Amino acid dipepetide frequency for Lactococcus phage 88605

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.422AlaAla: 0.422 ± 0.191
0.211AlaCys: 0.211 ± 0.146
3.588AlaAsp: 3.588 ± 0.766
4.749AlaGlu: 4.749 ± 0.884
2.744AlaPhe: 2.744 ± 0.445
4.327AlaGly: 4.327 ± 0.932
0.739AlaHis: 0.739 ± 0.298
4.538AlaIle: 4.538 ± 1.067
5.593AlaLys: 5.593 ± 0.985
5.593AlaLeu: 5.593 ± 0.951
2.322AlaMet: 2.322 ± 0.544
4.432AlaAsn: 4.432 ± 0.864
0.95AlaPro: 0.95 ± 0.363
2.849AlaGln: 2.849 ± 0.589
1.794AlaArg: 1.794 ± 0.387
4.116AlaSer: 4.116 ± 0.758
3.588AlaThr: 3.588 ± 0.747
3.588AlaVal: 3.588 ± 0.864
1.055AlaTrp: 1.055 ± 0.318
2.427AlaTyr: 2.427 ± 0.421
0.0AlaXaa: 0.0 ± 0.0
Cys
0.528CysAla: 0.528 ± 0.239
0.211CysCys: 0.211 ± 0.153
0.422CysAsp: 0.422 ± 0.208
0.211CysGlu: 0.211 ± 0.16
0.106CysPhe: 0.106 ± 0.1
0.633CysGly: 0.633 ± 0.311
0.317CysHis: 0.317 ± 0.183
0.317CysIle: 0.317 ± 0.207
0.844CysLys: 0.844 ± 0.362
0.422CysLeu: 0.422 ± 0.202
0.0CysMet: 0.0 ± 0.0
0.528CysAsn: 0.528 ± 0.227
0.317CysPro: 0.317 ± 0.182
0.422CysGln: 0.422 ± 0.2
0.528CysArg: 0.528 ± 0.231
0.106CysSer: 0.106 ± 0.125
0.211CysThr: 0.211 ± 0.165
0.528CysVal: 0.528 ± 0.295
0.211CysTrp: 0.211 ± 0.147
0.211CysTyr: 0.211 ± 0.12
0.0CysXaa: 0.0 ± 0.0
Asp
1.372AspAla: 1.372 ± 0.391
0.317AspCys: 0.317 ± 0.163
4.01AspAsp: 4.01 ± 0.903
4.327AspGlu: 4.327 ± 0.899
4.327AspPhe: 4.327 ± 0.642
4.327AspGly: 4.327 ± 0.585
1.055AspHis: 1.055 ± 0.358
3.799AspIle: 3.799 ± 0.876
4.96AspLys: 4.96 ± 0.656
6.015AspLeu: 6.015 ± 0.866
1.161AspMet: 1.161 ± 0.238
4.01AspAsn: 4.01 ± 0.717
1.372AspPro: 1.372 ± 0.515
0.95AspGln: 0.95 ± 0.285
2.005AspArg: 2.005 ± 0.501
2.955AspSer: 2.955 ± 0.56
4.538AspThr: 4.538 ± 0.927
3.588AspVal: 3.588 ± 0.605
0.739AspTrp: 0.739 ± 0.237
2.955AspTyr: 2.955 ± 0.554
0.0AspXaa: 0.0 ± 0.0
Glu
3.588GluAla: 3.588 ± 0.722
0.528GluCys: 0.528 ± 0.284
3.482GluAsp: 3.482 ± 0.737
4.749GluGlu: 4.749 ± 0.845
3.377GluPhe: 3.377 ± 0.547
2.322GluGly: 2.322 ± 0.466
0.528GluHis: 0.528 ± 0.343
5.804GluIle: 5.804 ± 0.968
6.332GluLys: 6.332 ± 1.184
9.92GluLeu: 9.92 ± 1.399
2.955GluMet: 2.955 ± 0.519
5.171GluAsn: 5.171 ± 0.76
1.477GluPro: 1.477 ± 0.428
3.588GluGln: 3.588 ± 0.715
2.849GluArg: 2.849 ± 0.599
4.01GluSer: 4.01 ± 0.613
3.905GluThr: 3.905 ± 0.65
3.799GluVal: 3.799 ± 0.595
1.055GluTrp: 1.055 ± 0.298
3.377GluTyr: 3.377 ± 0.759
0.0GluXaa: 0.0 ± 0.0
Phe
2.005PheAla: 2.005 ± 0.501
0.211PheCys: 0.211 ± 0.172
3.377PheAsp: 3.377 ± 0.639
2.427PheGlu: 2.427 ± 0.545
1.794PhePhe: 1.794 ± 0.489
2.638PheGly: 2.638 ± 0.48
0.317PheHis: 0.317 ± 0.19
3.377PheIle: 3.377 ± 0.601
4.327PheLys: 4.327 ± 0.601
2.216PheLeu: 2.216 ± 0.469
0.844PheMet: 0.844 ± 0.291
2.744PheAsn: 2.744 ± 0.722
0.739PhePro: 0.739 ± 0.29
1.055PheGln: 1.055 ± 0.333
1.161PheArg: 1.161 ± 0.293
4.327PheSer: 4.327 ± 0.686
3.06PheThr: 3.06 ± 0.469
2.533PheVal: 2.533 ± 0.331
0.528PheTrp: 0.528 ± 0.261
1.688PheTyr: 1.688 ± 0.374
0.0PheXaa: 0.0 ± 0.0
Gly
3.799GlyAla: 3.799 ± 1.122
0.317GlyCys: 0.317 ± 0.179
3.694GlyAsp: 3.694 ± 0.65
4.01GlyGlu: 4.01 ± 0.557
2.427GlyPhe: 2.427 ± 0.525
4.327GlyGly: 4.327 ± 0.75
0.739GlyHis: 0.739 ± 0.256
4.643GlyIle: 4.643 ± 1.119
6.121GlyLys: 6.121 ± 0.619
5.699GlyLeu: 5.699 ± 1.196
0.95GlyMet: 0.95 ± 0.339
3.799GlyAsn: 3.799 ± 0.68
0.106GlyPro: 0.106 ± 0.114
2.744GlyGln: 2.744 ± 0.463
1.583GlyArg: 1.583 ± 0.405
4.749GlySer: 4.749 ± 0.776
3.799GlyThr: 3.799 ± 0.745
5.593GlyVal: 5.593 ± 0.868
1.372GlyTrp: 1.372 ± 0.367
3.377GlyTyr: 3.377 ± 0.636
0.0GlyXaa: 0.0 ± 0.0
His
0.95HisAla: 0.95 ± 0.309
0.633HisCys: 0.633 ± 0.269
0.633HisAsp: 0.633 ± 0.261
0.844HisGlu: 0.844 ± 0.234
0.422HisPhe: 0.422 ± 0.235
1.055HisGly: 1.055 ± 0.43
0.211HisHis: 0.211 ± 0.152
0.844HisIle: 0.844 ± 0.279
0.739HisLys: 0.739 ± 0.31
1.161HisLeu: 1.161 ± 0.392
0.211HisMet: 0.211 ± 0.207
1.372HisAsn: 1.372 ± 0.429
0.106HisPro: 0.106 ± 0.087
0.211HisGln: 0.211 ± 0.141
0.211HisArg: 0.211 ± 0.174
0.422HisSer: 0.422 ± 0.284
0.739HisThr: 0.739 ± 0.275
0.633HisVal: 0.633 ± 0.339
0.211HisTrp: 0.211 ± 0.169
0.739HisTyr: 0.739 ± 0.309
0.0HisXaa: 0.0 ± 0.0
Ile
5.276IleAla: 5.276 ± 0.657
0.211IleCys: 0.211 ± 0.135
4.749IleAsp: 4.749 ± 0.53
5.804IleGlu: 5.804 ± 0.86
2.849IlePhe: 2.849 ± 0.539
4.116IleGly: 4.116 ± 0.844
1.055IleHis: 1.055 ± 0.35
5.065IleIle: 5.065 ± 0.742
6.859IleLys: 6.859 ± 0.77
5.171IleLeu: 5.171 ± 1.037
2.005IleMet: 2.005 ± 0.461
5.276IleAsn: 5.276 ± 0.828
1.477IlePro: 1.477 ± 0.328
2.005IleGln: 2.005 ± 0.423
1.9IleArg: 1.9 ± 0.497
3.799IleSer: 3.799 ± 0.681
5.065IleThr: 5.065 ± 0.837
4.327IleVal: 4.327 ± 0.776
1.266IleTrp: 1.266 ± 0.375
2.638IleTyr: 2.638 ± 0.57
0.0IleXaa: 0.0 ± 0.0
Lys
6.859LysAla: 6.859 ± 1.204
0.633LysCys: 0.633 ± 0.478
5.065LysAsp: 5.065 ± 0.693
8.02LysGlu: 8.02 ± 1.371
3.06LysPhe: 3.06 ± 0.624
5.276LysGly: 5.276 ± 0.758
1.266LysHis: 1.266 ± 0.428
5.488LysIle: 5.488 ± 0.804
8.02LysLys: 8.02 ± 1.116
6.965LysLeu: 6.965 ± 0.819
2.638LysMet: 2.638 ± 0.419
4.643LysAsn: 4.643 ± 0.857
2.005LysPro: 2.005 ± 0.507
3.166LysGln: 3.166 ± 0.663
4.432LysArg: 4.432 ± 0.714
4.854LysSer: 4.854 ± 0.561
5.171LysThr: 5.171 ± 0.98
5.91LysVal: 5.91 ± 0.824
1.583LysTrp: 1.583 ± 0.343
3.482LysTyr: 3.482 ± 0.737
0.0LysXaa: 0.0 ± 0.0
Leu
4.96LeuAla: 4.96 ± 0.674
0.211LeuCys: 0.211 ± 0.166
4.854LeuAsp: 4.854 ± 0.649
5.804LeuGlu: 5.804 ± 0.821
3.377LeuPhe: 3.377 ± 0.616
4.538LeuGly: 4.538 ± 0.716
1.266LeuHis: 1.266 ± 0.318
6.648LeuIle: 6.648 ± 0.792
7.387LeuLys: 7.387 ± 0.767
6.437LeuLeu: 6.437 ± 0.923
2.111LeuMet: 2.111 ± 0.639
5.382LeuAsn: 5.382 ± 0.734
3.271LeuPro: 3.271 ± 0.557
3.271LeuGln: 3.271 ± 0.487
2.533LeuArg: 2.533 ± 0.576
5.91LeuSer: 5.91 ± 0.799
6.121LeuThr: 6.121 ± 0.822
5.804LeuVal: 5.804 ± 0.764
1.055LeuTrp: 1.055 ± 0.31
5.065LeuTyr: 5.065 ± 0.777
0.0LeuXaa: 0.0 ± 0.0
Met
2.216MetAla: 2.216 ± 0.505
0.106MetCys: 0.106 ± 0.096
1.266MetAsp: 1.266 ± 0.316
1.477MetGlu: 1.477 ± 0.457
0.528MetPhe: 0.528 ± 0.231
1.372MetGly: 1.372 ± 0.345
0.317MetHis: 0.317 ± 0.165
2.216MetIle: 2.216 ± 0.531
2.638MetLys: 2.638 ± 0.491
1.794MetLeu: 1.794 ± 0.659
0.211MetMet: 0.211 ± 0.148
1.688MetAsn: 1.688 ± 0.382
0.528MetPro: 0.528 ± 0.25
2.005MetGln: 2.005 ± 0.413
0.528MetArg: 0.528 ± 0.212
1.583MetSer: 1.583 ± 0.432
1.688MetThr: 1.688 ± 0.446
1.583MetVal: 1.583 ± 0.371
0.317MetTrp: 0.317 ± 0.174
1.055MetTyr: 1.055 ± 0.372
0.0MetXaa: 0.0 ± 0.0
Asn
4.749AsnAla: 4.749 ± 1.047
0.106AsnCys: 0.106 ± 0.128
4.01AsnAsp: 4.01 ± 0.632
5.276AsnGlu: 5.276 ± 0.813
1.9AsnPhe: 1.9 ± 0.471
6.648AsnGly: 6.648 ± 0.799
0.739AsnHis: 0.739 ± 0.281
4.854AsnIle: 4.854 ± 0.74
6.754AsnLys: 6.754 ± 1.162
6.859AsnLeu: 6.859 ± 0.89
1.477AsnMet: 1.477 ± 0.402
4.116AsnAsn: 4.116 ± 0.984
2.005AsnPro: 2.005 ± 0.476
1.9AsnGln: 1.9 ± 0.488
1.688AsnArg: 1.688 ± 0.363
5.065AsnSer: 5.065 ± 0.925
3.905AsnThr: 3.905 ± 0.694
2.849AsnVal: 2.849 ± 0.607
1.055AsnTrp: 1.055 ± 0.42
2.533AsnTyr: 2.533 ± 0.709
0.0AsnXaa: 0.0 ± 0.0
Pro
1.266ProAla: 1.266 ± 0.368
0.106ProCys: 0.106 ± 0.119
1.266ProAsp: 1.266 ± 0.467
1.794ProGlu: 1.794 ± 0.49
1.055ProPhe: 1.055 ± 0.373
0.317ProGly: 0.317 ± 0.206
0.106ProHis: 0.106 ± 0.101
1.583ProIle: 1.583 ± 0.445
1.9ProLys: 1.9 ± 0.376
1.688ProLeu: 1.688 ± 0.387
0.528ProMet: 0.528 ± 0.234
2.322ProAsn: 2.322 ± 0.682
0.528ProPro: 0.528 ± 0.243
0.844ProGln: 0.844 ± 0.255
0.317ProArg: 0.317 ± 0.19
1.583ProSer: 1.583 ± 0.425
2.216ProThr: 2.216 ± 0.468
1.477ProVal: 1.477 ± 0.354
0.317ProTrp: 0.317 ± 0.175
0.844ProTyr: 0.844 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
3.694GlnAla: 3.694 ± 0.734
0.211GlnCys: 0.211 ± 0.168
1.477GlnAsp: 1.477 ± 0.517
2.111GlnGlu: 2.111 ± 0.539
1.266GlnPhe: 1.266 ± 0.352
2.533GlnGly: 2.533 ± 0.516
0.422GlnHis: 0.422 ± 0.197
1.477GlnIle: 1.477 ± 0.311
2.849GlnLys: 2.849 ± 0.66
3.377GlnLeu: 3.377 ± 0.638
0.844GlnMet: 0.844 ± 0.271
2.216GlnAsn: 2.216 ± 0.476
0.844GlnPro: 0.844 ± 0.249
1.372GlnGln: 1.372 ± 0.37
1.266GlnArg: 1.266 ± 0.319
2.005GlnSer: 2.005 ± 0.413
3.377GlnThr: 3.377 ± 0.514
2.849GlnVal: 2.849 ± 0.51
0.95GlnTrp: 0.95 ± 0.296
1.055GlnTyr: 1.055 ± 0.301
0.0GlnXaa: 0.0 ± 0.0
Arg
2.005ArgAla: 2.005 ± 0.567
0.422ArgCys: 0.422 ± 0.22
1.372ArgAsp: 1.372 ± 0.389
2.322ArgGlu: 2.322 ± 0.447
0.633ArgPhe: 0.633 ± 0.226
2.322ArgGly: 2.322 ± 0.59
0.528ArgHis: 0.528 ± 0.266
2.111ArgIle: 2.111 ± 0.526
3.694ArgLys: 3.694 ± 0.798
3.694ArgLeu: 3.694 ± 0.721
0.528ArgMet: 0.528 ± 0.259
2.744ArgAsn: 2.744 ± 0.554
0.528ArgPro: 0.528 ± 0.247
1.477ArgGln: 1.477 ± 0.312
1.583ArgArg: 1.583 ± 0.426
2.005ArgSer: 2.005 ± 0.364
2.216ArgThr: 2.216 ± 0.465
1.794ArgVal: 1.794 ± 0.517
0.317ArgTrp: 0.317 ± 0.202
1.372ArgTyr: 1.372 ± 0.382
0.0ArgXaa: 0.0 ± 0.0
Ser
4.96SerAla: 4.96 ± 1.023
0.633SerCys: 0.633 ± 0.246
3.694SerAsp: 3.694 ± 0.537
4.643SerGlu: 4.643 ± 0.768
2.638SerPhe: 2.638 ± 0.614
5.171SerGly: 5.171 ± 1.002
0.844SerHis: 0.844 ± 0.286
3.799SerIle: 3.799 ± 0.578
4.96SerLys: 4.96 ± 0.764
5.276SerLeu: 5.276 ± 0.755
2.216SerMet: 2.216 ± 0.413
4.643SerAsn: 4.643 ± 0.817
1.477SerPro: 1.477 ± 0.456
1.688SerGln: 1.688 ± 0.418
2.427SerArg: 2.427 ± 0.501
5.382SerSer: 5.382 ± 0.825
3.694SerThr: 3.694 ± 0.758
4.432SerVal: 4.432 ± 0.546
1.055SerTrp: 1.055 ± 0.305
2.216SerTyr: 2.216 ± 0.536
0.0SerXaa: 0.0 ± 0.0
Thr
4.854ThrAla: 4.854 ± 0.764
0.528ThrCys: 0.528 ± 0.272
4.432ThrAsp: 4.432 ± 0.86
4.327ThrGlu: 4.327 ± 0.587
2.955ThrPhe: 2.955 ± 0.691
4.854ThrGly: 4.854 ± 0.535
0.422ThrHis: 0.422 ± 0.187
4.643ThrIle: 4.643 ± 0.727
5.171ThrLys: 5.171 ± 0.612
5.065ThrLeu: 5.065 ± 0.733
0.739ThrMet: 0.739 ± 0.266
4.854ThrAsn: 4.854 ± 0.768
1.9ThrPro: 1.9 ± 0.41
2.427ThrGln: 2.427 ± 0.562
2.005ThrArg: 2.005 ± 0.403
4.538ThrSer: 4.538 ± 0.613
4.643ThrThr: 4.643 ± 0.663
5.171ThrVal: 5.171 ± 0.921
1.161ThrTrp: 1.161 ± 0.347
1.9ThrTyr: 1.9 ± 0.416
0.0ThrXaa: 0.0 ± 0.0
Val
3.482ValAla: 3.482 ± 0.591
0.422ValCys: 0.422 ± 0.192
4.116ValAsp: 4.116 ± 0.635
5.488ValGlu: 5.488 ± 0.673
2.744ValPhe: 2.744 ± 0.489
2.955ValGly: 2.955 ± 0.415
0.317ValHis: 0.317 ± 0.176
4.96ValIle: 4.96 ± 0.788
5.804ValLys: 5.804 ± 0.744
3.694ValLeu: 3.694 ± 0.553
2.005ValMet: 2.005 ± 0.525
3.377ValAsn: 3.377 ± 0.59
1.372ValPro: 1.372 ± 0.437
1.794ValGln: 1.794 ± 0.393
2.849ValArg: 2.849 ± 0.509
5.276ValSer: 5.276 ± 0.839
5.488ValThr: 5.488 ± 0.869
3.799ValVal: 3.799 ± 0.588
0.422ValTrp: 0.422 ± 0.199
2.744ValTyr: 2.744 ± 0.471
0.0ValXaa: 0.0 ± 0.0
Trp
1.055TrpAla: 1.055 ± 0.369
0.422TrpCys: 0.422 ± 0.202
0.844TrpAsp: 0.844 ± 0.303
0.844TrpGlu: 0.844 ± 0.329
0.95TrpPhe: 0.95 ± 0.395
0.95TrpGly: 0.95 ± 0.295
0.211TrpHis: 0.211 ± 0.152
1.161TrpIle: 1.161 ± 0.38
0.633TrpLys: 0.633 ± 0.296
1.688TrpLeu: 1.688 ± 0.451
0.317TrpMet: 0.317 ± 0.176
1.794TrpAsn: 1.794 ± 0.372
0.0TrpPro: 0.0 ± 0.0
0.844TrpGln: 0.844 ± 0.29
0.422TrpArg: 0.422 ± 0.28
1.055TrpSer: 1.055 ± 0.265
0.633TrpThr: 0.633 ± 0.254
0.317TrpVal: 0.317 ± 0.218
0.211TrpTrp: 0.211 ± 0.164
0.844TrpTyr: 0.844 ± 0.286
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.583TyrAla: 1.583 ± 0.509
0.633TyrCys: 0.633 ± 0.331
2.427TyrAsp: 2.427 ± 0.709
3.588TyrGlu: 3.588 ± 0.652
2.216TyrPhe: 2.216 ± 0.505
3.166TyrGly: 3.166 ± 0.643
0.95TyrHis: 0.95 ± 0.337
3.588TyrIle: 3.588 ± 0.832
2.955TyrLys: 2.955 ± 0.533
3.271TyrLeu: 3.271 ± 0.691
0.95TyrMet: 0.95 ± 0.336
3.482TyrAsn: 3.482 ± 0.471
1.055TyrPro: 1.055 ± 0.396
1.583TyrGln: 1.583 ± 0.427
1.583TyrArg: 1.583 ± 0.486
2.111TyrSer: 2.111 ± 0.469
2.533TyrThr: 2.533 ± 0.557
2.533TyrVal: 2.533 ± 0.555
0.317TyrTrp: 0.317 ± 0.171
1.9TyrTyr: 1.9 ± 0.558
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (9477 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski