Amino acid dipepetide frequency for Paramuribaculum intestinale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.043AlaAla: 9.043 ± 0.145	0.989AlaCys: 0.989 ± 0.034	6.545AlaAsp: 6.545 ± 0.105	5.423AlaGlu: 5.423 ± 0.093	3.14AlaPhe: 3.14 ± 0.061	6.413AlaGly: 6.413 ± 0.112	1.339AlaHis: 1.339 ± 0.042	5.588AlaIle: 5.588 ± 0.087	3.804AlaLys: 3.804 ± 0.077	8.091AlaLeu: 8.091 ± 0.114	2.822AlaMet: 2.822 ± 0.066	2.879AlaAsn: 2.879 ± 0.064	3.168AlaPro: 3.168 ± 0.072	2.636AlaGln: 2.636 ± 0.056	4.894AlaArg: 4.894 ± 0.092	5.573AlaSer: 5.573 ± 0.089	5.219AlaThr: 5.219 ± 0.098	6.612AlaVal: 6.612 ± 0.116	0.894AlaTrp: 0.894 ± 0.034	2.757AlaTyr: 2.757 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.906CysAla: 0.906 ± 0.032	0.204CysCys: 0.204 ± 0.015	0.765CysAsp: 0.765 ± 0.03	0.665CysGlu: 0.665 ± 0.029	0.495CysPhe: 0.495 ± 0.021	1.25CysGly: 1.25 ± 0.043	0.339CysHis: 0.339 ± 0.018	0.728CysIle: 0.728 ± 0.028	0.439CysLys: 0.439 ± 0.025	1.051CysLeu: 1.051 ± 0.04	0.285CysMet: 0.285 ± 0.016	0.52CysAsn: 0.52 ± 0.026	0.573CysPro: 0.573 ± 0.025	0.3CysGln: 0.3 ± 0.017	0.929CysArg: 0.929 ± 0.035	0.804CysSer: 0.804 ± 0.028	0.58CysThr: 0.58 ± 0.026	0.818CysVal: 0.818 ± 0.031	0.139CysTrp: 0.139 ± 0.014	0.503CysTyr: 0.503 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	5.128AspAla: 5.128 ± 0.09	0.772AspCys: 0.772 ± 0.029	3.875AspAsp: 3.875 ± 0.079	4.125AspGlu: 4.125 ± 0.072	2.927AspPhe: 2.927 ± 0.057	5.02AspGly: 5.02 ± 0.097	1.072AspHis: 1.072 ± 0.037	4.479AspIle: 4.479 ± 0.074	3.096AspLys: 3.096 ± 0.079	4.756AspLeu: 4.756 ± 0.084	2.005AspMet: 2.005 ± 0.046	2.952AspAsn: 2.952 ± 0.06	2.61AspPro: 2.61 ± 0.072	1.278AspGln: 1.278 ± 0.04	3.886AspArg: 3.886 ± 0.077	4.049AspSer: 4.049 ± 0.07	3.585AspThr: 3.585 ± 0.069	3.82AspVal: 3.82 ± 0.075	0.806AspTrp: 0.806 ± 0.037	2.745AspTyr: 2.745 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.733GluAla: 5.733 ± 0.108	0.702GluCys: 0.702 ± 0.029	2.653GluAsp: 2.653 ± 0.06	3.921GluGlu: 3.921 ± 0.075	2.197GluPhe: 2.197 ± 0.049	3.86GluGly: 3.86 ± 0.078	1.19GluHis: 1.19 ± 0.042	4.487GluIle: 4.487 ± 0.076	3.561GluLys: 3.561 ± 0.075	5.333GluLeu: 5.333 ± 0.071	1.923GluMet: 1.923 ± 0.045	2.569GluAsn: 2.569 ± 0.063	2.082GluPro: 2.082 ± 0.049	2.229GluGln: 2.229 ± 0.059	3.998GluArg: 3.998 ± 0.082	3.398GluSer: 3.398 ± 0.069	2.735GluThr: 2.735 ± 0.063	4.021GluVal: 4.021 ± 0.065	0.784GluTrp: 0.784 ± 0.033	2.26GluTyr: 2.26 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.353PheAla: 3.353 ± 0.074	0.578PheCys: 0.578 ± 0.026	2.938PheAsp: 2.938 ± 0.07	2.132PheGlu: 2.132 ± 0.049	1.746PhePhe: 1.746 ± 0.046	3.192PheGly: 3.192 ± 0.069	0.802PheHis: 0.802 ± 0.03	2.607PheIle: 2.607 ± 0.071	1.773PheLys: 1.773 ± 0.048	3.027PheLeu: 3.027 ± 0.062	1.125PheMet: 1.125 ± 0.038	2.089PheAsn: 2.089 ± 0.058	1.607PhePro: 1.607 ± 0.04	0.857PheGln: 0.857 ± 0.036	2.221PheArg: 2.221 ± 0.05	2.777PheSer: 2.777 ± 0.059	2.509PheThr: 2.509 ± 0.061	2.693PheVal: 2.693 ± 0.056	0.455PheTrp: 0.455 ± 0.022	1.485PheTyr: 1.485 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.553GlyAla: 5.553 ± 0.098	1.131GlyCys: 1.131 ± 0.039	3.953GlyAsp: 3.953 ± 0.069	3.953GlyGlu: 3.953 ± 0.081	3.147GlyPhe: 3.147 ± 0.062	5.024GlyGly: 5.024 ± 0.097	1.65GlyHis: 1.65 ± 0.048	4.945GlyIle: 4.945 ± 0.088	4.011GlyLys: 4.011 ± 0.076	5.926GlyLeu: 5.926 ± 0.091	2.218GlyMet: 2.218 ± 0.057	3.095GlyAsn: 3.095 ± 0.073	1.617GlyPro: 1.617 ± 0.047	2.237GlyGln: 2.237 ± 0.059	4.708GlyArg: 4.708 ± 0.085	4.379GlySer: 4.379 ± 0.075	3.941GlyThr: 3.941 ± 0.072	5.181GlyVal: 5.181 ± 0.094	0.962GlyTrp: 0.962 ± 0.035	3.122GlyTyr: 3.122 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.343HisAla: 1.343 ± 0.039	0.298HisCys: 0.298 ± 0.018	1.267HisAsp: 1.267 ± 0.04	1.009HisGlu: 1.009 ± 0.036	0.83HisPhe: 0.83 ± 0.029	1.512HisGly: 1.512 ± 0.045	0.575HisHis: 0.575 ± 0.029	1.515HisIle: 1.515 ± 0.043	0.886HisLys: 0.886 ± 0.032	1.732HisLeu: 1.732 ± 0.048	0.368HisMet: 0.368 ± 0.023	0.928HisAsn: 0.928 ± 0.032	1.132HisPro: 1.132 ± 0.036	0.526HisGln: 0.526 ± 0.025	1.35HisArg: 1.35 ± 0.043	1.267HisSer: 1.267 ± 0.039	1.28HisThr: 1.28 ± 0.037	1.052HisVal: 1.052 ± 0.036	0.238HisTrp: 0.238 ± 0.02	0.795HisTyr: 0.795 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.296IleAla: 6.296 ± 0.093	0.839IleCys: 0.839 ± 0.036	5.098IleAsp: 5.098 ± 0.066	4.2IleGlu: 4.2 ± 0.073	2.42IlePhe: 2.42 ± 0.062	4.692IleGly: 4.692 ± 0.091	1.228IleHis: 1.228 ± 0.037	4.372IleIle: 4.372 ± 0.098	3.235IleLys: 3.235 ± 0.074	4.978IleLeu: 4.978 ± 0.089	1.619IleMet: 1.619 ± 0.044	2.956IleAsn: 2.956 ± 0.07	2.905IlePro: 2.905 ± 0.064	1.583IleGln: 1.583 ± 0.043	3.637IleArg: 3.637 ± 0.064	4.532IleSer: 4.532 ± 0.071	3.812IleThr: 3.812 ± 0.07	4.522IleVal: 4.522 ± 0.08	0.641IleTrp: 0.641 ± 0.029	2.281IleTyr: 2.281 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.646LysAla: 4.646 ± 0.088	0.468LysCys: 0.468 ± 0.027	2.696LysAsp: 2.696 ± 0.062	3.443LysGlu: 3.443 ± 0.072	1.758LysPhe: 1.758 ± 0.05	3.396LysGly: 3.396 ± 0.072	0.934LysHis: 0.934 ± 0.032	3.285LysIle: 3.285 ± 0.064	3.032LysLys: 3.032 ± 0.073	3.944LysLeu: 3.944 ± 0.081	1.525LysMet: 1.525 ± 0.044	2.184LysAsn: 2.184 ± 0.058	2.011LysPro: 2.011 ± 0.052	1.564LysGln: 1.564 ± 0.052	2.954LysArg: 2.954 ± 0.068	2.997LysSer: 2.997 ± 0.064	2.764LysThr: 2.764 ± 0.061	3.369LysVal: 3.369 ± 0.057	0.598LysTrp: 0.598 ± 0.028	1.89LysTyr: 1.89 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	7.399LeuAla: 7.399 ± 0.099	1.242LeuCys: 1.242 ± 0.042	5.211LeuAsp: 5.211 ± 0.072	4.594LeuGlu: 4.594 ± 0.077	3.428LeuPhe: 3.428 ± 0.066	5.723LeuGly: 5.723 ± 0.092	1.797LeuHis: 1.797 ± 0.041	5.07LeuIle: 5.07 ± 0.096	4.589LeuLys: 4.589 ± 0.07	7.957LeuLeu: 7.957 ± 0.134	2.521LeuMet: 2.521 ± 0.063	3.712LeuAsn: 3.712 ± 0.08	4.238LeuPro: 4.238 ± 0.069	2.822LeuGln: 2.822 ± 0.061	5.826LeuArg: 5.826 ± 0.087	6.335LeuSer: 6.335 ± 0.092	6.281LeuThr: 6.281 ± 0.093	4.854LeuVal: 4.854 ± 0.081	1.042LeuTrp: 1.042 ± 0.041	3.081LeuTyr: 3.081 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	3.084MetAla: 3.084 ± 0.065	0.234MetCys: 0.234 ± 0.02	1.367MetAsp: 1.367 ± 0.041	1.749MetGlu: 1.749 ± 0.049	0.959MetPhe: 0.959 ± 0.034	1.754MetGly: 1.754 ± 0.049	0.499MetHis: 0.499 ± 0.024	1.821MetIle: 1.821 ± 0.046	1.981MetLys: 1.981 ± 0.046	2.814MetLeu: 2.814 ± 0.055	0.977MetMet: 0.977 ± 0.031	1.247MetAsn: 1.247 ± 0.041	1.5MetPro: 1.5 ± 0.046	0.964MetGln: 0.964 ± 0.032	1.797MetArg: 1.797 ± 0.045	1.87MetSer: 1.87 ± 0.052	2.076MetThr: 2.076 ± 0.046	1.636MetVal: 1.636 ± 0.047	0.285MetTrp: 0.285 ± 0.018	0.673MetTyr: 0.673 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.349AsnAla: 3.349 ± 0.073	0.444AsnCys: 0.444 ± 0.025	2.515AsnAsp: 2.515 ± 0.057	2.222AsnGlu: 2.222 ± 0.063	1.687AsnPhe: 1.687 ± 0.047	3.309AsnGly: 3.309 ± 0.072	0.874AsnHis: 0.874 ± 0.035	3.069AsnIle: 3.069 ± 0.065	1.983AsnLys: 1.983 ± 0.059	3.603AsnLeu: 3.603 ± 0.079	1.076AsnMet: 1.076 ± 0.034	1.971AsnAsn: 1.971 ± 0.055	2.588AsnPro: 2.588 ± 0.059	1.144AsnGln: 1.144 ± 0.041	2.515AsnArg: 2.515 ± 0.049	2.376AsnSer: 2.376 ± 0.052	2.313AsnThr: 2.313 ± 0.064	2.735AsnVal: 2.735 ± 0.061	0.481AsnTrp: 0.481 ± 0.028	1.632AsnTyr: 1.632 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.961ProAla: 3.961 ± 0.076	0.411ProCys: 0.411 ± 0.022	3.549ProAsp: 3.549 ± 0.071	3.46ProGlu: 3.46 ± 0.067	1.649ProPhe: 1.649 ± 0.042	3.013ProGly: 3.013 ± 0.07	0.838ProHis: 0.838 ± 0.031	2.032ProIle: 2.032 ± 0.049	1.739ProLys: 1.739 ± 0.056	3.582ProLeu: 3.582 ± 0.076	1.169ProMet: 1.169 ± 0.034	1.28ProAsn: 1.28 ± 0.041	1.093ProPro: 1.093 ± 0.04	1.539ProGln: 1.539 ± 0.039	2.037ProArg: 2.037 ± 0.054	2.841ProSer: 2.841 ± 0.061	2.246ProThr: 2.246 ± 0.052	3.387ProVal: 3.387 ± 0.068	0.491ProTrp: 0.491 ± 0.028	1.536ProTyr: 1.536 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.608GlnAla: 2.608 ± 0.058	0.32GlnCys: 0.32 ± 0.021	1.174GlnAsp: 1.174 ± 0.04	1.629GlnGlu: 1.629 ± 0.053	1.21GlnPhe: 1.21 ± 0.035	1.809GlnGly: 1.809 ± 0.049	0.563GlnHis: 0.563 ± 0.023	2.014GlnIle: 2.014 ± 0.05	1.613GlnLys: 1.613 ± 0.05	3.171GlnLeu: 3.171 ± 0.07	0.974GlnMet: 0.974 ± 0.037	1.228GlnAsn: 1.228 ± 0.04	1.379GlnPro: 1.379 ± 0.044	1.437GlnGln: 1.437 ± 0.063	2.134GlnArg: 2.134 ± 0.055	1.972GlnSer: 1.972 ± 0.052	1.858GlnThr: 1.858 ± 0.044	1.566GlnVal: 1.566 ± 0.046	0.519GlnTrp: 0.519 ± 0.024	1.141GlnTyr: 1.141 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	4.042ArgAla: 4.042 ± 0.083	0.729ArgCys: 0.729 ± 0.031	3.086ArgAsp: 3.086 ± 0.07	3.573ArgGlu: 3.573 ± 0.068	2.71ArgPhe: 2.71 ± 0.057	3.478ArgGly: 3.478 ± 0.07	1.738ArgHis: 1.738 ± 0.052	4.405ArgIle: 4.405 ± 0.08	3.103ArgLys: 3.103 ± 0.061	6.479ArgLeu: 6.479 ± 0.099	2.018ArgMet: 2.018 ± 0.045	2.482ArgAsn: 2.482 ± 0.053	2.637ArgPro: 2.637 ± 0.059	2.844ArgGln: 2.844 ± 0.067	5.179ArgArg: 5.179 ± 0.098	3.441ArgSer: 3.441 ± 0.065	3.031ArgThr: 3.031 ± 0.06	3.465ArgVal: 3.465 ± 0.072	0.862ArgTrp: 0.862 ± 0.031	2.667ArgTyr: 2.667 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.398SerAla: 5.398 ± 0.086	0.782SerCys: 0.782 ± 0.029	4.272SerAsp: 4.272 ± 0.079	3.595SerGlu: 3.595 ± 0.06	2.589SerPhe: 2.589 ± 0.054	4.92SerGly: 4.92 ± 0.081	1.386SerHis: 1.386 ± 0.047	4.062SerIle: 4.062 ± 0.083	2.706SerLys: 2.706 ± 0.06	6.232SerLeu: 6.232 ± 0.091	1.814SerMet: 1.814 ± 0.044	2.361SerAsn: 2.361 ± 0.059	2.696SerPro: 2.696 ± 0.059	1.996SerGln: 1.996 ± 0.049	4.008SerArg: 4.008 ± 0.067	3.928SerSer: 3.928 ± 0.082	3.607SerThr: 3.607 ± 0.066	4.516SerVal: 4.516 ± 0.077	0.746SerTrp: 0.746 ± 0.029	2.352SerTyr: 2.352 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	5.689ThrAla: 5.689 ± 0.113	0.504ThrCys: 0.504 ± 0.023	4.371ThrAsp: 4.371 ± 0.079	3.132ThrGlu: 3.132 ± 0.062	2.358ThrPhe: 2.358 ± 0.062	4.481ThrGly: 4.481 ± 0.083	1.118ThrHis: 1.118 ± 0.034	3.834ThrIle: 3.834 ± 0.084	2.063ThrLys: 2.063 ± 0.052	5.656ThrLeu: 5.656 ± 0.083	1.336ThrMet: 1.336 ± 0.04	1.87ThrAsn: 1.87 ± 0.052	3.342ThrPro: 3.342 ± 0.069	1.468ThrGln: 1.468 ± 0.044	2.849ThrArg: 2.849 ± 0.063	3.421ThrSer: 3.421 ± 0.069	3.312ThrThr: 3.312 ± 0.073	4.839ThrVal: 4.839 ± 0.084	0.573ThrTrp: 0.573 ± 0.027	2.023ThrTyr: 2.023 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	6.56ValAla: 6.56 ± 0.119	0.927ValCys: 0.927 ± 0.037	4.45ValAsp: 4.45 ± 0.078	4.208ValGlu: 4.208 ± 0.074	2.52ValPhe: 2.52 ± 0.062	4.356ValGly: 4.356 ± 0.086	0.949ValHis: 0.949 ± 0.04	4.442ValIle: 4.442 ± 0.071	3.769ValLys: 3.769 ± 0.072	4.813ValLeu: 4.813 ± 0.079	2.177ValMet: 2.177 ± 0.055	3.015ValAsn: 3.015 ± 0.058	2.606ValPro: 2.606 ± 0.06	1.424ValGln: 1.424 ± 0.039	3.703ValArg: 3.703 ± 0.071	4.722ValSer: 4.722 ± 0.078	4.295ValThr: 4.295 ± 0.079	4.812ValVal: 4.812 ± 0.098	0.733ValTrp: 0.733 ± 0.03	2.383ValTyr: 2.383 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.801TrpAla: 0.801 ± 0.032	0.169TrpCys: 0.169 ± 0.014	0.677TrpAsp: 0.677 ± 0.033	0.649TrpGlu: 0.649 ± 0.032	0.496TrpPhe: 0.496 ± 0.024	0.809TrpGly: 0.809 ± 0.036	0.268TrpHis: 0.268 ± 0.018	0.798TrpIle: 0.798 ± 0.031	0.557TrpLys: 0.557 ± 0.027	1.276TrpLeu: 1.276 ± 0.043	0.374TrpMet: 0.374 ± 0.021	0.637TrpAsn: 0.637 ± 0.027	0.366TrpPro: 0.366 ± 0.019	0.458TrpGln: 0.458 ± 0.024	0.831TrpArg: 0.831 ± 0.035	0.792TrpSer: 0.792 ± 0.03	0.666TrpThr: 0.666 ± 0.031	0.694TrpVal: 0.694 ± 0.03	0.189TrpTrp: 0.189 ± 0.018	0.387TrpTyr: 0.387 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.939TyrAla: 2.939 ± 0.067	0.551TyrCys: 0.551 ± 0.025	2.522TyrAsp: 2.522 ± 0.054	1.957TyrGlu: 1.957 ± 0.043	1.703TyrPhe: 1.703 ± 0.045	2.741TyrGly: 2.741 ± 0.066	0.746TyrHis: 0.746 ± 0.032	2.292TyrIle: 2.292 ± 0.051	1.517TyrLys: 1.517 ± 0.05	3.301TyrLeu: 3.301 ± 0.065	0.96TyrMet: 0.96 ± 0.031	1.914TyrAsn: 1.914 ± 0.055	1.702TyrPro: 1.702 ± 0.049	1.013TyrGln: 1.013 ± 0.04	2.513TyrArg: 2.513 ± 0.055	2.49TyrSer: 2.49 ± 0.055	2.129TyrThr: 2.129 ± 0.061	2.27TyrVal: 2.27 ± 0.049	0.454TyrTrp: 0.454 ± 0.027	1.616TyrTyr: 1.616 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2513 proteins (863129 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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