Amino acid dipepetide frequency for Candidatus Termititenax persephonae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.708AlaAla: 11.708 ± 0.254
0.85AlaCys: 0.85 ± 0.042
5.581AlaAsp: 5.581 ± 0.127
7.333AlaGlu: 7.333 ± 0.136
2.673AlaPhe: 2.673 ± 0.075
6.984AlaGly: 6.984 ± 0.125
1.383AlaHis: 1.383 ± 0.057
4.351AlaIle: 4.351 ± 0.106
5.639AlaLys: 5.639 ± 0.1
9.804AlaLeu: 9.804 ± 0.173
1.579AlaMet: 1.579 ± 0.058
3.602AlaAsn: 3.602 ± 0.093
3.123AlaPro: 3.123 ± 0.091
4.295AlaGln: 4.295 ± 0.108
5.057AlaArg: 5.057 ± 0.118
4.16AlaSer: 4.16 ± 0.104
4.042AlaThr: 4.042 ± 0.122
7.257AlaVal: 7.257 ± 0.134
0.922AlaTrp: 0.922 ± 0.044
3.306AlaTyr: 3.306 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.991CysAla: 0.991 ± 0.051
0.145CysCys: 0.145 ± 0.019
0.418CysAsp: 0.418 ± 0.03
0.432CysGlu: 0.432 ± 0.025
0.394CysPhe: 0.394 ± 0.026
1.042CysGly: 1.042 ± 0.054
0.166CysHis: 0.166 ± 0.018
0.423CysIle: 0.423 ± 0.031
0.427CysLys: 0.427 ± 0.027
1.112CysLeu: 1.112 ± 0.048
0.105CysMet: 0.105 ± 0.013
0.284CysAsn: 0.284 ± 0.022
0.479CysPro: 0.479 ± 0.033
0.365CysGln: 0.365 ± 0.028
0.622CysArg: 0.622 ± 0.034
0.528CysSer: 0.528 ± 0.034
0.358CysThr: 0.358 ± 0.024
0.59CysVal: 0.59 ± 0.038
0.116CysTrp: 0.116 ± 0.016
0.356CysTyr: 0.356 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.404AspAla: 4.404 ± 0.098
0.57AspCys: 0.57 ± 0.033
2.501AspAsp: 2.501 ± 0.102
2.975AspGlu: 2.975 ± 0.084
3.087AspPhe: 3.087 ± 0.075
4.038AspGly: 4.038 ± 0.132
0.642AspHis: 0.642 ± 0.035
4.16AspIle: 4.16 ± 0.083
3.848AspLys: 3.848 ± 0.104
5.583AspLeu: 5.583 ± 0.108
1.036AspMet: 1.036 ± 0.043
2.912AspAsn: 2.912 ± 0.098
1.892AspPro: 1.892 ± 0.065
1.38AspGln: 1.38 ± 0.051
2.322AspArg: 2.322 ± 0.065
3.121AspSer: 3.121 ± 0.078
3.129AspThr: 3.129 ± 0.085
3.04AspVal: 3.04 ± 0.077
0.834AspTrp: 0.834 ± 0.043
2.63AspTyr: 2.63 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
5.066GluAla: 5.066 ± 0.118
0.389GluCys: 0.389 ± 0.025
2.733GluAsp: 2.733 ± 0.071
3.584GluGlu: 3.584 ± 0.108
2.259GluPhe: 2.259 ± 0.07
2.593GluGly: 2.593 ± 0.075
1.121GluHis: 1.121 ± 0.042
5.167GluIle: 5.167 ± 0.115
5.19GluLys: 5.19 ± 0.128
6.549GluLeu: 6.549 ± 0.143
1.273GluMet: 1.273 ± 0.05
3.637GluAsn: 3.637 ± 0.092
1.861GluPro: 1.861 ± 0.06
2.866GluGln: 2.866 ± 0.086
3.474GluArg: 3.474 ± 0.097
2.454GluSer: 2.454 ± 0.075
3.48GluThr: 3.48 ± 0.093
3.559GluVal: 3.559 ± 0.094
0.631GluTrp: 0.631 ± 0.036
2.675GluTyr: 2.675 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
3.619PheAla: 3.619 ± 0.082
0.552PheCys: 0.552 ± 0.034
2.024PheAsp: 2.024 ± 0.065
1.756PheGlu: 1.756 ± 0.063
1.888PhePhe: 1.888 ± 0.073
2.874PheGly: 2.874 ± 0.079
0.573PheHis: 0.573 ± 0.033
2.29PheIle: 2.29 ± 0.072
2.02PheLys: 2.02 ± 0.053
4.042PheLeu: 4.042 ± 0.12
0.843PheMet: 0.843 ± 0.052
1.839PheAsn: 1.839 ± 0.061
1.346PhePro: 1.346 ± 0.043
1.414PheGln: 1.414 ± 0.044
1.87PheArg: 1.87 ± 0.059
2.742PheSer: 2.742 ± 0.087
2.291PheThr: 2.291 ± 0.063
2.631PheVal: 2.631 ± 0.067
0.582PheTrp: 0.582 ± 0.039
1.736PheTyr: 1.736 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
5.943GlyAla: 5.943 ± 0.132
0.713GlyCys: 0.713 ± 0.043
3.508GlyAsp: 3.508 ± 0.12
3.991GlyGlu: 3.991 ± 0.088
2.801GlyPhe: 2.801 ± 0.081
6.04GlyGly: 6.04 ± 0.18
1.268GlyHis: 1.268 ± 0.048
4.263GlyIle: 4.263 ± 0.103
4.169GlyLys: 4.169 ± 0.09
7.823GlyLeu: 7.823 ± 0.151
1.277GlyMet: 1.277 ± 0.049
3.427GlyAsn: 3.427 ± 0.121
1.212GlyPro: 1.212 ± 0.056
3.38GlyGln: 3.38 ± 0.092
4.051GlyArg: 4.051 ± 0.108
4.085GlySer: 4.085 ± 0.11
3.868GlyThr: 3.868 ± 0.101
4.888GlyVal: 4.888 ± 0.114
0.958GlyTrp: 0.958 ± 0.043
2.704GlyTyr: 2.704 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.279HisAla: 1.279 ± 0.053
0.235HisCys: 0.235 ± 0.02
0.796HisAsp: 0.796 ± 0.038
0.785HisGlu: 0.785 ± 0.039
0.749HisPhe: 0.749 ± 0.041
1.382HisGly: 1.382 ± 0.057
0.28HisHis: 0.28 ± 0.025
1.06HisIle: 1.06 ± 0.049
0.971HisLys: 0.971 ± 0.047
1.633HisLeu: 1.633 ± 0.061
0.195HisMet: 0.195 ± 0.019
0.966HisAsn: 0.966 ± 0.041
0.819HisPro: 0.819 ± 0.037
0.622HisGln: 0.622 ± 0.034
0.722HisArg: 0.722 ± 0.037
0.98HisSer: 0.98 ± 0.046
0.989HisThr: 0.989 ± 0.05
0.778HisVal: 0.778 ± 0.041
0.213HisTrp: 0.213 ± 0.018
0.747HisTyr: 0.747 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.386IleAla: 5.386 ± 0.114
0.754IleCys: 0.754 ± 0.039
3.588IleAsp: 3.588 ± 0.086
3.857IleGlu: 3.857 ± 0.11
2.771IlePhe: 2.771 ± 0.083
4.123IleGly: 4.123 ± 0.096
0.922IleHis: 0.922 ± 0.049
4.396IleIle: 4.396 ± 0.106
4.138IleLys: 4.138 ± 0.097
6.107IleLeu: 6.107 ± 0.125
1.195IleMet: 1.195 ± 0.045
3.185IleAsn: 3.185 ± 0.097
2.575IlePro: 2.575 ± 0.071
2.109IleGln: 2.109 ± 0.067
2.904IleArg: 2.904 ± 0.072
4.149IleSer: 4.149 ± 0.099
4.055IleThr: 4.055 ± 0.103
4.203IleVal: 4.203 ± 0.096
0.506IleTrp: 0.506 ± 0.027
2.583IleTyr: 2.583 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.613LysAla: 4.613 ± 0.121
0.403LysCys: 0.403 ± 0.032
3.463LysAsp: 3.463 ± 0.087
4.062LysGlu: 4.062 ± 0.121
2.212LysPhe: 2.212 ± 0.059
2.977LysGly: 2.977 ± 0.08
1.094LysHis: 1.094 ± 0.044
5.986LysIle: 5.986 ± 0.121
4.912LysLys: 4.912 ± 0.133
6.066LysLeu: 6.066 ± 0.118
1.539LysMet: 1.539 ± 0.06
3.852LysAsn: 3.852 ± 0.09
2.199LysPro: 2.199 ± 0.075
2.376LysGln: 2.376 ± 0.064
2.384LysArg: 2.384 ± 0.077
2.924LysSer: 2.924 ± 0.075
3.939LysThr: 3.939 ± 0.077
3.704LysVal: 3.704 ± 0.094
0.421LysTrp: 0.421 ± 0.033
3.011LysTyr: 3.011 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
10.932LeuAla: 10.932 ± 0.224
0.955LeuCys: 0.955 ± 0.046
6.089LeuAsp: 6.089 ± 0.121
5.744LeuGlu: 5.744 ± 0.114
3.639LeuPhe: 3.639 ± 0.1
7.664LeuGly: 7.664 ± 0.15
1.662LeuHis: 1.662 ± 0.056
5.272LeuIle: 5.272 ± 0.116
6.095LeuLys: 6.095 ± 0.131
11.169LeuLeu: 11.169 ± 0.239
1.528LeuMet: 1.528 ± 0.058
4.706LeuAsn: 4.706 ± 0.123
5.228LeuPro: 5.228 ± 0.124
4.32LeuGln: 4.32 ± 0.098
6.644LeuArg: 6.644 ± 0.138
6.704LeuSer: 6.704 ± 0.106
6.35LeuThr: 6.35 ± 0.109
5.784LeuVal: 5.784 ± 0.126
0.924LeuTrp: 0.924 ± 0.048
3.215LeuTyr: 3.215 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
1.629MetAla: 1.629 ± 0.054
0.139MetCys: 0.139 ± 0.018
0.94MetAsp: 0.94 ± 0.044
0.989MetGlu: 0.989 ± 0.049
0.678MetPhe: 0.678 ± 0.036
1.08MetGly: 1.08 ± 0.045
0.333MetHis: 0.333 ± 0.025
0.839MetIle: 0.839 ± 0.038
0.863MetLys: 0.863 ± 0.045
2.076MetLeu: 2.076 ± 0.068
0.291MetMet: 0.291 ± 0.023
0.772MetAsn: 0.772 ± 0.039
0.969MetPro: 0.969 ± 0.042
0.752MetGln: 0.752 ± 0.043
1.134MetArg: 1.134 ± 0.045
1.235MetSer: 1.235 ± 0.046
1.08MetThr: 1.08 ± 0.047
1.053MetVal: 1.053 ± 0.046
0.112MetTrp: 0.112 ± 0.014
0.606MetTyr: 0.606 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.711AsnAla: 3.711 ± 0.099
0.427AsnCys: 0.427 ± 0.03
2.188AsnAsp: 2.188 ± 0.079
2.255AsnGlu: 2.255 ± 0.081
2.02AsnPhe: 2.02 ± 0.068
3.275AsnGly: 3.275 ± 0.105
0.689AsnHis: 0.689 ± 0.037
4.391AsnIle: 4.391 ± 0.112
3.375AsnLys: 3.375 ± 0.095
4.771AsnLeu: 4.771 ± 0.105
0.921AsnMet: 0.921 ± 0.046
3.035AsnAsn: 3.035 ± 0.126
2.776AsnPro: 2.776 ± 0.084
1.593AsnGln: 1.593 ± 0.06
1.915AsnArg: 1.915 ± 0.062
2.805AsnSer: 2.805 ± 0.123
2.637AsnThr: 2.637 ± 0.099
2.957AsnVal: 2.957 ± 0.094
0.546AsnTrp: 0.546 ± 0.032
2.317AsnTyr: 2.317 ± 0.079
0.0AsnXaa: 0.0 ± 0.0
Pro
3.89ProAla: 3.89 ± 0.099
0.329ProCys: 0.329 ± 0.026
2.61ProAsp: 2.61 ± 0.074
3.456ProGlu: 3.456 ± 0.08
1.358ProPhe: 1.358 ± 0.058
2.915ProGly: 2.915 ± 0.081
0.731ProHis: 0.731 ± 0.039
1.841ProIle: 1.841 ± 0.063
1.767ProLys: 1.767 ± 0.071
4.127ProLeu: 4.127 ± 0.105
0.485ProMet: 0.485 ± 0.031
1.572ProAsn: 1.572 ± 0.067
2.179ProPro: 2.179 ± 0.092
2.054ProGln: 2.054 ± 0.064
2.219ProArg: 2.219 ± 0.076
2.369ProSer: 2.369 ± 0.072
2.214ProThr: 2.214 ± 0.08
2.595ProVal: 2.595 ± 0.068
0.353ProTrp: 0.353 ± 0.024
1.496ProTyr: 1.496 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.14GlnAla: 4.14 ± 0.106
0.271GlnCys: 0.271 ± 0.024
2.418GlnAsp: 2.418 ± 0.084
2.979GlnGlu: 2.979 ± 0.08
0.989GlnPhe: 0.989 ± 0.048
2.514GlnGly: 2.514 ± 0.063
0.651GlnHis: 0.651 ± 0.039
2.827GlnIle: 2.827 ± 0.071
3.617GlnLys: 3.617 ± 0.091
3.277GlnLeu: 3.277 ± 0.081
0.796GlnMet: 0.796 ± 0.037
2.427GlnAsn: 2.427 ± 0.075
1.658GlnPro: 1.658 ± 0.058
1.499GlnGln: 1.499 ± 0.047
1.993GlnArg: 1.993 ± 0.073
2.047GlnSer: 2.047 ± 0.065
2.573GlnThr: 2.573 ± 0.081
2.384GlnVal: 2.384 ± 0.073
0.322GlnTrp: 0.322 ± 0.028
1.506GlnTyr: 1.506 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
4.217ArgAla: 4.217 ± 0.106
0.411ArgCys: 0.411 ± 0.029
2.781ArgAsp: 2.781 ± 0.071
3.706ArgGlu: 3.706 ± 0.103
1.922ArgPhe: 1.922 ± 0.056
3.347ArgGly: 3.347 ± 0.082
1.091ArgHis: 1.091 ± 0.049
3.225ArgIle: 3.225 ± 0.078
3.109ArgLys: 3.109 ± 0.094
6.21ArgLeu: 6.21 ± 0.129
0.859ArgMet: 0.859 ± 0.042
2.203ArgAsn: 2.203 ± 0.07
2.078ArgPro: 2.078 ± 0.062
3.123ArgGln: 3.123 ± 0.074
3.481ArgArg: 3.481 ± 0.102
2.434ArgSer: 2.434 ± 0.061
2.668ArgThr: 2.668 ± 0.077
3.215ArgVal: 3.215 ± 0.092
0.544ArgTrp: 0.544 ± 0.042
2.143ArgTyr: 2.143 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
5.894SerAla: 5.894 ± 0.118
0.537SerCys: 0.537 ± 0.035
2.845SerAsp: 2.845 ± 0.098
2.944SerGlu: 2.944 ± 0.075
2.42SerPhe: 2.42 ± 0.072
5.662SerGly: 5.662 ± 0.153
0.745SerHis: 0.745 ± 0.037
3.219SerIle: 3.219 ± 0.087
2.534SerLys: 2.534 ± 0.073
5.977SerLeu: 5.977 ± 0.1
0.989SerMet: 0.989 ± 0.042
2.217SerAsn: 2.217 ± 0.09
2.586SerPro: 2.586 ± 0.08
1.886SerGln: 1.886 ± 0.057
2.834SerArg: 2.834 ± 0.08
3.414SerSer: 3.414 ± 0.114
2.957SerThr: 2.957 ± 0.09
3.843SerVal: 3.843 ± 0.093
0.676SerTrp: 0.676 ± 0.034
1.977SerTyr: 1.977 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
6.337ThrAla: 6.337 ± 0.14
0.445ThrCys: 0.445 ± 0.027
3.252ThrAsp: 3.252 ± 0.096
3.344ThrGlu: 3.344 ± 0.096
1.939ThrPhe: 1.939 ± 0.067
4.277ThrGly: 4.277 ± 0.11
0.98ThrHis: 0.98 ± 0.05
3.532ThrIle: 3.532 ± 0.113
3.069ThrLys: 3.069 ± 0.077
5.765ThrLeu: 5.765 ± 0.12
0.87ThrMet: 0.87 ± 0.038
2.338ThrAsn: 2.338 ± 0.089
2.698ThrPro: 2.698 ± 0.079
1.935ThrGln: 1.935 ± 0.062
2.418ThrArg: 2.418 ± 0.071
2.812ThrSer: 2.812 ± 0.093
3.188ThrThr: 3.188 ± 0.114
4.163ThrVal: 4.163 ± 0.103
0.541ThrTrp: 0.541 ± 0.031
2.065ThrTyr: 2.065 ± 0.102
0.0ThrXaa: 0.0 ± 0.0
Val
5.442ValAla: 5.442 ± 0.123
0.718ValCys: 0.718 ± 0.046
3.456ValAsp: 3.456 ± 0.086
3.742ValGlu: 3.742 ± 0.086
2.834ValPhe: 2.834 ± 0.085
4.029ValGly: 4.029 ± 0.101
0.884ValHis: 0.884 ± 0.037
3.716ValIle: 3.716 ± 0.087
3.836ValLys: 3.836 ± 0.084
7.011ValLeu: 7.011 ± 0.136
1.06ValMet: 1.06 ± 0.048
3.082ValAsn: 3.082 ± 0.079
2.727ValPro: 2.727 ± 0.085
2.244ValGln: 2.244 ± 0.066
3.736ValArg: 3.736 ± 0.089
4.315ValSer: 4.315 ± 0.128
3.281ValThr: 3.281 ± 0.112
4.181ValVal: 4.181 ± 0.105
0.774ValTrp: 0.774 ± 0.045
2.525ValTyr: 2.525 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.799TrpAla: 0.799 ± 0.038
0.096TrpCys: 0.096 ± 0.014
0.628TrpAsp: 0.628 ± 0.038
0.646TrpGlu: 0.646 ± 0.033
0.398TrpPhe: 0.398 ± 0.025
0.783TrpGly: 0.783 ± 0.043
0.25TrpHis: 0.25 ± 0.022
0.394TrpIle: 0.394 ± 0.032
0.436TrpLys: 0.436 ± 0.031
1.324TrpLeu: 1.324 ± 0.061
0.121TrpMet: 0.121 ± 0.015
0.472TrpAsn: 0.472 ± 0.031
0.374TrpPro: 0.374 ± 0.029
0.859TrpGln: 0.859 ± 0.047
0.819TrpArg: 0.819 ± 0.046
0.609TrpSer: 0.609 ± 0.034
0.573TrpThr: 0.573 ± 0.047
0.497TrpVal: 0.497 ± 0.034
0.15TrpTrp: 0.15 ± 0.016
0.391TrpTyr: 0.391 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.651TyrAla: 3.651 ± 0.105
0.416TyrCys: 0.416 ± 0.027
2.284TyrAsp: 2.284 ± 0.093
1.98TyrGlu: 1.98 ± 0.066
1.901TyrPhe: 1.901 ± 0.063
2.769TyrGly: 2.769 ± 0.086
0.734TyrHis: 0.734 ± 0.042
2.156TyrIle: 2.156 ± 0.069
2.125TyrLys: 2.125 ± 0.067
4.197TyrLeu: 4.197 ± 0.097
0.608TyrMet: 0.608 ± 0.033
2.076TyrAsn: 2.076 ± 0.089
1.778TyrPro: 1.778 ± 0.062
1.812TyrGln: 1.812 ± 0.061
2.168TyrArg: 2.168 ± 0.07
2.27TyrSer: 2.27 ± 0.079
2.299TyrThr: 2.299 ± 0.079
2.271TyrVal: 2.271 ± 0.081
0.492TyrTrp: 0.492 ± 0.043
1.848TyrTyr: 1.848 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1739 proteins (552951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski