Amino acid dipepetide frequency for Eggerthella sp. (strain YY7918)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.057AlaAla: 14.057 ± 0.189	2.076AlaCys: 2.076 ± 0.052	6.398AlaAsp: 6.398 ± 0.088	7.103AlaGlu: 7.103 ± 0.107	4.517AlaPhe: 4.517 ± 0.075	8.799AlaGly: 8.799 ± 0.116	2.102AlaHis: 2.102 ± 0.048	5.607AlaIle: 5.607 ± 0.087	4.281AlaLys: 4.281 ± 0.073	11.852AlaLeu: 11.852 ± 0.161	2.723AlaMet: 2.723 ± 0.054	3.163AlaAsn: 3.163 ± 0.068	4.162AlaPro: 4.162 ± 0.091	3.856AlaGln: 3.856 ± 0.083	6.35AlaArg: 6.35 ± 0.104	6.592AlaSer: 6.592 ± 0.095	5.762AlaThr: 5.762 ± 0.075	8.423AlaVal: 8.423 ± 0.113	1.15AlaTrp: 1.15 ± 0.04	2.98AlaTyr: 2.98 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.803CysAla: 1.803 ± 0.056	0.262CysCys: 0.262 ± 0.017	1.036CysAsp: 1.036 ± 0.036	0.96CysGlu: 0.96 ± 0.036	0.6CysPhe: 0.6 ± 0.028	1.476CysGly: 1.476 ± 0.042	0.328CysHis: 0.328 ± 0.026	0.86CysIle: 0.86 ± 0.032	0.511CysLys: 0.511 ± 0.024	1.22CysLeu: 1.22 ± 0.038	0.433CysMet: 0.433 ± 0.021	0.406CysAsn: 0.406 ± 0.021	0.77CysPro: 0.77 ± 0.033	0.34CysGln: 0.34 ± 0.023	0.735CysArg: 0.735 ± 0.03	0.874CysSer: 0.874 ± 0.029	0.857CysThr: 0.857 ± 0.03	1.29CysVal: 1.29 ± 0.041	0.166CysTrp: 0.166 ± 0.014	0.403CysTyr: 0.403 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	7.045AspAla: 7.045 ± 0.113	0.664AspCys: 0.664 ± 0.03	3.721AspAsp: 3.721 ± 0.072	5.39AspGlu: 5.39 ± 0.09	2.381AspPhe: 2.381 ± 0.059	4.762AspGly: 4.762 ± 0.087	0.984AspHis: 0.984 ± 0.039	3.467AspIle: 3.467 ± 0.062	2.207AspLys: 2.207 ± 0.051	5.18AspLeu: 5.18 ± 0.08	1.595AspMet: 1.595 ± 0.043	1.539AspAsn: 1.539 ± 0.044	2.987AspPro: 2.987 ± 0.08	1.525AspGln: 1.525 ± 0.045	2.974AspArg: 2.974 ± 0.07	2.686AspSer: 2.686 ± 0.06	3.123AspThr: 3.123 ± 0.066	4.894AspVal: 4.894 ± 0.086	0.699AspTrp: 0.699 ± 0.031	1.894AspTyr: 1.894 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.744GluAla: 7.744 ± 0.107	0.779GluCys: 0.779 ± 0.027	3.525GluAsp: 3.525 ± 0.069	4.905GluGlu: 4.905 ± 0.082	2.154GluPhe: 2.154 ± 0.053	5.442GluGly: 5.442 ± 0.08	1.457GluHis: 1.457 ± 0.042	3.152GluIle: 3.152 ± 0.065	3.096GluLys: 3.096 ± 0.073	6.207GluLeu: 6.207 ± 0.113	1.745GluMet: 1.745 ± 0.045	2.442GluAsn: 2.442 ± 0.057	2.613GluPro: 2.613 ± 0.064	2.56GluGln: 2.56 ± 0.06	4.864GluArg: 4.864 ± 0.092	3.419GluSer: 3.419 ± 0.076	3.627GluThr: 3.627 ± 0.073	4.642GluVal: 4.642 ± 0.078	0.697GluTrp: 0.697 ± 0.031	1.911GluTyr: 1.911 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.431PheAla: 4.431 ± 0.082	0.68PheCys: 0.68 ± 0.031	2.893PheAsp: 2.893 ± 0.055	2.581PheGlu: 2.581 ± 0.051	1.683PhePhe: 1.683 ± 0.046	3.622PheGly: 3.622 ± 0.072	0.59PheHis: 0.59 ± 0.024	2.055PheIle: 2.055 ± 0.051	1.433PheLys: 1.433 ± 0.045	3.383PheLeu: 3.383 ± 0.071	1.046PheMet: 1.046 ± 0.036	1.255PheAsn: 1.255 ± 0.036	1.447PhePro: 1.447 ± 0.046	0.904PheGln: 0.904 ± 0.033	1.49PheArg: 1.49 ± 0.047	2.714PheSer: 2.714 ± 0.055	2.175PheThr: 2.175 ± 0.046	3.4PheVal: 3.4 ± 0.08	0.475PheTrp: 0.475 ± 0.025	1.264PheTyr: 1.264 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	7.901GlyAla: 7.901 ± 0.107	1.487GlyCys: 1.487 ± 0.044	4.261GlyAsp: 4.261 ± 0.079	4.819GlyGlu: 4.819 ± 0.086	3.495GlyPhe: 3.495 ± 0.072	6.436GlyGly: 6.436 ± 0.116	1.429GlyHis: 1.429 ± 0.04	5.027GlyIle: 5.027 ± 0.087	3.586GlyLys: 3.586 ± 0.074	7.185GlyLeu: 7.185 ± 0.092	2.501GlyMet: 2.501 ± 0.067	2.404GlyAsn: 2.404 ± 0.057	2.219GlyPro: 2.219 ± 0.056	2.183GlyGln: 2.183 ± 0.053	4.192GlyArg: 4.192 ± 0.076	5.07GlySer: 5.07 ± 0.095	4.81GlyThr: 4.81 ± 0.096	6.605GlyVal: 6.605 ± 0.096	0.992GlyTrp: 0.992 ± 0.038	2.714GlyTyr: 2.714 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.976HisAla: 1.976 ± 0.052	0.297HisCys: 0.297 ± 0.019	1.17HisAsp: 1.17 ± 0.038	1.299HisGlu: 1.299 ± 0.039	0.672HisPhe: 0.672 ± 0.028	1.464HisGly: 1.464 ± 0.042	0.398HisHis: 0.398 ± 0.025	1.069HisIle: 1.069 ± 0.038	0.558HisLys: 0.558 ± 0.024	1.643HisLeu: 1.643 ± 0.044	0.528HisMet: 0.528 ± 0.022	0.505HisAsn: 0.505 ± 0.026	1.094HisPro: 1.094 ± 0.037	0.447HisGln: 0.447 ± 0.023	1.004HisArg: 1.004 ± 0.032	0.947HisSer: 0.947 ± 0.032	1.006HisThr: 1.006 ± 0.04	1.507HisVal: 1.507 ± 0.041	0.2HisTrp: 0.2 ± 0.014	0.581HisTyr: 0.581 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.807IleAla: 6.807 ± 0.098	0.828IleCys: 0.828 ± 0.03	3.803IleAsp: 3.803 ± 0.061	4.003IleGlu: 4.003 ± 0.066	1.688IlePhe: 1.688 ± 0.047	4.316IleGly: 4.316 ± 0.079	0.831IleHis: 0.831 ± 0.032	2.724IleIle: 2.724 ± 0.062	2.013IleLys: 2.013 ± 0.052	4.086IleLeu: 4.086 ± 0.08	1.396IleMet: 1.396 ± 0.045	1.718IleAsn: 1.718 ± 0.053	2.617IlePro: 2.617 ± 0.052	1.233IleGln: 1.233 ± 0.038	2.307IleArg: 2.307 ± 0.054	3.117IleSer: 3.117 ± 0.071	3.063IleThr: 3.063 ± 0.066	4.981IleVal: 4.981 ± 0.083	0.525IleTrp: 0.525 ± 0.026	1.29IleTyr: 1.29 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.096LysAla: 4.096 ± 0.08	0.423LysCys: 0.423 ± 0.022	2.263LysAsp: 2.263 ± 0.059	2.706LysGlu: 2.706 ± 0.06	1.024LysPhe: 1.024 ± 0.033	2.899LysGly: 2.899 ± 0.059	0.753LysHis: 0.753 ± 0.03	1.847LysIle: 1.847 ± 0.049	2.3LysLys: 2.3 ± 0.072	3.388LysLeu: 3.388 ± 0.071	1.044LysMet: 1.044 ± 0.029	1.585LysAsn: 1.585 ± 0.047	1.912LysPro: 1.912 ± 0.053	1.481LysGln: 1.481 ± 0.044	2.855LysArg: 2.855 ± 0.059	2.194LysSer: 2.194 ± 0.049	2.622LysThr: 2.622 ± 0.057	2.709LysVal: 2.709 ± 0.069	0.382LysTrp: 0.382 ± 0.022	1.029LysTyr: 1.029 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	11.26LeuAla: 11.26 ± 0.135	1.427LeuCys: 1.427 ± 0.042	5.622LeuAsp: 5.622 ± 0.085	5.532LeuGlu: 5.532 ± 0.093	3.943LeuPhe: 3.943 ± 0.078	7.114LeuGly: 7.114 ± 0.095	1.636LeuHis: 1.636 ± 0.047	4.75LeuIle: 4.75 ± 0.095	3.347LeuLys: 3.347 ± 0.067	8.552LeuLeu: 8.552 ± 0.128	2.552LeuMet: 2.552 ± 0.057	2.556LeuAsn: 2.556 ± 0.063	4.407LeuPro: 4.407 ± 0.072	2.327LeuGln: 2.327 ± 0.048	4.928LeuArg: 4.928 ± 0.101	6.349LeuSer: 6.349 ± 0.098	4.928LeuThr: 4.928 ± 0.062	8.198LeuVal: 8.198 ± 0.132	0.89LeuTrp: 0.89 ± 0.032	2.67LeuTyr: 2.67 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.91MetAla: 2.91 ± 0.067	0.353MetCys: 0.353 ± 0.021	1.433MetAsp: 1.433 ± 0.039	1.613MetGlu: 1.613 ± 0.041	0.896MetPhe: 0.896 ± 0.033	2.153MetGly: 2.153 ± 0.057	0.488MetHis: 0.488 ± 0.025	1.274MetIle: 1.274 ± 0.042	1.16MetLys: 1.16 ± 0.043	2.575MetLeu: 2.575 ± 0.062	0.741MetMet: 0.741 ± 0.033	1.032MetAsn: 1.032 ± 0.036	1.4MetPro: 1.4 ± 0.044	0.867MetGln: 0.867 ± 0.031	1.678MetArg: 1.678 ± 0.043	1.7MetSer: 1.7 ± 0.041	1.604MetThr: 1.604 ± 0.043	1.897MetVal: 1.897 ± 0.045	0.27MetTrp: 0.27 ± 0.015	0.614MetTyr: 0.614 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.547AsnAla: 3.547 ± 0.067	0.44AsnCys: 0.44 ± 0.03	1.913AsnAsp: 1.913 ± 0.047	2.093AsnGlu: 2.093 ± 0.052	1.014AsnPhe: 1.014 ± 0.036	2.462AsnGly: 2.462 ± 0.06	0.604AsnHis: 0.604 ± 0.024	1.738AsnIle: 1.738 ± 0.046	1.125AsnLys: 1.125 ± 0.04	2.79AsnLeu: 2.79 ± 0.062	0.862AsnMet: 0.862 ± 0.03	0.99AsnAsn: 0.99 ± 0.04	1.939AsnPro: 1.939 ± 0.049	0.897AsnGln: 0.897 ± 0.032	1.624AsnArg: 1.624 ± 0.045	1.65AsnSer: 1.65 ± 0.05	1.772AsnThr: 1.772 ± 0.055	2.459AsnVal: 2.459 ± 0.055	0.334AsnTrp: 0.334 ± 0.02	0.899AsnTyr: 0.899 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.592ProAla: 4.592 ± 0.093	0.539ProCys: 0.539 ± 0.027	3.0ProAsp: 3.0 ± 0.066	3.521ProGlu: 3.521 ± 0.067	1.894ProPhe: 1.894 ± 0.042	3.111ProGly: 3.111 ± 0.063	0.88ProHis: 0.88 ± 0.033	2.059ProIle: 2.059 ± 0.051	1.594ProLys: 1.594 ± 0.045	4.15ProLeu: 4.15 ± 0.068	0.898ProMet: 0.898 ± 0.034	1.276ProAsn: 1.276 ± 0.036	1.467ProPro: 1.467 ± 0.045	1.432ProGln: 1.432 ± 0.044	1.902ProArg: 1.902 ± 0.045	2.769ProSer: 2.769 ± 0.062	2.463ProThr: 2.463 ± 0.057	3.559ProVal: 3.559 ± 0.07	0.491ProTrp: 0.491 ± 0.026	1.421ProTyr: 1.421 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.438GlnAla: 3.438 ± 0.072	0.33GlnCys: 0.33 ± 0.023	1.484GlnAsp: 1.484 ± 0.043	1.862GlnGlu: 1.862 ± 0.047	0.993GlnPhe: 0.993 ± 0.035	2.318GlnGly: 2.318 ± 0.049	0.573GlnHis: 0.573 ± 0.025	1.566GlnIle: 1.566 ± 0.037	1.416GlnLys: 1.416 ± 0.038	2.677GlnLeu: 2.677 ± 0.062	0.911GlnMet: 0.911 ± 0.033	1.052GlnAsn: 1.052 ± 0.037	1.402GlnPro: 1.402 ± 0.045	1.193GlnGln: 1.193 ± 0.043	1.913GlnArg: 1.913 ± 0.047	1.595GlnSer: 1.595 ± 0.052	1.743GlnThr: 1.743 ± 0.041	2.298GlnVal: 2.298 ± 0.055	0.329GlnTrp: 0.329 ± 0.023	0.798GlnTyr: 0.798 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.887ArgAla: 5.887 ± 0.097	0.833ArgCys: 0.833 ± 0.033	3.084ArgAsp: 3.084 ± 0.066	4.102ArgGlu: 4.102 ± 0.074	2.447ArgPhe: 2.447 ± 0.053	3.735ArgGly: 3.735 ± 0.072	1.046ArgHis: 1.046 ± 0.033	3.4ArgIle: 3.4 ± 0.069	2.341ArgLys: 2.341 ± 0.054	4.899ArgLeu: 4.899 ± 0.101	1.801ArgMet: 1.801 ± 0.049	1.687ArgAsn: 1.687 ± 0.041	2.034ArgPro: 2.034 ± 0.056	1.655ArgGln: 1.655 ± 0.044	3.697ArgArg: 3.697 ± 0.081	2.952ArgSer: 2.952 ± 0.054	3.209ArgThr: 3.209 ± 0.064	4.096ArgVal: 4.096 ± 0.069	0.566ArgTrp: 0.566 ± 0.027	1.821ArgTyr: 1.821 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.002SerAla: 6.002 ± 0.093	0.853SerCys: 0.853 ± 0.034	3.396SerAsp: 3.396 ± 0.071	3.548SerGlu: 3.548 ± 0.074	2.755SerPhe: 2.755 ± 0.057	5.032SerGly: 5.032 ± 0.097	1.095SerHis: 1.095 ± 0.033	3.291SerIle: 3.291 ± 0.063	2.227SerLys: 2.227 ± 0.054	5.653SerLeu: 5.653 ± 0.098	1.609SerMet: 1.609 ± 0.043	1.786SerAsn: 1.786 ± 0.048	2.39SerPro: 2.39 ± 0.053	1.803SerGln: 1.803 ± 0.047	3.026SerArg: 3.026 ± 0.069	3.952SerSer: 3.952 ± 0.081	3.376SerThr: 3.376 ± 0.076	4.781SerVal: 4.781 ± 0.096	0.787SerTrp: 0.787 ± 0.034	1.855SerTyr: 1.855 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.471ThrAla: 5.471 ± 0.097	0.911ThrCys: 0.911 ± 0.035	3.083ThrAsp: 3.083 ± 0.074	3.087ThrGlu: 3.087 ± 0.06	2.365ThrPhe: 2.365 ± 0.054	4.745ThrGly: 4.745 ± 0.078	1.077ThrHis: 1.077 ± 0.038	3.285ThrIle: 3.285 ± 0.07	2.071ThrLys: 2.071 ± 0.058	5.54ThrLeu: 5.54 ± 0.092	1.307ThrMet: 1.307 ± 0.038	1.765ThrAsn: 1.765 ± 0.056	3.028ThrPro: 3.028 ± 0.063	1.631ThrGln: 1.631 ± 0.045	2.679ThrArg: 2.679 ± 0.056	3.347ThrSer: 3.347 ± 0.059	3.336ThrThr: 3.336 ± 0.085	4.793ThrVal: 4.793 ± 0.101	0.729ThrTrp: 0.729 ± 0.031	1.822ThrTyr: 1.822 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	8.853ValAla: 8.853 ± 0.124	1.438ValCys: 1.438 ± 0.043	4.909ValAsp: 4.909 ± 0.083	5.237ValGlu: 5.237 ± 0.078	3.377ValPhe: 3.377 ± 0.077	6.064ValGly: 6.064 ± 0.097	1.346ValHis: 1.346 ± 0.046	4.266ValIle: 4.266 ± 0.084	2.929ValLys: 2.929 ± 0.056	7.888ValLeu: 7.888 ± 0.115	1.988ValMet: 1.988 ± 0.042	2.52ValAsn: 2.52 ± 0.056	3.527ValPro: 3.527 ± 0.066	2.2ValGln: 2.2 ± 0.054	4.544ValArg: 4.544 ± 0.08	5.137ValSer: 5.137 ± 0.087	4.301ValThr: 4.301 ± 0.106	7.483ValVal: 7.483 ± 0.117	0.826ValTrp: 0.826 ± 0.03	2.256ValTyr: 2.256 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.003TrpAla: 1.003 ± 0.035	0.175TrpCys: 0.175 ± 0.014	0.646TrpAsp: 0.646 ± 0.029	0.663TrpGlu: 0.663 ± 0.031	0.471TrpPhe: 0.471 ± 0.024	0.866TrpGly: 0.866 ± 0.033	0.223TrpHis: 0.223 ± 0.018	0.65TrpIle: 0.65 ± 0.032	0.407TrpLys: 0.407 ± 0.022	1.135TrpLeu: 1.135 ± 0.044	0.345TrpMet: 0.345 ± 0.021	0.455TrpAsn: 0.455 ± 0.024	0.374TrpPro: 0.374 ± 0.021	0.41TrpGln: 0.41 ± 0.027	0.667TrpArg: 0.667 ± 0.029	0.622TrpSer: 0.622 ± 0.029	0.542TrpThr: 0.542 ± 0.03	0.803TrpVal: 0.803 ± 0.032	0.16TrpTrp: 0.16 ± 0.016	0.358TrpTyr: 0.358 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.129TyrAla: 3.129 ± 0.058	0.532TyrCys: 0.532 ± 0.026	2.08TyrAsp: 2.08 ± 0.048	1.958TyrGlu: 1.958 ± 0.051	1.151TyrPhe: 1.151 ± 0.039	2.501TyrGly: 2.501 ± 0.061	0.527TyrHis: 0.527 ± 0.028	1.262TyrIle: 1.262 ± 0.038	0.91TyrLys: 0.91 ± 0.032	2.985TyrLeu: 2.985 ± 0.066	0.631TyrMet: 0.631 ± 0.027	1.014TyrAsn: 1.014 ± 0.037	1.231TyrPro: 1.231 ± 0.038	0.946TyrGln: 0.946 ± 0.034	1.864TyrArg: 1.864 ± 0.051	1.529TyrSer: 1.529 ± 0.044	1.752TyrThr: 1.752 ± 0.054	2.273TyrVal: 2.273 ± 0.05	0.307TyrTrp: 0.307 ± 0.021	1.016TyrTyr: 1.016 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2674 proteins (912144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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