Amino acid dipepetide frequency for Granulicatella adiacens ATCC 49175

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.191AlaAla: 5.191 ± 0.132	0.493AlaCys: 0.493 ± 0.029	3.167AlaAsp: 3.167 ± 0.078	4.429AlaGlu: 4.429 ± 0.104	3.328AlaPhe: 3.328 ± 0.081	4.745AlaGly: 4.745 ± 0.111	1.257AlaHis: 1.257 ± 0.048	5.714AlaIle: 5.714 ± 0.121	5.306AlaLys: 5.306 ± 0.115	7.398AlaLeu: 7.398 ± 0.114	1.985AlaMet: 1.985 ± 0.062	2.909AlaAsn: 2.909 ± 0.066	2.118AlaPro: 2.118 ± 0.08	2.552AlaGln: 2.552 ± 0.078	2.571AlaArg: 2.571 ± 0.074	4.297AlaSer: 4.297 ± 0.09	4.408AlaThr: 4.408 ± 0.098	5.128AlaVal: 5.128 ± 0.114	0.535AlaTrp: 0.535 ± 0.026	2.486AlaTyr: 2.486 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	0.425CysAla: 0.425 ± 0.025	0.089CysCys: 0.089 ± 0.012	0.335CysAsp: 0.335 ± 0.023	0.394CysGlu: 0.394 ± 0.033	0.375CysPhe: 0.375 ± 0.028	0.624CysGly: 0.624 ± 0.036	0.167CysHis: 0.167 ± 0.019	0.451CysIle: 0.451 ± 0.029	0.307CysLys: 0.307 ± 0.029	0.57CysLeu: 0.57 ± 0.037	0.139CysMet: 0.139 ± 0.014	0.261CysAsn: 0.261 ± 0.025	0.277CysPro: 0.277 ± 0.026	0.232CysGln: 0.232 ± 0.02	0.234CysArg: 0.234 ± 0.022	0.41CysSer: 0.41 ± 0.025	0.328CysThr: 0.328 ± 0.023	0.462CysVal: 0.462 ± 0.029	0.063CysTrp: 0.063 ± 0.01	0.263CysTyr: 0.263 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.868AspAla: 3.868 ± 0.093	0.336AspCys: 0.336 ± 0.029	2.341AspAsp: 2.341 ± 0.078	4.455AspGlu: 4.455 ± 0.099	2.752AspPhe: 2.752 ± 0.069	3.722AspGly: 3.722 ± 0.101	0.943AspHis: 0.943 ± 0.048	3.824AspIle: 3.824 ± 0.075	3.431AspLys: 3.431 ± 0.084	4.609AspLeu: 4.609 ± 0.097	1.238AspMet: 1.238 ± 0.044	1.93AspAsn: 1.93 ± 0.066	1.708AspPro: 1.708 ± 0.062	1.6AspGln: 1.6 ± 0.054	1.916AspArg: 1.916 ± 0.063	2.848AspSer: 2.848 ± 0.069	2.683AspThr: 2.683 ± 0.065	3.659AspVal: 3.659 ± 0.086	0.68AspTrp: 0.68 ± 0.034	2.175AspTyr: 2.175 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	5.953GluAla: 5.953 ± 0.108	0.394GluCys: 0.394 ± 0.03	4.032GluAsp: 4.032 ± 0.09	7.501GluGlu: 7.501 ± 0.152	3.052GluPhe: 3.052 ± 0.086	4.618GluGly: 4.618 ± 0.098	1.396GluHis: 1.396 ± 0.052	5.676GluIle: 5.676 ± 0.107	6.556GluLys: 6.556 ± 0.12	7.311GluLeu: 7.311 ± 0.117	2.378GluMet: 2.378 ± 0.061	4.014GluAsn: 4.014 ± 0.105	1.775GluPro: 1.775 ± 0.068	3.209GluGln: 3.209 ± 0.088	3.296GluArg: 3.296 ± 0.085	3.582GluSer: 3.582 ± 0.084	4.114GluThr: 4.114 ± 0.092	5.918GluVal: 5.918 ± 0.118	0.852GluTrp: 0.852 ± 0.043	2.533GluTyr: 2.533 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	3.057PheAla: 3.057 ± 0.094	0.382PheCys: 0.382 ± 0.03	2.609PheAsp: 2.609 ± 0.072	3.295PheGlu: 3.295 ± 0.078	2.289PhePhe: 2.289 ± 0.087	3.261PheGly: 3.261 ± 0.089	0.819PheHis: 0.819 ± 0.037	3.575PheIle: 3.575 ± 0.096	2.956PheLys: 2.956 ± 0.078	4.504PheLeu: 4.504 ± 0.108	1.206PheMet: 1.206 ± 0.056	2.153PheAsn: 2.153 ± 0.07	1.553PhePro: 1.553 ± 0.056	1.564PheGln: 1.564 ± 0.054	1.515PheArg: 1.515 ± 0.046	3.105PheSer: 3.105 ± 0.08	2.606PheThr: 2.606 ± 0.078	3.587PheVal: 3.587 ± 0.086	0.451PheTrp: 0.451 ± 0.03	1.844PheTyr: 1.844 ± 0.062	0.0PheXaa: 0.0 ± 0.0
Gly	4.609GlyAla: 4.609 ± 0.104	0.486GlyCys: 0.486 ± 0.029	3.3GlyAsp: 3.3 ± 0.077	4.438GlyGlu: 4.438 ± 0.093	3.3GlyPhe: 3.3 ± 0.075	4.394GlyGly: 4.394 ± 0.12	1.292GlyHis: 1.292 ± 0.042	5.65GlyIle: 5.65 ± 0.092	4.898GlyLys: 4.898 ± 0.109	6.319GlyLeu: 6.319 ± 0.131	1.926GlyMet: 1.926 ± 0.065	2.808GlyAsn: 2.808 ± 0.066	1.408GlyPro: 1.408 ± 0.055	2.395GlyGln: 2.395 ± 0.067	2.55GlyArg: 2.55 ± 0.07	3.638GlySer: 3.638 ± 0.086	4.168GlyThr: 4.168 ± 0.094	5.358GlyVal: 5.358 ± 0.108	0.696GlyTrp: 0.696 ± 0.041	2.813GlyTyr: 2.813 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.17HisAla: 1.17 ± 0.046	0.15HisCys: 0.15 ± 0.017	0.872HisAsp: 0.872 ± 0.048	1.468HisGlu: 1.468 ± 0.053	1.112HisPhe: 1.112 ± 0.042	1.187HisGly: 1.187 ± 0.05	0.586HisHis: 0.586 ± 0.04	1.307HisIle: 1.307 ± 0.044	0.933HisLys: 0.933 ± 0.044	1.865HisLeu: 1.865 ± 0.064	0.366HisMet: 0.366 ± 0.026	0.657HisAsn: 0.657 ± 0.034	0.974HisPro: 0.974 ± 0.041	0.88HisGln: 0.88 ± 0.04	0.795HisArg: 0.795 ± 0.041	1.14HisSer: 1.14 ± 0.05	1.077HisThr: 1.077 ± 0.04	1.163HisVal: 1.163 ± 0.048	0.169HisTrp: 0.169 ± 0.018	0.947HisTyr: 0.947 ± 0.049	0.0HisXaa: 0.0 ± 0.0
Ile	5.965IleAla: 5.965 ± 0.106	0.612IleCys: 0.612 ± 0.035	3.95IleAsp: 3.95 ± 0.09	5.636IleGlu: 5.636 ± 0.111	3.228IlePhe: 3.228 ± 0.089	5.125IleGly: 5.125 ± 0.107	1.541IleHis: 1.541 ± 0.054	5.059IleIle: 5.059 ± 0.113	4.206IleLys: 4.206 ± 0.095	7.063IleLeu: 7.063 ± 0.148	1.597IleMet: 1.597 ± 0.065	2.826IleAsn: 2.826 ± 0.075	3.162IlePro: 3.162 ± 0.086	3.305IleGln: 3.305 ± 0.074	3.122IleArg: 3.122 ± 0.07	4.658IleSer: 4.658 ± 0.09	4.227IleThr: 4.227 ± 0.091	5.683IleVal: 5.683 ± 0.111	0.58IleTrp: 0.58 ± 0.037	2.472IleTyr: 2.472 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.842LysAla: 4.842 ± 0.109	0.293LysCys: 0.293 ± 0.026	4.084LysAsp: 4.084 ± 0.086	7.626LysGlu: 7.626 ± 0.124	2.191LysPhe: 2.191 ± 0.069	4.457LysGly: 4.457 ± 0.091	1.137LysHis: 1.137 ± 0.05	4.74LysIle: 4.74 ± 0.095	5.963LysLys: 5.963 ± 0.127	5.371LysLeu: 5.371 ± 0.093	2.259LysMet: 2.259 ± 0.054	3.682LysAsn: 3.682 ± 0.078	2.118LysPro: 2.118 ± 0.057	2.932LysGln: 2.932 ± 0.077	3.207LysArg: 3.207 ± 0.087	3.57LysSer: 3.57 ± 0.076	3.908LysThr: 3.908 ± 0.095	5.306LysVal: 5.306 ± 0.109	0.76LysTrp: 0.76 ± 0.044	2.352LysTyr: 2.352 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	6.891LeuAla: 6.891 ± 0.134	0.645LeuCys: 0.645 ± 0.035	4.766LeuAsp: 4.766 ± 0.088	7.464LeuGlu: 7.464 ± 0.13	4.694LeuPhe: 4.694 ± 0.113	6.291LeuGly: 6.291 ± 0.113	1.586LeuHis: 1.586 ± 0.055	5.953LeuIle: 5.953 ± 0.131	6.687LeuLys: 6.687 ± 0.127	9.582LeuLeu: 9.582 ± 0.194	2.704LeuMet: 2.704 ± 0.074	4.365LeuAsn: 4.365 ± 0.088	3.708LeuPro: 3.708 ± 0.084	3.577LeuGln: 3.577 ± 0.081	3.49LeuArg: 3.49 ± 0.085	6.725LeuSer: 6.725 ± 0.116	5.606LeuThr: 5.606 ± 0.107	6.795LeuVal: 6.795 ± 0.118	0.818LeuTrp: 0.818 ± 0.042	2.902LeuTyr: 2.902 ± 0.081	0.0LeuXaa: 0.0 ± 0.0
Met	1.841MetAla: 1.841 ± 0.065	0.145MetCys: 0.145 ± 0.014	1.473MetAsp: 1.473 ± 0.052	1.928MetGlu: 1.928 ± 0.057	0.999MetPhe: 0.999 ± 0.043	1.752MetGly: 1.752 ± 0.062	0.42MetHis: 0.42 ± 0.027	2.139MetIle: 2.139 ± 0.068	2.501MetLys: 2.501 ± 0.057	2.069MetLeu: 2.069 ± 0.062	0.856MetMet: 0.856 ± 0.048	1.612MetAsn: 1.612 ± 0.058	0.859MetPro: 0.859 ± 0.037	0.948MetGln: 0.948 ± 0.043	1.096MetArg: 1.096 ± 0.046	1.637MetSer: 1.637 ± 0.052	1.724MetThr: 1.724 ± 0.05	1.808MetVal: 1.808 ± 0.061	0.176MetTrp: 0.176 ± 0.016	0.671MetTyr: 0.671 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.0AsnAla: 3.0 ± 0.084	0.317AsnCys: 0.317 ± 0.024	2.221AsnAsp: 2.221 ± 0.073	3.326AsnGlu: 3.326 ± 0.082	1.912AsnPhe: 1.912 ± 0.059	3.678AsnGly: 3.678 ± 0.095	1.096AsnHis: 1.096 ± 0.045	3.193AsnIle: 3.193 ± 0.083	2.923AsnLys: 2.923 ± 0.08	3.99AsnLeu: 3.99 ± 0.085	1.126AsnMet: 1.126 ± 0.051	2.06AsnAsn: 2.06 ± 0.079	2.273AsnPro: 2.273 ± 0.066	2.109AsnGln: 2.109 ± 0.069	2.2AsnArg: 2.2 ± 0.076	2.446AsnSer: 2.446 ± 0.07	2.409AsnThr: 2.409 ± 0.072	3.082AsnVal: 3.082 ± 0.083	0.504AsnTrp: 0.504 ± 0.03	1.775AsnTyr: 1.775 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	1.999ProAla: 1.999 ± 0.062	0.167ProCys: 0.167 ± 0.018	1.738ProAsp: 1.738 ± 0.061	3.12ProGlu: 3.12 ± 0.085	1.766ProPhe: 1.766 ± 0.057	1.961ProGly: 1.961 ± 0.069	0.687ProHis: 0.687 ± 0.041	2.585ProIle: 2.585 ± 0.068	2.242ProLys: 2.242 ± 0.058	3.122ProLeu: 3.122 ± 0.081	0.819ProMet: 0.819 ± 0.04	1.639ProAsn: 1.639 ± 0.061	0.645ProPro: 0.645 ± 0.034	1.238ProGln: 1.238 ± 0.05	0.964ProArg: 0.964 ± 0.042	2.221ProSer: 2.221 ± 0.064	2.44ProThr: 2.44 ± 0.08	2.664ProVal: 2.664 ± 0.079	0.296ProTrp: 0.296 ± 0.025	1.351ProTyr: 1.351 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.759GlnAla: 2.759 ± 0.063	0.153GlnCys: 0.153 ± 0.016	1.639GlnAsp: 1.639 ± 0.056	3.3GlnGlu: 3.3 ± 0.09	1.755GlnPhe: 1.755 ± 0.057	2.076GlnGly: 2.076 ± 0.065	0.607GlnHis: 0.607 ± 0.034	2.686GlnIle: 2.686 ± 0.078	3.146GlnLys: 3.146 ± 0.078	4.267GlnLeu: 4.267 ± 0.089	1.184GlnMet: 1.184 ± 0.048	1.79GlnAsn: 1.79 ± 0.064	1.114GlnPro: 1.114 ± 0.049	1.816GlnGln: 1.816 ± 0.062	1.504GlnArg: 1.504 ± 0.048	2.156GlnSer: 2.156 ± 0.06	2.399GlnThr: 2.399 ± 0.063	2.623GlnVal: 2.623 ± 0.065	0.418GlnTrp: 0.418 ± 0.027	1.424GlnTyr: 1.424 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	2.338ArgAla: 2.338 ± 0.067	0.235ArgCys: 0.235 ± 0.023	2.022ArgAsp: 2.022 ± 0.067	3.178ArgGlu: 3.178 ± 0.084	1.926ArgPhe: 1.926 ± 0.062	2.207ArgGly: 2.207 ± 0.067	0.708ArgHis: 0.708 ± 0.036	3.139ArgIle: 3.139 ± 0.076	2.972ArgLys: 2.972 ± 0.07	3.861ArgLeu: 3.861 ± 0.091	1.222ArgMet: 1.222 ± 0.046	1.931ArgAsn: 1.931 ± 0.069	1.239ArgPro: 1.239 ± 0.051	1.604ArgGln: 1.604 ± 0.059	2.026ArgArg: 2.026 ± 0.068	1.952ArgSer: 1.952 ± 0.055	2.036ArgThr: 2.036 ± 0.06	2.993ArgVal: 2.993 ± 0.089	0.338ArgTrp: 0.338 ± 0.027	1.602ArgTyr: 1.602 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.593SerAla: 3.593 ± 0.083	0.35SerCys: 0.35 ± 0.026	2.827SerAsp: 2.827 ± 0.066	4.072SerGlu: 4.072 ± 0.084	3.125SerPhe: 3.125 ± 0.097	4.208SerGly: 4.208 ± 0.097	1.206SerHis: 1.206 ± 0.053	4.687SerIle: 4.687 ± 0.091	4.021SerLys: 4.021 ± 0.086	5.813SerLeu: 5.813 ± 0.113	1.522SerMet: 1.522 ± 0.053	2.974SerAsn: 2.974 ± 0.064	1.987SerPro: 1.987 ± 0.051	2.149SerGln: 2.149 ± 0.071	2.303SerArg: 2.303 ± 0.061	3.753SerSer: 3.753 ± 0.084	3.523SerThr: 3.523 ± 0.091	4.356SerVal: 4.356 ± 0.095	0.57SerTrp: 0.57 ± 0.032	2.242SerTyr: 2.242 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	4.091ThrAla: 4.091 ± 0.1	0.303ThrCys: 0.303 ± 0.024	2.709ThrAsp: 2.709 ± 0.067	3.605ThrGlu: 3.605 ± 0.089	2.813ThrPhe: 2.813 ± 0.082	4.067ThrGly: 4.067 ± 0.104	1.135ThrHis: 1.135 ± 0.043	4.884ThrIle: 4.884 ± 0.093	4.149ThrLys: 4.149 ± 0.09	5.796ThrLeu: 5.796 ± 0.111	1.231ThrMet: 1.231 ± 0.051	2.63ThrAsn: 2.63 ± 0.07	2.566ThrPro: 2.566 ± 0.083	2.048ThrGln: 2.048 ± 0.064	1.978ThrArg: 1.978 ± 0.063	3.511ThrSer: 3.511 ± 0.084	4.363ThrThr: 4.363 ± 0.202	4.916ThrVal: 4.916 ± 0.114	0.493ThrTrp: 0.493 ± 0.03	2.045ThrTyr: 2.045 ± 0.079	0.0ThrXaa: 0.0 ± 0.0
Val	5.606ValAla: 5.606 ± 0.12	0.528ValCys: 0.528 ± 0.035	4.156ValAsp: 4.156 ± 0.087	5.813ValGlu: 5.813 ± 0.11	3.288ValPhe: 3.288 ± 0.085	4.97ValGly: 4.97 ± 0.114	1.187ValHis: 1.187 ± 0.043	5.601ValIle: 5.601 ± 0.1	4.623ValLys: 4.623 ± 0.097	7.074ValLeu: 7.074 ± 0.14	1.781ValMet: 1.781 ± 0.06	3.153ValAsn: 3.153 ± 0.071	2.629ValPro: 2.629 ± 0.072	2.632ValGln: 2.632 ± 0.077	2.782ValArg: 2.782 ± 0.082	4.876ValSer: 4.876 ± 0.094	4.755ValThr: 4.755 ± 0.115	5.747ValVal: 5.747 ± 0.118	0.533ValTrp: 0.533 ± 0.029	2.461ValTyr: 2.461 ± 0.072	0.0ValXaa: 0.0 ± 0.0
Trp	0.485TrpAla: 0.485 ± 0.029	0.051TrpCys: 0.051 ± 0.01	0.458TrpAsp: 0.458 ± 0.027	0.596TrpGlu: 0.596 ± 0.031	0.492TrpPhe: 0.492 ± 0.035	0.631TrpGly: 0.631 ± 0.03	0.187TrpHis: 0.187 ± 0.019	0.863TrpIle: 0.863 ± 0.045	0.75TrpLys: 0.75 ± 0.039	0.879TrpLeu: 0.879 ± 0.039	0.3TrpMet: 0.3 ± 0.026	0.617TrpAsn: 0.617 ± 0.036	0.206TrpPro: 0.206 ± 0.019	0.35TrpGln: 0.35 ± 0.029	0.38TrpArg: 0.38 ± 0.027	0.519TrpSer: 0.519 ± 0.035	0.504TrpThr: 0.504 ± 0.03	0.608TrpVal: 0.608 ± 0.037	0.099TrpTrp: 0.099 ± 0.013	0.415TrpTyr: 0.415 ± 0.036	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.336TyrAla: 2.336 ± 0.067	0.275TyrCys: 0.275 ± 0.023	2.02TyrAsp: 2.02 ± 0.06	2.515TyrGlu: 2.515 ± 0.081	1.935TyrPhe: 1.935 ± 0.067	2.474TyrGly: 2.474 ± 0.066	0.861TyrHis: 0.861 ± 0.04	2.289TyrIle: 2.289 ± 0.072	2.228TyrLys: 2.228 ± 0.067	3.784TyrLeu: 3.784 ± 0.084	0.814TyrMet: 0.814 ± 0.04	1.63TyrAsn: 1.63 ± 0.06	1.344TyrPro: 1.344 ± 0.046	1.677TyrGln: 1.677 ± 0.056	1.6TyrArg: 1.6 ± 0.045	2.24TyrSer: 2.24 ± 0.07	2.055TyrThr: 2.055 ± 0.06	2.339TyrVal: 2.339 ± 0.071	0.356TyrTrp: 0.356 ± 0.024	1.761TyrTyr: 1.761 ± 0.075	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1920 proteins (573676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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