Amino acid dipepetide frequency for Rhizorhabdus dicambivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.388AlaAla: 19.388 ± 0.15	1.091AlaCys: 1.091 ± 0.03	7.71AlaAsp: 7.71 ± 0.077	7.863AlaGlu: 7.863 ± 0.088	4.336AlaPhe: 4.336 ± 0.057	11.627AlaGly: 11.627 ± 0.099	2.324AlaHis: 2.324 ± 0.043	7.148AlaIle: 7.148 ± 0.081	3.924AlaLys: 3.924 ± 0.063	13.594AlaLeu: 13.594 ± 0.119	3.904AlaMet: 3.904 ± 0.056	2.978AlaAsn: 2.978 ± 0.054	6.313AlaPro: 6.313 ± 0.083	4.234AlaGln: 4.234 ± 0.062	10.206AlaArg: 10.206 ± 0.1	6.412AlaSer: 6.412 ± 0.07	6.379AlaThr: 6.379 ± 0.065	8.475AlaVal: 8.475 ± 0.075	1.675AlaTrp: 1.675 ± 0.033	2.693AlaTyr: 2.693 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.008CysAla: 1.008 ± 0.028	0.104CysCys: 0.104 ± 0.009	0.539CysAsp: 0.539 ± 0.02	0.416CysGlu: 0.416 ± 0.017	0.322CysPhe: 0.322 ± 0.015	0.896CysGly: 0.896 ± 0.026	0.254CysHis: 0.254 ± 0.017	0.395CysIle: 0.395 ± 0.015	0.156CysLys: 0.156 ± 0.009	0.742CysLeu: 0.742 ± 0.023	0.165CysMet: 0.165 ± 0.011	0.182CysAsn: 0.182 ± 0.01	0.48CysPro: 0.48 ± 0.02	0.216CysGln: 0.216 ± 0.011	0.624CysArg: 0.624 ± 0.02	0.478CysSer: 0.478 ± 0.017	0.388CysThr: 0.388 ± 0.015	0.56CysVal: 0.56 ± 0.02	0.134CysTrp: 0.134 ± 0.01	0.186CysTyr: 0.186 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.269AspAla: 7.269 ± 0.079	0.494AspCys: 0.494 ± 0.02	3.291AspAsp: 3.291 ± 0.054	3.416AspGlu: 3.416 ± 0.053	2.173AspPhe: 2.173 ± 0.039	5.678AspGly: 5.678 ± 0.073	1.461AspHis: 1.461 ± 0.031	3.185AspIle: 3.185 ± 0.046	1.593AspLys: 1.593 ± 0.03	5.849AspLeu: 5.849 ± 0.06	1.451AspMet: 1.451 ± 0.027	1.238AspAsn: 1.238 ± 0.032	3.933AspPro: 3.933 ± 0.055	1.812AspGln: 1.812 ± 0.037	5.353AspArg: 5.353 ± 0.071	2.383AspSer: 2.383 ± 0.046	2.276AspThr: 2.276 ± 0.048	3.974AspVal: 3.974 ± 0.05	1.062AspTrp: 1.062 ± 0.033	1.684AspTyr: 1.684 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.971GluAla: 7.971 ± 0.09	0.321GluCys: 0.321 ± 0.015	2.665GluAsp: 2.665 ± 0.048	3.098GluGlu: 3.098 ± 0.056	1.41GluPhe: 1.41 ± 0.031	4.553GluGly: 4.553 ± 0.06	1.229GluHis: 1.229 ± 0.029	3.086GluIle: 3.086 ± 0.048	1.952GluLys: 1.952 ± 0.041	5.278GluLeu: 5.278 ± 0.071	1.43GluMet: 1.43 ± 0.035	1.244GluAsn: 1.244 ± 0.035	2.667GluPro: 2.667 ± 0.041	2.15GluGln: 2.15 ± 0.043	5.147GluArg: 5.147 ± 0.067	2.166GluSer: 2.166 ± 0.038	2.997GluThr: 2.997 ± 0.049	3.446GluVal: 3.446 ± 0.056	0.713GluTrp: 0.713 ± 0.022	0.914GluTyr: 0.914 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.769PheAla: 4.769 ± 0.059	0.33PheCys: 0.33 ± 0.017	2.705PheAsp: 2.705 ± 0.04	2.075PheGlu: 2.075 ± 0.041	1.263PhePhe: 1.263 ± 0.035	3.661PheGly: 3.661 ± 0.054	0.775PheHis: 0.775 ± 0.023	1.439PheIle: 1.439 ± 0.029	0.85PheLys: 0.85 ± 0.026	3.098PheLeu: 3.098 ± 0.053	0.732PheMet: 0.732 ± 0.023	1.012PheAsn: 1.012 ± 0.024	1.515PhePro: 1.515 ± 0.032	0.914PheGln: 0.914 ± 0.023	2.348PheArg: 2.348 ± 0.04	1.993PheSer: 1.993 ± 0.037	1.96PheThr: 1.96 ± 0.037	2.5PheVal: 2.5 ± 0.044	0.485PheTrp: 0.485 ± 0.018	0.864PheTyr: 0.864 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.033GlyAla: 10.033 ± 0.103	0.865GlyCys: 0.865 ± 0.024	5.018GlyAsp: 5.018 ± 0.073	4.822GlyGlu: 4.822 ± 0.062	3.666GlyPhe: 3.666 ± 0.045	8.409GlyGly: 8.409 ± 0.225	1.984GlyHis: 1.984 ± 0.035	4.64GlyIle: 4.64 ± 0.057	3.076GlyLys: 3.076 ± 0.051	9.053GlyLeu: 9.053 ± 0.082	2.33GlyMet: 2.33 ± 0.045	2.263GlyAsn: 2.263 ± 0.068	3.822GlyPro: 3.822 ± 0.053	3.06GlyGln: 3.06 ± 0.055	7.229GlyArg: 7.229 ± 0.069	5.01GlySer: 5.01 ± 0.085	4.595GlyThr: 4.595 ± 0.075	6.1GlyVal: 6.1 ± 0.069	1.668GlyTrp: 1.668 ± 0.041	2.376GlyTyr: 2.376 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.394HisAla: 2.394 ± 0.042	0.252HisCys: 0.252 ± 0.011	1.261HisAsp: 1.261 ± 0.029	0.998HisGlu: 0.998 ± 0.026	0.824HisPhe: 0.824 ± 0.023	2.111HisGly: 2.111 ± 0.039	0.577HisHis: 0.577 ± 0.023	1.0HisIle: 1.0 ± 0.026	0.434HisLys: 0.434 ± 0.018	1.99HisLeu: 1.99 ± 0.037	0.516HisMet: 0.516 ± 0.021	0.457HisAsn: 0.457 ± 0.016	1.332HisPro: 1.332 ± 0.033	0.572HisGln: 0.572 ± 0.02	1.612HisArg: 1.612 ± 0.037	0.999HisSer: 0.999 ± 0.027	0.613HisThr: 0.613 ± 0.017	1.559HisVal: 1.559 ± 0.032	0.378HisTrp: 0.378 ± 0.019	0.608HisTyr: 0.608 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.107IleAla: 8.107 ± 0.073	0.466IleCys: 0.466 ± 0.016	4.248IleAsp: 4.248 ± 0.054	3.846IleGlu: 3.846 ± 0.054	1.682IlePhe: 1.682 ± 0.034	5.413IleGly: 5.413 ± 0.064	0.962IleHis: 0.962 ± 0.026	2.18IleIle: 2.18 ± 0.038	1.185IleLys: 1.185 ± 0.032	4.301IleLeu: 4.301 ± 0.058	0.921IleMet: 0.921 ± 0.025	1.366IleAsn: 1.366 ± 0.035	2.302IlePro: 2.302 ± 0.046	1.282IleGln: 1.282 ± 0.027	3.51IleArg: 3.51 ± 0.045	2.87IleSer: 2.87 ± 0.045	2.49IleThr: 2.49 ± 0.048	4.227IleVal: 4.227 ± 0.054	0.598IleTrp: 0.598 ± 0.019	1.016IleTyr: 1.016 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.068LysAla: 4.068 ± 0.062	0.148LysCys: 0.148 ± 0.01	1.437LysAsp: 1.437 ± 0.032	1.207LysGlu: 1.207 ± 0.031	0.721LysPhe: 0.721 ± 0.022	2.634LysGly: 2.634 ± 0.049	0.498LysHis: 0.498 ± 0.019	1.493LysIle: 1.493 ± 0.034	1.02LysLys: 1.02 ± 0.03	3.195LysLeu: 3.195 ± 0.051	0.698LysMet: 0.698 ± 0.022	0.669LysAsn: 0.669 ± 0.023	1.982LysPro: 1.982 ± 0.039	0.854LysGln: 0.854 ± 0.025	2.252LysArg: 2.252 ± 0.046	1.498LysSer: 1.498 ± 0.036	1.507LysThr: 1.507 ± 0.037	2.147LysVal: 2.147 ± 0.045	0.345LysTrp: 0.345 ± 0.016	0.552LysTyr: 0.552 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.92LeuAla: 13.92 ± 0.108	0.875LeuCys: 0.875 ± 0.027	6.332LeuAsp: 6.332 ± 0.06	4.745LeuGlu: 4.745 ± 0.064	3.698LeuPhe: 3.698 ± 0.055	8.596LeuGly: 8.596 ± 0.084	1.85LeuHis: 1.85 ± 0.037	5.318LeuIle: 5.318 ± 0.067	3.061LeuLys: 3.061 ± 0.048	9.836LeuLeu: 9.836 ± 0.118	2.087LeuMet: 2.087 ± 0.044	2.369LeuAsn: 2.369 ± 0.043	5.488LeuPro: 5.488 ± 0.058	2.473LeuGln: 2.473 ± 0.043	7.146LeuArg: 7.146 ± 0.066	6.119LeuSer: 6.119 ± 0.066	5.32LeuThr: 5.32 ± 0.065	6.997LeuVal: 6.997 ± 0.075	1.266LeuTrp: 1.266 ± 0.03	1.953LeuTyr: 1.953 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.362MetAla: 3.362 ± 0.054	0.158MetCys: 0.158 ± 0.01	1.063MetAsp: 1.063 ± 0.027	1.083MetGlu: 1.083 ± 0.031	0.71MetPhe: 0.71 ± 0.02	1.911MetGly: 1.911 ± 0.041	0.434MetHis: 0.434 ± 0.017	1.508MetIle: 1.508 ± 0.033	0.891MetLys: 0.891 ± 0.029	2.675MetLeu: 2.675 ± 0.048	0.716MetMet: 0.716 ± 0.026	0.626MetAsn: 0.626 ± 0.02	1.459MetPro: 1.459 ± 0.034	0.686MetGln: 0.686 ± 0.021	1.889MetArg: 1.889 ± 0.034	1.568MetSer: 1.568 ± 0.033	1.631MetThr: 1.631 ± 0.036	1.592MetVal: 1.592 ± 0.033	0.237MetTrp: 0.237 ± 0.015	0.262MetTyr: 0.262 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.069AsnAla: 3.069 ± 0.049	0.217AsnCys: 0.217 ± 0.012	1.354AsnAsp: 1.354 ± 0.036	1.135AsnGlu: 1.135 ± 0.028	0.93AsnPhe: 0.93 ± 0.031	2.295AsnGly: 2.295 ± 0.067	0.491AsnHis: 0.491 ± 0.017	1.362AsnIle: 1.362 ± 0.031	0.586AsnLys: 0.586 ± 0.022	2.425AsnLeu: 2.425 ± 0.042	0.595AsnMet: 0.595 ± 0.019	0.67AsnAsn: 0.67 ± 0.023	1.679AsnPro: 1.679 ± 0.032	0.732AsnGln: 0.732 ± 0.022	1.898AsnArg: 1.898 ± 0.04	1.253AsnSer: 1.253 ± 0.033	0.954AsnThr: 0.954 ± 0.029	1.814AsnVal: 1.814 ± 0.039	0.413AsnTrp: 0.413 ± 0.016	0.672AsnTyr: 0.672 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.202ProAla: 7.202 ± 0.087	0.341ProCys: 0.341 ± 0.015	3.772ProAsp: 3.772 ± 0.049	3.35ProGlu: 3.35 ± 0.045	1.916ProPhe: 1.916 ± 0.033	4.926ProGly: 4.926 ± 0.062	1.049ProHis: 1.049 ± 0.029	2.726ProIle: 2.726 ± 0.043	1.505ProLys: 1.505 ± 0.036	5.003ProLeu: 5.003 ± 0.062	1.218ProMet: 1.218 ± 0.03	1.278ProAsn: 1.278 ± 0.03	3.018ProPro: 3.018 ± 0.095	1.613ProGln: 1.613 ± 0.031	3.29ProArg: 3.29 ± 0.052	2.824ProSer: 2.824 ± 0.047	2.54ProThr: 2.54 ± 0.044	4.15ProVal: 4.15 ± 0.059	0.677ProTrp: 0.677 ± 0.02	1.095ProTyr: 1.095 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.199GlnAla: 4.199 ± 0.055	0.208GlnCys: 0.208 ± 0.01	1.386GlnAsp: 1.386 ± 0.033	1.249GlnGlu: 1.249 ± 0.033	1.072GlnPhe: 1.072 ± 0.029	2.588GlnGly: 2.588 ± 0.041	0.614GlnHis: 0.614 ± 0.02	1.744GlnIle: 1.744 ± 0.038	0.888GlnLys: 0.888 ± 0.023	3.088GlnLeu: 3.088 ± 0.05	0.786GlnMet: 0.786 ± 0.025	0.768GlnAsn: 0.768 ± 0.026	1.771GlnPro: 1.771 ± 0.036	1.112GlnGln: 1.112 ± 0.035	2.57GlnArg: 2.57 ± 0.048	1.681GlnSer: 1.681 ± 0.034	1.531GlnThr: 1.531 ± 0.036	2.096GlnVal: 2.096 ± 0.045	0.425GlnTrp: 0.425 ± 0.019	0.6GlnTyr: 0.6 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.256ArgAla: 9.256 ± 0.089	0.612ArgCys: 0.612 ± 0.021	4.488ArgAsp: 4.488 ± 0.054	4.111ArgGlu: 4.111 ± 0.06	3.223ArgPhe: 3.223 ± 0.048	5.442ArgGly: 5.442 ± 0.066	1.851ArgHis: 1.851 ± 0.039	4.492ArgIle: 4.492 ± 0.062	2.153ArgLys: 2.153 ± 0.039	8.709ArgLeu: 8.709 ± 0.095	2.032ArgMet: 2.032 ± 0.039	1.909ArgAsn: 1.909 ± 0.039	4.098ArgPro: 4.098 ± 0.059	2.608ArgGln: 2.608 ± 0.046	6.384ArgArg: 6.384 ± 0.085	4.125ArgSer: 4.125 ± 0.063	3.664ArgThr: 3.664 ± 0.05	4.699ArgVal: 4.699 ± 0.063	1.265ArgTrp: 1.265 ± 0.031	2.003ArgTyr: 2.003 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.461SerAla: 6.461 ± 0.073	0.456SerCys: 0.456 ± 0.018	3.074SerAsp: 3.074 ± 0.038	2.575SerGlu: 2.575 ± 0.043	2.31SerPhe: 2.31 ± 0.04	5.414SerGly: 5.414 ± 0.075	1.019SerHis: 1.019 ± 0.026	2.897SerIle: 2.897 ± 0.048	1.402SerLys: 1.402 ± 0.034	5.252SerLeu: 5.252 ± 0.068	1.236SerMet: 1.236 ± 0.03	1.375SerAsn: 1.375 ± 0.034	2.901SerPro: 2.901 ± 0.051	1.517SerGln: 1.517 ± 0.028	3.766SerArg: 3.766 ± 0.043	2.858SerSer: 2.858 ± 0.056	2.58SerThr: 2.58 ± 0.05	3.69SerVal: 3.69 ± 0.047	0.797SerTrp: 0.797 ± 0.021	1.424SerTyr: 1.424 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.218ThrAla: 6.218 ± 0.063	0.372ThrCys: 0.372 ± 0.015	2.707ThrAsp: 2.707 ± 0.043	2.279ThrGlu: 2.279 ± 0.039	1.62ThrPhe: 1.62 ± 0.03	5.134ThrGly: 5.134 ± 0.077	0.898ThrHis: 0.898 ± 0.025	3.035ThrIle: 3.035 ± 0.051	1.246ThrLys: 1.246 ± 0.03	5.418ThrLeu: 5.418 ± 0.065	1.194ThrMet: 1.194 ± 0.028	1.234ThrAsn: 1.234 ± 0.03	3.172ThrPro: 3.172 ± 0.042	1.31ThrGln: 1.31 ± 0.03	3.311ThrArg: 3.311 ± 0.053	2.687ThrSer: 2.687 ± 0.045	2.549ThrThr: 2.549 ± 0.047	3.858ThrVal: 3.858 ± 0.054	0.507ThrTrp: 0.507 ± 0.015	1.085ThrTyr: 1.085 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.489ValAla: 9.489 ± 0.088	0.564ValCys: 0.564 ± 0.021	4.345ValAsp: 4.345 ± 0.051	4.408ValGlu: 4.408 ± 0.055	2.039ValPhe: 2.039 ± 0.038	5.522ValGly: 5.522 ± 0.065	1.359ValHis: 1.359 ± 0.03	3.691ValIle: 3.691 ± 0.057	1.948ValLys: 1.948 ± 0.044	6.08ValLeu: 6.08 ± 0.065	1.638ValMet: 1.638 ± 0.035	1.888ValAsn: 1.888 ± 0.039	3.816ValPro: 3.816 ± 0.057	1.968ValGln: 1.968 ± 0.039	5.286ValArg: 5.286 ± 0.057	3.984ValSer: 3.984 ± 0.061	4.144ValThr: 4.144 ± 0.061	4.972ValVal: 4.972 ± 0.062	0.759ValTrp: 0.759 ± 0.023	1.335ValTyr: 1.335 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.405TrpAla: 1.405 ± 0.036	0.134TrpCys: 0.134 ± 0.009	0.681TrpAsp: 0.681 ± 0.022	0.604TrpGlu: 0.604 ± 0.022	0.529TrpPhe: 0.529 ± 0.019	0.953TrpGly: 0.953 ± 0.03	0.341TrpHis: 0.341 ± 0.016	0.73TrpIle: 0.73 ± 0.025	0.482TrpLys: 0.482 ± 0.02	1.769TrpLeu: 1.769 ± 0.043	0.365TrpMet: 0.365 ± 0.014	0.447TrpAsn: 0.447 ± 0.018	0.713TrpPro: 0.713 ± 0.026	0.571TrpGln: 0.571 ± 0.02	1.318TrpArg: 1.318 ± 0.034	0.895TrpSer: 0.895 ± 0.022	0.77TrpThr: 0.77 ± 0.025	0.772TrpVal: 0.772 ± 0.026	0.226TrpTrp: 0.226 ± 0.013	0.277TrpTyr: 0.277 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.687TyrAla: 2.687 ± 0.053	0.24TyrCys: 0.24 ± 0.013	1.502TyrAsp: 1.502 ± 0.03	1.157TyrGlu: 1.157 ± 0.029	0.841TyrPhe: 0.841 ± 0.027	2.257TyrGly: 2.257 ± 0.037	0.515TyrHis: 0.515 ± 0.017	0.903TyrIle: 0.903 ± 0.025	0.571TyrLys: 0.571 ± 0.021	2.093TyrLeu: 2.093 ± 0.038	0.446TyrMet: 0.446 ± 0.019	0.571TyrAsn: 0.571 ± 0.019	1.033TyrPro: 1.033 ± 0.029	0.694TyrGln: 0.694 ± 0.02	1.985TyrArg: 1.985 ± 0.038	1.201TyrSer: 1.201 ± 0.03	0.946TyrThr: 0.946 ± 0.027	1.607TyrVal: 1.607 ± 0.031	0.354TyrTrp: 0.354 ± 0.016	0.67TyrTyr: 0.67 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4856 proteins (1542366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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