Amino acid dipepetide frequency for Syntrophus aciditrophicus (strain SB)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.087AlaAla: 8.087 ± 0.131	1.181AlaCys: 1.181 ± 0.037	4.614AlaAsp: 4.614 ± 0.083	5.549AlaGlu: 5.549 ± 0.081	3.449AlaPhe: 3.449 ± 0.071	7.172AlaGly: 7.172 ± 0.101	1.425AlaHis: 1.425 ± 0.04	5.053AlaIle: 5.053 ± 0.083	3.576AlaLys: 3.576 ± 0.071	8.729AlaLeu: 8.729 ± 0.121	2.376AlaMet: 2.376 ± 0.053	2.184AlaAsn: 2.184 ± 0.05	2.644AlaPro: 2.644 ± 0.061	2.284AlaGln: 2.284 ± 0.05	5.235AlaArg: 5.235 ± 0.087	4.407AlaSer: 4.407 ± 0.087	3.589AlaThr: 3.589 ± 0.065	6.655AlaVal: 6.655 ± 0.082	0.933AlaTrp: 0.933 ± 0.039	2.255AlaTyr: 2.255 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.035	0.263CysCys: 0.263 ± 0.018	0.608CysAsp: 0.608 ± 0.026	0.678CysGlu: 0.678 ± 0.028	0.574CysPhe: 0.574 ± 0.023	1.23CysGly: 1.23 ± 0.044	0.412CysHis: 0.412 ± 0.027	0.709CysIle: 0.709 ± 0.029	0.464CysLys: 0.464 ± 0.021	1.322CysLeu: 1.322 ± 0.037	0.327CysMet: 0.327 ± 0.019	0.432CysAsn: 0.432 ± 0.022	0.891CysPro: 0.891 ± 0.039	0.36CysGln: 0.36 ± 0.023	1.182CysArg: 1.182 ± 0.035	0.95CysSer: 0.95 ± 0.039	0.546CysThr: 0.546 ± 0.027	0.8CysVal: 0.8 ± 0.03	0.135CysTrp: 0.135 ± 0.013	0.355CysTyr: 0.355 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.18AspAla: 4.18 ± 0.078	0.66AspCys: 0.66 ± 0.028	2.528AspAsp: 2.528 ± 0.062	3.68AspGlu: 3.68 ± 0.066	2.663AspPhe: 2.663 ± 0.057	3.658AspGly: 3.658 ± 0.073	1.075AspHis: 1.075 ± 0.039	4.064AspIle: 4.064 ± 0.066	2.379AspLys: 2.379 ± 0.061	5.651AspLeu: 5.651 ± 0.091	1.431AspMet: 1.431 ± 0.037	1.543AspAsn: 1.543 ± 0.046	2.618AspPro: 2.618 ± 0.055	1.508AspGln: 1.508 ± 0.044	3.818AspArg: 3.818 ± 0.073	3.038AspSer: 3.038 ± 0.06	2.173AspThr: 2.173 ± 0.051	3.853AspVal: 3.853 ± 0.059	0.655AspTrp: 0.655 ± 0.029	1.921AspTyr: 1.921 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.971GluAla: 5.971 ± 0.09	0.604GluCys: 0.604 ± 0.026	3.336GluAsp: 3.336 ± 0.066	5.526GluGlu: 5.526 ± 0.097	2.289GluPhe: 2.289 ± 0.056	4.731GluGly: 4.731 ± 0.069	1.207GluHis: 1.207 ± 0.038	5.409GluIle: 5.409 ± 0.074	5.871GluLys: 5.871 ± 0.091	6.206GluLeu: 6.206 ± 0.096	2.049GluMet: 2.049 ± 0.049	2.833GluAsn: 2.833 ± 0.058	2.172GluPro: 2.172 ± 0.052	2.406GluGln: 2.406 ± 0.057	4.472GluArg: 4.472 ± 0.077	3.648GluSer: 3.648 ± 0.07	3.611GluThr: 3.611 ± 0.066	4.12GluVal: 4.12 ± 0.069	0.59GluTrp: 0.59 ± 0.023	1.821GluTyr: 1.821 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.902PheAla: 2.902 ± 0.056	0.696PheCys: 0.696 ± 0.029	2.309PheAsp: 2.309 ± 0.05	2.326PheGlu: 2.326 ± 0.052	2.327PhePhe: 2.327 ± 0.06	3.005PheGly: 3.005 ± 0.062	1.028PheHis: 1.028 ± 0.035	2.642PheIle: 2.642 ± 0.06	1.89PheLys: 1.89 ± 0.053	4.864PheLeu: 4.864 ± 0.075	1.036PheMet: 1.036 ± 0.035	1.475PheAsn: 1.475 ± 0.041	2.01PhePro: 2.01 ± 0.047	1.465PheGln: 1.465 ± 0.041	2.629PheArg: 2.629 ± 0.052	3.267PheSer: 3.267 ± 0.05	2.121PheThr: 2.121 ± 0.039	2.695PheVal: 2.695 ± 0.052	0.511PheTrp: 0.511 ± 0.022	1.476PheTyr: 1.476 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.447GlyAla: 5.447 ± 0.094	1.204GlyCys: 1.204 ± 0.043	3.691GlyAsp: 3.691 ± 0.063	4.539GlyGlu: 4.539 ± 0.077	3.318GlyPhe: 3.318 ± 0.063	5.709GlyGly: 5.709 ± 0.092	1.551GlyHis: 1.551 ± 0.037	6.101GlyIle: 6.101 ± 0.087	5.107GlyLys: 5.107 ± 0.076	6.919GlyLeu: 6.919 ± 0.102	2.397GlyMet: 2.397 ± 0.054	2.798GlyAsn: 2.798 ± 0.053	2.222GlyPro: 2.222 ± 0.045	2.239GlyGln: 2.239 ± 0.043	5.097GlyArg: 5.097 ± 0.076	4.372GlySer: 4.372 ± 0.068	3.95GlyThr: 3.95 ± 0.076	4.827GlyVal: 4.827 ± 0.077	0.918GlyTrp: 0.918 ± 0.034	2.568GlyTyr: 2.568 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.491HisAla: 1.491 ± 0.041	0.304HisCys: 0.304 ± 0.016	1.041HisAsp: 1.041 ± 0.033	1.185HisGlu: 1.185 ± 0.037	0.953HisPhe: 0.953 ± 0.035	1.504HisGly: 1.504 ± 0.042	0.564HisHis: 0.564 ± 0.027	1.34HisIle: 1.34 ± 0.034	0.815HisLys: 0.815 ± 0.029	2.079HisLeu: 2.079 ± 0.054	0.44HisMet: 0.44 ± 0.023	0.682HisAsn: 0.682 ± 0.028	1.275HisPro: 1.275 ± 0.032	0.613HisGln: 0.613 ± 0.026	1.34HisArg: 1.34 ± 0.037	1.15HisSer: 1.15 ± 0.035	0.859HisThr: 0.859 ± 0.031	1.275HisVal: 1.275 ± 0.037	0.223HisTrp: 0.223 ± 0.015	0.719HisTyr: 0.719 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.932IleAla: 5.932 ± 0.078	0.864IleCys: 0.864 ± 0.03	3.853IleAsp: 3.853 ± 0.061	4.414IleGlu: 4.414 ± 0.081	2.994IlePhe: 2.994 ± 0.054	4.916IleGly: 4.916 ± 0.081	1.402IleHis: 1.402 ± 0.043	4.04IleIle: 4.04 ± 0.075	3.228IleLys: 3.228 ± 0.067	7.385IleLeu: 7.385 ± 0.094	1.679IleMet: 1.679 ± 0.041	2.365IleAsn: 2.365 ± 0.055	3.555IlePro: 3.555 ± 0.068	2.14IleGln: 2.14 ± 0.048	4.925IleArg: 4.925 ± 0.082	4.854IleSer: 4.854 ± 0.073	3.39IleThr: 3.39 ± 0.062	4.674IleVal: 4.674 ± 0.066	0.503IleTrp: 0.503 ± 0.026	1.863IleTyr: 1.863 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.55LysAla: 4.55 ± 0.077	0.529LysCys: 0.529 ± 0.022	2.852LysAsp: 2.852 ± 0.06	4.497LysGlu: 4.497 ± 0.082	1.568LysPhe: 1.568 ± 0.043	4.118LysGly: 4.118 ± 0.082	0.913LysHis: 0.913 ± 0.032	4.266LysIle: 4.266 ± 0.064	4.298LysLys: 4.298 ± 0.085	4.431LysLeu: 4.431 ± 0.069	1.682LysMet: 1.682 ± 0.04	2.444LysAsn: 2.444 ± 0.059	2.301LysPro: 2.301 ± 0.047	1.662LysGln: 1.662 ± 0.043	3.542LysArg: 3.542 ± 0.061	3.106LysSer: 3.106 ± 0.061	3.229LysThr: 3.229 ± 0.056	3.46LysVal: 3.46 ± 0.069	0.515LysTrp: 0.515 ± 0.023	1.537LysTyr: 1.537 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	8.343LeuAla: 8.343 ± 0.113	1.37LeuCys: 1.37 ± 0.039	5.405LeuAsp: 5.405 ± 0.078	6.545LeuGlu: 6.545 ± 0.095	4.458LeuPhe: 4.458 ± 0.088	6.607LeuGly: 6.607 ± 0.092	1.978LeuHis: 1.978 ± 0.054	6.554LeuIle: 6.554 ± 0.097	6.468LeuLys: 6.468 ± 0.089	9.989LeuLeu: 9.989 ± 0.15	2.581LeuMet: 2.581 ± 0.056	3.81LeuAsn: 3.81 ± 0.069	4.841LeuPro: 4.841 ± 0.08	3.27LeuGln: 3.27 ± 0.062	6.048LeuArg: 6.048 ± 0.095	7.187LeuSer: 7.187 ± 0.094	5.196LeuThr: 5.196 ± 0.074	5.979LeuVal: 5.979 ± 0.08	0.979LeuTrp: 0.979 ± 0.037	2.827LeuTyr: 2.827 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.514MetAla: 2.514 ± 0.053	0.209MetCys: 0.209 ± 0.016	1.519MetAsp: 1.519 ± 0.041	2.13MetGlu: 2.13 ± 0.053	0.734MetPhe: 0.734 ± 0.027	1.962MetGly: 1.962 ± 0.048	0.442MetHis: 0.442 ± 0.022	1.974MetIle: 1.974 ± 0.047	2.228MetLys: 2.228 ± 0.053	2.248MetLeu: 2.248 ± 0.044	0.828MetMet: 0.828 ± 0.034	1.275MetAsn: 1.275 ± 0.037	1.263MetPro: 1.263 ± 0.038	0.786MetGln: 0.786 ± 0.03	1.448MetArg: 1.448 ± 0.039	1.493MetSer: 1.493 ± 0.037	1.767MetThr: 1.767 ± 0.041	1.628MetVal: 1.628 ± 0.044	0.199MetTrp: 0.199 ± 0.013	0.409MetTyr: 0.409 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.829AsnAla: 2.829 ± 0.051	0.473AsnCys: 0.473 ± 0.028	1.674AsnAsp: 1.674 ± 0.043	1.985AsnGlu: 1.985 ± 0.052	1.49AsnPhe: 1.49 ± 0.038	2.399AsnGly: 2.399 ± 0.057	0.683AsnHis: 0.683 ± 0.024	2.644AsnIle: 2.644 ± 0.061	1.513AsnLys: 1.513 ± 0.043	3.846AsnLeu: 3.846 ± 0.069	0.889AsnMet: 0.889 ± 0.034	1.166AsnAsn: 1.166 ± 0.04	2.37AsnPro: 2.37 ± 0.052	1.083AsnGln: 1.083 ± 0.037	2.648AsnArg: 2.648 ± 0.062	2.049AsnSer: 2.049 ± 0.05	1.548AsnThr: 1.548 ± 0.046	2.427AsnVal: 2.427 ± 0.052	0.455AsnTrp: 0.455 ± 0.022	1.141AsnTyr: 1.141 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.772ProAla: 3.772 ± 0.075	0.537ProCys: 0.537 ± 0.023	3.02ProAsp: 3.02 ± 0.067	4.129ProGlu: 4.129 ± 0.074	2.031ProPhe: 2.031 ± 0.051	3.683ProGly: 3.683 ± 0.067	0.931ProHis: 0.931 ± 0.032	2.237ProIle: 2.237 ± 0.048	1.689ProLys: 1.689 ± 0.042	4.403ProLeu: 4.403 ± 0.067	1.037ProMet: 1.037 ± 0.035	1.114ProAsn: 1.114 ± 0.03	2.016ProPro: 2.016 ± 0.048	1.369ProGln: 1.369 ± 0.046	2.195ProArg: 2.195 ± 0.05	2.629ProSer: 2.629 ± 0.051	1.811ProThr: 1.811 ± 0.047	3.711ProVal: 3.711 ± 0.067	0.539ProTrp: 0.539 ± 0.024	1.37ProTyr: 1.37 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.929GlnAla: 2.929 ± 0.053	0.363GlnCys: 0.363 ± 0.019	1.607GlnAsp: 1.607 ± 0.04	2.444GlnGlu: 2.444 ± 0.048	1.034GlnPhe: 1.034 ± 0.029	2.286GlnGly: 2.286 ± 0.058	0.538GlnHis: 0.538 ± 0.022	2.195GlnIle: 2.195 ± 0.054	2.166GlnLys: 2.166 ± 0.056	2.668GlnLeu: 2.668 ± 0.053	0.803GlnMet: 0.803 ± 0.028	1.208GlnAsn: 1.208 ± 0.044	1.253GlnPro: 1.253 ± 0.044	1.169GlnGln: 1.169 ± 0.042	2.047GlnArg: 2.047 ± 0.053	1.686GlnSer: 1.686 ± 0.042	1.617GlnThr: 1.617 ± 0.043	2.056GlnVal: 2.056 ± 0.054	0.342GlnTrp: 0.342 ± 0.022	0.834GlnTyr: 0.834 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.031ArgAla: 4.031 ± 0.062	0.822ArgCys: 0.822 ± 0.029	3.467ArgAsp: 3.467 ± 0.064	5.423ArgGlu: 5.423 ± 0.085	2.965ArgPhe: 2.965 ± 0.052	4.162ArgGly: 4.162 ± 0.078	1.371ArgHis: 1.371 ± 0.041	5.232ArgIle: 5.232 ± 0.087	4.278ArgLys: 4.278 ± 0.067	6.53ArgLeu: 6.53 ± 0.096	1.931ArgMet: 1.931 ± 0.052	2.727ArgAsn: 2.727 ± 0.065	2.414ArgPro: 2.414 ± 0.055	2.398ArgGln: 2.398 ± 0.059	4.468ArgArg: 4.468 ± 0.086	3.51ArgSer: 3.51 ± 0.069	3.012ArgThr: 3.012 ± 0.059	3.972ArgVal: 3.972 ± 0.066	0.719ArgTrp: 0.719 ± 0.027	2.194ArgTyr: 2.194 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.778SerAla: 4.778 ± 0.078	0.956SerCys: 0.956 ± 0.035	3.134SerAsp: 3.134 ± 0.066	3.669SerGlu: 3.669 ± 0.059	2.918SerPhe: 2.918 ± 0.057	5.528SerGly: 5.528 ± 0.088	1.23SerHis: 1.23 ± 0.034	3.962SerIle: 3.962 ± 0.06	2.39SerLys: 2.39 ± 0.055	6.727SerLeu: 6.727 ± 0.092	1.678SerMet: 1.678 ± 0.043	1.809SerAsn: 1.809 ± 0.049	2.885SerPro: 2.885 ± 0.044	1.793SerGln: 1.793 ± 0.046	4.444SerArg: 4.444 ± 0.071	4.166SerSer: 4.166 ± 0.09	2.669SerThr: 2.669 ± 0.062	3.949SerVal: 3.949 ± 0.067	0.762SerTrp: 0.762 ± 0.027	1.764SerTyr: 1.764 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.491ThrAla: 4.491 ± 0.071	0.631ThrCys: 0.631 ± 0.029	2.571ThrAsp: 2.571 ± 0.055	3.198ThrGlu: 3.198 ± 0.056	2.01ThrPhe: 2.01 ± 0.052	4.726ThrGly: 4.726 ± 0.081	0.902ThrHis: 0.902 ± 0.03	3.234ThrIle: 3.234 ± 0.057	1.767ThrLys: 1.767 ± 0.053	5.265ThrLeu: 5.265 ± 0.083	1.166ThrMet: 1.166 ± 0.036	1.393ThrAsn: 1.393 ± 0.047	2.544ThrPro: 2.544 ± 0.048	1.299ThrGln: 1.299 ± 0.04	2.775ThrArg: 2.775 ± 0.053	2.807ThrSer: 2.807 ± 0.054	2.468ThrThr: 2.468 ± 0.069	3.858ThrVal: 3.858 ± 0.061	0.513ThrTrp: 0.513 ± 0.021	1.353ThrTyr: 1.353 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.347ValAla: 5.347 ± 0.09	0.935ValCys: 0.935 ± 0.038	3.721ValAsp: 3.721 ± 0.077	4.341ValGlu: 4.341 ± 0.083	2.919ValPhe: 2.919 ± 0.06	4.423ValGly: 4.423 ± 0.077	1.29ValHis: 1.29 ± 0.034	4.993ValIle: 4.993 ± 0.075	3.529ValLys: 3.529 ± 0.068	6.897ValLeu: 6.897 ± 0.09	1.814ValMet: 1.814 ± 0.047	2.487ValAsn: 2.487 ± 0.058	2.972ValPro: 2.972 ± 0.057	1.914ValGln: 1.914 ± 0.037	4.23ValArg: 4.23 ± 0.076	4.461ValSer: 4.461 ± 0.074	3.55ValThr: 3.55 ± 0.067	4.835ValVal: 4.835 ± 0.086	0.611ValTrp: 0.611 ± 0.027	1.874ValTyr: 1.874 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.647TrpAla: 0.647 ± 0.026	0.138TrpCys: 0.138 ± 0.013	0.509TrpAsp: 0.509 ± 0.022	0.681TrpGlu: 0.681 ± 0.03	0.488TrpPhe: 0.488 ± 0.025	0.768TrpGly: 0.768 ± 0.031	0.218TrpHis: 0.218 ± 0.015	0.767TrpIle: 0.767 ± 0.031	0.651TrpLys: 0.651 ± 0.025	1.094TrpLeu: 1.094 ± 0.037	0.338TrpMet: 0.338 ± 0.019	0.503TrpAsn: 0.503 ± 0.024	0.431TrpPro: 0.431 ± 0.022	0.446TrpGln: 0.446 ± 0.022	0.742TrpArg: 0.742 ± 0.028	0.559TrpSer: 0.559 ± 0.025	0.527TrpThr: 0.527 ± 0.022	0.632TrpVal: 0.632 ± 0.029	0.168TrpTrp: 0.168 ± 0.014	0.314TrpTyr: 0.314 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.182TyrAla: 2.182 ± 0.046	0.472TyrCys: 0.472 ± 0.022	1.638TyrAsp: 1.638 ± 0.047	1.93TyrGlu: 1.93 ± 0.045	1.495TyrPhe: 1.495 ± 0.046	2.387TyrGly: 2.387 ± 0.05	0.692TyrHis: 0.692 ± 0.025	1.559TyrIle: 1.559 ± 0.041	1.193TyrLys: 1.193 ± 0.04	3.181TyrLeu: 3.181 ± 0.062	0.572TyrMet: 0.572 ± 0.025	1.065TyrAsn: 1.065 ± 0.037	1.546TyrPro: 1.546 ± 0.044	1.042TyrGln: 1.042 ± 0.036	2.339TyrArg: 2.339 ± 0.051	1.871TyrSer: 1.871 ± 0.052	1.339TyrThr: 1.339 ± 0.034	1.737TyrVal: 1.737 ± 0.046	0.352TyrTrp: 0.352 ± 0.02	1.012TyrTyr: 1.012 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3145 proteins (933651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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