Amino acid dipepetide frequency for Parahaliea aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.32AlaAla: 14.32 ± 0.158	1.286AlaCys: 1.286 ± 0.035	6.412AlaAsp: 6.412 ± 0.07	7.172AlaGlu: 7.172 ± 0.088	3.751AlaPhe: 3.751 ± 0.058	10.411AlaGly: 10.411 ± 0.122	1.996AlaHis: 1.996 ± 0.042	4.947AlaIle: 4.947 ± 0.059	2.441AlaLys: 2.441 ± 0.052	13.194AlaLeu: 13.194 ± 0.122	2.951AlaMet: 2.951 ± 0.054	2.88AlaAsn: 2.88 ± 0.055	4.821AlaPro: 4.821 ± 0.071	4.061AlaGln: 4.061 ± 0.064	7.602AlaArg: 7.602 ± 0.09	6.566AlaSer: 6.566 ± 0.076	5.38AlaThr: 5.38 ± 0.074	8.128AlaVal: 8.128 ± 0.094	1.481AlaTrp: 1.481 ± 0.032	2.562AlaTyr: 2.562 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.166CysAla: 1.166 ± 0.031	0.156CysCys: 0.156 ± 0.011	0.597CysAsp: 0.597 ± 0.023	0.646CysGlu: 0.646 ± 0.027	0.361CysPhe: 0.361 ± 0.017	1.01CysGly: 1.01 ± 0.027	0.332CysHis: 0.332 ± 0.019	0.483CysIle: 0.483 ± 0.019	0.235CysLys: 0.235 ± 0.013	1.114CysLeu: 1.114 ± 0.029	0.219CysMet: 0.219 ± 0.012	0.295CysAsn: 0.295 ± 0.014	0.535CysPro: 0.535 ± 0.023	0.414CysGln: 0.414 ± 0.018	0.777CysArg: 0.777 ± 0.027	0.665CysSer: 0.665 ± 0.024	0.45CysThr: 0.45 ± 0.016	0.635CysVal: 0.635 ± 0.023	0.147CysTrp: 0.147 ± 0.01	0.3CysTyr: 0.3 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.109AspAla: 6.109 ± 0.072	0.703AspCys: 0.703 ± 0.024	3.393AspAsp: 3.393 ± 0.059	3.688AspGlu: 3.688 ± 0.057	2.502AspPhe: 2.502 ± 0.046	4.913AspGly: 4.913 ± 0.079	1.151AspHis: 1.151 ± 0.028	3.448AspIle: 3.448 ± 0.063	1.699AspLys: 1.699 ± 0.04	5.804AspLeu: 5.804 ± 0.064	1.383AspMet: 1.383 ± 0.031	2.095AspAsn: 2.095 ± 0.048	3.073AspPro: 3.073 ± 0.054	1.863AspGln: 1.863 ± 0.043	3.563AspArg: 3.563 ± 0.054	3.829AspSer: 3.829 ± 0.065	3.064AspThr: 3.064 ± 0.062	3.847AspVal: 3.847 ± 0.054	1.067AspTrp: 1.067 ± 0.03	2.222AspTyr: 2.222 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.954GluAla: 6.954 ± 0.082	0.447GluCys: 0.447 ± 0.019	3.332GluAsp: 3.332 ± 0.061	3.797GluGlu: 3.797 ± 0.073	2.11GluPhe: 2.11 ± 0.044	4.618GluGly: 4.618 ± 0.062	1.494GluHis: 1.494 ± 0.032	2.932GluIle: 2.932 ± 0.059	2.01GluLys: 2.01 ± 0.042	7.124GluLeu: 7.124 ± 0.088	1.402GluMet: 1.402 ± 0.034	1.765GluAsn: 1.765 ± 0.046	2.699GluPro: 2.699 ± 0.058	3.617GluGln: 3.617 ± 0.057	4.899GluArg: 4.899 ± 0.071	3.342GluSer: 3.342 ± 0.045	2.822GluThr: 2.822 ± 0.039	4.699GluVal: 4.699 ± 0.064	0.794GluTrp: 0.794 ± 0.027	1.589GluTyr: 1.589 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.819PheAla: 3.819 ± 0.059	0.445PheCys: 0.445 ± 0.018	2.672PheAsp: 2.672 ± 0.05	2.214PheGlu: 2.214 ± 0.048	1.343PhePhe: 1.343 ± 0.034	3.252PheGly: 3.252 ± 0.064	0.815PheHis: 0.815 ± 0.031	1.682PheIle: 1.682 ± 0.036	0.874PheLys: 0.874 ± 0.027	3.289PheLeu: 3.289 ± 0.053	0.828PheMet: 0.828 ± 0.028	1.331PheAsn: 1.331 ± 0.031	1.526PhePro: 1.526 ± 0.036	1.161PheGln: 1.161 ± 0.029	2.219PheArg: 2.219 ± 0.041	2.688PheSer: 2.688 ± 0.048	1.955PheThr: 1.955 ± 0.043	2.374PheVal: 2.374 ± 0.04	0.455PheTrp: 0.455 ± 0.019	1.151PheTyr: 1.151 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.322GlyAla: 8.322 ± 0.085	0.896GlyCys: 0.896 ± 0.031	4.97GlyAsp: 4.97 ± 0.07	5.832GlyGlu: 5.832 ± 0.065	3.364GlyPhe: 3.364 ± 0.056	7.25GlyGly: 7.25 ± 0.125	1.795GlyHis: 1.795 ± 0.037	4.274GlyIle: 4.274 ± 0.061	2.862GlyLys: 2.862 ± 0.045	8.672GlyLeu: 8.672 ± 0.088	2.28GlyMet: 2.28 ± 0.043	2.629GlyAsn: 2.629 ± 0.052	2.942GlyPro: 2.942 ± 0.057	3.21GlyGln: 3.21 ± 0.048	5.299GlyArg: 5.299 ± 0.07	5.2GlySer: 5.2 ± 0.09	4.031GlyThr: 4.031 ± 0.082	6.013GlyVal: 6.013 ± 0.081	1.291GlyTrp: 1.291 ± 0.033	2.583GlyTyr: 2.583 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.771HisAla: 1.771 ± 0.038	0.378HisCys: 0.378 ± 0.016	0.949HisAsp: 0.949 ± 0.026	0.993HisGlu: 0.993 ± 0.033	1.009HisPhe: 1.009 ± 0.027	1.73HisGly: 1.73 ± 0.038	0.617HisHis: 0.617 ± 0.024	1.074HisIle: 1.074 ± 0.025	0.525HisLys: 0.525 ± 0.024	2.316HisLeu: 2.316 ± 0.045	0.502HisMet: 0.502 ± 0.019	0.689HisAsn: 0.689 ± 0.019	1.377HisPro: 1.377 ± 0.036	0.86HisGln: 0.86 ± 0.027	1.671HisArg: 1.671 ± 0.035	1.404HisSer: 1.404 ± 0.034	1.045HisThr: 1.045 ± 0.029	1.14HisVal: 1.14 ± 0.032	0.443HisTrp: 0.443 ± 0.019	0.841HisTyr: 0.841 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.674IleAla: 5.674 ± 0.061	0.51IleCys: 0.51 ± 0.021	3.528IleAsp: 3.528 ± 0.052	3.179IleGlu: 3.179 ± 0.058	1.405IlePhe: 1.405 ± 0.033	3.971IleGly: 3.971 ± 0.06	1.003IleHis: 1.003 ± 0.028	1.859IleIle: 1.859 ± 0.045	1.302IleLys: 1.302 ± 0.038	3.846IleLeu: 3.846 ± 0.059	0.813IleMet: 0.813 ± 0.025	1.702IleAsn: 1.702 ± 0.036	2.296IlePro: 2.296 ± 0.044	1.415IleGln: 1.415 ± 0.029	2.833IleArg: 2.833 ± 0.047	2.893IleSer: 2.893 ± 0.054	2.637IleThr: 2.637 ± 0.049	3.188IleVal: 3.188 ± 0.055	0.465IleTrp: 0.465 ± 0.022	1.248IleTyr: 1.248 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.125LysAla: 3.125 ± 0.064	0.183LysCys: 0.183 ± 0.014	1.367LysAsp: 1.367 ± 0.037	1.41LysGlu: 1.41 ± 0.039	0.728LysPhe: 0.728 ± 0.026	2.08LysGly: 2.08 ± 0.043	0.59LysHis: 0.59 ± 0.022	1.222LysIle: 1.222 ± 0.035	1.023LysLys: 1.023 ± 0.041	2.934LysLeu: 2.934 ± 0.055	0.578LysMet: 0.578 ± 0.02	0.783LysAsn: 0.783 ± 0.025	1.564LysPro: 1.564 ± 0.036	1.217LysGln: 1.217 ± 0.032	1.916LysArg: 1.916 ± 0.045	1.565LysSer: 1.565 ± 0.04	1.416LysThr: 1.416 ± 0.041	2.186LysVal: 2.186 ± 0.047	0.299LysTrp: 0.299 ± 0.016	0.693LysTyr: 0.693 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.667LeuAla: 13.667 ± 0.135	1.266LeuCys: 1.266 ± 0.034	6.608LeuAsp: 6.608 ± 0.072	6.722LeuGlu: 6.722 ± 0.084	3.662LeuPhe: 3.662 ± 0.062	8.572LeuGly: 8.572 ± 0.086	2.181LeuHis: 2.181 ± 0.041	4.178LeuIle: 4.178 ± 0.059	3.072LeuLys: 3.072 ± 0.062	12.222LeuLeu: 12.222 ± 0.155	2.304LeuMet: 2.304 ± 0.043	3.135LeuAsn: 3.135 ± 0.055	5.972LeuPro: 5.972 ± 0.069	4.964LeuGln: 4.964 ± 0.077	7.297LeuArg: 7.297 ± 0.093	6.678LeuSer: 6.678 ± 0.079	4.948LeuThr: 4.948 ± 0.072	7.531LeuVal: 7.531 ± 0.097	1.369LeuTrp: 1.369 ± 0.034	2.728LeuTyr: 2.728 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.758MetAla: 2.758 ± 0.047	0.178MetCys: 0.178 ± 0.012	1.315MetAsp: 1.315 ± 0.038	1.253MetGlu: 1.253 ± 0.029	0.64MetPhe: 0.64 ± 0.023	1.74MetGly: 1.74 ± 0.044	0.467MetHis: 0.467 ± 0.02	1.03MetIle: 1.03 ± 0.028	0.832MetLys: 0.832 ± 0.027	2.368MetLeu: 2.368 ± 0.046	0.524MetMet: 0.524 ± 0.021	0.769MetAsn: 0.769 ± 0.025	1.314MetPro: 1.314 ± 0.034	1.027MetGln: 1.027 ± 0.027	1.413MetArg: 1.413 ± 0.029	1.505MetSer: 1.505 ± 0.03	1.348MetThr: 1.348 ± 0.033	1.536MetVal: 1.536 ± 0.037	0.194MetTrp: 0.194 ± 0.012	0.429MetTyr: 0.429 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.195AsnAla: 3.195 ± 0.049	0.327AsnCys: 0.327 ± 0.015	1.578AsnAsp: 1.578 ± 0.04	1.504AsnGlu: 1.504 ± 0.035	1.133AsnPhe: 1.133 ± 0.031	2.478AsnGly: 2.478 ± 0.055	0.599AsnHis: 0.599 ± 0.021	1.605AsnIle: 1.605 ± 0.039	0.769AsnLys: 0.769 ± 0.026	3.156AsnLeu: 3.156 ± 0.045	0.657AsnMet: 0.657 ± 0.019	1.032AsnAsn: 1.032 ± 0.033	2.019AsnPro: 2.019 ± 0.037	1.049AsnGln: 1.049 ± 0.027	2.004AsnArg: 2.004 ± 0.041	1.78AsnSer: 1.78 ± 0.045	1.746AsnThr: 1.746 ± 0.042	1.962AsnVal: 1.962 ± 0.045	0.515AsnTrp: 0.515 ± 0.02	0.966AsnTyr: 0.966 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.974ProAla: 5.974 ± 0.095	0.422ProCys: 0.422 ± 0.015	3.287ProAsp: 3.287 ± 0.06	3.851ProGlu: 3.851 ± 0.059	1.721ProPhe: 1.721 ± 0.039	4.829ProGly: 4.829 ± 0.076	0.999ProHis: 0.999 ± 0.029	1.691ProIle: 1.691 ± 0.033	0.99ProLys: 0.99 ± 0.03	5.276ProLeu: 5.276 ± 0.064	1.067ProMet: 1.067 ± 0.028	1.234ProAsn: 1.234 ± 0.032	2.367ProPro: 2.367 ± 0.055	1.831ProGln: 1.831 ± 0.036	2.827ProArg: 2.827 ± 0.053	2.34ProSer: 2.34 ± 0.045	2.087ProThr: 2.087 ± 0.044	4.044ProVal: 4.044 ± 0.061	0.728ProTrp: 0.728 ± 0.025	1.162ProTyr: 1.162 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.842GlnAla: 4.842 ± 0.075	0.379GlnCys: 0.379 ± 0.018	1.878GlnAsp: 1.878 ± 0.04	1.954GlnGlu: 1.954 ± 0.036	1.368GlnPhe: 1.368 ± 0.035	2.987GlnGly: 2.987 ± 0.056	0.975GlnHis: 0.975 ± 0.024	1.619GlnIle: 1.619 ± 0.036	0.968GlnLys: 0.968 ± 0.031	5.0GlnLeu: 5.0 ± 0.094	0.928GlnMet: 0.928 ± 0.026	0.871GlnAsn: 0.871 ± 0.029	1.974GlnPro: 1.974 ± 0.04	2.451GlnGln: 2.451 ± 0.056	3.762GlnArg: 3.762 ± 0.063	2.205GlnSer: 2.205 ± 0.041	1.667GlnThr: 1.667 ± 0.032	3.196GlnVal: 3.196 ± 0.054	0.703GlnTrp: 0.703 ± 0.022	0.974GlnTyr: 0.974 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.628ArgAla: 6.628 ± 0.089	0.712ArgCys: 0.712 ± 0.026	4.146ArgAsp: 4.146 ± 0.063	5.029ArgGlu: 5.029 ± 0.076	2.708ArgPhe: 2.708 ± 0.048	4.893ArgGly: 4.893 ± 0.052	1.707ArgHis: 1.707 ± 0.039	3.438ArgIle: 3.438 ± 0.05	2.036ArgLys: 2.036 ± 0.04	7.46ArgLeu: 7.46 ± 0.087	1.521ArgMet: 1.521 ± 0.033	2.078ArgAsn: 2.078 ± 0.04	2.898ArgPro: 2.898 ± 0.048	3.302ArgGln: 3.302 ± 0.061	5.083ArgArg: 5.083 ± 0.076	3.75ArgSer: 3.75 ± 0.059	2.679ArgThr: 2.679 ± 0.041	4.613ArgVal: 4.613 ± 0.063	1.178ArgTrp: 1.178 ± 0.031	2.291ArgTyr: 2.291 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.703SerAla: 6.703 ± 0.08	0.532SerCys: 0.532 ± 0.024	3.644SerAsp: 3.644 ± 0.062	3.652SerGlu: 3.652 ± 0.053	2.15SerPhe: 2.15 ± 0.044	5.977SerGly: 5.977 ± 0.091	1.23SerHis: 1.23 ± 0.028	2.678SerIle: 2.678 ± 0.052	1.384SerLys: 1.384 ± 0.032	6.692SerLeu: 6.692 ± 0.091	1.251SerMet: 1.251 ± 0.032	1.742SerAsn: 1.742 ± 0.042	3.02SerPro: 3.02 ± 0.053	2.134SerGln: 2.134 ± 0.041	4.001SerArg: 4.001 ± 0.06	3.536SerSer: 3.536 ± 0.062	2.863SerThr: 2.863 ± 0.047	4.133SerVal: 4.133 ± 0.065	0.815SerTrp: 0.815 ± 0.026	1.725SerTyr: 1.725 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.464ThrAla: 5.464 ± 0.084	0.455ThrCys: 0.455 ± 0.018	2.698ThrAsp: 2.698 ± 0.046	2.665ThrGlu: 2.665 ± 0.044	1.804ThrPhe: 1.804 ± 0.047	4.714ThrGly: 4.714 ± 0.081	0.989ThrHis: 0.989 ± 0.029	2.156ThrIle: 2.156 ± 0.043	0.827ThrLys: 0.827 ± 0.025	6.046ThrLeu: 6.046 ± 0.08	0.918ThrMet: 0.918 ± 0.028	1.236ThrAsn: 1.236 ± 0.036	2.901ThrPro: 2.901 ± 0.047	1.38ThrGln: 1.38 ± 0.032	3.162ThrArg: 3.162 ± 0.051	2.698ThrSer: 2.698 ± 0.053	2.546ThrThr: 2.546 ± 0.053	4.009ThrVal: 4.009 ± 0.072	0.688ThrTrp: 0.688 ± 0.024	1.333ThrTyr: 1.333 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.157ValAla: 8.157 ± 0.091	0.744ValCys: 0.744 ± 0.021	4.676ValAsp: 4.676 ± 0.063	4.75ValGlu: 4.75 ± 0.066	2.626ValPhe: 2.626 ± 0.042	5.072ValGly: 5.072 ± 0.058	1.385ValHis: 1.385 ± 0.033	3.71ValIle: 3.71 ± 0.055	2.003ValLys: 2.003 ± 0.04	7.451ValLeu: 7.451 ± 0.081	1.627ValMet: 1.627 ± 0.035	2.441ValAsn: 2.441 ± 0.048	3.405ValPro: 3.405 ± 0.056	2.456ValGln: 2.456 ± 0.046	4.123ValArg: 4.123 ± 0.062	4.585ValSer: 4.585 ± 0.07	3.925ValThr: 3.925 ± 0.066	5.687ValVal: 5.687 ± 0.085	0.81ValTrp: 0.81 ± 0.025	1.823ValTyr: 1.823 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.094TrpAla: 1.094 ± 0.03	0.174TrpCys: 0.174 ± 0.011	0.758TrpAsp: 0.758 ± 0.026	0.711TrpGlu: 0.711 ± 0.023	0.532TrpPhe: 0.532 ± 0.02	0.958TrpGly: 0.958 ± 0.03	0.355TrpHis: 0.355 ± 0.017	0.601TrpIle: 0.601 ± 0.023	0.359TrpLys: 0.359 ± 0.017	1.955TrpLeu: 1.955 ± 0.047	0.349TrpMet: 0.349 ± 0.015	0.442TrpAsn: 0.442 ± 0.019	0.659TrpPro: 0.659 ± 0.023	1.001TrpGln: 1.001 ± 0.03	1.193TrpArg: 1.193 ± 0.032	0.835TrpSer: 0.835 ± 0.027	0.587TrpThr: 0.587 ± 0.021	0.903TrpVal: 0.903 ± 0.026	0.226TrpTrp: 0.226 ± 0.015	0.407TrpTyr: 0.407 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.621TyrAla: 2.621 ± 0.048	0.345TyrCys: 0.345 ± 0.016	1.608TyrAsp: 1.608 ± 0.042	1.426TyrGlu: 1.426 ± 0.035	1.176TyrPhe: 1.176 ± 0.032	2.257TyrGly: 2.257 ± 0.042	0.655TyrHis: 0.655 ± 0.022	1.138TyrIle: 1.138 ± 0.028	0.669TyrLys: 0.669 ± 0.026	3.157TyrLeu: 3.157 ± 0.047	0.535TyrMet: 0.535 ± 0.019	0.923TyrAsn: 0.923 ± 0.029	1.368TyrPro: 1.368 ± 0.034	1.289TyrGln: 1.289 ± 0.031	2.505TyrArg: 2.505 ± 0.044	1.798TyrSer: 1.798 ± 0.044	1.491TyrThr: 1.491 ± 0.039	1.635TyrVal: 1.635 ± 0.041	0.432TyrTrp: 0.432 ± 0.018	0.945TyrTyr: 0.945 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3815 proteins (1363449 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---