Amino acid dipepetide frequency for Methanoculleus taiwanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.765AlaAla: 11.765 ± 0.189
1.311AlaCys: 1.311 ± 0.053
5.684AlaAsp: 5.684 ± 0.096
7.029AlaGlu: 7.029 ± 0.12
3.725AlaPhe: 3.725 ± 0.074
9.561AlaGly: 9.561 ± 0.131
1.586AlaHis: 1.586 ± 0.054
6.544AlaIle: 6.544 ± 0.098
2.998AlaLys: 2.998 ± 0.08
10.27AlaLeu: 10.27 ± 0.171
2.724AlaMet: 2.724 ± 0.06
2.175AlaAsn: 2.175 ± 0.063
3.621AlaPro: 3.621 ± 0.073
1.826AlaGln: 1.826 ± 0.058
5.959AlaArg: 5.959 ± 0.106
4.817AlaSer: 4.817 ± 0.114
4.881AlaThr: 4.881 ± 0.093
9.299AlaVal: 9.299 ± 0.146
1.061AlaTrp: 1.061 ± 0.049
2.712AlaTyr: 2.712 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.983CysAla: 0.983 ± 0.038
0.257CysCys: 0.257 ± 0.021
0.692CysAsp: 0.692 ± 0.036
0.677CysGlu: 0.677 ± 0.03
0.42CysPhe: 0.42 ± 0.03
1.478CysGly: 1.478 ± 0.053
0.309CysHis: 0.309 ± 0.023
0.918CysIle: 0.918 ± 0.039
0.277CysLys: 0.277 ± 0.021
0.928CysLeu: 0.928 ± 0.04
0.332CysMet: 0.332 ± 0.022
0.349CysAsn: 0.349 ± 0.026
0.915CysPro: 0.915 ± 0.045
0.228CysGln: 0.228 ± 0.018
1.104CysArg: 1.104 ± 0.044
0.824CysSer: 0.824 ± 0.043
0.956CysThr: 0.956 ± 0.039
0.773CysVal: 0.773 ± 0.034
0.106CysTrp: 0.106 ± 0.011
0.447CysTyr: 0.447 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
6.145AspAla: 6.145 ± 0.107
0.688AspCys: 0.688 ± 0.03
2.965AspAsp: 2.965 ± 0.075
4.366AspGlu: 4.366 ± 0.079
1.734AspPhe: 1.734 ± 0.054
4.583AspGly: 4.583 ± 0.097
1.095AspHis: 1.095 ± 0.039
3.932AspIle: 3.932 ± 0.083
1.251AspLys: 1.251 ± 0.044
6.733AspLeu: 6.733 ± 0.105
1.263AspMet: 1.263 ± 0.042
1.06AspAsn: 1.06 ± 0.049
3.329AspPro: 3.329 ± 0.096
1.271AspGln: 1.271 ± 0.039
4.118AspArg: 4.118 ± 0.084
2.063AspSer: 2.063 ± 0.055
3.061AspThr: 3.061 ± 0.069
4.355AspVal: 4.355 ± 0.094
0.619AspTrp: 0.619 ± 0.031
1.676AspTyr: 1.676 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
6.479GluAla: 6.479 ± 0.119
0.746GluCys: 0.746 ± 0.036
3.373GluAsp: 3.373 ± 0.075
5.928GluGlu: 5.928 ± 0.104
2.185GluPhe: 2.185 ± 0.062
4.858GluGly: 4.858 ± 0.09
1.581GluHis: 1.581 ± 0.066
5.175GluIle: 5.175 ± 0.095
3.33GluLys: 3.33 ± 0.084
5.678GluLeu: 5.678 ± 0.109
2.103GluMet: 2.103 ± 0.06
2.304GluAsn: 2.304 ± 0.059
2.71GluPro: 2.71 ± 0.067
2.392GluGln: 2.392 ± 0.064
5.667GluArg: 5.667 ± 0.13
3.544GluSer: 3.544 ± 0.072
4.014GluThr: 4.014 ± 0.087
5.162GluVal: 5.162 ± 0.086
0.626GluTrp: 0.626 ± 0.03
2.198GluTyr: 2.198 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.61PheAla: 3.61 ± 0.073
0.509PheCys: 0.509 ± 0.028
2.323PheAsp: 2.323 ± 0.06
2.238PheGlu: 2.238 ± 0.051
1.636PhePhe: 1.636 ± 0.054
3.333PheGly: 3.333 ± 0.085
0.664PheHis: 0.664 ± 0.028
2.364PheIle: 2.364 ± 0.067
0.905PheLys: 0.905 ± 0.043
3.414PheLeu: 3.414 ± 0.092
0.806PheMet: 0.806 ± 0.035
1.02PheAsn: 1.02 ± 0.037
1.615PhePro: 1.615 ± 0.054
0.766PheGln: 0.766 ± 0.033
2.172PheArg: 2.172 ± 0.06
2.571PheSer: 2.571 ± 0.058
2.212PheThr: 2.212 ± 0.061
2.916PheVal: 2.916 ± 0.074
0.433PheTrp: 0.433 ± 0.029
1.006PheTyr: 1.006 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
7.283GlyAla: 7.283 ± 0.135
1.327GlyCys: 1.327 ± 0.06
4.882GlyAsp: 4.882 ± 0.099
5.925GlyGlu: 5.925 ± 0.105
3.252GlyPhe: 3.252 ± 0.073
6.838GlyGly: 6.838 ± 0.145
1.442GlyHis: 1.442 ± 0.042
6.572GlyIle: 6.572 ± 0.098
3.584GlyLys: 3.584 ± 0.08
7.08GlyLeu: 7.08 ± 0.124
2.551GlyMet: 2.551 ± 0.068
2.45GlyAsn: 2.45 ± 0.08
2.096GlyPro: 2.096 ± 0.05
1.911GlyGln: 1.911 ± 0.053
5.607GlyArg: 5.607 ± 0.109
5.362GlySer: 5.362 ± 0.103
5.532GlyThr: 5.532 ± 0.101
6.584GlyVal: 6.584 ± 0.12
0.983GlyTrp: 0.983 ± 0.035
3.017GlyTyr: 3.017 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.879HisAla: 1.879 ± 0.07
0.322HisCys: 0.322 ± 0.02
1.111HisAsp: 1.111 ± 0.042
1.149HisGlu: 1.149 ± 0.042
0.734HisPhe: 0.734 ± 0.033
1.684HisGly: 1.684 ± 0.053
0.545HisHis: 0.545 ± 0.029
1.215HisIle: 1.215 ± 0.042
0.453HisLys: 0.453 ± 0.025
2.133HisLeu: 2.133 ± 0.057
0.38HisMet: 0.38 ± 0.024
0.511HisAsn: 0.511 ± 0.028
1.358HisPro: 1.358 ± 0.052
0.48HisGln: 0.48 ± 0.023
1.491HisArg: 1.491 ± 0.052
0.822HisSer: 0.822 ± 0.033
1.098HisThr: 1.098 ± 0.042
1.273HisVal: 1.273 ± 0.039
0.182HisTrp: 0.182 ± 0.016
0.637HisTyr: 0.637 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
7.4IleAla: 7.4 ± 0.121
0.843IleCys: 0.843 ± 0.036
4.089IleAsp: 4.089 ± 0.07
4.577IleGlu: 4.577 ± 0.086
2.415IlePhe: 2.415 ± 0.071
6.062IleGly: 6.062 ± 0.117
1.181IleHis: 1.181 ± 0.047
3.886IleIle: 3.886 ± 0.075
1.745IleLys: 1.745 ± 0.054
6.077IleLeu: 6.077 ± 0.121
1.298IleMet: 1.298 ± 0.044
1.714IleAsn: 1.714 ± 0.057
3.517IlePro: 3.517 ± 0.064
1.382IleGln: 1.382 ± 0.048
4.892IleArg: 4.892 ± 0.09
3.621IleSer: 3.621 ± 0.08
4.13IleThr: 4.13 ± 0.091
5.583IleVal: 5.583 ± 0.112
0.551IleTrp: 0.551 ± 0.028
1.874IleTyr: 1.874 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
3.137LysAla: 3.137 ± 0.072
0.345LysCys: 0.345 ± 0.024
1.854LysAsp: 1.854 ± 0.066
2.743LysGlu: 2.743 ± 0.075
0.919LysPhe: 0.919 ± 0.043
2.648LysGly: 2.648 ± 0.072
0.7LysHis: 0.7 ± 0.034
2.328LysIle: 2.328 ± 0.058
2.091LysLys: 2.091 ± 0.058
2.442LysLeu: 2.442 ± 0.082
0.982LysMet: 0.982 ± 0.036
1.342LysAsn: 1.342 ± 0.045
1.619LysPro: 1.619 ± 0.05
1.152LysGln: 1.152 ± 0.041
2.387LysArg: 2.387 ± 0.066
1.754LysSer: 1.754 ± 0.05
2.255LysThr: 2.255 ± 0.061
2.443LysVal: 2.443 ± 0.069
0.289LysTrp: 0.289 ± 0.021
1.005LysTyr: 1.005 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
10.608LeuAla: 10.608 ± 0.154
1.117LeuCys: 1.117 ± 0.041
5.339LeuAsp: 5.339 ± 0.101
5.957LeuGlu: 5.957 ± 0.098
3.895LeuPhe: 3.895 ± 0.101
7.558LeuGly: 7.558 ± 0.142
1.873LeuHis: 1.873 ± 0.054
6.381LeuIle: 6.381 ± 0.125
3.444LeuLys: 3.444 ± 0.079
10.296LeuLeu: 10.296 ± 0.201
2.12LeuMet: 2.12 ± 0.055
2.439LeuAsn: 2.439 ± 0.065
4.829LeuPro: 4.829 ± 0.105
2.632LeuGln: 2.632 ± 0.08
5.938LeuArg: 5.938 ± 0.11
5.693LeuSer: 5.693 ± 0.1
4.958LeuThr: 4.958 ± 0.098
7.211LeuVal: 7.211 ± 0.114
0.834LeuTrp: 0.834 ± 0.036
2.632LeuTyr: 2.632 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.426MetAla: 2.426 ± 0.055
0.196MetCys: 0.196 ± 0.016
1.287MetAsp: 1.287 ± 0.048
1.745MetGlu: 1.745 ± 0.052
0.614MetPhe: 0.614 ± 0.03
1.889MetGly: 1.889 ± 0.059
0.627MetHis: 0.627 ± 0.03
1.515MetIle: 1.515 ± 0.047
1.305MetLys: 1.305 ± 0.042
2.445MetLeu: 2.445 ± 0.057
0.691MetMet: 0.691 ± 0.03
0.84MetAsn: 0.84 ± 0.032
1.293MetPro: 1.293 ± 0.043
1.015MetGln: 1.015 ± 0.04
1.666MetArg: 1.666 ± 0.049
1.195MetSer: 1.195 ± 0.04
1.741MetThr: 1.741 ± 0.058
1.93MetVal: 1.93 ± 0.055
0.176MetTrp: 0.176 ± 0.016
0.592MetTyr: 0.592 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.628AsnAla: 2.628 ± 0.063
0.345AsnCys: 0.345 ± 0.027
1.339AsnAsp: 1.339 ± 0.041
1.527AsnGlu: 1.527 ± 0.052
0.851AsnPhe: 0.851 ± 0.037
2.211AsnGly: 2.211 ± 0.068
0.555AsnHis: 0.555 ± 0.031
1.917AsnIle: 1.917 ± 0.053
0.745AsnLys: 0.745 ± 0.041
2.946AsnLeu: 2.946 ± 0.084
0.596AsnMet: 0.596 ± 0.033
0.793AsnAsn: 0.793 ± 0.042
1.92AsnPro: 1.92 ± 0.055
0.671AsnGln: 0.671 ± 0.035
2.012AsnArg: 2.012 ± 0.064
1.155AsnSer: 1.155 ± 0.041
1.669AsnThr: 1.669 ± 0.073
2.164AsnVal: 2.164 ± 0.063
0.305AsnTrp: 0.305 ± 0.021
0.8AsnTyr: 0.8 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
5.148ProAla: 5.148 ± 0.097
0.603ProCys: 0.603 ± 0.025
3.385ProAsp: 3.385 ± 0.077
4.309ProGlu: 4.309 ± 0.096
1.87ProPhe: 1.87 ± 0.062
4.491ProGly: 4.491 ± 0.088
0.942ProHis: 0.942 ± 0.036
2.484ProIle: 2.484 ± 0.065
1.412ProLys: 1.412 ± 0.053
4.437ProLeu: 4.437 ± 0.094
0.938ProMet: 0.938 ± 0.034
1.007ProAsn: 1.007 ± 0.039
2.276ProPro: 2.276 ± 0.061
0.959ProGln: 0.959 ± 0.039
2.221ProArg: 2.221 ± 0.059
2.277ProSer: 2.277 ± 0.056
2.354ProThr: 2.354 ± 0.068
4.321ProVal: 4.321 ± 0.079
0.414ProTrp: 0.414 ± 0.023
1.442ProTyr: 1.442 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.245GlnAla: 2.245 ± 0.059
0.304GlnCys: 0.304 ± 0.022
1.271GlnAsp: 1.271 ± 0.037
1.877GlnGlu: 1.877 ± 0.059
0.942GlnPhe: 0.942 ± 0.039
1.823GlnGly: 1.823 ± 0.054
0.507GlnHis: 0.507 ± 0.026
1.772GlnIle: 1.772 ± 0.054
1.408GlnLys: 1.408 ± 0.048
1.85GlnLeu: 1.85 ± 0.055
0.789GlnMet: 0.789 ± 0.034
0.942GlnAsn: 0.942 ± 0.039
1.026GlnPro: 1.026 ± 0.043
1.091GlnGln: 1.091 ± 0.045
1.732GlnArg: 1.732 ± 0.055
1.264GlnSer: 1.264 ± 0.043
1.385GlnThr: 1.385 ± 0.047
1.994GlnVal: 1.994 ± 0.045
0.244GlnTrp: 0.244 ± 0.02
0.904GlnTyr: 0.904 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
5.505ArgAla: 5.505 ± 0.109
0.966ArgCys: 0.966 ± 0.044
4.007ArgAsp: 4.007 ± 0.081
5.878ArgGlu: 5.878 ± 0.104
2.636ArgPhe: 2.636 ± 0.062
4.399ArgGly: 4.399 ± 0.087
1.456ArgHis: 1.456 ± 0.05
4.78ArgIle: 4.78 ± 0.087
2.692ArgLys: 2.692 ± 0.057
6.02ArgLeu: 6.02 ± 0.112
2.177ArgMet: 2.177 ± 0.055
2.001ArgAsn: 2.001 ± 0.06
2.673ArgPro: 2.673 ± 0.064
2.096ArgGln: 2.096 ± 0.069
4.911ArgArg: 4.911 ± 0.101
3.797ArgSer: 3.797 ± 0.082
3.36ArgThr: 3.36 ± 0.07
4.539ArgVal: 4.539 ± 0.098
0.705ArgTrp: 0.705 ± 0.034
2.558ArgTyr: 2.558 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
4.918SerAla: 4.918 ± 0.076
0.664SerCys: 0.664 ± 0.032
2.834SerAsp: 2.834 ± 0.071
3.139SerGlu: 3.139 ± 0.071
2.032SerPhe: 2.032 ± 0.066
5.691SerGly: 5.691 ± 0.099
0.997SerHis: 0.997 ± 0.038
3.509SerIle: 3.509 ± 0.072
1.331SerLys: 1.331 ± 0.043
5.314SerLeu: 5.314 ± 0.098
1.24SerMet: 1.24 ± 0.037
1.244SerAsn: 1.244 ± 0.042
2.974SerPro: 2.974 ± 0.068
1.219SerGln: 1.219 ± 0.044
3.637SerArg: 3.637 ± 0.081
3.114SerSer: 3.114 ± 0.078
2.97SerThr: 2.97 ± 0.083
4.444SerVal: 4.444 ± 0.082
0.509SerTrp: 0.509 ± 0.028
1.537SerTyr: 1.537 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.976ThrAla: 5.976 ± 0.117
0.698ThrCys: 0.698 ± 0.039
3.114ThrAsp: 3.114 ± 0.077
3.595ThrGlu: 3.595 ± 0.092
2.195ThrPhe: 2.195 ± 0.059
5.842ThrGly: 5.842 ± 0.115
0.956ThrHis: 0.956 ± 0.045
3.981ThrIle: 3.981 ± 0.091
1.627ThrLys: 1.627 ± 0.059
5.783ThrLeu: 5.783 ± 0.086
1.298ThrMet: 1.298 ± 0.051
1.371ThrAsn: 1.371 ± 0.044
3.439ThrPro: 3.439 ± 0.086
0.996ThrGln: 0.996 ± 0.041
3.0ThrArg: 3.0 ± 0.069
2.748ThrSer: 2.748 ± 0.068
3.336ThrThr: 3.336 ± 0.07
5.549ThrVal: 5.549 ± 0.116
0.525ThrTrp: 0.525 ± 0.031
1.768ThrTyr: 1.768 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
7.807ValAla: 7.807 ± 0.119
1.141ValCys: 1.141 ± 0.041
4.399ValAsp: 4.399 ± 0.09
4.958ValGlu: 4.958 ± 0.094
2.974ValPhe: 2.974 ± 0.074
5.904ValGly: 5.904 ± 0.103
1.578ValHis: 1.578 ± 0.049
5.149ValIle: 5.149 ± 0.088
2.639ValLys: 2.639 ± 0.065
7.835ValLeu: 7.835 ± 0.12
2.026ValMet: 2.026 ± 0.054
2.25ValAsn: 2.25 ± 0.066
4.139ValPro: 4.139 ± 0.086
2.05ValGln: 2.05 ± 0.055
5.524ValArg: 5.524 ± 0.108
4.566ValSer: 4.566 ± 0.098
5.385ValThr: 5.385 ± 0.117
6.676ValVal: 6.676 ± 0.119
0.789ValTrp: 0.789 ± 0.039
2.36ValTyr: 2.36 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.697TrpAla: 0.697 ± 0.029
0.139TrpCys: 0.139 ± 0.013
0.551TrpAsp: 0.551 ± 0.032
0.681TrpGlu: 0.681 ± 0.031
0.396TrpPhe: 0.396 ± 0.025
0.653TrpGly: 0.653 ± 0.029
0.23TrpHis: 0.23 ± 0.018
0.643TrpIle: 0.643 ± 0.034
0.491TrpLys: 0.491 ± 0.028
0.946TrpLeu: 0.946 ± 0.041
0.264TrpMet: 0.264 ± 0.021
0.431TrpAsn: 0.431 ± 0.028
0.304TrpPro: 0.304 ± 0.023
0.407TrpGln: 0.407 ± 0.03
0.685TrpArg: 0.685 ± 0.035
0.546TrpSer: 0.546 ± 0.03
0.536TrpThr: 0.536 ± 0.031
0.753TrpVal: 0.753 ± 0.042
0.15TrpTrp: 0.15 ± 0.015
0.348TrpTyr: 0.348 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.912TyrAla: 2.912 ± 0.071
0.455TyrCys: 0.455 ± 0.03
1.805TyrAsp: 1.805 ± 0.056
1.755TyrGlu: 1.755 ± 0.049
1.087TyrPhe: 1.087 ± 0.045
2.775TyrGly: 2.775 ± 0.06
0.631TyrHis: 0.631 ± 0.032
1.772TyrIle: 1.772 ± 0.051
0.707TyrLys: 0.707 ± 0.033
3.126TyrLeu: 3.126 ± 0.076
0.607TyrMet: 0.607 ± 0.032
0.902TyrAsn: 0.902 ± 0.037
1.639TyrPro: 1.639 ± 0.054
0.824TyrGln: 0.824 ± 0.039
2.433TyrArg: 2.433 ± 0.059
1.582TyrSer: 1.582 ± 0.048
1.968TyrThr: 1.968 ± 0.055
2.179TyrVal: 2.179 ± 0.052
0.349TyrTrp: 0.349 ± 0.025
1.066TyrTyr: 1.066 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2433 proteins (704774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski