Amino acid dipepetide frequency for Mycobacteriaceae bacterium 1482268.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.066AlaAla: 19.066 ± 0.179	1.012AlaCys: 1.012 ± 0.028	8.369AlaAsp: 8.369 ± 0.074	7.654AlaGlu: 7.654 ± 0.088	3.553AlaPhe: 3.553 ± 0.052	11.11AlaGly: 11.11 ± 0.101	2.426AlaHis: 2.426 ± 0.038	5.425AlaIle: 5.425 ± 0.068	3.356AlaLys: 3.356 ± 0.064	12.481AlaLeu: 12.481 ± 0.103	2.978AlaMet: 2.978 ± 0.049	2.721AlaAsn: 2.721 ± 0.045	6.075AlaPro: 6.075 ± 0.096	3.842AlaGln: 3.842 ± 0.058	8.216AlaArg: 8.216 ± 0.078	6.102AlaSer: 6.102 ± 0.067	7.023AlaThr: 7.023 ± 0.075	11.433AlaVal: 11.433 ± 0.096	1.605AlaTrp: 1.605 ± 0.037	2.337AlaTyr: 2.337 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.05CysAla: 1.05 ± 0.027	0.09CysCys: 0.09 ± 0.008	0.567CysAsp: 0.567 ± 0.019	0.447CysGlu: 0.447 ± 0.017	0.228CysPhe: 0.228 ± 0.014	0.93CysGly: 0.93 ± 0.025	0.201CysHis: 0.201 ± 0.012	0.29CysIle: 0.29 ± 0.015	0.154CysLys: 0.154 ± 0.011	0.679CysLeu: 0.679 ± 0.019	0.143CysMet: 0.143 ± 0.011	0.176CysAsn: 0.176 ± 0.012	0.511CysPro: 0.511 ± 0.023	0.215CysGln: 0.215 ± 0.012	0.576CysArg: 0.576 ± 0.021	0.463CysSer: 0.463 ± 0.02	0.477CysThr: 0.477 ± 0.02	0.672CysVal: 0.672 ± 0.019	0.118CysTrp: 0.118 ± 0.009	0.201CysTyr: 0.201 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.76AspAla: 7.76 ± 0.075	0.471AspCys: 0.471 ± 0.017	4.786AspAsp: 4.786 ± 0.067	4.412AspGlu: 4.412 ± 0.066	1.892AspPhe: 1.892 ± 0.029	5.934AspGly: 5.934 ± 0.078	1.412AspHis: 1.412 ± 0.034	2.855AspIle: 2.855 ± 0.042	1.554AspLys: 1.554 ± 0.035	6.047AspLeu: 6.047 ± 0.068	1.105AspMet: 1.105 ± 0.027	1.371AspAsn: 1.371 ± 0.034	4.284AspPro: 4.284 ± 0.058	1.714AspGln: 1.714 ± 0.035	4.556AspArg: 4.556 ± 0.061	2.872AspSer: 2.872 ± 0.037	3.182AspThr: 3.182 ± 0.045	5.568AspVal: 5.568 ± 0.059	1.023AspTrp: 1.023 ± 0.029	1.485AspTyr: 1.485 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.263GluAla: 6.263 ± 0.086	0.382GluCys: 0.382 ± 0.017	2.595GluAsp: 2.595 ± 0.047	2.75GluGlu: 2.75 ± 0.053	1.947GluPhe: 1.947 ± 0.036	3.534GluGly: 3.534 ± 0.053	1.561GluHis: 1.561 ± 0.035	2.755GluIle: 2.755 ± 0.043	1.643GluLys: 1.643 ± 0.043	6.621GluLeu: 6.621 ± 0.08	1.166GluMet: 1.166 ± 0.029	1.206GluAsn: 1.206 ± 0.031	3.092GluPro: 3.092 ± 0.059	2.212GluGln: 2.212 ± 0.041	4.47GluArg: 4.47 ± 0.066	2.745GluSer: 2.745 ± 0.048	2.776GluThr: 2.776 ± 0.047	4.495GluVal: 4.495 ± 0.056	0.768GluTrp: 0.768 ± 0.022	1.177GluTyr: 1.177 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.003PheAla: 4.003 ± 0.057	0.343PheCys: 0.343 ± 0.015	2.603PheAsp: 2.603 ± 0.049	1.676PheGlu: 1.676 ± 0.034	1.049PhePhe: 1.049 ± 0.027	3.511PheGly: 3.511 ± 0.054	0.635PheHis: 0.635 ± 0.022	1.19PheIle: 1.19 ± 0.031	0.617PheLys: 0.617 ± 0.019	2.532PheLeu: 2.532 ± 0.043	0.531PheMet: 0.531 ± 0.021	0.853PheAsn: 0.853 ± 0.025	1.471PhePro: 1.471 ± 0.034	0.685PheGln: 0.685 ± 0.021	1.758PheArg: 1.758 ± 0.037	1.765PheSer: 1.765 ± 0.034	2.155PheThr: 2.155 ± 0.036	2.706PheVal: 2.706 ± 0.042	0.467PheTrp: 0.467 ± 0.017	0.751PheTyr: 0.751 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.714GlyAla: 9.714 ± 0.087	0.802GlyCys: 0.802 ± 0.023	5.097GlyAsp: 5.097 ± 0.059	4.453GlyGlu: 4.453 ± 0.059	3.096GlyPhe: 3.096 ± 0.044	7.603GlyGly: 7.603 ± 0.097	1.993GlyHis: 1.993 ± 0.04	4.198GlyIle: 4.198 ± 0.059	2.43GlyLys: 2.43 ± 0.049	8.365GlyLeu: 8.365 ± 0.081	2.142GlyMet: 2.142 ± 0.038	1.974GlyAsn: 1.974 ± 0.046	4.376GlyPro: 4.376 ± 0.057	2.747GlyGln: 2.747 ± 0.046	6.042GlyArg: 6.042 ± 0.069	5.047GlySer: 5.047 ± 0.066	5.059GlyThr: 5.059 ± 0.065	7.637GlyVal: 7.637 ± 0.069	1.649GlyTrp: 1.649 ± 0.035	2.396GlyTyr: 2.396 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.371HisAla: 2.371 ± 0.039	0.201HisCys: 0.201 ± 0.011	1.334HisAsp: 1.334 ± 0.031	1.114HisGlu: 1.114 ± 0.029	0.728HisPhe: 0.728 ± 0.023	2.043HisGly: 2.043 ± 0.036	0.668HisHis: 0.668 ± 0.022	0.935HisIle: 0.935 ± 0.028	0.397HisLys: 0.397 ± 0.018	2.072HisLeu: 2.072 ± 0.036	0.36HisMet: 0.36 ± 0.016	0.508HisAsn: 0.508 ± 0.02	1.629HisPro: 1.629 ± 0.036	0.628HisGln: 0.628 ± 0.022	1.828HisArg: 1.828 ± 0.035	1.145HisSer: 1.145 ± 0.033	1.202HisThr: 1.202 ± 0.03	1.775HisVal: 1.775 ± 0.036	0.401HisTrp: 0.401 ± 0.017	0.547HisTyr: 0.547 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.588IleAla: 6.588 ± 0.079	0.41IleCys: 0.41 ± 0.017	3.593IleAsp: 3.593 ± 0.053	2.85IleGlu: 2.85 ± 0.051	1.131IlePhe: 1.131 ± 0.03	4.6IleGly: 4.6 ± 0.059	0.803IleHis: 0.803 ± 0.022	1.612IleIle: 1.612 ± 0.036	1.04IleLys: 1.04 ± 0.027	3.145IleLeu: 3.145 ± 0.05	0.619IleMet: 0.619 ± 0.023	1.234IleAsn: 1.234 ± 0.028	2.489IlePro: 2.489 ± 0.041	1.018IleGln: 1.018 ± 0.028	2.736IleArg: 2.736 ± 0.038	2.342IleSer: 2.342 ± 0.042	2.788IleThr: 2.788 ± 0.043	3.916IleVal: 3.916 ± 0.051	0.521IleTrp: 0.521 ± 0.019	0.855IleTyr: 0.855 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.044LysAla: 3.044 ± 0.055	0.137LysCys: 0.137 ± 0.011	1.315LysAsp: 1.315 ± 0.032	1.19LysGlu: 1.19 ± 0.033	0.7LysPhe: 0.7 ± 0.025	1.784LysGly: 1.784 ± 0.042	0.577LysHis: 0.577 ± 0.023	1.134LysIle: 1.134 ± 0.03	0.828LysLys: 0.828 ± 0.034	2.463LysLeu: 2.463 ± 0.046	0.553LysMet: 0.553 ± 0.018	0.613LysAsn: 0.613 ± 0.022	1.688LysPro: 1.688 ± 0.034	0.807LysGln: 0.807 ± 0.024	1.895LysArg: 1.895 ± 0.037	1.404LysSer: 1.404 ± 0.027	1.534LysThr: 1.534 ± 0.032	2.138LysVal: 2.138 ± 0.048	0.35LysTrp: 0.35 ± 0.014	0.513LysTyr: 0.513 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.444LeuAla: 13.444 ± 0.111	0.796LeuCys: 0.796 ± 0.022	6.352LeuAsp: 6.352 ± 0.073	4.567LeuGlu: 4.567 ± 0.062	2.753LeuPhe: 2.753 ± 0.049	8.328LeuGly: 8.328 ± 0.078	2.023LeuHis: 2.023 ± 0.039	4.308LeuIle: 4.308 ± 0.06	2.111LeuLys: 2.111 ± 0.044	9.331LeuLeu: 9.331 ± 0.11	1.831LeuMet: 1.831 ± 0.036	2.277LeuAsn: 2.277 ± 0.046	5.63LeuPro: 5.63 ± 0.057	2.522LeuGln: 2.522 ± 0.042	7.335LeuArg: 7.335 ± 0.071	5.643LeuSer: 5.643 ± 0.068	6.146LeuThr: 6.146 ± 0.06	8.321LeuVal: 8.321 ± 0.085	1.211LeuTrp: 1.211 ± 0.035	1.724LeuTyr: 1.724 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.744MetAla: 2.744 ± 0.044	0.202MetCys: 0.202 ± 0.013	0.914MetAsp: 0.914 ± 0.024	0.77MetGlu: 0.77 ± 0.024	0.666MetPhe: 0.666 ± 0.023	1.561MetGly: 1.561 ± 0.036	0.469MetHis: 0.469 ± 0.019	0.932MetIle: 0.932 ± 0.024	0.525MetLys: 0.525 ± 0.019	2.112MetLeu: 2.112 ± 0.037	0.446MetMet: 0.446 ± 0.018	0.541MetAsn: 0.541 ± 0.018	1.293MetPro: 1.293 ± 0.031	0.568MetGln: 0.568 ± 0.019	1.656MetArg: 1.656 ± 0.031	1.578MetSer: 1.578 ± 0.036	1.936MetThr: 1.936 ± 0.036	1.707MetVal: 1.707 ± 0.033	0.287MetTrp: 0.287 ± 0.013	0.344MetTyr: 0.344 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.807AsnAla: 2.807 ± 0.048	0.206AsnCys: 0.206 ± 0.013	1.364AsnAsp: 1.364 ± 0.034	1.135AsnGlu: 1.135 ± 0.031	0.671AsnPhe: 0.671 ± 0.021	2.247AsnGly: 2.247 ± 0.044	0.5AsnHis: 0.5 ± 0.02	1.021AsnIle: 1.021 ± 0.028	0.611AsnLys: 0.611 ± 0.02	2.138AsnLeu: 2.138 ± 0.038	0.476AsnMet: 0.476 ± 0.019	0.699AsnAsn: 0.699 ± 0.034	1.85AsnPro: 1.85 ± 0.04	0.689AsnGln: 0.689 ± 0.021	1.639AsnArg: 1.639 ± 0.037	1.231AsnSer: 1.231 ± 0.031	1.423AsnThr: 1.423 ± 0.041	1.897AsnVal: 1.897 ± 0.036	0.419AsnTrp: 0.419 ± 0.019	0.622AsnTyr: 0.622 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.887ProAla: 6.887 ± 0.097	0.303ProCys: 0.303 ± 0.017	4.501ProAsp: 4.501 ± 0.054	3.587ProGlu: 3.587 ± 0.044	1.698ProPhe: 1.698 ± 0.04	5.349ProGly: 5.349 ± 0.063	1.232ProHis: 1.232 ± 0.031	2.243ProIle: 2.243 ± 0.047	1.501ProLys: 1.501 ± 0.037	4.887ProLeu: 4.887 ± 0.064	1.26ProMet: 1.26 ± 0.028	1.406ProAsn: 1.406 ± 0.035	3.817ProPro: 3.817 ± 0.091	1.891ProGln: 1.891 ± 0.039	3.277ProArg: 3.277 ± 0.049	3.177ProSer: 3.177 ± 0.055	3.396ProThr: 3.396 ± 0.049	5.031ProVal: 5.031 ± 0.063	0.842ProTrp: 0.842 ± 0.027	1.231ProTyr: 1.231 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.506GlnAla: 3.506 ± 0.054	0.238GlnCys: 0.238 ± 0.013	1.196GlnAsp: 1.196 ± 0.028	1.213GlnGlu: 1.213 ± 0.028	1.029GlnPhe: 1.029 ± 0.025	1.926GlnGly: 1.926 ± 0.038	0.761GlnHis: 0.761 ± 0.022	1.511GlnIle: 1.511 ± 0.031	0.741GlnLys: 0.741 ± 0.024	3.467GlnLeu: 3.467 ± 0.051	0.757GlnMet: 0.757 ± 0.022	0.667GlnAsn: 0.667 ± 0.021	1.917GlnPro: 1.917 ± 0.043	1.349GlnGln: 1.349 ± 0.041	2.77GlnArg: 2.77 ± 0.045	1.502GlnSer: 1.502 ± 0.032	1.591GlnThr: 1.591 ± 0.036	2.346GlnVal: 2.346 ± 0.048	0.609GlnTrp: 0.609 ± 0.02	0.671GlnTyr: 0.671 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.844ArgAla: 7.844 ± 0.097	0.586ArgCys: 0.586 ± 0.019	4.355ArgAsp: 4.355 ± 0.062	3.911ArgGlu: 3.911 ± 0.058	2.507ArgPhe: 2.507 ± 0.037	5.079ArgGly: 5.079 ± 0.061	1.644ArgHis: 1.644 ± 0.034	3.512ArgIle: 3.512 ± 0.046	1.735ArgLys: 1.735 ± 0.04	7.428ArgLeu: 7.428 ± 0.093	1.811ArgMet: 1.811 ± 0.03	1.711ArgAsn: 1.711 ± 0.032	3.818ArgPro: 3.818 ± 0.055	2.331ArgGln: 2.331 ± 0.047	6.409ArgArg: 6.409 ± 0.089	3.928ArgSer: 3.928 ± 0.059	3.998ArgThr: 3.998 ± 0.058	5.422ArgVal: 5.422 ± 0.064	1.337ArgTrp: 1.337 ± 0.033	1.911ArgTyr: 1.911 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.867SerAla: 6.867 ± 0.073	0.434SerCys: 0.434 ± 0.019	3.477SerAsp: 3.477 ± 0.049	2.768SerGlu: 2.768 ± 0.047	1.701SerPhe: 1.701 ± 0.034	5.472SerGly: 5.472 ± 0.066	1.099SerHis: 1.099 ± 0.028	2.318SerIle: 2.318 ± 0.043	1.253SerLys: 1.253 ± 0.031	4.801SerLeu: 4.801 ± 0.057	1.403SerMet: 1.403 ± 0.032	1.188SerAsn: 1.188 ± 0.032	3.05SerPro: 3.05 ± 0.043	1.569SerGln: 1.569 ± 0.034	3.775SerArg: 3.775 ± 0.049	3.213SerSer: 3.213 ± 0.044	3.316SerThr: 3.316 ± 0.051	4.481SerVal: 4.481 ± 0.052	0.885SerTrp: 0.885 ± 0.024	1.23SerTyr: 1.23 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.615ThrAla: 7.615 ± 0.081	0.428ThrCys: 0.428 ± 0.018	3.753ThrAsp: 3.753 ± 0.05	3.127ThrGlu: 3.127 ± 0.054	1.909ThrPhe: 1.909 ± 0.032	5.528ThrGly: 5.528 ± 0.07	1.18ThrHis: 1.18 ± 0.025	2.483ThrIle: 2.483 ± 0.042	1.447ThrLys: 1.447 ± 0.033	5.491ThrLeu: 5.491 ± 0.059	1.287ThrMet: 1.287 ± 0.028	1.373ThrAsn: 1.373 ± 0.04	3.683ThrPro: 3.683 ± 0.062	1.53ThrGln: 1.53 ± 0.03	3.514ThrArg: 3.514 ± 0.05	3.292ThrSer: 3.292 ± 0.05	3.885ThrThr: 3.885 ± 0.067	5.723ThrVal: 5.723 ± 0.064	0.867ThrTrp: 0.867 ± 0.025	1.355ThrTyr: 1.355 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.256ValAla: 11.256 ± 0.107	0.72ValCys: 0.72 ± 0.027	5.839ValAsp: 5.839 ± 0.071	4.693ValGlu: 4.693 ± 0.062	2.673ValPhe: 2.673 ± 0.041	7.153ValGly: 7.153 ± 0.075	1.839ValHis: 1.839 ± 0.038	4.133ValIle: 4.133 ± 0.051	1.917ValLys: 1.917 ± 0.039	8.618ValLeu: 8.618 ± 0.079	1.668ValMet: 1.668 ± 0.034	2.206ValAsn: 2.206 ± 0.033	4.664ValPro: 4.664 ± 0.063	2.125ValGln: 2.125 ± 0.041	5.673ValArg: 5.673 ± 0.065	4.758ValSer: 4.758 ± 0.059	5.467ValThr: 5.467 ± 0.071	8.565ValVal: 8.565 ± 0.087	1.06ValTrp: 1.06 ± 0.025	1.651ValTyr: 1.651 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.528TrpAla: 1.528 ± 0.036	0.181TrpCys: 0.181 ± 0.012	0.835TrpAsp: 0.835 ± 0.025	0.671TrpGlu: 0.671 ± 0.02	0.531TrpPhe: 0.531 ± 0.02	1.037TrpGly: 1.037 ± 0.026	0.389TrpHis: 0.389 ± 0.015	0.666TrpIle: 0.666 ± 0.022	0.342TrpLys: 0.342 ± 0.017	1.717TrpLeu: 1.717 ± 0.04	0.357TrpMet: 0.357 ± 0.015	0.415TrpAsn: 0.415 ± 0.018	0.866TrpPro: 0.866 ± 0.027	0.625TrpGln: 0.625 ± 0.021	1.281TrpArg: 1.281 ± 0.034	0.922TrpSer: 0.922 ± 0.023	0.918TrpThr: 0.918 ± 0.026	1.151TrpVal: 1.151 ± 0.028	0.362TrpTrp: 0.362 ± 0.017	0.36TrpTyr: 0.36 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.428TyrAla: 2.428 ± 0.043	0.246TyrCys: 0.246 ± 0.014	1.435TyrAsp: 1.435 ± 0.031	1.171TyrGlu: 1.171 ± 0.029	0.842TyrPhe: 0.842 ± 0.023	2.088TyrGly: 2.088 ± 0.039	0.474TyrHis: 0.474 ± 0.017	0.771TyrIle: 0.771 ± 0.024	0.465TyrLys: 0.465 ± 0.02	2.259TyrLeu: 2.259 ± 0.041	0.355TyrMet: 0.355 ± 0.015	0.505TyrAsn: 0.505 ± 0.017	1.314TyrPro: 1.314 ± 0.033	0.697TyrGln: 0.697 ± 0.022	1.87TyrArg: 1.87 ± 0.037	1.17TyrSer: 1.17 ± 0.028	1.198TyrThr: 1.198 ± 0.029	1.697TyrVal: 1.697 ± 0.036	0.374TyrTrp: 0.374 ± 0.019	0.55TyrTyr: 0.55 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4776 proteins (1485318 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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