Amino acid dipepetide frequency for Azoarcus communis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.202AlaAla: 16.202 ± 0.149	1.422AlaCys: 1.422 ± 0.037	6.85AlaAsp: 6.85 ± 0.081	7.364AlaGlu: 7.364 ± 0.09	4.189AlaPhe: 4.189 ± 0.067	10.476AlaGly: 10.476 ± 0.101	2.582AlaHis: 2.582 ± 0.053	5.666AlaIle: 5.666 ± 0.074	3.229AlaLys: 3.229 ± 0.06	14.214AlaLeu: 14.214 ± 0.128	3.381AlaMet: 3.381 ± 0.053	2.758AlaAsn: 2.758 ± 0.044	5.365AlaPro: 5.365 ± 0.087	4.162AlaGln: 4.162 ± 0.068	8.888AlaArg: 8.888 ± 0.115	6.706AlaSer: 6.706 ± 0.082	5.376AlaThr: 5.376 ± 0.064	8.55AlaVal: 8.55 ± 0.084	1.683AlaTrp: 1.683 ± 0.043	2.389AlaTyr: 2.389 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.209CysAla: 1.209 ± 0.03	0.163CysCys: 0.163 ± 0.012	0.619CysAsp: 0.619 ± 0.02	0.592CysGlu: 0.592 ± 0.021	0.38CysPhe: 0.38 ± 0.015	1.1CysGly: 1.1 ± 0.032	0.331CysHis: 0.331 ± 0.02	0.451CysIle: 0.451 ± 0.02	0.256CysLys: 0.256 ± 0.014	0.926CysLeu: 0.926 ± 0.028	0.22CysMet: 0.22 ± 0.012	0.312CysAsn: 0.312 ± 0.015	0.571CysPro: 0.571 ± 0.025	0.244CysGln: 0.244 ± 0.015	0.657CysArg: 0.657 ± 0.023	0.59CysSer: 0.59 ± 0.019	0.514CysThr: 0.514 ± 0.021	0.807CysVal: 0.807 ± 0.027	0.123CysTrp: 0.123 ± 0.01	0.259CysTyr: 0.259 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.026AspAla: 7.026 ± 0.082	0.576AspCys: 0.576 ± 0.02	3.063AspAsp: 3.063 ± 0.053	3.742AspGlu: 3.742 ± 0.059	2.239AspPhe: 2.239 ± 0.036	4.833AspGly: 4.833 ± 0.073	1.23AspHis: 1.23 ± 0.031	2.822AspIle: 2.822 ± 0.043	1.678AspLys: 1.678 ± 0.042	5.511AspLeu: 5.511 ± 0.071	1.33AspMet: 1.33 ± 0.034	1.32AspAsn: 1.32 ± 0.032	2.98AspPro: 2.98 ± 0.055	1.592AspGln: 1.592 ± 0.039	3.726AspArg: 3.726 ± 0.06	2.491AspSer: 2.491 ± 0.043	2.846AspThr: 2.846 ± 0.043	4.052AspVal: 4.052 ± 0.058	0.99AspTrp: 0.99 ± 0.027	1.475AspTyr: 1.475 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.515GluAla: 7.515 ± 0.089	0.492GluCys: 0.492 ± 0.023	2.669GluAsp: 2.669 ± 0.042	2.907GluGlu: 2.907 ± 0.055	1.873GluPhe: 1.873 ± 0.038	4.161GluGly: 4.161 ± 0.061	1.53GluHis: 1.53 ± 0.036	3.204GluIle: 3.204 ± 0.053	2.024GluLys: 2.024 ± 0.042	6.342GluLeu: 6.342 ± 0.073	1.466GluMet: 1.466 ± 0.036	1.524GluAsn: 1.524 ± 0.037	2.495GluPro: 2.495 ± 0.044	2.524GluGln: 2.524 ± 0.046	5.128GluArg: 5.128 ± 0.067	2.985GluSer: 2.985 ± 0.043	2.952GluThr: 2.952 ± 0.042	4.403GluVal: 4.403 ± 0.062	0.838GluTrp: 0.838 ± 0.027	1.139GluTyr: 1.139 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.362PheAla: 4.362 ± 0.06	0.437PheCys: 0.437 ± 0.02	2.561PheAsp: 2.561 ± 0.037	2.261PheGlu: 2.261 ± 0.044	1.481PhePhe: 1.481 ± 0.036	3.646PheGly: 3.646 ± 0.053	0.829PheHis: 0.829 ± 0.026	1.769PheIle: 1.769 ± 0.043	1.11PheLys: 1.11 ± 0.03	3.29PheLeu: 3.29 ± 0.054	0.852PheMet: 0.852 ± 0.026	1.16PheAsn: 1.16 ± 0.028	1.589PhePro: 1.589 ± 0.035	0.946PheGln: 0.946 ± 0.027	2.203PheArg: 2.203 ± 0.04	2.387PheSer: 2.387 ± 0.044	1.716PheThr: 1.716 ± 0.037	2.975PheVal: 2.975 ± 0.056	0.494PheTrp: 0.494 ± 0.02	0.895PheTyr: 0.895 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.646GlyAla: 8.646 ± 0.089	1.021GlyCys: 1.021 ± 0.033	4.19GlyAsp: 4.19 ± 0.052	5.128GlyGlu: 5.128 ± 0.064	3.494GlyPhe: 3.494 ± 0.049	6.674GlyGly: 6.674 ± 0.094	1.946GlyHis: 1.946 ± 0.037	4.447GlyIle: 4.447 ± 0.067	3.306GlyLys: 3.306 ± 0.06	9.256GlyLeu: 9.256 ± 0.087	2.516GlyMet: 2.516 ± 0.045	2.163GlyAsn: 2.163 ± 0.041	2.698GlyPro: 2.698 ± 0.047	2.717GlyGln: 2.717 ± 0.047	5.86GlyArg: 5.86 ± 0.079	4.609GlySer: 4.609 ± 0.066	4.141GlyThr: 4.141 ± 0.061	6.592GlyVal: 6.592 ± 0.073	1.324GlyTrp: 1.324 ± 0.033	2.213GlyTyr: 2.213 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.77HisAla: 2.77 ± 0.05	0.302HisCys: 0.302 ± 0.016	1.338HisAsp: 1.338 ± 0.034	1.18HisGlu: 1.18 ± 0.032	1.017HisPhe: 1.017 ± 0.026	2.1HisGly: 2.1 ± 0.049	0.668HisHis: 0.668 ± 0.025	0.992HisIle: 0.992 ± 0.031	0.532HisLys: 0.532 ± 0.018	2.434HisLeu: 2.434 ± 0.05	0.479HisMet: 0.479 ± 0.019	0.535HisAsn: 0.535 ± 0.021	1.509HisPro: 1.509 ± 0.035	0.702HisGln: 0.702 ± 0.024	1.553HisArg: 1.553 ± 0.037	1.045HisSer: 1.045 ± 0.028	1.039HisThr: 1.039 ± 0.026	1.518HisVal: 1.518 ± 0.034	0.363HisTrp: 0.363 ± 0.018	0.698HisTyr: 0.698 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.488IleAla: 6.488 ± 0.065	0.502IleCys: 0.502 ± 0.021	3.52IleAsp: 3.52 ± 0.058	3.648IleGlu: 3.648 ± 0.055	1.541IlePhe: 1.541 ± 0.041	4.738IleGly: 4.738 ± 0.059	1.058IleHis: 1.058 ± 0.027	2.008IleIle: 2.008 ± 0.044	1.45IleLys: 1.45 ± 0.038	4.166IleLeu: 4.166 ± 0.065	0.926IleMet: 0.926 ± 0.026	1.529IleAsn: 1.529 ± 0.033	2.289IlePro: 2.289 ± 0.043	1.297IleGln: 1.297 ± 0.031	3.279IleArg: 3.279 ± 0.052	2.8IleSer: 2.8 ± 0.048	2.605IleThr: 2.605 ± 0.048	3.761IleVal: 3.761 ± 0.055	0.478IleTrp: 0.478 ± 0.018	1.063IleTyr: 1.063 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.685LysAla: 3.685 ± 0.065	0.199LysCys: 0.199 ± 0.012	1.635LysAsp: 1.635 ± 0.036	1.449LysGlu: 1.449 ± 0.042	0.818LysPhe: 0.818 ± 0.023	2.456LysGly: 2.456 ± 0.046	0.685LysHis: 0.685 ± 0.025	1.45LysIle: 1.45 ± 0.036	1.142LysLys: 1.142 ± 0.033	3.357LysLeu: 3.357 ± 0.057	0.797LysMet: 0.797 ± 0.026	0.9LysAsn: 0.9 ± 0.029	1.861LysPro: 1.861 ± 0.043	1.142LysGln: 1.142 ± 0.03	2.275LysArg: 2.275 ± 0.047	1.623LysSer: 1.623 ± 0.037	1.741LysThr: 1.741 ± 0.043	2.623LysVal: 2.623 ± 0.047	0.363LysTrp: 0.363 ± 0.017	0.647LysTyr: 0.647 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.391LeuAla: 14.391 ± 0.133	1.082LeuCys: 1.082 ± 0.031	6.38LeuAsp: 6.38 ± 0.079	6.031LeuGlu: 6.031 ± 0.068	3.818LeuPhe: 3.818 ± 0.062	8.856LeuGly: 8.856 ± 0.081	2.266LeuHis: 2.266 ± 0.046	5.315LeuIle: 5.315 ± 0.072	3.589LeuLys: 3.589 ± 0.056	11.455LeuLeu: 11.455 ± 0.133	2.651LeuMet: 2.651 ± 0.05	2.838LeuAsn: 2.838 ± 0.046	6.085LeuPro: 6.085 ± 0.079	3.509LeuGln: 3.509 ± 0.063	7.664LeuArg: 7.664 ± 0.082	6.773LeuSer: 6.773 ± 0.079	5.522LeuThr: 5.522 ± 0.071	7.667LeuVal: 7.667 ± 0.095	1.166LeuTrp: 1.166 ± 0.035	2.061LeuTyr: 2.061 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.792MetAla: 2.792 ± 0.048	0.194MetCys: 0.194 ± 0.011	1.179MetAsp: 1.179 ± 0.029	1.191MetGlu: 1.191 ± 0.034	0.739MetPhe: 0.739 ± 0.029	1.785MetGly: 1.785 ± 0.039	0.562MetHis: 0.562 ± 0.02	1.23MetIle: 1.23 ± 0.032	1.076MetLys: 1.076 ± 0.028	2.974MetLeu: 2.974 ± 0.052	0.725MetMet: 0.725 ± 0.024	0.933MetAsn: 0.933 ± 0.028	1.468MetPro: 1.468 ± 0.033	1.033MetGln: 1.033 ± 0.028	1.779MetArg: 1.779 ± 0.043	1.817MetSer: 1.817 ± 0.035	1.529MetThr: 1.529 ± 0.032	1.844MetVal: 1.844 ± 0.049	0.238MetTrp: 0.238 ± 0.014	0.403MetTyr: 0.403 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.145AsnAla: 3.145 ± 0.058	0.314AsnCys: 0.314 ± 0.014	1.344AsnAsp: 1.344 ± 0.033	1.357AsnGlu: 1.357 ± 0.032	0.95AsnPhe: 0.95 ± 0.03	2.241AsnGly: 2.241 ± 0.044	0.543AsnHis: 0.543 ± 0.02	1.298AsnIle: 1.298 ± 0.034	0.768AsnLys: 0.768 ± 0.025	2.73AsnLeu: 2.73 ± 0.052	0.644AsnMet: 0.644 ± 0.024	0.717AsnAsn: 0.717 ± 0.024	1.835AsnPro: 1.835 ± 0.044	0.801AsnGln: 0.801 ± 0.023	1.874AsnArg: 1.874 ± 0.036	1.227AsnSer: 1.227 ± 0.033	1.445AsnThr: 1.445 ± 0.035	1.839AsnVal: 1.839 ± 0.04	0.415AsnTrp: 0.415 ± 0.02	0.682AsnTyr: 0.682 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.584ProAla: 6.584 ± 0.101	0.388ProCys: 0.388 ± 0.017	3.388ProAsp: 3.388 ± 0.049	3.617ProGlu: 3.617 ± 0.062	1.841ProPhe: 1.841 ± 0.034	4.264ProGly: 4.264 ± 0.062	1.044ProHis: 1.044 ± 0.032	1.973ProIle: 1.973 ± 0.042	1.358ProLys: 1.358 ± 0.043	5.108ProLeu: 5.108 ± 0.061	1.216ProMet: 1.216 ± 0.03	1.21ProAsn: 1.21 ± 0.031	2.423ProPro: 2.423 ± 0.048	1.722ProGln: 1.722 ± 0.037	2.781ProArg: 2.781 ± 0.056	2.457ProSer: 2.457 ± 0.044	2.222ProThr: 2.222 ± 0.041	4.2ProVal: 4.2 ± 0.061	0.726ProTrp: 0.726 ± 0.026	1.082ProTyr: 1.082 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.229GlnAla: 4.229 ± 0.066	0.267GlnCys: 0.267 ± 0.015	1.447GlnAsp: 1.447 ± 0.038	1.426GlnGlu: 1.426 ± 0.032	1.151GlnPhe: 1.151 ± 0.029	2.411GlnGly: 2.411 ± 0.044	0.837GlnHis: 0.837 ± 0.026	1.784GlnIle: 1.784 ± 0.038	0.956GlnLys: 0.956 ± 0.028	3.799GlnLeu: 3.799 ± 0.066	0.862GlnMet: 0.862 ± 0.026	0.725GlnAsn: 0.725 ± 0.023	1.846GlnPro: 1.846 ± 0.046	1.483GlnGln: 1.483 ± 0.038	2.795GlnArg: 2.795 ± 0.054	1.794GlnSer: 1.794 ± 0.038	1.742GlnThr: 1.742 ± 0.037	2.543GlnVal: 2.543 ± 0.043	0.509GlnTrp: 0.509 ± 0.017	0.676GlnTyr: 0.676 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.536ArgAla: 7.536 ± 0.092	0.679ArgCys: 0.679 ± 0.024	3.901ArgAsp: 3.901 ± 0.052	4.533ArgGlu: 4.533 ± 0.068	3.102ArgPhe: 3.102 ± 0.053	4.613ArgGly: 4.613 ± 0.059	1.951ArgHis: 1.951 ± 0.039	4.055ArgIle: 4.055 ± 0.056	2.346ArgLys: 2.346 ± 0.048	8.47ArgLeu: 8.47 ± 0.088	1.978ArgMet: 1.978 ± 0.04	2.08ArgAsn: 2.08 ± 0.038	3.157ArgPro: 3.157 ± 0.054	2.641ArgGln: 2.641 ± 0.052	5.342ArgArg: 5.342 ± 0.07	3.824ArgSer: 3.824 ± 0.053	3.21ArgThr: 3.21 ± 0.043	5.015ArgVal: 5.015 ± 0.067	1.059ArgTrp: 1.059 ± 0.028	1.997ArgTyr: 1.997 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.779SerAla: 6.779 ± 0.074	0.554SerCys: 0.554 ± 0.023	2.907SerAsp: 2.907 ± 0.052	2.9SerGlu: 2.9 ± 0.048	2.143SerPhe: 2.143 ± 0.048	5.494SerGly: 5.494 ± 0.082	1.196SerHis: 1.196 ± 0.031	2.844SerIle: 2.844 ± 0.047	1.533SerLys: 1.533 ± 0.036	6.0SerLeu: 6.0 ± 0.077	1.468SerMet: 1.468 ± 0.034	1.479SerAsn: 1.479 ± 0.034	2.758SerPro: 2.758 ± 0.046	1.65SerGln: 1.65 ± 0.037	3.983SerArg: 3.983 ± 0.052	3.137SerSer: 3.137 ± 0.058	2.861SerThr: 2.861 ± 0.046	4.022SerVal: 4.022 ± 0.059	0.748SerTrp: 0.748 ± 0.025	1.198SerTyr: 1.198 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.596ThrAla: 5.596 ± 0.068	0.461ThrCys: 0.461 ± 0.018	2.543ThrAsp: 2.543 ± 0.048	2.737ThrGlu: 2.737 ± 0.047	1.618ThrPhe: 1.618 ± 0.033	4.602ThrGly: 4.602 ± 0.071	1.152ThrHis: 1.152 ± 0.029	2.228ThrIle: 2.228 ± 0.044	1.098ThrLys: 1.098 ± 0.033	6.24ThrLeu: 6.24 ± 0.076	1.09ThrMet: 1.09 ± 0.034	1.147ThrAsn: 1.147 ± 0.034	3.178ThrPro: 3.178 ± 0.05	1.528ThrGln: 1.528 ± 0.037	3.472ThrArg: 3.472 ± 0.051	2.558ThrSer: 2.558 ± 0.055	2.647ThrThr: 2.647 ± 0.055	4.066ThrVal: 4.066 ± 0.064	0.669ThrTrp: 0.669 ± 0.024	1.044ThrTyr: 1.044 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.84ValAla: 8.84 ± 0.092	0.85ValCys: 0.85 ± 0.026	4.109ValAsp: 4.109 ± 0.059	4.42ValGlu: 4.42 ± 0.054	3.062ValPhe: 3.062 ± 0.054	5.636ValGly: 5.636 ± 0.072	1.483ValHis: 1.483 ± 0.037	3.991ValIle: 3.991 ± 0.059	2.346ValLys: 2.346 ± 0.05	8.369ValLeu: 8.369 ± 0.105	2.014ValMet: 2.014 ± 0.041	1.868ValAsn: 1.868 ± 0.038	3.657ValPro: 3.657 ± 0.056	2.217ValGln: 2.217 ± 0.041	5.201ValArg: 5.201 ± 0.063	4.854ValSer: 4.854 ± 0.066	3.855ValThr: 3.855 ± 0.055	6.322ValVal: 6.322 ± 0.092	0.943ValTrp: 0.943 ± 0.029	1.403ValTyr: 1.403 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.221TrpAla: 1.221 ± 0.03	0.17TrpCys: 0.17 ± 0.011	0.619TrpAsp: 0.619 ± 0.024	0.61TrpGlu: 0.61 ± 0.022	0.546TrpPhe: 0.546 ± 0.021	0.885TrpGly: 0.885 ± 0.024	0.355TrpHis: 0.355 ± 0.015	0.701TrpIle: 0.701 ± 0.026	0.453TrpLys: 0.453 ± 0.021	1.929TrpLeu: 1.929 ± 0.042	0.402TrpMet: 0.402 ± 0.017	0.41TrpAsn: 0.41 ± 0.019	0.641TrpPro: 0.641 ± 0.022	0.631TrpGln: 0.631 ± 0.025	1.133TrpArg: 1.133 ± 0.026	0.8TrpSer: 0.8 ± 0.026	0.606TrpThr: 0.606 ± 0.024	1.037TrpVal: 1.037 ± 0.027	0.232TrpTrp: 0.232 ± 0.016	0.304TrpTyr: 0.304 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.435TyrAla: 2.435 ± 0.044	0.251TyrCys: 0.251 ± 0.013	1.259TyrAsp: 1.259 ± 0.028	1.078TyrGlu: 1.078 ± 0.028	0.959TyrPhe: 0.959 ± 0.028	1.97TyrGly: 1.97 ± 0.039	0.526TyrHis: 0.526 ± 0.02	0.92TyrIle: 0.92 ± 0.031	0.6TyrLys: 0.6 ± 0.021	2.551TyrLeu: 2.551 ± 0.049	0.472TyrMet: 0.472 ± 0.019	0.562TyrAsn: 0.562 ± 0.021	1.199TyrPro: 1.199 ± 0.027	0.744TyrGln: 0.744 ± 0.024	1.894TyrArg: 1.894 ± 0.037	1.177TyrSer: 1.177 ± 0.03	1.107TyrThr: 1.107 ± 0.025	1.605TyrVal: 1.605 ± 0.035	0.32TyrTrp: 0.32 ± 0.015	0.624TyrTyr: 0.624 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4055 proteins (1367352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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