 0.826 ± 0.021	0.155TrpCys: 0.155 ± 0.007	0.702TrpAsp: 0.702 ± 0.018	0.947TrpGlu: 0.947 ± 0.018	0.586TrpPhe: 0.586 ± 0.015	0.89TrpGly: 0.89 ± 0.021	0.334TrpHis: 0.334 ± 0.01	0.867TrpIle: 0.867 ± 0.018	0.686TrpLys: 0.686 ± 0.016	1.811TrpLeu: 1.811 ± 0.027	0.298TrpMet: 0.298 ± 0.01	0.717TrpAsn: 0.717 ± 0.016	0.198TrpPro: 0.198 ± 0.008	1.085TrpGln: 1.085 ± 0.02	0.842TrpArg: 0.842 ± 0.017	0.916TrpSer: 0.916 ± 0.021	0.631TrpThr: 0.631 ± 0.016	0.945TrpVal: 0.945 ± 0.018	0.224TrpTrp: 0.224 ± 0.008	0.455TrpTyr: 0.455 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.06TyrAla: 2.06 ± 0.028	0.4TyrCys: 0.4 ± 0.011	1.485TyrAsp: 1.485 ± 0.033	1.865TyrGlu: 1.865 ± 0.029	1.346TyrPhe: 1.346 ± 0.024	1.956TyrGly: 1.956 ± 0.03	0.677TyrHis: 0.677 ± 0.015	1.756TyrIle: 1.756 ± 0.023	1.463TyrLys: 1.463 ± 0.022	3.557TyrLeu: 3.557 ± 0.035	0.414TyrMet: 0.414 ± 0.011	1.296TyrAsn: 1.296 ± 0.026	1.548TyrPro: 1.548 ± 0.026	1.958TyrGln: 1.958 ± 0.03	1.986TyrArg: 1.986 ± 0.026	2.026TyrSer: 2.026 ± 0.027	1.588TyrThr: 1.588 ± 0.028	1.706TyrVal: 1.706 ± 0.026	0.567TyrTrp: 0.567 ± 0.013	1.107TyrTyr: 1.107 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9705 proteins (3138299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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