Amino acid dipepetide frequency for Mesorhizobium wenxiniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.099AlaAla: 17.099 ± 0.131	1.029AlaCys: 1.029 ± 0.026	6.932AlaAsp: 6.932 ± 0.066	7.61AlaGlu: 7.61 ± 0.091	4.633AlaPhe: 4.633 ± 0.057	10.714AlaGly: 10.714 ± 0.089	2.131AlaHis: 2.131 ± 0.037	6.888AlaIle: 6.888 ± 0.069	4.638AlaLys: 4.638 ± 0.069	12.736AlaLeu: 12.736 ± 0.096	3.467AlaMet: 3.467 ± 0.05	3.103AlaAsn: 3.103 ± 0.048	5.04AlaPro: 5.04 ± 0.067	3.433AlaGln: 3.433 ± 0.048	8.24AlaArg: 8.24 ± 0.072	6.586AlaSer: 6.586 ± 0.063	5.922AlaThr: 5.922 ± 0.059	8.795AlaVal: 8.795 ± 0.08	1.454AlaTrp: 1.454 ± 0.03	2.677AlaTyr: 2.677 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.926CysAla: 0.926 ± 0.024	0.119CysCys: 0.119 ± 0.009	0.518CysAsp: 0.518 ± 0.015	0.431CysGlu: 0.431 ± 0.017	0.351CysPhe: 0.351 ± 0.014	0.92CysGly: 0.92 ± 0.025	0.252CysHis: 0.252 ± 0.012	0.393CysIle: 0.393 ± 0.016	0.198CysLys: 0.198 ± 0.012	0.788CysLeu: 0.788 ± 0.021	0.172CysMet: 0.172 ± 0.008	0.224CysAsn: 0.224 ± 0.011	0.413CysPro: 0.413 ± 0.016	0.232CysGln: 0.232 ± 0.013	0.65CysArg: 0.65 ± 0.018	0.483CysSer: 0.483 ± 0.018	0.449CysThr: 0.449 ± 0.016	0.614CysVal: 0.614 ± 0.019	0.134CysTrp: 0.134 ± 0.008	0.205CysTyr: 0.205 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.585AspAla: 6.585 ± 0.071	0.494AspCys: 0.494 ± 0.019	3.121AspAsp: 3.121 ± 0.05	3.511AspGlu: 3.511 ± 0.051	2.384AspPhe: 2.384 ± 0.04	5.1AspGly: 5.1 ± 0.054	1.277AspHis: 1.277 ± 0.024	3.363AspIle: 3.363 ± 0.038	1.966AspLys: 1.966 ± 0.038	5.689AspLeu: 5.689 ± 0.062	1.391AspMet: 1.391 ± 0.028	1.398AspAsn: 1.398 ± 0.028	3.403AspPro: 3.403 ± 0.05	1.774AspGln: 1.774 ± 0.031	4.418AspArg: 4.418 ± 0.051	2.167AspSer: 2.167 ± 0.034	2.504AspThr: 2.504 ± 0.036	4.102AspVal: 4.102 ± 0.046	0.965AspTrp: 0.965 ± 0.023	1.497AspTyr: 1.497 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.389GluAla: 7.389 ± 0.069	0.393GluCys: 0.393 ± 0.015	2.645GluAsp: 2.645 ± 0.039	3.015GluGlu: 3.015 ± 0.048	1.945GluPhe: 1.945 ± 0.032	4.033GluGly: 4.033 ± 0.049	1.199GluHis: 1.199 ± 0.026	3.633GluIle: 3.633 ± 0.048	2.69GluLys: 2.69 ± 0.049	5.351GluLeu: 5.351 ± 0.06	1.526GluMet: 1.526 ± 0.027	1.701GluAsn: 1.701 ± 0.033	2.876GluPro: 2.876 ± 0.047	2.102GluGln: 2.102 ± 0.04	4.843GluArg: 4.843 ± 0.064	2.298GluSer: 2.298 ± 0.034	3.445GluThr: 3.445 ± 0.043	3.643GluVal: 3.643 ± 0.047	0.716GluTrp: 0.716 ± 0.019	1.028GluTyr: 1.028 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.694PheAla: 4.694 ± 0.052	0.417PheCys: 0.417 ± 0.015	2.781PheAsp: 2.781 ± 0.04	2.253PheGlu: 2.253 ± 0.034	1.572PhePhe: 1.572 ± 0.034	3.811PheGly: 3.811 ± 0.046	0.785PheHis: 0.785 ± 0.02	1.854PheIle: 1.854 ± 0.04	1.081PheLys: 1.081 ± 0.028	3.522PheLeu: 3.522 ± 0.054	0.84PheMet: 0.84 ± 0.022	1.06PheAsn: 1.06 ± 0.027	1.685PhePro: 1.685 ± 0.028	1.085PheGln: 1.085 ± 0.027	2.398PheArg: 2.398 ± 0.035	2.467PheSer: 2.467 ± 0.04	1.901PheThr: 1.901 ± 0.033	3.065PheVal: 3.065 ± 0.041	0.617PheTrp: 0.617 ± 0.02	0.965PheTyr: 0.965 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.888GlyAla: 8.888 ± 0.072	0.84GlyCys: 0.84 ± 0.02	4.479GlyAsp: 4.479 ± 0.056	4.713GlyGlu: 4.713 ± 0.055	3.698GlyPhe: 3.698 ± 0.048	7.109GlyGly: 7.109 ± 0.08	1.864GlyHis: 1.864 ± 0.032	4.934GlyIle: 4.934 ± 0.057	3.827GlyLys: 3.827 ± 0.053	8.548GlyLeu: 8.548 ± 0.079	2.309GlyMet: 2.309 ± 0.036	2.294GlyAsn: 2.294 ± 0.042	3.445GlyPro: 3.445 ± 0.047	2.696GlyGln: 2.696 ± 0.039	5.881GlyArg: 5.881 ± 0.059	4.802GlySer: 4.802 ± 0.046	4.624GlyThr: 4.624 ± 0.056	6.131GlyVal: 6.131 ± 0.065	1.377GlyTrp: 1.377 ± 0.03	2.255GlyTyr: 2.255 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.255HisAla: 2.255 ± 0.04	0.246HisCys: 0.246 ± 0.012	1.236HisAsp: 1.236 ± 0.027	1.066HisGlu: 1.066 ± 0.024	0.908HisPhe: 0.908 ± 0.022	1.914HisGly: 1.914 ± 0.034	0.576HisHis: 0.576 ± 0.024	1.002HisIle: 1.002 ± 0.028	0.551HisLys: 0.551 ± 0.017	2.011HisLeu: 2.011 ± 0.033	0.514HisMet: 0.514 ± 0.016	0.481HisAsn: 0.481 ± 0.017	1.311HisPro: 1.311 ± 0.029	0.617HisGln: 0.617 ± 0.02	1.414HisArg: 1.414 ± 0.034	1.004HisSer: 1.004 ± 0.023	0.825HisThr: 0.825 ± 0.022	1.553HisVal: 1.553 ± 0.031	0.344HisTrp: 0.344 ± 0.015	0.545HisTyr: 0.545 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.738IleAla: 7.738 ± 0.07	0.52IleCys: 0.52 ± 0.018	3.803IleAsp: 3.803 ± 0.043	3.66IleGlu: 3.66 ± 0.047	1.932IlePhe: 1.932 ± 0.038	5.345IleGly: 5.345 ± 0.055	1.008IleHis: 1.008 ± 0.023	2.601IleIle: 2.601 ± 0.044	1.673IleLys: 1.673 ± 0.037	4.577IleLeu: 4.577 ± 0.052	1.131IleMet: 1.131 ± 0.024	1.511IleAsn: 1.511 ± 0.027	2.401IlePro: 2.401 ± 0.033	1.207IleGln: 1.207 ± 0.026	3.446IleArg: 3.446 ± 0.05	3.258IleSer: 3.258 ± 0.045	2.616IleThr: 2.616 ± 0.039	4.696IleVal: 4.696 ± 0.06	0.617IleTrp: 0.617 ± 0.019	1.181IleTyr: 1.181 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.784LysAla: 4.784 ± 0.065	0.19LysCys: 0.19 ± 0.01	1.944LysAsp: 1.944 ± 0.038	1.686LysGlu: 1.686 ± 0.036	1.039LysPhe: 1.039 ± 0.023	2.859LysGly: 2.859 ± 0.043	0.699LysHis: 0.699 ± 0.021	2.089LysIle: 2.089 ± 0.038	1.619LysLys: 1.619 ± 0.033	3.689LysLeu: 3.689 ± 0.057	0.932LysMet: 0.932 ± 0.025	1.06LysAsn: 1.06 ± 0.026	2.396LysPro: 2.396 ± 0.048	1.179LysGln: 1.179 ± 0.028	2.628LysArg: 2.628 ± 0.044	2.118LysSer: 2.118 ± 0.03	2.201LysThr: 2.201 ± 0.037	2.705LysVal: 2.705 ± 0.044	0.446LysTrp: 0.446 ± 0.016	0.716LysTyr: 0.716 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.235LeuAla: 13.235 ± 0.101	0.872LeuCys: 0.872 ± 0.022	5.902LeuAsp: 5.902 ± 0.064	5.153LeuGlu: 5.153 ± 0.066	3.693LeuPhe: 3.693 ± 0.051	8.147LeuGly: 8.147 ± 0.073	1.781LeuHis: 1.781 ± 0.03	5.1LeuIle: 5.1 ± 0.059	3.919LeuLys: 3.919 ± 0.052	9.177LeuLeu: 9.177 ± 0.093	2.299LeuMet: 2.299 ± 0.035	2.56LeuAsn: 2.56 ± 0.043	5.219LeuPro: 5.219 ± 0.061	2.619LeuGln: 2.619 ± 0.041	6.335LeuArg: 6.335 ± 0.062	6.5LeuSer: 6.5 ± 0.067	5.282LeuThr: 5.282 ± 0.057	7.495LeuVal: 7.495 ± 0.074	1.165LeuTrp: 1.165 ± 0.03	2.07LeuTyr: 2.07 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.256MetAla: 3.256 ± 0.041	0.153MetCys: 0.153 ± 0.009	1.127MetAsp: 1.127 ± 0.024	1.113MetGlu: 1.113 ± 0.026	0.734MetPhe: 0.734 ± 0.019	1.739MetGly: 1.739 ± 0.036	0.46MetHis: 0.46 ± 0.016	1.412MetIle: 1.412 ± 0.031	1.058MetLys: 1.058 ± 0.025	2.576MetLeu: 2.576 ± 0.036	0.687MetMet: 0.687 ± 0.02	0.837MetAsn: 0.837 ± 0.019	1.495MetPro: 1.495 ± 0.031	0.843MetGln: 0.843 ± 0.021	1.823MetArg: 1.823 ± 0.031	1.646MetSer: 1.646 ± 0.028	1.844MetThr: 1.844 ± 0.033	1.759MetVal: 1.759 ± 0.03	0.22MetTrp: 0.22 ± 0.01	0.31MetTyr: 0.31 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.269AsnAla: 3.269 ± 0.05	0.267AsnCys: 0.267 ± 0.013	1.482AsnAsp: 1.482 ± 0.027	1.345AsnGlu: 1.345 ± 0.03	1.065AsnPhe: 1.065 ± 0.024	2.489AsnGly: 2.489 ± 0.039	0.553AsnHis: 0.553 ± 0.016	1.454AsnIle: 1.454 ± 0.025	0.77AsnLys: 0.77 ± 0.023	2.532AsnLeu: 2.532 ± 0.043	0.653AsnMet: 0.653 ± 0.02	0.73AsnAsn: 0.73 ± 0.024	1.889AsnPro: 1.889 ± 0.036	0.801AsnGln: 0.801 ± 0.024	1.879AsnArg: 1.879 ± 0.031	1.416AsnSer: 1.416 ± 0.03	1.288AsnThr: 1.288 ± 0.027	2.038AsnVal: 2.038 ± 0.031	0.476AsnTrp: 0.476 ± 0.017	0.719AsnTyr: 0.719 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.157ProAla: 6.157 ± 0.079	0.324ProCys: 0.324 ± 0.012	3.554ProAsp: 3.554 ± 0.044	3.532ProGlu: 3.532 ± 0.043	2.041ProPhe: 2.041 ± 0.037	4.242ProGly: 4.242 ± 0.046	1.02ProHis: 1.02 ± 0.02	2.398ProIle: 2.398 ± 0.03	1.914ProLys: 1.914 ± 0.037	4.678ProLeu: 4.678 ± 0.053	1.127ProMet: 1.127 ± 0.023	1.436ProAsn: 1.436 ± 0.032	2.328ProPro: 2.328 ± 0.043	1.587ProGln: 1.587 ± 0.029	2.729ProArg: 2.729 ± 0.041	2.777ProSer: 2.777 ± 0.043	2.427ProThr: 2.427 ± 0.036	4.066ProVal: 4.066 ± 0.047	0.719ProTrp: 0.719 ± 0.021	1.241ProTyr: 1.241 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.912GlnAla: 3.912 ± 0.048	0.218GlnCys: 0.218 ± 0.011	1.422GlnAsp: 1.422 ± 0.028	1.464GlnGlu: 1.464 ± 0.03	1.05GlnPhe: 1.05 ± 0.024	2.186GlnGly: 2.186 ± 0.036	0.655GlnHis: 0.655 ± 0.022	1.818GlnIle: 1.818 ± 0.033	1.26GlnLys: 1.26 ± 0.027	2.711GlnLeu: 2.711 ± 0.037	0.898GlnMet: 0.898 ± 0.023	0.879GlnAsn: 0.879 ± 0.024	1.647GlnPro: 1.647 ± 0.034	1.181GlnGln: 1.181 ± 0.031	2.393GlnArg: 2.393 ± 0.042	1.811GlnSer: 1.811 ± 0.031	1.667GlnThr: 1.667 ± 0.033	2.047GlnVal: 2.047 ± 0.031	0.397GlnTrp: 0.397 ± 0.014	0.589GlnTyr: 0.589 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.398ArgAla: 7.398 ± 0.075	0.537ArgCys: 0.537 ± 0.019	3.966ArgAsp: 3.966 ± 0.054	3.963ArgGlu: 3.963 ± 0.06	2.94ArgPhe: 2.94 ± 0.046	4.654ArgGly: 4.654 ± 0.061	1.751ArgHis: 1.751 ± 0.036	4.056ArgIle: 4.056 ± 0.048	2.637ArgLys: 2.637 ± 0.037	7.637ArgLeu: 7.637 ± 0.077	1.818ArgMet: 1.818 ± 0.03	1.952ArgAsn: 1.952 ± 0.031	3.441ArgPro: 3.441 ± 0.046	2.631ArgGln: 2.631 ± 0.042	5.493ArgArg: 5.493 ± 0.069	3.805ArgSer: 3.805 ± 0.049	3.414ArgThr: 3.414 ± 0.045	4.464ArgVal: 4.464 ± 0.053	0.967ArgTrp: 0.967 ± 0.026	1.71ArgTyr: 1.71 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.37SerAla: 6.37 ± 0.056	0.425SerCys: 0.425 ± 0.017	3.099SerAsp: 3.099 ± 0.051	2.885SerGlu: 2.885 ± 0.044	2.398SerPhe: 2.398 ± 0.037	5.818SerGly: 5.818 ± 0.063	1.141SerHis: 1.141 ± 0.02	3.064SerIle: 3.064 ± 0.049	1.81SerLys: 1.81 ± 0.036	5.495SerLeu: 5.495 ± 0.065	1.412SerMet: 1.412 ± 0.03	1.514SerAsn: 1.514 ± 0.03	2.797SerPro: 2.797 ± 0.035	1.63SerGln: 1.63 ± 0.031	3.736SerArg: 3.736 ± 0.054	3.117SerSer: 3.117 ± 0.049	2.786SerThr: 2.786 ± 0.041	4.206SerVal: 4.206 ± 0.054	0.796SerTrp: 0.796 ± 0.019	1.305SerTyr: 1.305 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.153ThrAla: 6.153 ± 0.058	0.413ThrCys: 0.413 ± 0.017	2.682ThrAsp: 2.682 ± 0.035	2.699ThrGlu: 2.699 ± 0.037	2.01ThrPhe: 2.01 ± 0.033	4.996ThrGly: 4.996 ± 0.055	0.981ThrHis: 0.981 ± 0.024	3.18ThrIle: 3.18 ± 0.043	1.698ThrLys: 1.698 ± 0.033	5.472ThrLeu: 5.472 ± 0.059	1.279ThrMet: 1.279 ± 0.027	1.303ThrAsn: 1.303 ± 0.028	2.993ThrPro: 2.993 ± 0.041	1.303ThrGln: 1.303 ± 0.03	3.132ThrArg: 3.132 ± 0.043	2.96ThrSer: 2.96 ± 0.041	2.775ThrThr: 2.775 ± 0.041	4.322ThrVal: 4.322 ± 0.045	0.687ThrTrp: 0.687 ± 0.02	1.185ThrTyr: 1.185 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	9.268ValAla: 9.268 ± 0.08	0.618ValCys: 0.618 ± 0.018	4.283ValAsp: 4.283 ± 0.048	4.579ValGlu: 4.579 ± 0.054	2.926ValPhe: 2.926 ± 0.045	5.691ValGly: 5.691 ± 0.064	1.401ValHis: 1.401 ± 0.027	4.051ValIle: 4.051 ± 0.054	2.464ValLys: 2.464 ± 0.04	7.432ValLeu: 7.432 ± 0.067	1.823ValMet: 1.823 ± 0.038	1.964ValAsn: 1.964 ± 0.032	3.695ValPro: 3.695 ± 0.046	1.939ValGln: 1.939 ± 0.03	4.844ValArg: 4.844 ± 0.054	4.485ValSer: 4.485 ± 0.052	4.351ValThr: 4.351 ± 0.052	6.073ValVal: 6.073 ± 0.072	0.894ValTrp: 0.894 ± 0.024	1.515ValTyr: 1.515 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.283TrpAla: 1.283 ± 0.028	0.142TrpCys: 0.142 ± 0.01	0.643TrpAsp: 0.643 ± 0.021	0.549TrpGlu: 0.549 ± 0.018	0.556TrpPhe: 0.556 ± 0.018	0.863TrpGly: 0.863 ± 0.023	0.339TrpHis: 0.339 ± 0.014	0.664TrpIle: 0.664 ± 0.018	0.527TrpLys: 0.527 ± 0.016	1.642TrpLeu: 1.642 ± 0.034	0.368TrpMet: 0.368 ± 0.013	0.524TrpAsn: 0.524 ± 0.017	0.702TrpPro: 0.702 ± 0.02	0.608TrpGln: 0.608 ± 0.019	1.146TrpArg: 1.146 ± 0.03	0.878TrpSer: 0.878 ± 0.022	0.801TrpThr: 0.801 ± 0.022	0.82TrpVal: 0.82 ± 0.022	0.228TrpTrp: 0.228 ± 0.011	0.303TrpTyr: 0.303 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.471TyrAla: 2.471 ± 0.039	0.254TyrCys: 0.254 ± 0.012	1.489TyrAsp: 1.489 ± 0.029	1.244TyrGlu: 1.244 ± 0.031	0.98TyrPhe: 0.98 ± 0.022	2.084TyrGly: 2.084 ± 0.04	0.5TyrHis: 0.5 ± 0.016	0.968TyrIle: 0.968 ± 0.021	0.68TyrLys: 0.68 ± 0.021	2.259TyrLeu: 2.259 ± 0.04	0.448TyrMet: 0.448 ± 0.018	0.584TyrAsn: 0.584 ± 0.02	1.12TyrPro: 1.12 ± 0.023	0.737TyrGln: 0.737 ± 0.02	1.806TyrArg: 1.806 ± 0.033	1.23TyrSer: 1.23 ± 0.026	1.1TyrThr: 1.1 ± 0.025	1.698TyrVal: 1.698 ± 0.03	0.367TyrTrp: 0.367 ± 0.013	0.594TyrTyr: 0.594 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6099 proteins (1827117 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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