Amino acid dipepetide frequency for Maritimibacter alkaliphilus HTCC2654

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.446AlaAla: 15.446 ± 0.153	0.998AlaCys: 0.998 ± 0.03	7.215AlaAsp: 7.215 ± 0.08	8.027AlaGlu: 8.027 ± 0.103	4.592AlaPhe: 4.592 ± 0.064	10.504AlaGly: 10.504 ± 0.123	2.251AlaHis: 2.251 ± 0.041	5.865AlaIle: 5.865 ± 0.073	4.057AlaLys: 4.057 ± 0.061	13.067AlaLeu: 13.067 ± 0.126	3.891AlaMet: 3.891 ± 0.057	2.81AlaAsn: 2.81 ± 0.053	5.694AlaPro: 5.694 ± 0.077	3.984AlaGln: 3.984 ± 0.06	8.666AlaArg: 8.666 ± 0.096	5.542AlaSer: 5.542 ± 0.076	6.262AlaThr: 6.262 ± 0.077	8.396AlaVal: 8.396 ± 0.099	1.413AlaTrp: 1.413 ± 0.037	2.54AlaTyr: 2.54 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.938CysAla: 0.938 ± 0.029	0.102CysCys: 0.102 ± 0.008	0.623CysAsp: 0.623 ± 0.019	0.435CysGlu: 0.435 ± 0.02	0.298CysPhe: 0.298 ± 0.015	0.82CysGly: 0.82 ± 0.027	0.258CysHis: 0.258 ± 0.014	0.351CysIle: 0.351 ± 0.02	0.197CysLys: 0.197 ± 0.01	0.701CysLeu: 0.701 ± 0.022	0.168CysMet: 0.168 ± 0.011	0.21CysAsn: 0.21 ± 0.013	0.497CysPro: 0.497 ± 0.02	0.219CysGln: 0.219 ± 0.015	0.511CysArg: 0.511 ± 0.018	0.391CysSer: 0.391 ± 0.019	0.412CysThr: 0.412 ± 0.017	0.538CysVal: 0.538 ± 0.022	0.111CysTrp: 0.111 ± 0.009	0.194CysTyr: 0.194 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.618AspAla: 7.618 ± 0.105	0.508AspCys: 0.508 ± 0.02	4.271AspAsp: 4.271 ± 0.116	4.268AspGlu: 4.268 ± 0.056	2.53AspPhe: 2.53 ± 0.05	6.066AspGly: 6.066 ± 0.111	1.507AspHis: 1.507 ± 0.037	3.272AspIle: 3.272 ± 0.059	1.854AspLys: 1.854 ± 0.037	6.704AspLeu: 6.704 ± 0.076	1.928AspMet: 1.928 ± 0.041	1.355AspAsn: 1.355 ± 0.031	3.963AspPro: 3.963 ± 0.067	1.783AspGln: 1.783 ± 0.039	4.737AspArg: 4.737 ± 0.063	2.03AspSer: 2.03 ± 0.045	3.389AspThr: 3.389 ± 0.088	4.665AspVal: 4.665 ± 0.067	1.287AspTrp: 1.287 ± 0.032	1.672AspTyr: 1.672 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.532GluAla: 8.532 ± 0.103	0.343GluCys: 0.343 ± 0.015	3.823GluAsp: 3.823 ± 0.061	3.667GluGlu: 3.667 ± 0.068	1.807GluPhe: 1.807 ± 0.043	5.256GluGly: 5.256 ± 0.055	1.192GluHis: 1.192 ± 0.033	3.55GluIle: 3.55 ± 0.055	2.239GluLys: 2.239 ± 0.048	4.975GluLeu: 4.975 ± 0.073	1.907GluMet: 1.907 ± 0.04	1.844GluAsn: 1.844 ± 0.039	2.749GluPro: 2.749 ± 0.055	1.832GluGln: 1.832 ± 0.039	4.502GluArg: 4.502 ± 0.075	2.11GluSer: 2.11 ± 0.04	4.079GluThr: 4.079 ± 0.055	4.799GluVal: 4.799 ± 0.063	0.712GluTrp: 0.712 ± 0.02	1.085GluTyr: 1.085 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.728PheAla: 4.728 ± 0.062	0.365PheCys: 0.365 ± 0.017	3.006PheAsp: 3.006 ± 0.051	2.303PheGlu: 2.303 ± 0.042	1.491PhePhe: 1.491 ± 0.041	3.86PheGly: 3.86 ± 0.066	0.781PheHis: 0.781 ± 0.025	1.672PheIle: 1.672 ± 0.042	0.97PheLys: 0.97 ± 0.028	3.364PheLeu: 3.364 ± 0.059	0.91PheMet: 0.91 ± 0.028	1.046PheAsn: 1.046 ± 0.026	1.65PhePro: 1.65 ± 0.032	0.968PheGln: 0.968 ± 0.026	2.281PheArg: 2.281 ± 0.038	2.021PheSer: 2.021 ± 0.043	2.216PheThr: 2.216 ± 0.047	2.789PheVal: 2.789 ± 0.046	0.574PheTrp: 0.574 ± 0.021	0.944PheTyr: 0.944 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.936GlyAla: 9.936 ± 0.101	0.792GlyCys: 0.792 ± 0.026	5.455GlyAsp: 5.455 ± 0.158	5.335GlyGlu: 5.335 ± 0.065	3.835GlyPhe: 3.835 ± 0.065	7.719GlyGly: 7.719 ± 0.152	1.941GlyHis: 1.941 ± 0.042	4.527GlyIle: 4.527 ± 0.065	3.209GlyLys: 3.209 ± 0.059	8.867GlyLeu: 8.867 ± 0.086	2.691GlyMet: 2.691 ± 0.048	2.227GlyAsn: 2.227 ± 0.062	3.843GlyPro: 3.843 ± 0.055	3.042GlyGln: 3.042 ± 0.055	5.798GlyArg: 5.798 ± 0.071	4.196GlySer: 4.196 ± 0.071	5.091GlyThr: 5.091 ± 0.094	6.626GlyVal: 6.626 ± 0.069	1.51GlyTrp: 1.51 ± 0.038	2.307GlyTyr: 2.307 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.311HisAla: 2.311 ± 0.044	0.2HisCys: 0.2 ± 0.013	1.325HisAsp: 1.325 ± 0.034	1.146HisGlu: 1.146 ± 0.034	0.825HisPhe: 0.825 ± 0.025	1.937HisGly: 1.937 ± 0.039	0.591HisHis: 0.591 ± 0.024	0.913HisIle: 0.913 ± 0.025	0.535HisLys: 0.535 ± 0.02	2.033HisLeu: 2.033 ± 0.048	0.596HisMet: 0.596 ± 0.023	0.423HisAsn: 0.423 ± 0.016	1.397HisPro: 1.397 ± 0.034	0.505HisGln: 0.505 ± 0.019	1.43HisArg: 1.43 ± 0.04	0.841HisSer: 0.841 ± 0.029	0.882HisThr: 0.882 ± 0.026	1.552HisVal: 1.552 ± 0.034	0.364HisTrp: 0.364 ± 0.017	0.546HisTyr: 0.546 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.984IleAla: 6.984 ± 0.074	0.534IleCys: 0.534 ± 0.022	3.78IleAsp: 3.78 ± 0.058	3.69IleGlu: 3.69 ± 0.054	1.752IlePhe: 1.752 ± 0.04	4.865IleGly: 4.865 ± 0.064	0.943IleHis: 0.943 ± 0.025	2.149IleIle: 2.149 ± 0.046	1.357IleLys: 1.357 ± 0.037	4.687IleLeu: 4.687 ± 0.072	1.112IleMet: 1.112 ± 0.034	1.232IleAsn: 1.232 ± 0.03	2.346IlePro: 2.346 ± 0.046	1.225IleGln: 1.225 ± 0.028	3.195IleArg: 3.195 ± 0.05	2.723IleSer: 2.723 ± 0.052	2.856IleThr: 2.856 ± 0.053	4.001IleVal: 4.001 ± 0.061	0.684IleTrp: 0.684 ± 0.024	1.171IleTyr: 1.171 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.019LysAla: 4.019 ± 0.071	0.173LysCys: 0.173 ± 0.012	1.808LysAsp: 1.808 ± 0.042	1.474LysGlu: 1.474 ± 0.038	0.957LysPhe: 0.957 ± 0.025	2.75LysGly: 2.75 ± 0.048	0.646LysHis: 0.646 ± 0.021	1.641LysIle: 1.641 ± 0.038	1.258LysLys: 1.258 ± 0.037	2.978LysLeu: 2.978 ± 0.054	0.857LysMet: 0.857 ± 0.028	0.801LysAsn: 0.801 ± 0.026	1.895LysPro: 1.895 ± 0.048	0.884LysGln: 0.884 ± 0.028	2.41LysArg: 2.41 ± 0.05	1.86LysSer: 1.86 ± 0.036	1.934LysThr: 1.934 ± 0.043	2.454LysVal: 2.454 ± 0.052	0.412LysTrp: 0.412 ± 0.019	0.651LysTyr: 0.651 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.475LeuAla: 12.475 ± 0.103	0.764LeuCys: 0.764 ± 0.025	6.266LeuAsp: 6.266 ± 0.069	5.128LeuGlu: 5.128 ± 0.068	3.5LeuPhe: 3.5 ± 0.064	8.192LeuGly: 8.192 ± 0.091	1.711LeuHis: 1.711 ± 0.039	5.271LeuIle: 5.271 ± 0.079	3.123LeuLys: 3.123 ± 0.053	7.676LeuLeu: 7.676 ± 0.11	2.638LeuMet: 2.638 ± 0.048	2.561LeuAsn: 2.561 ± 0.049	5.134LeuPro: 5.134 ± 0.062	2.108LeuGln: 2.108 ± 0.042	6.253LeuArg: 6.253 ± 0.072	6.118LeuSer: 6.118 ± 0.073	6.276LeuThr: 6.276 ± 0.074	6.953LeuVal: 6.953 ± 0.082	1.262LeuTrp: 1.262 ± 0.034	1.893LeuTyr: 1.893 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.353MetAla: 3.353 ± 0.054	0.171MetCys: 0.171 ± 0.011	1.603MetAsp: 1.603 ± 0.04	1.518MetGlu: 1.518 ± 0.037	0.907MetPhe: 0.907 ± 0.025	2.447MetGly: 2.447 ± 0.045	0.464MetHis: 0.464 ± 0.018	1.54MetIle: 1.54 ± 0.039	1.162MetLys: 1.162 ± 0.031	2.568MetLeu: 2.568 ± 0.047	0.771MetMet: 0.771 ± 0.032	0.935MetAsn: 0.935 ± 0.025	1.559MetPro: 1.559 ± 0.035	0.918MetGln: 0.918 ± 0.027	1.923MetArg: 1.923 ± 0.037	1.805MetSer: 1.805 ± 0.043	2.172MetThr: 2.172 ± 0.045	1.944MetVal: 1.944 ± 0.038	0.265MetTrp: 0.265 ± 0.013	0.327MetTyr: 0.327 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.18AsnAla: 3.18 ± 0.052	0.234AsnCys: 0.234 ± 0.015	1.594AsnAsp: 1.594 ± 0.06	1.334AsnGlu: 1.334 ± 0.032	0.943AsnPhe: 0.943 ± 0.027	2.543AsnGly: 2.543 ± 0.07	0.501AsnHis: 0.501 ± 0.02	1.339AsnIle: 1.339 ± 0.035	0.665AsnLys: 0.665 ± 0.024	2.427AsnLeu: 2.427 ± 0.046	0.699AsnMet: 0.699 ± 0.022	0.618AsnAsn: 0.618 ± 0.028	1.78AsnPro: 1.78 ± 0.033	0.651AsnGln: 0.651 ± 0.022	1.771AsnArg: 1.771 ± 0.035	1.113AsnSer: 1.113 ± 0.037	1.34AsnThr: 1.34 ± 0.037	1.913AsnVal: 1.913 ± 0.046	0.45AsnTrp: 0.45 ± 0.019	0.64AsnTyr: 0.64 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.514ProAla: 5.514 ± 0.083	0.323ProCys: 0.323 ± 0.013	4.403ProAsp: 4.403 ± 0.061	4.201ProGlu: 4.201 ± 0.064	2.031ProPhe: 2.031 ± 0.041	4.579ProGly: 4.579 ± 0.063	1.07ProHis: 1.07 ± 0.031	2.312ProIle: 2.312 ± 0.045	1.728ProLys: 1.728 ± 0.041	4.312ProLeu: 4.312 ± 0.062	1.375ProMet: 1.375 ± 0.036	1.372ProAsn: 1.372 ± 0.036	2.238ProPro: 2.238 ± 0.046	1.386ProGln: 1.386 ± 0.031	2.857ProArg: 2.857 ± 0.057	2.46ProSer: 2.46 ± 0.046	2.639ProThr: 2.639 ± 0.051	4.308ProVal: 4.308 ± 0.059	0.661ProTrp: 0.661 ± 0.022	1.136ProTyr: 1.136 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.641GlnAla: 3.641 ± 0.056	0.178GlnCys: 0.178 ± 0.011	1.644GlnAsp: 1.644 ± 0.037	1.425GlnGlu: 1.425 ± 0.038	1.009GlnPhe: 1.009 ± 0.026	2.425GlnGly: 2.425 ± 0.05	0.544GlnHis: 0.544 ± 0.023	1.832GlnIle: 1.832 ± 0.037	1.008GlnLys: 1.008 ± 0.032	2.389GlnLeu: 2.389 ± 0.045	0.978GlnMet: 0.978 ± 0.027	0.868GlnAsn: 0.868 ± 0.028	1.466GlnPro: 1.466 ± 0.036	0.827GlnGln: 0.827 ± 0.03	1.918GlnArg: 1.918 ± 0.038	1.616GlnSer: 1.616 ± 0.035	1.683GlnThr: 1.683 ± 0.04	2.239GlnVal: 2.239 ± 0.047	0.36GlnTrp: 0.36 ± 0.018	0.553GlnTyr: 0.553 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.068ArgAla: 8.068 ± 0.086	0.461ArgCys: 0.461 ± 0.02	4.669ArgAsp: 4.669 ± 0.065	4.037ArgGlu: 4.037 ± 0.06	2.686ArgPhe: 2.686 ± 0.05	4.762ArgGly: 4.762 ± 0.058	1.54ArgHis: 1.54 ± 0.037	3.79ArgIle: 3.79 ± 0.055	2.259ArgLys: 2.259 ± 0.047	7.001ArgLeu: 7.001 ± 0.088	1.992ArgMet: 1.992 ± 0.036	1.671ArgAsn: 1.671 ± 0.036	3.305ArgPro: 3.305 ± 0.055	2.124ArgGln: 2.124 ± 0.043	4.994ArgArg: 4.994 ± 0.079	3.1ArgSer: 3.1 ± 0.056	3.189ArgThr: 3.189 ± 0.054	5.001ArgVal: 5.001 ± 0.058	0.92ArgTrp: 0.92 ± 0.027	1.543ArgTyr: 1.543 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.49SerAla: 5.49 ± 0.074	0.412SerCys: 0.412 ± 0.019	3.362SerAsp: 3.362 ± 0.055	2.823SerGlu: 2.823 ± 0.048	2.132SerPhe: 2.132 ± 0.039	5.276SerGly: 5.276 ± 0.08	1.048SerHis: 1.048 ± 0.031	2.355SerIle: 2.355 ± 0.049	1.435SerLys: 1.435 ± 0.034	4.558SerLeu: 4.558 ± 0.061	1.339SerMet: 1.339 ± 0.031	1.329SerAsn: 1.329 ± 0.037	2.487SerPro: 2.487 ± 0.046	1.443SerGln: 1.443 ± 0.032	3.147SerArg: 3.147 ± 0.049	2.485SerSer: 2.485 ± 0.049	2.565SerThr: 2.565 ± 0.05	3.794SerVal: 3.794 ± 0.064	0.622SerTrp: 0.622 ± 0.022	1.246SerTyr: 1.246 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.113ThrAla: 6.113 ± 0.077	0.494ThrCys: 0.494 ± 0.02	3.565ThrAsp: 3.565 ± 0.074	3.206ThrGlu: 3.206 ± 0.052	2.239ThrPhe: 2.239 ± 0.053	5.782ThrGly: 5.782 ± 0.082	1.168ThrHis: 1.168 ± 0.028	3.005ThrIle: 3.005 ± 0.054	1.533ThrLys: 1.533 ± 0.036	6.052ThrLeu: 6.052 ± 0.062	1.388ThrMet: 1.388 ± 0.035	1.367ThrAsn: 1.367 ± 0.041	3.522ThrPro: 3.522 ± 0.061	1.558ThrGln: 1.558 ± 0.034	3.707ThrArg: 3.707 ± 0.054	2.691ThrSer: 2.691 ± 0.043	3.151ThrThr: 3.151 ± 0.064	4.512ThrVal: 4.512 ± 0.09	0.711ThrTrp: 0.711 ± 0.023	1.465ThrTyr: 1.465 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.074ValAla: 9.074 ± 0.092	0.568ValCys: 0.568 ± 0.02	4.488ValAsp: 4.488 ± 0.065	4.91ValGlu: 4.91 ± 0.066	2.932ValPhe: 2.932 ± 0.053	5.972ValGly: 5.972 ± 0.088	1.355ValHis: 1.355 ± 0.032	4.256ValIle: 4.256 ± 0.061	2.233ValLys: 2.233 ± 0.045	7.214ValLeu: 7.214 ± 0.078	2.154ValMet: 2.154 ± 0.04	2.096ValAsn: 2.096 ± 0.05	3.612ValPro: 3.612 ± 0.056	2.001ValGln: 2.001 ± 0.042	4.429ValArg: 4.429 ± 0.06	4.259ValSer: 4.259 ± 0.059	5.111ValThr: 5.111 ± 0.074	6.059ValVal: 6.059 ± 0.079	0.957ValTrp: 0.957 ± 0.025	1.549ValTyr: 1.549 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.309TrpAla: 1.309 ± 0.036	0.124TrpCys: 0.124 ± 0.01	0.806TrpAsp: 0.806 ± 0.029	0.702TrpGlu: 0.702 ± 0.023	0.584TrpPhe: 0.584 ± 0.023	1.046TrpGly: 1.046 ± 0.027	0.35TrpHis: 0.35 ± 0.016	0.721TrpIle: 0.721 ± 0.024	0.463TrpLys: 0.463 ± 0.017	1.55TrpLeu: 1.55 ± 0.036	0.434TrpMet: 0.434 ± 0.02	0.423TrpAsn: 0.423 ± 0.021	0.684TrpPro: 0.684 ± 0.026	0.521TrpGln: 0.521 ± 0.017	1.023TrpArg: 1.023 ± 0.027	0.86TrpSer: 0.86 ± 0.026	0.808TrpThr: 0.808 ± 0.026	1.0TrpVal: 1.0 ± 0.035	0.211TrpTrp: 0.211 ± 0.012	0.261TrpTyr: 0.261 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.492TyrAla: 2.492 ± 0.041	0.227TyrCys: 0.227 ± 0.011	1.701TyrAsp: 1.701 ± 0.041	1.375TyrGlu: 1.375 ± 0.035	0.888TyrPhe: 0.888 ± 0.029	2.145TyrGly: 2.145 ± 0.039	0.492TyrHis: 0.492 ± 0.021	0.923TyrIle: 0.923 ± 0.031	0.575TyrLys: 0.575 ± 0.023	2.181TyrLeu: 2.181 ± 0.038	0.522TyrMet: 0.522 ± 0.021	0.548TyrAsn: 0.548 ± 0.021	1.086TyrPro: 1.086 ± 0.03	0.624TyrGln: 0.624 ± 0.02	1.56TyrArg: 1.56 ± 0.039	1.13TyrSer: 1.13 ± 0.028	1.171TyrThr: 1.171 ± 0.045	1.685TyrVal: 1.685 ± 0.037	0.397TyrTrp: 0.397 ± 0.016	0.604TyrTyr: 0.604 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4692 proteins (1363242 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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