Amino acid dipepetide frequency for Corynebacterium marinum DSM 44953

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.618AlaAla: 17.618 ± 0.24	0.778AlaCys: 0.778 ± 0.032	7.821AlaAsp: 7.821 ± 0.114	8.729AlaGlu: 8.729 ± 0.135	3.471AlaPhe: 3.471 ± 0.07	12.076AlaGly: 12.076 ± 0.148	2.385AlaHis: 2.385 ± 0.066	4.448AlaIle: 4.448 ± 0.089	2.757AlaLys: 2.757 ± 0.067	12.03AlaLeu: 12.03 ± 0.159	2.665AlaMet: 2.665 ± 0.062	2.382AlaAsn: 2.382 ± 0.066	5.631AlaPro: 5.631 ± 0.108	3.732AlaGln: 3.732 ± 0.071	8.017AlaArg: 8.017 ± 0.126	5.431AlaSer: 5.431 ± 0.081	6.679AlaThr: 6.679 ± 0.109	10.999AlaVal: 10.999 ± 0.141	1.636AlaTrp: 1.636 ± 0.049	2.146AlaTyr: 2.146 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.69CysAla: 0.69 ± 0.033	0.065CysCys: 0.065 ± 0.01	0.382CysAsp: 0.382 ± 0.021	0.304CysGlu: 0.304 ± 0.018	0.181CysPhe: 0.181 ± 0.016	0.675CysGly: 0.675 ± 0.03	0.163CysHis: 0.163 ± 0.016	0.223CysIle: 0.223 ± 0.018	0.082CysLys: 0.082 ± 0.01	0.515CysLeu: 0.515 ± 0.024	0.087CysMet: 0.087 ± 0.01	0.141CysAsn: 0.141 ± 0.014	0.414CysPro: 0.414 ± 0.025	0.164CysGln: 0.164 ± 0.017	0.434CysArg: 0.434 ± 0.022	0.401CysSer: 0.401 ± 0.023	0.426CysThr: 0.426 ± 0.022	0.478CysVal: 0.478 ± 0.026	0.07CysTrp: 0.07 ± 0.009	0.119CysTyr: 0.119 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.344AspAla: 7.344 ± 0.109	0.349AspCys: 0.349 ± 0.023	3.566AspAsp: 3.566 ± 0.077	4.114AspGlu: 4.114 ± 0.087	1.971AspPhe: 1.971 ± 0.05	5.391AspGly: 5.391 ± 0.08	1.478AspHis: 1.478 ± 0.046	2.923AspIle: 2.923 ± 0.069	1.446AspLys: 1.446 ± 0.045	6.317AspLeu: 6.317 ± 0.1	1.191AspMet: 1.191 ± 0.037	1.49AspAsn: 1.49 ± 0.045	4.238AspPro: 4.238 ± 0.073	1.694AspGln: 1.694 ± 0.048	4.272AspArg: 4.272 ± 0.079	2.866AspSer: 2.866 ± 0.056	3.32AspThr: 3.32 ± 0.064	5.217AspVal: 5.217 ± 0.076	0.898AspTrp: 0.898 ± 0.036	1.403AspTyr: 1.403 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.758GluAla: 6.758 ± 0.13	0.322GluCys: 0.322 ± 0.021	3.673GluAsp: 3.673 ± 0.078	4.407GluGlu: 4.407 ± 0.081	2.016GluPhe: 2.016 ± 0.058	4.756GluGly: 4.756 ± 0.081	1.576GluHis: 1.576 ± 0.043	3.406GluIle: 3.406 ± 0.065	2.175GluLys: 2.175 ± 0.058	7.087GluLeu: 7.087 ± 0.111	1.322GluMet: 1.322 ± 0.037	1.665GluAsn: 1.665 ± 0.05	2.849GluPro: 2.849 ± 0.065	2.538GluGln: 2.538 ± 0.065	4.393GluArg: 4.393 ± 0.081	3.102GluSer: 3.102 ± 0.068	3.285GluThr: 3.285 ± 0.066	5.162GluVal: 5.162 ± 0.078	0.885GluTrp: 0.885 ± 0.04	1.279GluTyr: 1.279 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.631PheAla: 3.631 ± 0.071	0.208PheCys: 0.208 ± 0.015	2.272PheAsp: 2.272 ± 0.056	1.8PheGlu: 1.8 ± 0.047	1.1PhePhe: 1.1 ± 0.038	3.359PheGly: 3.359 ± 0.067	0.75PheHis: 0.75 ± 0.032	1.5PheIle: 1.5 ± 0.046	0.527PheLys: 0.527 ± 0.026	3.162PheLeu: 3.162 ± 0.068	0.613PheMet: 0.613 ± 0.03	0.846PheAsn: 0.846 ± 0.036	1.513PhePro: 1.513 ± 0.047	0.819PheGln: 0.819 ± 0.028	1.912PheArg: 1.912 ± 0.052	1.925PheSer: 1.925 ± 0.052	2.306PheThr: 2.306 ± 0.048	2.381PheVal: 2.381 ± 0.06	0.464PheTrp: 0.464 ± 0.026	0.722PheTyr: 0.722 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.289GlyAla: 9.289 ± 0.148	0.6GlyCys: 0.6 ± 0.029	4.966GlyAsp: 4.966 ± 0.074	5.638GlyGlu: 5.638 ± 0.08	3.108GlyPhe: 3.108 ± 0.064	7.659GlyGly: 7.659 ± 0.137	2.176GlyHis: 2.176 ± 0.064	4.348GlyIle: 4.348 ± 0.082	2.393GlyLys: 2.393 ± 0.065	8.957GlyLeu: 8.957 ± 0.132	2.333GlyMet: 2.333 ± 0.052	2.098GlyAsn: 2.098 ± 0.053	3.93GlyPro: 3.93 ± 0.077	2.892GlyGln: 2.892 ± 0.057	6.589GlyArg: 6.589 ± 0.11	4.912GlySer: 4.912 ± 0.082	5.584GlyThr: 5.584 ± 0.081	8.002GlyVal: 8.002 ± 0.115	1.604GlyTrp: 1.604 ± 0.047	2.176GlyTyr: 2.176 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.224HisAla: 2.224 ± 0.062	0.168HisCys: 0.168 ± 0.014	1.406HisAsp: 1.406 ± 0.038	1.303HisGlu: 1.303 ± 0.04	0.662HisPhe: 0.662 ± 0.029	2.097HisGly: 2.097 ± 0.049	0.765HisHis: 0.765 ± 0.037	0.944HisIle: 0.944 ± 0.037	0.395HisLys: 0.395 ± 0.023	2.387HisLeu: 2.387 ± 0.064	0.401HisMet: 0.401 ± 0.022	0.526HisAsn: 0.526 ± 0.028	1.641HisPro: 1.641 ± 0.044	0.687HisGln: 0.687 ± 0.033	1.809HisArg: 1.809 ± 0.051	1.125HisSer: 1.125 ± 0.039	1.257HisThr: 1.257 ± 0.05	1.642HisVal: 1.642 ± 0.05	0.281HisTrp: 0.281 ± 0.02	0.51HisTyr: 0.51 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.769IleAla: 5.769 ± 0.094	0.316IleCys: 0.316 ± 0.021	3.397IleAsp: 3.397 ± 0.07	2.738IleGlu: 2.738 ± 0.071	1.409IlePhe: 1.409 ± 0.047	4.148IleGly: 4.148 ± 0.077	0.995IleHis: 0.995 ± 0.038	2.212IleIle: 2.212 ± 0.058	0.963IleLys: 0.963 ± 0.041	4.223IleLeu: 4.223 ± 0.079	0.911IleMet: 0.911 ± 0.039	1.305IleAsn: 1.305 ± 0.049	2.543IlePro: 2.543 ± 0.061	1.072IleGln: 1.072 ± 0.037	3.023IleArg: 3.023 ± 0.064	2.551IleSer: 2.551 ± 0.061	3.029IleThr: 3.029 ± 0.062	3.902IleVal: 3.902 ± 0.076	0.499IleTrp: 0.499 ± 0.027	0.917IleTyr: 0.917 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.782LysAla: 2.782 ± 0.077	0.087LysCys: 0.087 ± 0.01	1.325LysAsp: 1.325 ± 0.042	1.418LysGlu: 1.418 ± 0.053	0.703LysPhe: 0.703 ± 0.031	1.777LysGly: 1.777 ± 0.05	0.513LysHis: 0.513 ± 0.028	1.281LysIle: 1.281 ± 0.043	1.191LysLys: 1.191 ± 0.052	2.33LysLeu: 2.33 ± 0.058	0.62LysMet: 0.62 ± 0.028	0.728LysAsn: 0.728 ± 0.03	1.202LysPro: 1.202 ± 0.052	0.852LysGln: 0.852 ± 0.035	1.586LysArg: 1.586 ± 0.05	1.239LysSer: 1.239 ± 0.037	1.386LysThr: 1.386 ± 0.051	2.12LysVal: 2.12 ± 0.063	0.319LysTrp: 0.319 ± 0.02	0.564LysTyr: 0.564 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.718LeuAla: 13.718 ± 0.148	0.57LeuCys: 0.57 ± 0.027	6.515LeuAsp: 6.515 ± 0.098	5.269LeuGlu: 5.269 ± 0.096	2.923LeuPhe: 2.923 ± 0.058	9.258LeuGly: 9.258 ± 0.122	2.137LeuHis: 2.137 ± 0.057	4.953LeuIle: 4.953 ± 0.092	2.218LeuLys: 2.218 ± 0.06	10.402LeuLeu: 10.402 ± 0.163	1.936LeuMet: 1.936 ± 0.052	2.336LeuAsn: 2.336 ± 0.055	5.725LeuPro: 5.725 ± 0.098	2.466LeuGln: 2.466 ± 0.056	7.079LeuArg: 7.079 ± 0.1	5.868LeuSer: 5.868 ± 0.096	6.413LeuThr: 6.413 ± 0.091	8.682LeuVal: 8.682 ± 0.132	1.18LeuTrp: 1.18 ± 0.044	1.635LeuTyr: 1.635 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.624MetAla: 2.624 ± 0.056	0.132MetCys: 0.132 ± 0.011	1.099MetAsp: 1.099 ± 0.033	1.02MetGlu: 1.02 ± 0.035	0.725MetPhe: 0.725 ± 0.027	1.64MetGly: 1.64 ± 0.045	0.397MetHis: 0.397 ± 0.022	1.212MetIle: 1.212 ± 0.04	0.596MetLys: 0.596 ± 0.024	2.116MetLeu: 2.116 ± 0.055	0.466MetMet: 0.466 ± 0.026	0.635MetAsn: 0.635 ± 0.03	1.164MetPro: 1.164 ± 0.038	0.561MetGln: 0.561 ± 0.026	1.343MetArg: 1.343 ± 0.04	1.734MetSer: 1.734 ± 0.044	1.77MetThr: 1.77 ± 0.046	1.672MetVal: 1.672 ± 0.048	0.288MetTrp: 0.288 ± 0.016	0.373MetTyr: 0.373 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.586AsnAla: 2.586 ± 0.058	0.165AsnCys: 0.165 ± 0.016	1.32AsnAsp: 1.32 ± 0.043	1.287AsnGlu: 1.287 ± 0.041	0.75AsnPhe: 0.75 ± 0.039	1.899AsnGly: 1.899 ± 0.05	0.531AsnHis: 0.531 ± 0.027	1.252AsnIle: 1.252 ± 0.043	0.58AsnLys: 0.58 ± 0.028	2.545AsnLeu: 2.545 ± 0.067	0.521AsnMet: 0.521 ± 0.028	0.657AsnAsn: 0.657 ± 0.031	1.785AsnPro: 1.785 ± 0.052	0.832AsnGln: 0.832 ± 0.031	1.694AsnArg: 1.694 ± 0.049	1.244AsnSer: 1.244 ± 0.041	1.349AsnThr: 1.349 ± 0.045	1.823AsnVal: 1.823 ± 0.05	0.362AsnTrp: 0.362 ± 0.023	0.619AsnTyr: 0.619 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.246ProAla: 7.246 ± 0.111	0.229ProCys: 0.229 ± 0.018	3.69ProAsp: 3.69 ± 0.074	4.55ProGlu: 4.55 ± 0.082	1.63ProPhe: 1.63 ± 0.048	5.572ProGly: 5.572 ± 0.092	1.156ProHis: 1.156 ± 0.044	1.536ProIle: 1.536 ± 0.048	1.271ProLys: 1.271 ± 0.046	4.782ProLeu: 4.782 ± 0.087	0.991ProMet: 0.991 ± 0.032	1.098ProAsn: 1.098 ± 0.034	2.1ProPro: 2.1 ± 0.068	1.578ProGln: 1.578 ± 0.045	3.216ProArg: 3.216 ± 0.076	2.634ProSer: 2.634 ± 0.052	3.037ProThr: 3.037 ± 0.065	5.277ProVal: 5.277 ± 0.083	0.779ProTrp: 0.779 ± 0.028	1.115ProTyr: 1.115 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.741GlnAla: 3.741 ± 0.078	0.123GlnCys: 0.123 ± 0.014	1.396GlnAsp: 1.396 ± 0.042	1.689GlnGlu: 1.689 ± 0.051	0.966GlnPhe: 0.966 ± 0.039	2.154GlnGly: 2.154 ± 0.053	0.578GlnHis: 0.578 ± 0.026	1.616GlnIle: 1.616 ± 0.043	0.782GlnLys: 0.782 ± 0.037	3.494GlnLeu: 3.494 ± 0.075	0.761GlnMet: 0.761 ± 0.032	0.664GlnAsn: 0.664 ± 0.026	1.616GlnPro: 1.616 ± 0.051	1.191GlnGln: 1.191 ± 0.043	2.246GlnArg: 2.246 ± 0.063	1.381GlnSer: 1.381 ± 0.043	1.468GlnThr: 1.468 ± 0.043	2.678GlnVal: 2.678 ± 0.057	0.469GlnTrp: 0.469 ± 0.026	0.588GlnTyr: 0.588 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.529ArgAla: 7.529 ± 0.111	0.357ArgCys: 0.357 ± 0.019	4.062ArgAsp: 4.062 ± 0.078	4.854ArgGlu: 4.854 ± 0.089	2.243ArgPhe: 2.243 ± 0.053	5.377ArgGly: 5.377 ± 0.093	1.674ArgHis: 1.674 ± 0.051	3.538ArgIle: 3.538 ± 0.075	1.827ArgLys: 1.827 ± 0.058	6.771ArgLeu: 6.771 ± 0.113	1.805ArgMet: 1.805 ± 0.051	1.716ArgAsn: 1.716 ± 0.05	3.58ArgPro: 3.58 ± 0.064	2.319ArgGln: 2.319 ± 0.063	6.225ArgArg: 6.225 ± 0.118	3.74ArgSer: 3.74 ± 0.06	4.113ArgThr: 4.113 ± 0.077	5.3ArgVal: 5.3 ± 0.099	1.076ArgTrp: 1.076 ± 0.037	1.619ArgTyr: 1.619 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.22SerAla: 6.22 ± 0.079	0.332SerCys: 0.332 ± 0.023	2.945SerAsp: 2.945 ± 0.069	2.843SerGlu: 2.843 ± 0.054	1.892SerPhe: 1.892 ± 0.055	5.408SerGly: 5.408 ± 0.091	1.096SerHis: 1.096 ± 0.04	2.203SerIle: 2.203 ± 0.054	1.092SerLys: 1.092 ± 0.04	5.363SerLeu: 5.363 ± 0.094	1.373SerMet: 1.373 ± 0.039	1.147SerAsn: 1.147 ± 0.038	3.221SerPro: 3.221 ± 0.071	1.603SerGln: 1.603 ± 0.042	3.779SerArg: 3.779 ± 0.066	3.167SerSer: 3.167 ± 0.075	3.569SerThr: 3.569 ± 0.066	4.343SerVal: 4.343 ± 0.081	0.866SerTrp: 0.866 ± 0.034	1.255SerTyr: 1.255 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.153ThrAla: 7.153 ± 0.105	0.386ThrCys: 0.386 ± 0.022	3.6ThrAsp: 3.6 ± 0.069	3.194ThrGlu: 3.194 ± 0.069	1.961ThrPhe: 1.961 ± 0.047	6.076ThrGly: 6.076 ± 0.09	1.208ThrHis: 1.208 ± 0.039	2.656ThrIle: 2.656 ± 0.065	1.165ThrLys: 1.165 ± 0.038	5.864ThrLeu: 5.864 ± 0.089	1.187ThrMet: 1.187 ± 0.039	1.315ThrAsn: 1.315 ± 0.041	3.95ThrPro: 3.95 ± 0.079	1.448ThrGln: 1.448 ± 0.05	3.957ThrArg: 3.957 ± 0.07	3.399ThrSer: 3.399 ± 0.064	3.952ThrThr: 3.952 ± 0.082	5.912ThrVal: 5.912 ± 0.097	0.975ThrTrp: 0.975 ± 0.036	1.31ThrTyr: 1.31 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	10.72ValAla: 10.72 ± 0.14	0.564ValCys: 0.564 ± 0.029	6.043ValAsp: 6.043 ± 0.093	5.577ValGlu: 5.577 ± 0.082	2.691ValPhe: 2.691 ± 0.069	7.024ValGly: 7.024 ± 0.114	1.886ValHis: 1.886 ± 0.051	4.196ValIle: 4.196 ± 0.079	1.839ValLys: 1.839 ± 0.053	8.669ValLeu: 8.669 ± 0.128	1.733ValMet: 1.733 ± 0.047	2.07ValAsn: 2.07 ± 0.059	4.506ValPro: 4.506 ± 0.083	1.935ValGln: 1.935 ± 0.052	5.349ValArg: 5.349 ± 0.082	4.876ValSer: 4.876 ± 0.081	5.784ValThr: 5.784 ± 0.091	8.039ValVal: 8.039 ± 0.142	1.157ValTrp: 1.157 ± 0.042	1.562ValTyr: 1.562 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.593TrpAla: 1.593 ± 0.049	0.115TrpCys: 0.115 ± 0.013	0.752TrpAsp: 0.752 ± 0.031	0.778TrpGlu: 0.778 ± 0.033	0.607TrpPhe: 0.607 ± 0.029	0.962TrpGly: 0.962 ± 0.036	0.312TrpHis: 0.312 ± 0.019	0.701TrpIle: 0.701 ± 0.029	0.333TrpLys: 0.333 ± 0.018	1.864TrpLeu: 1.864 ± 0.057	0.322TrpMet: 0.322 ± 0.021	0.424TrpAsn: 0.424 ± 0.024	0.746TrpPro: 0.746 ± 0.036	0.539TrpGln: 0.539 ± 0.029	1.127TrpArg: 1.127 ± 0.038	0.835TrpSer: 0.835 ± 0.034	0.787TrpThr: 0.787 ± 0.034	1.088TrpVal: 1.088 ± 0.038	0.376TrpTrp: 0.376 ± 0.023	0.257TrpTyr: 0.257 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.194TyrAla: 2.194 ± 0.048	0.147TyrCys: 0.147 ± 0.014	1.259TyrAsp: 1.259 ± 0.036	1.146TyrGlu: 1.146 ± 0.036	0.803TyrPhe: 0.803 ± 0.032	1.948TyrGly: 1.948 ± 0.051	0.451TyrHis: 0.451 ± 0.024	0.776TyrIle: 0.776 ± 0.031	0.388TyrLys: 0.388 ± 0.021	2.407TyrLeu: 2.407 ± 0.056	0.326TyrMet: 0.326 ± 0.022	0.559TyrAsn: 0.559 ± 0.027	1.131TyrPro: 1.131 ± 0.042	0.68TyrGln: 0.68 ± 0.029	1.673TyrArg: 1.673 ± 0.051	1.287TyrSer: 1.287 ± 0.043	1.154TyrThr: 1.154 ± 0.039	1.505TyrVal: 1.505 ± 0.046	0.336TyrTrp: 0.336 ± 0.019	0.415TyrTyr: 0.415 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2547 proteins (816021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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