Amino acid dipepetide frequency for Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.528AlaAla: 3.528 ± 0.366
1.229AlaCys: 1.229 ± 0.187
2.458AlaAsp: 2.458 ± 0.25
2.868AlaGlu: 2.868 ± 0.283
3.095AlaPhe: 3.095 ± 0.337
2.094AlaGly: 2.094 ± 0.229
1.229AlaHis: 1.229 ± 0.189
3.801AlaIle: 3.801 ± 0.278
2.618AlaLys: 2.618 ± 0.246
4.916AlaLeu: 4.916 ± 0.377
1.07AlaMet: 1.07 ± 0.193
2.253AlaAsn: 2.253 ± 0.227
1.593AlaPro: 1.593 ± 0.194
1.707AlaGln: 1.707 ± 0.158
2.982AlaArg: 2.982 ± 0.398
5.007AlaSer: 5.007 ± 1.095
3.187AlaThr: 3.187 ± 0.282
3.847AlaVal: 3.847 ± 0.338
0.455AlaTrp: 0.455 ± 0.096
1.73AlaTyr: 1.73 ± 0.17
0.0AlaXaa: 0.0 ± 0.0
Cys
1.388CysAla: 1.388 ± 0.182
0.455CysCys: 0.455 ± 0.085
1.343CysAsp: 1.343 ± 0.198
1.434CysGlu: 1.434 ± 0.178
1.229CysPhe: 1.229 ± 0.201
1.343CysGly: 1.343 ± 0.186
0.546CysHis: 0.546 ± 0.101
1.889CysIle: 1.889 ± 0.237
1.366CysLys: 1.366 ± 0.188
2.709CysLeu: 2.709 ± 0.243
0.751CysMet: 0.751 ± 0.128
0.979CysAsn: 0.979 ± 0.129
0.842CysPro: 0.842 ± 0.161
0.842CysGln: 0.842 ± 0.16
1.366CysArg: 1.366 ± 0.218
1.98CysSer: 1.98 ± 0.206
1.252CysThr: 1.252 ± 0.188
2.299CysVal: 2.299 ± 0.319
0.205CysTrp: 0.205 ± 0.062
0.819CysTyr: 0.819 ± 0.152
0.0CysXaa: 0.0 ± 0.0
Asp
2.549AspAla: 2.549 ± 0.227
1.252AspCys: 1.252 ± 0.139
2.276AspAsp: 2.276 ± 0.213
3.528AspGlu: 3.528 ± 0.361
2.731AspPhe: 2.731 ± 0.294
2.322AspGly: 2.322 ± 0.245
0.956AspHis: 0.956 ± 0.156
3.938AspIle: 3.938 ± 0.401
2.709AspLys: 2.709 ± 0.311
5.645AspLeu: 5.645 ± 0.376
1.297AspMet: 1.297 ± 0.181
2.731AspAsn: 2.731 ± 0.288
2.094AspPro: 2.094 ± 0.243
1.115AspGln: 1.115 ± 0.112
1.935AspArg: 1.935 ± 0.204
3.437AspSer: 3.437 ± 0.316
3.164AspThr: 3.164 ± 0.244
3.801AspVal: 3.801 ± 0.365
0.432AspTrp: 0.432 ± 0.1
1.889AspTyr: 1.889 ± 0.241
0.0AspXaa: 0.0 ± 0.0
Glu
2.344GluAla: 2.344 ± 0.23
1.07GluCys: 1.07 ± 0.141
3.187GluAsp: 3.187 ± 0.26
3.665GluGlu: 3.665 ± 0.294
2.504GluPhe: 2.504 ± 0.253
1.957GluGly: 1.957 ± 0.265
1.411GluHis: 1.411 ± 0.167
4.279GluIle: 4.279 ± 0.28
4.803GluLys: 4.803 ± 0.428
5.303GluLeu: 5.303 ± 0.336
1.889GluMet: 1.889 ± 0.197
4.347GluAsn: 4.347 ± 0.319
1.821GluPro: 1.821 ± 0.186
2.526GluGln: 2.526 ± 0.254
2.845GluArg: 2.845 ± 0.303
4.347GluSer: 4.347 ± 0.517
4.78GluThr: 4.78 ± 0.358
2.663GluVal: 2.663 ± 0.226
0.455GluTrp: 0.455 ± 0.102
1.889GluTyr: 1.889 ± 0.205
0.023GluXaa: 0.023 ± 0.019
Phe
2.868PheAla: 2.868 ± 0.24
1.798PheCys: 1.798 ± 0.2
2.572PheAsp: 2.572 ± 0.256
2.435PheGlu: 2.435 ± 0.211
3.665PhePhe: 3.665 ± 0.394
2.162PheGly: 2.162 ± 0.302
1.366PheHis: 1.366 ± 0.182
3.71PheIle: 3.71 ± 0.364
2.754PheLys: 2.754 ± 0.278
6.145PheLeu: 6.145 ± 0.517
1.206PheMet: 1.206 ± 0.147
2.868PheAsn: 2.868 ± 0.24
2.39PhePro: 2.39 ± 0.166
1.616PheGln: 1.616 ± 0.221
2.094PheArg: 2.094 ± 0.241
4.757PheSer: 4.757 ± 0.321
2.959PheThr: 2.959 ± 0.292
3.573PheVal: 3.573 ± 0.345
0.25PheTrp: 0.25 ± 0.082
2.117PheTyr: 2.117 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
2.14GlyAla: 2.14 ± 0.274
0.774GlyCys: 0.774 ± 0.145
2.64GlyAsp: 2.64 ± 0.308
2.435GlyGlu: 2.435 ± 0.286
1.912GlyPhe: 1.912 ± 0.209
1.957GlyGly: 1.957 ± 0.288
1.184GlyHis: 1.184 ± 0.199
2.458GlyIle: 2.458 ± 0.289
3.141GlyLys: 3.141 ± 0.301
4.279GlyLeu: 4.279 ± 0.325
1.001GlyMet: 1.001 ± 0.178
2.435GlyAsn: 2.435 ± 0.298
1.411GlyPro: 1.411 ± 0.197
1.798GlyGln: 1.798 ± 0.168
2.64GlyArg: 2.64 ± 0.438
2.686GlySer: 2.686 ± 0.303
2.8GlyThr: 2.8 ± 0.288
2.8GlyVal: 2.8 ± 0.308
0.455GlyTrp: 0.455 ± 0.106
1.525GlyTyr: 1.525 ± 0.209
0.0GlyXaa: 0.0 ± 0.0
His
1.252HisAla: 1.252 ± 0.147
0.774HisCys: 0.774 ± 0.154
1.479HisAsp: 1.479 ± 0.231
1.252HisGlu: 1.252 ± 0.17
1.434HisPhe: 1.434 ± 0.196
1.548HisGly: 1.548 ± 0.185
0.683HisHis: 0.683 ± 0.137
1.548HisIle: 1.548 ± 0.22
1.388HisLys: 1.388 ± 0.191
2.458HisLeu: 2.458 ± 0.272
0.683HisMet: 0.683 ± 0.122
1.343HisAsn: 1.343 ± 0.181
1.001HisPro: 1.001 ± 0.164
0.706HisGln: 0.706 ± 0.155
1.662HisArg: 1.662 ± 0.239
1.753HisSer: 1.753 ± 0.256
1.366HisThr: 1.366 ± 0.168
2.048HisVal: 2.048 ± 0.222
0.182HisTrp: 0.182 ± 0.061
0.797HisTyr: 0.797 ± 0.15
0.0HisXaa: 0.0 ± 0.0
Ile
3.346IleAla: 3.346 ± 0.298
1.662IleCys: 1.662 ± 0.186
3.004IleAsp: 3.004 ± 0.322
3.437IleGlu: 3.437 ± 0.342
3.187IlePhe: 3.187 ± 0.322
2.777IleGly: 2.777 ± 0.306
1.571IleHis: 1.571 ± 0.187
3.71IleIle: 3.71 ± 0.305
4.234IleLys: 4.234 ± 0.368
6.76IleLeu: 6.76 ± 0.552
1.639IleMet: 1.639 ± 0.231
3.665IleAsn: 3.665 ± 0.316
3.3IlePro: 3.3 ± 0.294
2.253IleGln: 2.253 ± 0.251
3.232IleArg: 3.232 ± 0.235
5.986IleSer: 5.986 ± 0.375
4.142IleThr: 4.142 ± 0.483
4.211IleVal: 4.211 ± 0.317
0.387IleTrp: 0.387 ± 0.099
3.164IleTyr: 3.164 ± 0.243
0.0IleXaa: 0.0 ± 0.0
Lys
2.458LysAla: 2.458 ± 0.22
1.525LysCys: 1.525 ± 0.209
2.959LysAsp: 2.959 ± 0.259
3.71LysGlu: 3.71 ± 0.31
2.709LysPhe: 2.709 ± 0.325
1.889LysGly: 1.889 ± 0.209
1.98LysHis: 1.98 ± 0.199
4.871LysIle: 4.871 ± 0.372
5.007LysLys: 5.007 ± 0.521
5.918LysLeu: 5.918 ± 0.428
1.548LysMet: 1.548 ± 0.186
4.325LysAsn: 4.325 ± 0.329
2.231LysPro: 2.231 ± 0.209
3.232LysGln: 3.232 ± 0.313
3.073LysArg: 3.073 ± 0.317
4.552LysSer: 4.552 ± 0.33
5.667LysThr: 5.667 ± 0.504
2.709LysVal: 2.709 ± 0.297
0.432LysTrp: 0.432 ± 0.09
1.821LysTyr: 1.821 ± 0.231
0.0LysXaa: 0.0 ± 0.0
Leu
4.438LeuAla: 4.438 ± 0.341
3.141LeuCys: 3.141 ± 0.329
4.347LeuAsp: 4.347 ± 0.359
5.189LeuGlu: 5.189 ± 0.375
5.645LeuPhe: 5.645 ± 0.389
4.689LeuGly: 4.689 ± 0.441
2.891LeuHis: 2.891 ± 0.249
5.508LeuIle: 5.508 ± 0.464
6.441LeuLys: 6.441 ± 0.407
10.834LeuLeu: 10.834 ± 0.669
2.299LeuMet: 2.299 ± 0.261
5.076LeuAsn: 5.076 ± 0.431
5.303LeuPro: 5.303 ± 0.389
3.938LeuGln: 3.938 ± 0.281
5.258LeuArg: 5.258 ± 0.437
9.264LeuSer: 9.264 ± 0.519
7.01LeuThr: 7.01 ± 0.407
4.302LeuVal: 4.302 ± 0.399
1.252LeuTrp: 1.252 ± 0.17
4.029LeuTyr: 4.029 ± 0.402
0.023LeuXaa: 0.023 ± 0.018
Met
1.571MetAla: 1.571 ± 0.215
0.637MetCys: 0.637 ± 0.12
1.502MetAsp: 1.502 ± 0.176
1.866MetGlu: 1.866 ± 0.23
1.206MetPhe: 1.206 ± 0.194
1.07MetGly: 1.07 ± 0.211
0.615MetHis: 0.615 ± 0.116
1.502MetIle: 1.502 ± 0.212
1.457MetLys: 1.457 ± 0.219
2.549MetLeu: 2.549 ± 0.273
0.66MetMet: 0.66 ± 0.147
1.297MetAsn: 1.297 ± 0.183
0.956MetPro: 0.956 ± 0.157
0.91MetGln: 0.91 ± 0.131
1.184MetArg: 1.184 ± 0.166
1.98MetSer: 1.98 ± 0.219
1.343MetThr: 1.343 ± 0.133
1.047MetVal: 1.047 ± 0.167
0.273MetTrp: 0.273 ± 0.072
1.047MetTyr: 1.047 ± 0.136
0.0MetXaa: 0.0 ± 0.0
Asn
2.777AsnAla: 2.777 ± 0.319
1.229AsnCys: 1.229 ± 0.19
2.822AsnAsp: 2.822 ± 0.284
3.141AsnGlu: 3.141 ± 0.238
2.754AsnPhe: 2.754 ± 0.216
2.504AsnGly: 2.504 ± 0.265
1.297AsnHis: 1.297 ± 0.214
3.915AsnIle: 3.915 ± 0.354
3.687AsnLys: 3.687 ± 0.322
5.713AsnLeu: 5.713 ± 0.468
1.184AsnMet: 1.184 ± 0.273
3.073AsnAsn: 3.073 ± 0.286
2.208AsnPro: 2.208 ± 0.327
1.411AsnGln: 1.411 ± 0.176
2.458AsnArg: 2.458 ± 0.234
4.552AsnSer: 4.552 ± 0.449
3.369AsnThr: 3.369 ± 0.495
4.029AsnVal: 4.029 ± 0.369
0.501AsnTrp: 0.501 ± 0.107
1.889AsnTyr: 1.889 ± 0.282
0.0AsnXaa: 0.0 ± 0.0
Pro
1.957ProAla: 1.957 ± 0.233
1.024ProCys: 1.024 ± 0.174
2.14ProAsp: 2.14 ± 0.226
2.709ProGlu: 2.709 ± 0.244
2.299ProPhe: 2.299 ± 0.223
2.026ProGly: 2.026 ± 0.305
0.956ProHis: 0.956 ± 0.161
3.004ProIle: 3.004 ± 0.281
2.777ProLys: 2.777 ± 0.313
3.915ProLeu: 3.915 ± 0.376
1.206ProMet: 1.206 ± 0.165
2.299ProAsn: 2.299 ± 0.25
2.14ProPro: 2.14 ± 0.367
1.32ProGln: 1.32 ± 0.18
2.367ProArg: 2.367 ± 0.326
3.824ProSer: 3.824 ± 0.503
2.686ProThr: 2.686 ± 0.288
3.027ProVal: 3.027 ± 0.275
0.455ProTrp: 0.455 ± 0.133
1.206ProTyr: 1.206 ± 0.157
0.0ProXaa: 0.0 ± 0.0
Gln
1.343GlnAla: 1.343 ± 0.195
0.728GlnCys: 0.728 ± 0.116
1.775GlnAsp: 1.775 ± 0.251
2.094GlnGlu: 2.094 ± 0.231
1.889GlnPhe: 1.889 ± 0.213
1.32GlnGly: 1.32 ± 0.224
0.865GlnHis: 0.865 ± 0.126
2.686GlnIle: 2.686 ± 0.256
2.481GlnLys: 2.481 ± 0.269
3.505GlnLeu: 3.505 ± 0.311
0.797GlnMet: 0.797 ± 0.128
2.595GlnAsn: 2.595 ± 0.339
1.138GlnPro: 1.138 ± 0.18
1.73GlnGln: 1.73 ± 0.27
2.162GlnArg: 2.162 ± 0.258
2.8GlnSer: 2.8 ± 0.261
2.549GlnThr: 2.549 ± 0.262
1.684GlnVal: 1.684 ± 0.221
0.455GlnTrp: 0.455 ± 0.182
1.457GlnTyr: 1.457 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
3.756ArgAla: 3.756 ± 1.054
1.093ArgCys: 1.093 ± 0.159
2.845ArgAsp: 2.845 ± 0.34
3.027ArgGlu: 3.027 ± 0.324
2.549ArgPhe: 2.549 ± 0.287
2.39ArgGly: 2.39 ± 0.37
1.73ArgHis: 1.73 ± 0.235
2.845ArgIle: 2.845 ± 0.309
3.278ArgLys: 3.278 ± 0.287
5.303ArgLeu: 5.303 ± 0.423
1.479ArgMet: 1.479 ± 0.225
2.413ArgAsn: 2.413 ± 0.216
2.003ArgPro: 2.003 ± 0.303
2.299ArgGln: 2.299 ± 0.227
3.573ArgArg: 3.573 ± 0.469
3.824ArgSer: 3.824 ± 0.367
2.094ArgThr: 2.094 ± 0.265
3.095ArgVal: 3.095 ± 0.318
0.387ArgTrp: 0.387 ± 0.1
1.821ArgTyr: 1.821 ± 0.214
0.046ArgXaa: 0.046 ± 0.036
Ser
4.529SerAla: 4.529 ± 0.384
1.98SerCys: 1.98 ± 0.184
4.393SerAsp: 4.393 ± 0.34
4.894SerGlu: 4.894 ± 0.394
4.325SerPhe: 4.325 ± 0.341
3.482SerGly: 3.482 ± 0.39
1.844SerHis: 1.844 ± 0.231
5.258SerIle: 5.258 ± 0.371
5.281SerLys: 5.281 ± 0.411
8.444SerLeu: 8.444 ± 0.385
2.094SerMet: 2.094 ± 0.237
3.756SerAsn: 3.756 ± 0.492
4.325SerPro: 4.325 ± 0.516
2.39SerGln: 2.39 ± 0.292
4.939SerArg: 4.939 ± 1.321
8.717SerSer: 8.717 ± 1.533
4.461SerThr: 4.461 ± 0.498
5.372SerVal: 5.372 ± 0.386
0.91SerTrp: 0.91 ± 0.148
2.14SerTyr: 2.14 ± 0.22
0.0SerXaa: 0.0 ± 0.0
Thr
3.824ThrAla: 3.824 ± 0.36
1.707ThrCys: 1.707 ± 0.216
3.141ThrAsp: 3.141 ± 0.27
4.575ThrGlu: 4.575 ± 0.478
3.3ThrPhe: 3.3 ± 0.268
2.572ThrGly: 2.572 ± 0.257
1.844ThrHis: 1.844 ± 0.247
3.733ThrIle: 3.733 ± 0.351
3.255ThrLys: 3.255 ± 0.379
5.827ThrLeu: 5.827 ± 0.469
1.593ThrMet: 1.593 ± 0.203
3.346ThrAsn: 3.346 ± 0.341
3.3ThrPro: 3.3 ± 0.442
2.458ThrGln: 2.458 ± 0.33
2.344ThrArg: 2.344 ± 0.217
4.939ThrSer: 4.939 ± 0.443
4.734ThrThr: 4.734 ± 0.553
4.894ThrVal: 4.894 ± 0.362
0.501ThrTrp: 0.501 ± 0.115
2.071ThrTyr: 2.071 ± 0.196
0.0ThrXaa: 0.0 ± 0.0
Val
3.232ValAla: 3.232 ± 0.237
1.912ValCys: 1.912 ± 0.245
2.822ValAsp: 2.822 ± 0.266
2.936ValGlu: 2.936 ± 0.245
4.234ValPhe: 4.234 ± 0.396
2.117ValGly: 2.117 ± 0.228
1.707ValHis: 1.707 ± 0.196
3.915ValIle: 3.915 ± 0.304
3.073ValLys: 3.073 ± 0.339
6.373ValLeu: 6.373 ± 0.423
1.388ValMet: 1.388 ± 0.198
3.05ValAsn: 3.05 ± 0.248
3.3ValPro: 3.3 ± 0.354
2.39ValGln: 2.39 ± 0.257
3.346ValArg: 3.346 ± 0.346
5.531ValSer: 5.531 ± 0.328
4.029ValThr: 4.029 ± 0.333
3.847ValVal: 3.847 ± 0.334
0.455ValTrp: 0.455 ± 0.095
2.913ValTyr: 2.913 ± 0.249
0.0ValXaa: 0.0 ± 0.0
Trp
0.296TrpAla: 0.296 ± 0.082
0.273TrpCys: 0.273 ± 0.076
0.25TrpAsp: 0.25 ± 0.063
0.615TrpGlu: 0.615 ± 0.128
0.569TrpPhe: 0.569 ± 0.129
0.41TrpGly: 0.41 ± 0.103
0.091TrpHis: 0.091 ± 0.04
0.774TrpIle: 0.774 ± 0.112
0.455TrpLys: 0.455 ± 0.096
0.865TrpLeu: 0.865 ± 0.15
0.25TrpMet: 0.25 ± 0.085
0.455TrpAsn: 0.455 ± 0.094
0.683TrpPro: 0.683 ± 0.165
0.319TrpGln: 0.319 ± 0.079
0.432TrpArg: 0.432 ± 0.112
0.592TrpSer: 0.592 ± 0.095
0.751TrpThr: 0.751 ± 0.143
0.569TrpVal: 0.569 ± 0.188
0.091TrpTrp: 0.091 ± 0.039
0.273TrpTyr: 0.273 ± 0.076
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.071TyrAla: 2.071 ± 0.219
0.774TyrCys: 0.774 ± 0.126
1.844TyrAsp: 1.844 ± 0.211
2.299TyrGlu: 2.299 ± 0.214
2.071TyrPhe: 2.071 ± 0.161
1.844TyrGly: 1.844 ± 0.177
0.592TyrHis: 0.592 ± 0.1
2.322TyrIle: 2.322 ± 0.317
2.413TyrLys: 2.413 ± 0.244
3.391TyrLeu: 3.391 ± 0.388
0.592TyrMet: 0.592 ± 0.103
2.185TyrAsn: 2.185 ± 0.234
1.297TyrPro: 1.297 ± 0.158
1.093TyrGln: 1.093 ± 0.178
1.957TyrArg: 1.957 ± 0.255
3.027TyrSer: 3.027 ± 0.282
1.593TyrThr: 1.593 ± 0.202
2.754TyrVal: 2.754 ± 0.237
0.478TyrTrp: 0.478 ± 0.107
0.91TyrTyr: 0.91 ± 0.146
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.023XaaLeu: 0.023 ± 0.019
0.023XaaMet: 0.023 ± 0.018
0.023XaaAsn: 0.023 ± 0.018
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.023XaaThr: 0.023 ± 0.018
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 99 proteins (43936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski